MMH
label: MUTM
label: OGG1
label: OGH1
label: UniProt:O15527 OGG1

MBD4
label: MED1
label: UniProt:O95243 MBD4

POLB
label: UniProt:P06746 POLB

MGMT
label: UniProt:P16455 MGMT

LIG1
label: UniProt:P18858 LIG1

CCNO
label: UniProt:P22674 CCNO

APE
label: APE1
label: APEX
label: APEX1
label: APX
label: HAP1
label: REF1
label: UniProt:P27695 APEX1

AAG
label: ANPG
label: MID1
label: MPG
label: UniProt:P29372 MPG

FEN1
label: RAD2
label: UniProt:P39748 FEN1

LIG3
label: UniProt:P49916 LIG3

LIG4
label: UniProt:P49917 LIG4

HYRC
label: HYRC1
label: PRKDC
label: UniProt:P78527 PRKDC

NTH1
label: NTHL1
label: OCTS3
label: UniProt:P78549 NTHL1

ATM
label: UniProt:Q13315 ATM

TDG
label: UniProt:Q13569 TDG

SMUG1
label: UniProt:Q53HV7 SMUG1

ABH2
label: ALKBH2
label: UniProt:Q6NS38 ALKBH2

ABH3
label: ALKBH3
label: DEPC1
label: UniProt:Q96Q83 ALKBH3

MUTYH
label: MYH
label: UniProt:Q9UIF7 MUTYH

MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of thymine by MBD4 glycosylase
directly activates: Catalysis47

MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by MBD4 glycosylase
directly activates: Catalysis46

hNTH1 glycosylase mediated recognition and binding of cytosine glycol
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of cytosine glycol by hNTH1 glycosylase
directly activates: Catalysis43

hNTH1 glycosylase mediated recognition and binding of dihydrouracil
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of dihydrouracil by hNTH1 glycosylase
directly activates: Catalysis44

hNTH1 glycosylase mediated recognition and binding of formamidopyrimidine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of formamidopyrimidine by hNTH1 glycosylase
directly activates: Catalysis45

hNTH1 glycosylase mediated recognition and binding of thymine glycol
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of thymine glycol by hNTH1 glycosylase
directly activates: Catalysis42

Cleavage of uracil by UNG2 glycosylase
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: GO_0004844
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of UNG2 glycosylase by APE1 at the AP site

Cleavage of 5-hydroxyluracil by UNG2 glycosylase
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: GO_0004844
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of UNG2 glycosylase by APE1 at the AP site

Cleavage of uracil by TDG glycosylase
type: GO_0003674
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of TDG glycosylase by APE1 at the AP site

Cleavage of thymine by TDG glycosylase
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of TDG glycosylase by APE1 at the AP site

Cleavage of uracil by hSMUG1 glycosylase
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: GO_0017065
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of hSMUG1 glycosylase by APE1 at the AP site

Cleavage of thymine glycol by hNTH1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of hNTH1 glycosylase by APE1 at the AP site

Cleavage of cytosine glycol by hNTH1 glycosylase
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of hNTH1 glycosylase by APE1 at the AP site

Cleavage of dihydrouracil by hNTH1 glycosylase
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of hNTH1 glycosylase by APE1 at the AP site

Cleavage of formamidopyrimidine by hNTH1 glycosylase
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of hNTH1 glycosylase by APE1 at the AP site

Cleavage of uracil by MBD4 glycosylase
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of MBD4 glycosylase by APE1 at the AP site

Cleavage of thymine by MBD4 glycosylase
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of MBD4 glycosylase by APE1 at the AP site

Cleavage of ethenocytosine by TDG glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of TDG glycosylase by APE1 at the AP site

Displacement of UNG2 glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of TDG glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of hSMUG1 glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of hNTH1 glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of MBD4 glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of hOGG1 glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of MYH glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of MPG glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004520
BFO_0000050: Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: Recruitment of POL Beta to the AP site

