MMH
MUTM
OGG1
OGH1
UniProt:O15527 OGG1
MBD4
MED1
UniProt:O95243 MBD4
POLB
UniProt:P06746 POLB
LIG1
UniProt:P18858 LIG1
CCNO
UniProt:P22674 CCNO
APE
APE1
APEX
APEX1
APX
HAP1
REF1
UniProt:P27695 APEX1
AAG
ANPG
MID1
MPG
UniProt:P29372 MPG
FEN1
RAD2
UniProt:P39748 FEN1
LIG3
UniProt:P49916 LIG3
NTH1
NTHL1
OCTS3
UniProt:P78549 NTHL1
TDG
UniProt:Q13569 TDG
SMUG1
UniProt:Q53HV7 SMUG1
MUTYH
MYH
UniProt:Q9UIF7 MUTYH
MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences
MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences
hNTH1 glycosylase mediated recognition and binding of cytosine glycol
hNTH1 glycosylase mediated recognition and binding of dihydrouracil
hNTH1 glycosylase mediated recognition and binding of formamidopyrimidine
hNTH1 glycosylase mediated recognition and binding of thymine glycol
Cleavage of uracil by UNG2 glycosylase
Cleavage of 5-hydroxyluracil by UNG2 glycosylase
Cleavage of uracil by TDG glycosylase
Cleavage of thymine by TDG glycosylase
Cleavage of uracil by hSMUG1 glycosylase
Cleavage of thymine glycol by hNTH1 glycosylase
Cleavage of cytosine glycol by hNTH1 glycosylase
Cleavage of dihydrouracil by hNTH1 glycosylase
Cleavage of formamidopyrimidine by hNTH1 glycosylase
Cleavage of uracil by MBD4 glycosylase
Cleavage of thymine by MBD4 glycosylase
Cleavage of ethenocytosine by TDG glycosylase
Displacement of UNG2 glycosylase by APE1 at the AP site
Displacement of TDG glycosylase by APE1 at the AP site
Displacement of hSMUG1 glycosylase by APE1 at the AP site
Displacement of hNTH1 glycosylase by APE1 at the AP site
Displacement of MBD4 glycosylase by APE1 at the AP site
Displacement of hOGG1 glycosylase by APE1 at the AP site
Displacement of MYH glycosylase by APE1 at the AP site
Displacement of MPG glycosylase by APE1 at the AP site
APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue
Recruitment of POL Beta to the AP site
Excision of the abasic sugar phosphate (dRP) residue at the strand break
Recruitment of LIG3:XRRC1 complex to the site of repair by POL Beta
Resynthesis of excised residue
DNA ligation via the single-nucleotide replacement pathway
Dissociation of LIG3:XRCC1 complex from site of BER
POL Beta mediated incorporation of the first replacement nucleotide
POL delta associates with AP site displacing POL Beta
DNA strand displacement synthesis
Interaction of APE1 with DNA ligase I
Interaction of APE1 with FEN1
Interaction between FEN1 and PCNA
Cleavage of flap structures
Ligation of DNA at sites of patch replacement
MPG glycosylase mediated recognition and binding of 3-methyladenine
MPG glycosylase mediated recognition and binding of ethenoadenine
MPG glycosylase mediated recognition and binding of hypoxanthine
MYH glycosylase mediated recognition and binding of an adenine opposite to an 8-oxo guanine
hOGG1 glycosylase mediated recognition and binding of an 8-oxo guanine opposite to a cytosine
hOGG1 glycosylase mediated recognition and binding of a formamidopyrimidine
Cleavage 8-oxo guanine by MYH glycosylase
Cleavage of 3-methyladenine by MPG glycosylase
Cleavage of ethenoadenine by MPG glycosylase
Cleavage of hypoxanthine by MPG glycosylase
Cleavage of 8-oxo guanine by hOGG1 glycosylase
Cleavage of formamidopyrimidine by hOGG1 glycosylase
UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine
UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine
TDG glycosylase mediated recognition and binding of an ethenocytosine
TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine
TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine
hSMUG1 glycosylase mediated recognition and binding of uracil within single-stranded DNA
Base Excision Repair
Base-Excision Repair, AP Site Formation
Depurination
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Depyrimidination
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Resolution of Abasic Sites (AP sites)
Resolution of AP sites via the single-nucleotide replacement pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
Displacement of DNA glycosylase by APE1
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Removal of DNA patch containing abasic residue