COT
label: ESTF
label: MAP3K8
label: UniProt:P41279 MAP3K8

PI3K binds CD28
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: CD28 bound PI3K phosphorylates PIP2 to PIP3
directly activates: Catalysis249

CD28 bound PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: BiochemicalReaction2321
directly activates: BiochemicalReaction656
directly activates: PIP3 recruits PDPK1 to the membrane
directly activates: PIP3 recruits AKT to the membrane
directly activates: Control158

PIP3 recruits PDPK1 to the membrane
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling

PIP3 recruits AKT to the membrane
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling

TORC2 (mTOR) phosphorylates AKT at S473
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: AKT interacts and phosphorylates Cot
directly activates: BiochemicalReaction735
directly activates: BiochemicalReaction736
directly activates: BiochemicalReaction737
directly activates: BiochemicalReaction738
directly activates: BiochemicalReaction739
directly activates: BiochemicalReaction740
directly activates: BiochemicalReaction741
directly activates: BiochemicalReaction742
directly activates: Catalysis252
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

AKT binds PDPK1
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling

PDPK1 phosphorylates AKT at T308
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: BiochemicalReaction735
directly activates: BiochemicalReaction736
directly activates: BiochemicalReaction737
directly activates: BiochemicalReaction738
directly activates: BiochemicalReaction739
directly activates: BiochemicalReaction740
directly activates: BiochemicalReaction741
directly activates: BiochemicalReaction742
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

AKT interacts and phosphorylates Cot
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: p-S400-Cot phosphorylates NIK
directly activates: Catalysis253

p-S400-Cot phosphorylates NIK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: COT
type: GO_0004709
BFO_0000050: CD28 dependent PI3K/Akt signaling

CD28 dependent PI3K/Akt signaling
type: GO_0008150