Recruitment of POL Beta to the AP site
type: GO_0003674
BFO_0000050: Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: Excision of the abasic sugar phosphate (dRP) residue at the strand break
directly activates: POL Beta mediated incorporation of the first replacement nucleotide
directly activates: Catalysis50
directly activates: Catalysis53

Excision of the abasic sugar phosphate (dRP) residue at the strand break
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: GO_0003906
type: GO_0006286
BFO_0000050: Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
directly activates: Recruitment of LIG3:XRRC1 complex to the site of repair by POL Beta
directly activates: Resynthesis of excised residue
directly activates: Catalysis51

Recruitment of LIG3:XRRC1 complex to the site of repair by POL Beta
type: GO_0003674
BFO_0000050: Resolution of AP sites via the single-nucleotide replacement pathway
directly activates: Resynthesis of excised residue
directly activates: Catalysis51

Resynthesis of excised residue
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: GO_0003887
BFO_0000050: Resolution of AP sites via the single-nucleotide replacement pathway
directly activates: DNA ligation via the single-nucleotide replacement pathway
directly activates: Catalysis52

DNA ligation via the single-nucleotide replacement pathway
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: enabled by
  some values from: LIG3
type: GO_0003909
type: GO_0006288
BFO_0000050: Resolution of AP sites via the single-nucleotide replacement pathway
directly activates: Dissociation of LIG3:XRCC1 complex from site of BER

Dissociation of LIG3:XRCC1 complex from site of BER
type: GO_0003674
BFO_0000050: Resolution of AP sites via the single-nucleotide replacement pathway

POL Beta mediated incorporation of the first replacement nucleotide
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: GO_0003887
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: POL delta associates with AP site displacing POL Beta

POL delta associates with AP site displacing POL Beta
type: GO_0003674
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: DNA strand displacement synthesis
directly activates: Catalysis54

DNA strand displacement synthesis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: Cleavage of flap structures
directly activates: Catalysis55
directly activates: Control3
directly activates: Control4

Interaction of APE1 with DNA ligase I
type: GO_0003674
BFO_0000050: Removal of DNA patch containing abasic residue

Interaction of APE1 with FEN1
type: GO_0003674
BFO_0000050: Removal of DNA patch containing abasic residue

Interaction between FEN1 and PCNA
type: GO_0003674
BFO_0000050: Removal of DNA patch containing abasic residue

Cleavage of flap structures
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: GO_0017108
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: Ligation of DNA at sites of patch replacement
directly activates: Catalysis56
directly activates: Control5

Ligation of DNA at sites of patch replacement
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: GO_0003909
type: GO_0006288
BFO_0000050: Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Binding of REV1 to lesioned DNA template
type: GO_0003674
BFO_0000050: Translesion synthesis by HREV1
directly activates: Misinsertion of bases opposite to the lesion by HREV1
directly activates: Catalysis57

Misinsertion of bases opposite to the lesion by HREV1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Translesion synthesis by HREV1
directly activates: Elongation by REV1 protein
directly activates: Catalysis58

Elongation by REV1 protein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Translesion synthesis by HREV1

Binding of Pol eta to lesioned DNA template
type: GO_0003674
BFO_0000050: Translesion synthesis by Pol eta
directly activates: Insertion of correct bases opposite to the lesion by Pol eta
directly activates: Catalysis59

Insertion of correct bases opposite to the lesion by Pol eta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Translesion synthesis by Pol eta
directly activates: Elongation by Pol eta
directly activates: Catalysis60

Elongation by Pol eta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Translesion synthesis by Pol eta

Binding of Pol zeta to lesioned DNA template
type: GO_0003674
BFO_0000050: Translesion synthesis by Pol zeta
directly activates: Elongation by Pol zeta complex
directly activates: Catalysis61

Formation of Pol zeta complex
type: GO_0003674
BFO_0000050: Translesion synthesis by Pol zeta
directly activates: Binding of Pol zeta to lesioned DNA template

Elongation by Pol zeta complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Translesion synthesis by Pol zeta

MGMT/hAGT mediated DNA Damage Reversal
type: Restriction
  on property: enabled by
  some values from: MGMT
type: Restriction
  on property: enabled by
  some values from: MGMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003908
type: GO_0006307
BFO_0000050: DNA Damage Reversal

