COT
ESTF
MAP3K8
UniProt:P41279 MAP3K8
PI3K binds CD28
CD28 bound PI3K phosphorylates PIP2 to PIP3
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
AKT interacts and phosphorylates Cot
p-S400-Cot phosphorylates NIK
CD28 dependent PI3K/Akt signaling