MMH
label: MUTM
label: OGG1
label: OGH1
label: UniProt:O15527 OGG1

MBD4
label: MED1
label: UniProt:O95243 MBD4

POLB
label: UniProt:P06746 POLB

LIG1
label: UniProt:P18858 LIG1

CCNO
label: UniProt:P22674 CCNO

APE
label: APE1
label: APEX
label: APEX1
label: APX
label: HAP1
label: REF1
label: UniProt:P27695 APEX1

AAG
label: ANPG
label: MID1
label: MPG
label: UniProt:P29372 MPG

FEN1
label: RAD2
label: UniProt:P39748 FEN1

LIG3
label: UniProt:P49916 LIG3

NTH1
label: NTHL1
label: OCTS3
label: UniProt:P78549 NTHL1

TDG
label: UniProt:Q13569 TDG

SMUG1
label: UniProt:Q53HV7 SMUG1

MUTYH
label: MYH
label: UniProt:Q9UIF7 MUTYH

MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of thymine by MBD4 glycosylase
directly activates: Catalysis47

MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by MBD4 glycosylase
directly activates: Catalysis46

hNTH1 glycosylase mediated recognition and binding of cytosine glycol
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of cytosine glycol by hNTH1 glycosylase
directly activates: Catalysis43

hNTH1 glycosylase mediated recognition and binding of dihydrouracil
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of dihydrouracil by hNTH1 glycosylase
directly activates: Catalysis44

hNTH1 glycosylase mediated recognition and binding of formamidopyrimidine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of formamidopyrimidine by hNTH1 glycosylase
directly activates: Catalysis45

hNTH1 glycosylase mediated recognition and binding of thymine glycol
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of thymine glycol by hNTH1 glycosylase
directly activates: Catalysis42

Cleavage of uracil by UNG2 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004844
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of UNG2 glycosylase by APE1 at the AP site

Cleavage of 5-hydroxyluracil by UNG2 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: enabled by
  some values from: CCNO
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004844
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of UNG2 glycosylase by APE1 at the AP site

Cleavage of uracil by TDG glycosylase
type: GO_0003674
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of TDG glycosylase by APE1 at the AP site

Cleavage of thymine by TDG glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of TDG glycosylase by APE1 at the AP site

Cleavage of uracil by hSMUG1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: enabled by
  some values from: SMUG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0017065
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of hSMUG1 glycosylase by APE1 at the AP site

Cleavage of thymine glycol by hNTH1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of hNTH1 glycosylase by APE1 at the AP site

Cleavage of cytosine glycol by hNTH1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of hNTH1 glycosylase by APE1 at the AP site

Cleavage of dihydrouracil by hNTH1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of hNTH1 glycosylase by APE1 at the AP site

Cleavage of formamidopyrimidine by hNTH1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: enabled by
  some values from: NTH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000703
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of hNTH1 glycosylase by APE1 at the AP site

Cleavage of uracil by MBD4 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of MBD4 glycosylase by APE1 at the AP site

Cleavage of thymine by MBD4 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: enabled by
  some values from: MBD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of MBD4 glycosylase by APE1 at the AP site

Cleavage of ethenocytosine by TDG glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged pyrimidine
directly activates: Displacement of TDG glycosylase by APE1 at the AP site

Displacement of UNG2 glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of TDG glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of hSMUG1 glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of hNTH1 glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of MBD4 glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of hOGG1 glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of MYH glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

Displacement of MPG glycosylase by APE1 at the AP site
type: GO_0003674
BFO_0000050: Displacement of DNA glycosylase by APE1

APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: enabled by
  some values from: APE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004520
BFO_0000050: Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: Recruitment of POL Beta to the AP site

Recruitment of POL Beta to the AP site
type: GO_0003674
BFO_0000050: Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: Excision of the abasic sugar phosphate (dRP) residue at the strand break
directly activates: POL Beta mediated incorporation of the first replacement nucleotide
directly activates: Catalysis50
directly activates: Catalysis53

Excision of the abasic sugar phosphate (dRP) residue at the strand break
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003906
type: GO_0006286
BFO_0000050: Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
directly activates: Recruitment of LIG3:XRRC1 complex to the site of repair by POL Beta
directly activates: Resynthesis of excised residue
directly activates: Catalysis51

Recruitment of LIG3:XRRC1 complex to the site of repair by POL Beta
type: GO_0003674
BFO_0000050: Resolution of AP sites via the single-nucleotide replacement pathway
directly activates: Resynthesis of excised residue
directly activates: Catalysis51

Resynthesis of excised residue
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Resolution of AP sites via the single-nucleotide replacement pathway
directly activates: DNA ligation via the single-nucleotide replacement pathway
directly activates: Catalysis52

DNA ligation via the single-nucleotide replacement pathway
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: enabled by
  some values from: LIG3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003909
type: GO_0006288
BFO_0000050: Resolution of AP sites via the single-nucleotide replacement pathway
directly activates: Dissociation of LIG3:XRCC1 complex from site of BER

Dissociation of LIG3:XRCC1 complex from site of BER
type: GO_0003674
BFO_0000050: Resolution of AP sites via the single-nucleotide replacement pathway

POL Beta mediated incorporation of the first replacement nucleotide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: enabled by
  some values from: POLB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: POL delta associates with AP site displacing POL Beta