Oxidative demethylation of 1-MeA damaged DNA By ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003684
BFO_0000050: ABH2 mediated Reversal of Alkylation Damage

Oxidative demethylation of 3-MeC damaged DNA By ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003684
BFO_0000050: ABH2 mediated Reversal of Alkylation Damage

Oxidative demethylation of 1-EtA damaged DNA By ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: enabled by
  some values from: ABH2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003684
BFO_0000050: ABH2 mediated Reversal of Alkylation Damage

Oxidative demethylation of 1-MeA damaged DNA By ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003684
BFO_0000050: ABH3 mediated Reversal of Alkylation Damage

Oxidative demethylation of 3-MeC damaged DNA By ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003684
BFO_0000050: ABH3 mediated Reversal of Alkylation Damage

Oxidative demethylation of 1-EtA damaged DNA By ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: enabled by
  some values from: ABH3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003684
BFO_0000050: ABH3 mediated Reversal of Alkylation Damage

Intermolecular autophosphorylation of ATM within dimeric ATM complexes
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
type: GO_0046777
BFO_0000050: ATM mediated response to DNA double-strand break
directly activates: Dissociation of dimeric phospho-ATM complexes

Dissociation of dimeric phospho-ATM complexes
type: GO_0003674
BFO_0000050: ATM mediated response to DNA double-strand break
directly activates: Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB
directly activates: phospho-ATM (Serine 1981) associates with DNA at the site of double-strand breaks
directly activates: Formation of RAD50:MRE11 complex
directly activates: BiochemicalReaction1833
directly activates: BiochemicalReaction1834
directly activates: BiochemicalReaction1845
directly activates: BiochemicalReaction1848
directly activates: Catalysis70
directly activates: Catalysis803
directly activates: Catalysis804
directly activates: Catalysis813
directly activates: Catalysis816
directly activates: ATM mediated phosphorylation of repair proteins
directly activates: Recruitment of repair and signaling proteins to double-strand breaks

Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: ATM mediated phosphorylation of repair proteins
directly activates: MDC1/NFBD1 associates with gamma H2AX at nuclear foci
directly activates: Control8

Phosphorylation of BRCA1 at multiple sites by ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: ATM mediated phosphorylation of repair proteins

Phosphorylation of NBS1 by ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: ATM mediated phosphorylation of repair proteins

Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains)
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: ATM mediated phosphorylation of repair proteins

MDC1/NFBD1 associates with gamma H2AX at nuclear foci
type: GO_0003674
BFO_0000050: Recruitment of repair and signaling proteins to double-strand breaks
directly activates: phospho-ATM (Serine 1981) associates with DNA at the site of double-strand breaks

phospho-ATM (Serine 1981) associates with DNA at the site of double-strand breaks
type: GO_0003674
BFO_0000050: Recruitment of repair and signaling proteins to double-strand breaks
directly activates: 53BP1 associates with gamma H2AX at nuclear foci
directly activates: Association of gamma-H2AX with NBS1
directly activates: Control9
directly activates: MRN complex relocalizes to nuclear foci

53BP1 associates with gamma H2AX at nuclear foci
type: GO_0003674
BFO_0000050: Recruitment of repair and signaling proteins to double-strand breaks
directly activates: BRCA1 associates with 53BP1at the site of DNA double-strand break
directly activates: Control10

Association of gamma-H2AX with NBS1
type: GO_0003674
BFO_0000050: MRN complex relocalizes to nuclear foci
directly activates: Association of RAD50:MRE11 complex with NBS1 via MRE11 interaction
directly activates: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks

Formation of RAD50:MRE11 complex
type: GO_0003674
BFO_0000050: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
directly activates: Association of RAD50:MRE11 complex with NBS1 via MRE11 interaction

Association of RAD50:MRE11 complex with NBS1 via MRE11 interaction
type: GO_0003674
BFO_0000050: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
directly activates: Association of MRN with sites of DSB

Association of MRN with sites of DSB
type: GO_0003674
BFO_0000050: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks

