BPNT1
UniProt:O95861 BPNT1
SLC26A1,2 transport extracellular SO4(2-) to cytosol
SLC35B2,3 transport cytosolic PAPS to Golgi lumen
ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate
Activation of inorganic sulfate forms APS
PAPSS1,2 transfer PO4(2-) group from ATP to form APS
APS reacts with another ATP molecule to form PAPS
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
adenylyl sulfate (APS) + ATP => PAPS + ADP
Acetaminophen can form an O- sulfate conjugate
N-hydroxy-4-aminobiphenyl can form a sulfate conjugate
Phenol can form a sulfate conjugate
Dopamine can form an O-sulfate conjugate
3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP
N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
cholesterol + PAPS => cholesterol sulfate + PAP
27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP
SULTs transfer (SO4)2- group to 27HCHOL
SULTs transfer (SO4)2- group to PREG
pregnenolone + PAPS => pregnenolone sulfate + PAP
estrone + PAPS => estrone 3-sulfate + PAP
dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP
beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP
lithocholate + PAPS => lithocholate sulfate + PAP
taurolithocholate + PAPS => taurolithocholate sulfate + PAP
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
Cytosolic sulfonation of small molecules
Transport and synthesis of PAPS