MBD4
label: MED1
label: UniProt:O95243 MBD4

CCNO
label: UniProt:P22674 CCNO

NTH1
label: NTHL1
label: OCTS3
label: UniProt:P78549 NTHL1

TDG
label: UniProt:Q13569 TDG

SMUG1
label: UniProt:Q53HV7 SMUG1

MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of thymine by MBD4 glycosylase
directly activates: Catalysis47

MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by MBD4 glycosylase
directly activates: Catalysis46

hNTH1 glycosylase mediated recognition and binding of cytosine glycol
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of cytosine glycol by hNTH1 glycosylase
directly activates: Catalysis43

hNTH1 glycosylase mediated recognition and binding of dihydrouracil
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of dihydrouracil by hNTH1 glycosylase
directly activates: Catalysis44

hNTH1 glycosylase mediated recognition and binding of formamidopyrimidine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of formamidopyrimidine by hNTH1 glycosylase
directly activates: Catalysis45

hNTH1 glycosylase mediated recognition and binding of thymine glycol
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of thymine glycol by hNTH1 glycosylase
directly activates: Catalysis42

Cleavage of uracil by UNG2 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: GO_0004844
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction118

Cleavage of 5-hydroxyluracil by UNG2 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: GO_0004844
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction118

Cleavage of uracil by TDG glycosylase
type: GO_0003674
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction119

Cleavage of thymine by TDG glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction119

Cleavage of uracil by hSMUG1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: GO_0017065
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction120

Cleavage of thymine glycol by hNTH1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction121

Cleavage of cytosine glycol by hNTH1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction121

Cleavage of dihydrouracil by hNTH1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction121

Cleavage of formamidopyrimidine by hNTH1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction121

Cleavage of uracil by MBD4 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction122

Cleavage of thymine by MBD4 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction122

Cleavage of ethenocytosine by TDG glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: BiochemicalReaction119

UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of 5-hydroxyluracil by UNG2 glycosylase
directly activates: Catalysis39

UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by UNG2 glycosylase
directly activates: Catalysis38

TDG glycosylase mediated recognition and binding of an ethenocytosine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of ethenocytosine by TDG glycosylase
directly activates: Catalysis48

TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: GO_0019104
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of thymine by TDG glycosylase
directly activates: Catalysis40

TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by TDG glycosylase

hSMUG1 glycosylase mediated recognition and binding of uracil within single-stranded DNA
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by hSMUG1 glycosylase
directly activates: Catalysis41

Depyrimidination
type: GO_0008150

Recognition and association of DNA glycosylase with site containing an affected pyrimidine
type: GO_0008150
BFO_0000050: Depyrimidination

Cleavage of the damaged pyrimidine
type: GO_0008150
BFO_0000050: Depyrimidination