BRCA1 associates with 53BP1at the site of DNA double-strand break
type: GO_0003674
BFO_0000050: Recruitment of repair and signaling proteins to double-strand breaks

Resection of double-strand break ends
type: GO_0000729
BFO_0000050: Processing of DNA double-strand break ends
directly activates: Association of RPA complexes with ssDNA
directly activates: Association of RAD52 with ssDNA at resected ends of double-strand break

Association of RPA complexes with ssDNA
type: GO_0003674
BFO_0000050: Processing of DNA double-strand break ends
directly activates: Association of RAD51 with the RPA complex
directly activates: Homologous DNA pairing and strand exchange
directly activates: Presynaptic phase of homologous DNA pairing and strand exchange

Association of RAD51 with BRCA2
type: GO_0003674
BFO_0000050: Presynaptic phase of homologous DNA pairing and strand exchange

Formation of RAD52 heptameric ring structure complexes on ssDNA
type: GO_0003674
BFO_0000050: Presynaptic phase of homologous DNA pairing and strand exchange

Association of RAD52 with the RPA complex
type: GO_0003674
BFO_0000050: Presynaptic phase of homologous DNA pairing and strand exchange

Association of RAD52 with ssDNA at resected ends of double-strand break
type: GO_0003674
BFO_0000050: Presynaptic phase of homologous DNA pairing and strand exchange
directly activates: Association of RAD51 with RAD52:DNA double-strand break ends
directly activates: Association of RAD51 with the resected ends of the DNA double-strand break
directly activates: Assembly of the RAD51-ssDNA nucleoprotein complex

Association of RAD51 with RAD52:DNA double-strand break ends
type: GO_0003674
BFO_0000050: Assembly of the RAD51-ssDNA nucleoprotein complex

Association of RAD51 with the RPA complex
type: GO_0003674
BFO_0000050: Assembly of the RAD51-ssDNA nucleoprotein complex

Association of RAD51 with the resected ends of the DNA double-strand break
type: GO_0003674
BFO_0000050: Assembly of the RAD51-ssDNA nucleoprotein complex

Strand exchange/Branch migration
type: GO_0003674
BFO_0000050: Homologous DNA pairing and strand exchange
directly activates: DNA repair synthesis

DNA repair synthesis
type: GO_0000731
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks
directly activates: Ligation of DNA and formation of Holliday structures following repair synthesis
directly activates: Dissociation of the extended strands
directly activates: Catalysis74
directly activates: Resolution of D-loop structures
directly activates: Resolution of D-loop structures through Holliday junction intermediates
directly activates: Resolution of D-loop structures through synthesis-dependent strand-annealing

Ligation of DNA and formation of Holliday structures following repair synthesis
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003909
BFO_0000050: Resolution of D-loop structures through Holliday junction intermediates
directly activates: Cleavage of Holliday junctions

Cleavage of Holliday junctions
type: GO_0003674
BFO_0000050: Resolution of D-loop structures through Holliday junction intermediates

Dissociation of the extended strands
type: GO_0000732
BFO_0000050: Resolution of D-loop structures through synthesis-dependent strand-annealing
directly activates: Fill-in DNA synthesis

Fill-in DNA synthesis
type: GO_0003674
BFO_0000050: Resolution of D-loop structures through synthesis-dependent strand-annealing

Association of Ku heterodimer with ends of DNA double-strand break
type: GO_0003674
BFO_0000050: Nonhomologous End-joining (NHEJ)
directly activates: Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks

Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks
type: GO_0003674
BFO_0000050: Nonhomologous End-joining (NHEJ)
directly activates: Synapsis, or interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB

Autophosphorylation of DNA-PKcs
type: Restriction
  on property: enabled by
  some values from: HYRC
type: Restriction
  on property: enabled by
  some values from: HYRC
type: Restriction
  on property: enabled by
  some values from: HYRC
type: Restriction
  on property: enabled by
  some values from: HYRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Nonhomologous End-joining (NHEJ)
directly activates: Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks

