GDA
label: SLC25A16
label: UniProt:P16260 SLC25A16

COASY
label: PSEC0106
label: UniProt:Q13057 COASY

C20orf48
label: PANK2
label: UniProt:Q9BZ23 PANK2

PANK2 phosphorylates PanK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: enabled by
  some values from: C20orf48
type: GO_0004594
BFO_0000050: Coenzyme A biosynthesis
directly activates: 2xPPCS ligates PPanK with Cys
directly activates: Catalysis2755
label: Pantothenate is phosphorylated [PANK2]

PANK1/3/4 phosphorylate PanK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004594
BFO_0000050: Coenzyme A biosynthesis
directly activates: 2xPPCS ligates PPanK with Cys
directly activates: Catalysis2755
label: Pantothenate is phosphorylated [PANK1;3;4]
label: pantothenate + ATP => phosphopanthothenate + ADP

2xPPCS ligates PPanK with Cys
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004632
BFO_0000050: Coenzyme A biosynthesis
directly activates: 3xPPCDC:3FMN decarboxylates PPC
directly activates: Catalysis2756
label: Condensation of phosphopantothenate with cysteine

3xPPCDC:3FMN decarboxylates PPC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004633
BFO_0000050: Coenzyme A biosynthesis
directly activates: Adenylation of phosphopantetheine
directly activates: Catalysis2757
label: Phosphopantothenoylcysteine is decarboxylated

Adenylation of phosphopantetheine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: enabled by
  some values from: COASY
type: GO_0004595
BFO_0000050: Coenzyme A biosynthesis
directly activates: COASY phosphorylates DP-CoA
directly activates: Catalysis2758
label: COASY transfers an adenylyl group from ATP to PPANT

COASY phosphorylates DP-CoA
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004140
BFO_0000050: Coenzyme A biosynthesis
directly activates: BiochemicalReaction5580
directly activates: Catalysis2760
label: Phosphorylation of dephospho-CoA to produce CoA

CoA transport across the inner mitochondrial membrane
type: Restriction
  on property: enabled by
  some values from: GDA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0015291
BFO_0000050: Coenzyme A biosynthesis
label: SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix

Coenzyme A biosynthesis
type: GO_0008150