BTD
label: UniProt:P43251 BTD

HLCS
label: UniProt:P50747 HLCS

SLC5A6
label: SMVT
label: UniProt:Q9Y289 SLC5A6

SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: SLC5A6
type: GO_0008523
BFO_0000050: Biotin transport and metabolism
directly activates: HLCS biotinylates PCCA:PCCB
directly activates: HLCS biotinylates PC:Mn2+
directly activates: HLCS biotinylates MCCC1:MCCC2
directly activates: HLCS biotinylates ACACA/B:Mn2+
directly activates: Catalysis2779
directly activates: Catalysis2780
directly activates: Catalysis2781
directly activates: Catalysis2782
label: biotin [extracellular] + 2 Na+ [extracellular] => biotin [cytosol] + 2 Na+ [cytosol]

HLCS biotinylates PCCA:PCCB
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0018271
BFO_0000050: Biotin transport and metabolism
directly activates: Cytoslic carboxylases translocate to mitochondrial matrix
directly activates: An unknown protease degrades hCBXs
directly activates: Catalysis2783

HLCS biotinylates PC:Mn2+
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0018271
BFO_0000050: Biotin transport and metabolism
directly activates: Cytoslic carboxylases translocate to mitochondrial matrix
directly activates: An unknown protease degrades hCBXs
directly activates: Catalysis2783

HLCS biotinylates MCCC1:MCCC2
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0018271
BFO_0000050: Biotin transport and metabolism
directly activates: Cytoslic carboxylases translocate to mitochondrial matrix
directly activates: An unknown protease degrades hCBXs
directly activates: Catalysis2783

Cytoslic carboxylases translocate to mitochondrial matrix
type: GO_0003674
BFO_0000050: Biotin transport and metabolism

HLCS biotinylates ACACA/B:Mn2+
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0018271
BFO_0000050: Biotin transport and metabolism
directly activates: An unknown protease degrades ACACA/B:Mn2+
directly activates: Catalysis2784

An unknown protease degrades hCBXs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0070011
BFO_0000050: Biotin transport and metabolism
directly activates: BCTN translocates to extracellular region

An unknown protease degrades ACACA/B:Mn2+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0070011
BFO_0000050: Biotin transport and metabolism
directly activates: BCTN translocates to extracellular region

BCTN translocates to extracellular region
type: GO_0003674
BFO_0000050: Biotin transport and metabolism
directly activates: BTD hydrolyses BCTN
directly activates: Catalysis2785

BTD hydrolyses BCTN
type: Restriction
  on property: enabled by
  some values from: BTD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0047708
BFO_0000050: Biotin transport and metabolism

Biotin transport and metabolism
type: GO_0008150