Synapsis, or interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB
type: GO_0003674
BFO_0000050: Nonhomologous End-joining (NHEJ)
directly activates: Removal of 3'-phosphoglycolate (PG) moiety from DSB ends
directly activates: Removal of 3'-phosphate moiety from DSB ends
directly activates: Catalysis76
directly activates: Catalysis77
directly activates: Processing of DNA ends prior to end rejoining

Removal of 3'-phosphoglycolate (PG) moiety from DSB ends
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004519
BFO_0000050: Processing of DNA ends prior to end rejoining
directly activates: Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex

Removal of 3'-phosphate moiety from DSB ends
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004519
BFO_0000050: Processing of DNA ends prior to end rejoining
directly activates: Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex

Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex
type: GO_0003674
BFO_0000050: Nonhomologous End-joining (NHEJ)
directly activates: Removal of repair proteins and ligation of the processed ends of the DNA double-strand break
directly activates: Catalysis78

Removal of repair proteins and ligation of the processed ends of the DNA double-strand break
type: Restriction
  on property: enabled by
  some values from: LIG4
type: Restriction
  on property: enabled by
  some values from: LIG4
type: Restriction
  on property: enabled by
  some values from: LIG4
type: Restriction
  on property: enabled by
  some values from: LIG4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003909
BFO_0000050: Nonhomologous End-joining (NHEJ)

XPC binds to HR23B forming a heterodimeric complex
type: GO_0003674
BFO_0000050: DNA Damage Recognition in GG-NER
directly activates: XPC:HR23B complex binds to damaged DNA site with lesion

XPC:HR23B complex binds to damaged DNA site with lesion
type: GO_0003674
BFO_0000050: DNA Damage Recognition in GG-NER
directly activates: Recruitment of repair factors to form preincision complex

Recruitment of repair factors to form preincision complex
type: GO_0006294
BFO_0000050: Formation of incision complex in GG-NER
directly activates: Formation of open bubble structure in DNA by helicases
directly activates: Catalysis79

Formation of open bubble structure in DNA by helicases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000717
type: GO_0004386
BFO_0000050: Formation of incision complex in GG-NER
directly activates: Binding of ERCC1-XPF to preincision complex

Formation of ERCC1-XPF heterodimeric complex
type: GO_0003674
BFO_0000050: Formation of incision complex in GG-NER
directly activates: Binding of ERCC1-XPF to preincision complex

Binding of ERCC1-XPF to preincision complex
type: GO_0006293
BFO_0000050: Formation of incision complex in GG-NER
directly activates: 3'- incision of DNA by XPG in GG-NER
directly activates: Catalysis80

3'- incision of DNA by XPG in GG-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004519
type: GO_0006295
BFO_0000050: Dual incision reaction in GG-NER
directly activates: 5'-incision of DNA by ERCC1-XPF in GG-NER
directly activates: Catalysis81

5'-incision of DNA by ERCC1-XPF in GG-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004520
type: GO_0006296
BFO_0000050: Dual incision reaction in GG-NER
directly activates: Repair synthesis of patch ~27-30 bases long by DNA polymerase

Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Repair synthesis of patch ~27-30 bases long by DNA polymerase
directly activates: Ligation of newly synthesized repair patch to incised DNA in GG-NER
directly activates: Catalysis84

Repair synthesis of patch ~27-30 bases long by DNA Pol Delta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Repair synthesis of patch ~27-30 bases long by DNA polymerase
directly activates: Ligation of newly synthesized repair patch to incised DNA in GG-NER
directly activates: Catalysis84

Ligation of newly synthesized repair patch to incised DNA in GG-NER
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003909
BFO_0000050: Gap-filling DNA repair synthesis and ligation in GG-NER

Formation of active Pol II complex with lesioned DNA template
type: GO_0003674
BFO_0000050: Formation of transcription-coupled NER (TC-NER) repair complex
directly activates: RNA Pol II is blocked by the lesion leading to reduced transcription

RNA Pol II is blocked by the lesion leading to reduced transcription
type: GO_0000716
BFO_0000050: Formation of transcription-coupled NER (TC-NER) repair complex
directly activates: Assembly of repair proteins at the site of Pol II blockage

