GDA
SLC25A16
UniProt:P16260 SLC25A16
COASY
PSEC0106
UniProt:Q13057 COASY
C20orf48
PANK2
UniProt:Q9BZ23 PANK2
PANK2 phosphorylates PanK
Pantothenate is phosphorylated [PANK2]
PANK1/3/4 phosphorylate PanK
Pantothenate is phosphorylated [PANK1;3;4]
pantothenate + ATP => phosphopanthothenate + ADP
2xPPCS ligates PPanK with Cys
Condensation of phosphopantothenate with cysteine
3xPPCDC:3FMN decarboxylates PPC
Phosphopantothenoylcysteine is decarboxylated
Adenylation of phosphopantetheine
COASY transfers an adenylyl group from ATP to PPANT
COASY phosphorylates DP-CoA
Phosphorylation of dephospho-CoA to produce CoA
CoA transport across the inner mitochondrial membrane
SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix
Coenzyme A biosynthesis