POL delta associates with AP site displacing POL Beta
type: GO_0003674
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: DNA strand displacement synthesis
directly activates: Catalysis54

DNA strand displacement synthesis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: Cleavage of flap structures
directly activates: Catalysis55
directly activates: Control3
directly activates: Control4

Interaction of APE1 with DNA ligase I
type: GO_0003674
BFO_0000050: Removal of DNA patch containing abasic residue

Interaction of APE1 with FEN1
type: GO_0003674
BFO_0000050: Removal of DNA patch containing abasic residue

Interaction between FEN1 and PCNA
type: GO_0003674
BFO_0000050: Removal of DNA patch containing abasic residue

Cleavage of flap structures
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0017108
BFO_0000050: Removal of DNA patch containing abasic residue
directly activates: Ligation of DNA at sites of patch replacement
directly activates: Catalysis56
directly activates: Control5

Ligation of DNA at sites of patch replacement
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003909
type: GO_0006288
BFO_0000050: Resolution of AP sites via the multiple-nucleotide patch replacement pathway

MPG glycosylase mediated recognition and binding of 3-methyladenine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage of 3-methyladenine by MPG glycosylase
directly activates: Catalysis32

MPG glycosylase mediated recognition and binding of ethenoadenine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage of ethenoadenine by MPG glycosylase
directly activates: Catalysis33

MPG glycosylase mediated recognition and binding of hypoxanthine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage of hypoxanthine by MPG glycosylase
directly activates: Catalysis34

MYH glycosylase mediated recognition and binding of an adenine opposite to an 8-oxo guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage 8-oxo guanine by MYH glycosylase
directly activates: Catalysis31

hOGG1 glycosylase mediated recognition and binding of an 8-oxo guanine opposite to a cytosine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage of 8-oxo guanine by hOGG1 glycosylase
directly activates: Catalysis35

hOGG1 glycosylase mediated recognition and binding of a formamidopyrimidine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected purine
directly activates: Cleavage of formamidopyrimidine by hOGG1 glycosylase
directly activates: Catalysis36

Cleavage 8-oxo guanine by MYH glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: enabled by
  some values from: MUTYH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of MYH glycosylase by APE1 at the AP site

Cleavage of 3-methyladenine by MPG glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of MPG glycosylase by APE1 at the AP site

Cleavage of ethenoadenine by MPG glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of MPG glycosylase by APE1 at the AP site

Cleavage of hypoxanthine by MPG glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: enabled by
  some values from: AAG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0019104
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of MPG glycosylase by APE1 at the AP site

Cleavage of 8-oxo guanine by hOGG1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0008534
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of hOGG1 glycosylase by APE1 at the AP site

Cleavage of formamidopyrimidine by hOGG1 glycosylase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: enabled by
  some values from: MMH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0008534
BFO_0000050: Cleavage of the damaged purine
directly activates: Displacement of hOGG1 glycosylase by APE1 at the AP site

UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of 5-hydroxyluracil by UNG2 glycosylase
directly activates: Catalysis39

UNG glycosylase mediated recognition and binding of an uracil opposite to a guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by UNG2 glycosylase
directly activates: Catalysis38

TDG glycosylase mediated recognition and binding of an ethenocytosine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of ethenocytosine by TDG glycosylase
directly activates: Catalysis48

TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: Restriction
  on property: enabled by
  some values from: TDG
type: GO_0019104
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of thymine by TDG glycosylase
directly activates: Catalysis40

TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by TDG glycosylase

hSMUG1 glycosylase mediated recognition and binding of uracil within single-stranded DNA
type: GO_0003674
BFO_0000050: Recognition and association of DNA glycosylase with site containing an affected pyrimidine
directly activates: Cleavage of uracil by hSMUG1 glycosylase
directly activates: Catalysis41

Base Excision Repair
type: GO_0008150

Base-Excision Repair, AP Site Formation
type: GO_0008150
BFO_0000050: Base Excision Repair

Depurination
type: GO_0008150
BFO_0000050: Base-Excision Repair, AP Site Formation

Recognition and association of DNA glycosylase with site containing an affected purine
type: GO_0008150
BFO_0000050: Depurination

Cleavage of the damaged purine
type: GO_0008150
BFO_0000050: Depurination

Depyrimidination
type: GO_0008150
BFO_0000050: Base-Excision Repair, AP Site Formation

Recognition and association of DNA glycosylase with site containing an affected pyrimidine
type: GO_0008150
BFO_0000050: Depyrimidination

Cleavage of the damaged pyrimidine
type: GO_0008150
BFO_0000050: Depyrimidination

Resolution of Abasic Sites (AP sites)
type: GO_0008150
BFO_0000050: Base Excision Repair

Resolution of AP sites via the single-nucleotide replacement pathway
type: GO_0008150
BFO_0000050: Resolution of Abasic Sites (AP sites)

Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
type: GO_0008150
BFO_0000050: Resolution of AP sites via the single-nucleotide replacement pathway

Displacement of DNA glycosylase by APE1
type: GO_0008150
BFO_0000050: Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
BFO_0000050: Removal of DNA patch containing abasic residue

Resolution of AP sites via the multiple-nucleotide patch replacement pathway
type: GO_0008150
BFO_0000050: Resolution of Abasic Sites (AP sites)

Removal of DNA patch containing abasic residue
type: GO_0008150
BFO_0000050: Resolution of AP sites via the multiple-nucleotide patch replacement pathway