Assembly of repair proteins at the site of Pol II blockage
type: GO_0003674
BFO_0000050: Formation of transcription-coupled NER (TC-NER) repair complex
directly activates: Displacement of stalled Pol II from the lesion site

Displacement of stalled Pol II from the lesion site
type: GO_0003674
BFO_0000050: Dual incision reaction in TC-NER
directly activates: 3' incision of the lesioned strand of DNA in TC-NER
directly activates: Catalysis85

3' incision of the lesioned strand of DNA in TC-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004520
BFO_0000050: Dual incision reaction in TC-NER
directly activates: 5' incision leading to excision of DNA fragment with lesion in TC-NER
directly activates: Catalysis86

5' incision leading to excision of DNA fragment with lesion in TC-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004520
BFO_0000050: Dual incision reaction in TC-NER
directly activates: Repair synthesis for gap-filling by DNA pol delta in TC-NER
directly activates: Repair synthesis for gap-filling by DNA pol epsilon in TC-NER
directly activates: Catalysis87
directly activates: Catalysis88
directly activates: Repair synthesis for gap-filling by DNA polymerase in TC-NER

Repair synthesis for gap-filling by DNA pol delta in TC-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Repair synthesis for gap-filling by DNA polymerase in TC-NER
directly activates: Ligation of newly synthesized repair patch to incised DNA in TC-NER
directly activates: Catalysis89

Repair synthesis for gap-filling by DNA pol epsilon in TC-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Repair synthesis for gap-filling by DNA polymerase in TC-NER
directly activates: Ligation of newly synthesized repair patch to incised DNA in TC-NER
directly activates: Catalysis89

Ligation of newly synthesized repair patch to incised DNA in TC-NER
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003909
BFO_0000050: Gap-filling DNA repair synthesis and ligation in TC-NER
directly activates: Resumption of transcription after TC-NER

Resumption of transcription after TC-NER
type: GO_0003674
BFO_0000050: Transcription-coupled NER (TC-NER)

Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Fanconi Anemia pathway
directly activates: FANCD2 deubiquitination by USP1/UAF1
directly activates: Catalysis92

Monoubiquitination of FANCI by the FA ubiquitin ligase complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Fanconi Anemia pathway
directly activates: FANCD2 deubiquitination by USP1/UAF1
directly activates: Catalysis92

Translocation of ub-FANCD2 and ub-FANCI to chromatin
type: GO_0003674
BFO_0000050: Fanconi Anemia pathway

Formation of the BRCA1-PALB2-BRCA2 complex
type: GO_0003674
BFO_0000050: Fanconi Anemia pathway

FANCD2 deubiquitination by USP1/UAF1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004843
BFO_0000050: Regulation of the Fanconi anemia pathway

Phosphorylation of FANCD2 by ATR/ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Regulation of the Fanconi anemia pathway

Phosphorylation of FANCI by ATM/ATR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Regulation of the Fanconi anemia pathway

MPG glycosylase mediated recognition and binding of 3-methyladenine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage of 3-methyladenine by MPG glycosylase
directly activates: Catalysis32

MPG glycosylase mediated recognition and binding of ethenoadenine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage of ethenoadenine by MPG glycosylase
directly activates: Catalysis33

MPG glycosylase mediated recognition and binding of hypoxanthine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage of hypoxanthine by MPG glycosylase
directly activates: Catalysis34

MYH glycosylase mediated recognition and binding of an adenine opposite to an 8-oxo guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage 8-oxo guanine by MYH glycosylase
directly activates: Catalysis31

hOGG1 glycosylase mediated recognition and binding of an 8-oxo guanine opposite to a cytosine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage of 8-oxo guanine by hOGG1 glycosylase
directly activates: Catalysis35

hOGG1 glycosylase mediated recognition and binding of a formamidopyrimidine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage of formamidopyrimidine by hOGG1 glycosylase
directly activates: Catalysis36

Cleavage 8-oxo guanine by MYH glycosylase
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: GO_0019104
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of MYH glycosylase by APE1 at the AP site

Cleavage of 3-methyladenine by MPG glycosylase
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: GO_0019104
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of MPG glycosylase by APE1 at the AP site

Cleavage of ethenoadenine by MPG glycosylase
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: GO_0019104
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of MPG glycosylase by APE1 at the AP site

Cleavage of hypoxanthine by MPG glycosylase
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: GO_0019104
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of MPG glycosylase by APE1 at the AP site

Cleavage of 8-oxo guanine by hOGG1 glycosylase
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: GO_0008534
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of hOGG1 glycosylase by APE1 at the AP site

Cleavage of formamidopyrimidine by hOGG1 glycosylase
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: GO_0008534
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of hOGG1 glycosylase by APE1 at the AP site

UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of 5-hydroxyluracil by UNG2 glycosylase
directly activates: Catalysis39

UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by UNG2 glycosylase
directly activates: Catalysis38

TDG glycosylase mediated recognition and binding of an ethenocytosine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of ethenocytosine by TDG glycosylase
directly activates: Catalysis48

TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: GO_0019104
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of thymine by TDG glycosylase
directly activates: Catalysis40

TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by TDG glycosylase

hSMUG1 glycosylase mediated recognition and binding of uracil within single-stranded DNA
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by hSMUG1 glycosylase
directly activates: Catalysis41

DNA Repair
type: GO_0008150

Base Excision Repair
type: GO_0008150
BFO_0000050: DNA Repair

Base-Excision Repair, AP Site Formation
type: GO_0008150
BFO_0000050: Base Excision Repair

Depurination
type: GO_0008150
BFO_0000050: Base-Excision Repair, AP Site Formation

Recognition and association of DNA glycosylase with site containing an affected purine
type: GO_0008150
BFO_0000050: Depurination

Cleavage of the damaged purine
type: GO_0008150
BFO_0000050: Depurination

Depyrimidination
type: GO_0008150
BFO_0000050: Base-Excision Repair, AP Site Formation

Recognition and association of DNA glycosylase with site containing an affected pyrimidine
type: GO_0008150
BFO_0000050: Depyrimidination

Cleavage of the damaged pyrimidine
type: GO_0008150
BFO_0000050: Depyrimidination

Resolution of Abasic Sites (AP sites)
type: GO_0008150
BFO_0000050: Base Excision Repair

Resolution of AP sites via the single-nucleotide replacement pathway
type: GO_0008150
BFO_0000050: Resolution of Abasic Sites (AP sites)

Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
type: GO_0008150
BFO_0000050: Resolution of AP sites via the single-nucleotide replacement pathway

Displacement of DNA glycosylase by APE1
type: GO_0008150
BFO_0000050: Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
BFO_0000050: Removal of DNA patch containing abasic residue

Resolution of AP sites via the multiple-nucleotide patch replacement pathway
type: GO_0008150
BFO_0000050: Resolution of Abasic Sites (AP sites)

Removal of DNA patch containing abasic residue
type: GO_0008150
BFO_0000050: Resolution of AP sites via the multiple-nucleotide patch replacement pathway

DNA Damage Bypass
type: GO_0008150
BFO_0000050: DNA Repair

Translesion synthesis by DNA polymerases bypassing lesion on DNA template
type: GO_0008150
BFO_0000050: DNA Damage Bypass

Translesion synthesis by HREV1
type: GO_0008150
BFO_0000050: Translesion synthesis by DNA polymerases bypassing lesion on DNA template

Translesion synthesis by Pol eta
type: GO_0008150
BFO_0000050: Translesion synthesis by DNA polymerases bypassing lesion on DNA template

Translesion synthesis by Pol zeta
type: GO_0008150
BFO_0000050: Translesion synthesis by DNA polymerases bypassing lesion on DNA template

DNA Damage Reversal
type: GO_0008150
BFO_0000050: DNA Repair

Reversal of Alkylation Damage By DNA Dioxygenases
type: GO_0008150
BFO_0000050: DNA Damage Reversal

ABH2 mediated Reversal of Alkylation Damage
type: GO_0008150
BFO_0000050: Reversal of Alkylation Damage By DNA Dioxygenases

ABH3 mediated Reversal of Alkylation Damage
type: GO_0008150
BFO_0000050: Reversal of Alkylation Damage By DNA Dioxygenases

Double-Strand Break Repair
type: GO_0008150
BFO_0000050: DNA Repair

Homologous Recombination Repair
type: GO_0008150
BFO_0000050: Double-Strand Break Repair

Homologous recombination repair of replication-independent double-strand breaks
type: GO_0008150
BFO_0000050: Homologous Recombination Repair

ATM mediated response to DNA double-strand break
type: GO_0008150
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks

ATM mediated phosphorylation of repair proteins
type: GO_0008150
BFO_0000050: ATM mediated response to DNA double-strand break

Recruitment of repair and signaling proteins to double-strand breaks
type: GO_0008150
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks

MRN complex relocalizes to nuclear foci
type: GO_0008150
BFO_0000050: Recruitment of repair and signaling proteins to double-strand breaks

Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
type: GO_0008150
BFO_0000050: MRN complex relocalizes to nuclear foci

Processing of DNA double-strand break ends
type: GO_0008150
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks

Homologous DNA pairing and strand exchange
type: GO_0008150
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks

Presynaptic phase of homologous DNA pairing and strand exchange
type: GO_0008150
BFO_0000050: Homologous DNA pairing and strand exchange

Assembly of the RAD51-ssDNA nucleoprotein complex
type: GO_0008150
BFO_0000050: Presynaptic phase of homologous DNA pairing and strand exchange

Resolution of D-loop structures
type: GO_0008150
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks

Resolution of D-loop structures through Holliday junction intermediates
type: GO_0008150
BFO_0000050: Resolution of D-loop structures

Resolution of D-loop structures through synthesis-dependent strand-annealing
type: GO_0008150
BFO_0000050: Resolution of D-loop structures

Homologous recombination repair of replication-dependent double-strand breaks
type: GO_0003674
BFO_0000050: Homologous Recombination Repair

Nonhomologous End-joining (NHEJ)
type: GO_0008150
BFO_0000050: Double-Strand Break Repair

Processing of DNA ends prior to end rejoining
type: GO_0008150
BFO_0000050: Nonhomologous End-joining (NHEJ)

Nucleotide Excision Repair
type: GO_0008150
BFO_0000050: DNA Repair

Global Genomic NER (GG-NER)
type: GO_0008150
BFO_0000050: Nucleotide Excision Repair

DNA Damage Recognition in GG-NER
type: GO_0008150
BFO_0000050: Global Genomic NER (GG-NER)

Formation of incision complex in GG-NER
type: GO_0008150
BFO_0000050: Global Genomic NER (GG-NER)

Dual incision reaction in GG-NER
type: GO_0008150
BFO_0000050: Global Genomic NER (GG-NER)

Gap-filling DNA repair synthesis and ligation in GG-NER
type: GO_0008150
BFO_0000050: Global Genomic NER (GG-NER)

Repair synthesis of patch ~27-30 bases long by DNA polymerase
type: GO_0008150
BFO_0000050: Gap-filling DNA repair synthesis and ligation in GG-NER

Transcription-coupled NER (TC-NER)
type: GO_0008150
BFO_0000050: Nucleotide Excision Repair

Formation of transcription-coupled NER (TC-NER) repair complex
type: GO_0008150
BFO_0000050: Transcription-coupled NER (TC-NER)

Dual incision reaction in TC-NER
type: GO_0008150
BFO_0000050: Transcription-coupled NER (TC-NER)

Gap-filling DNA repair synthesis and ligation in TC-NER
type: GO_0008150
BFO_0000050: Transcription-coupled NER (TC-NER)

Repair synthesis for gap-filling by DNA polymerase in TC-NER
type: GO_0008150
BFO_0000050: Gap-filling DNA repair synthesis and ligation in TC-NER

Fanconi Anemia pathway
type: GO_0008150
BFO_0000050: DNA Repair

Regulation of the Fanconi anemia pathway
type: GO_0008150
BFO_0000050: Fanconi Anemia pathway