CTSS
label: UniProt:P25774 CTSS

Interaction of particulate antigens with dendritic cell receptors
type: GO_0003674
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)
directly activates: Engulfment of particulate antigen into phagocytic vesicle

Engulfment of particulate antigen into phagocytic vesicle
type: GO_0003674
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)
directly activates: Maturation of phagosome into phagolysosome

Maturation of phagosome into phagolysosome
type: GO_0003674
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)

Alkalization of the phagosomal lumen by NOX2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: GO_0016175
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)

Partial proteolysis of antigen in phagolysosomes
type: GO_0003674
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)
directly activates: Escape of antigens from phagosome to cytosol
directly activates: Egress of internalized antigen to the cytosol via sec61
directly activates: Catalysis307

Escape of antigens from phagosome to cytosol
type: GO_0003674
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)

Egress of internalized antigen to the cytosol via sec61
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: GO_0022857
BFO_0000050: ER-Phagosome pathway
directly activates: Proteasomal cleavage of substrate
directly activates: Catalysis308

Proteasomal cleavage of substrate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: ER-Phagosome pathway
directly activates: Translocation of antigenic peptides back to phagosomes via TAP
directly activates: Catalysis309

Translocation of antigenic peptides back to phagosomes via TAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: GO_0015433
BFO_0000050: ER-Phagosome pathway
directly activates: Peptide loading on MHC class I in phagosome

Peptide loading on MHC class I in phagosome
type: GO_0003674
BFO_0000050: ER-Phagosome pathway
directly activates: Export of peptide loaded MHC class I complex to PM

Export of peptide loaded MHC class I complex to PM
type: GO_0003674
BFO_0000050: ER-Phagosome pathway

Antigen processing by cathepsin S in endosoytic vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031905
type: Restriction
  on property: enabled by
  some values from: CTSS
type: Restriction
  on property: enabled by
  some values from: CTSS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031905
type: GO_0004197
BFO_0000050: Endosomal/Vacuolar pathway
directly activates: Trimming of peptides by IRAP in endocytic vesicles
directly activates: Catalysis311

Trimming of peptides by IRAP in endocytic vesicles
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: GO_0004177
BFO_0000050: Endosomal/Vacuolar pathway
directly activates: Loading of antigen peptide onto MHC class I molecule

Loading of antigen peptide onto MHC class I molecule
type: GO_0003674
BFO_0000050: Endosomal/Vacuolar pathway
directly activates: Translocation of peptide bound MHC class I complex to cell surface

Translocation of peptide bound MHC class I complex to cell surface
type: GO_0003674
BFO_0000050: Endosomal/Vacuolar pathway

Interaction of exogenous soluble antigen with its corresponding receptor
type: GO_0003674
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)
directly activates: Internalization of receptor bound antigen into clathrin coted vesicles

Internalization of receptor bound antigen into clathrin coted vesicles
type: GO_0003674
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)
directly activates: Movement of clathrin coated vesicles into early endosome

Movement of clathrin coated vesicles into early endosome
type: GO_0006898
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)
directly activates: Exogenous soluble antigen targeted to more stable early endosome

Exogenous soluble antigen targeted to more stable early endosome
type: GO_0003674
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)
directly activates: Egress of internalized antigen into cytosol from early endosome

Egress of internalized antigen into cytosol from early endosome
type: GO_0003674
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)
directly activates: Proteasomal clevage of exogenous antigen
directly activates: Catalysis312

Proteasomal clevage of exogenous antigen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)

Antigen processing-Cross presentation
type: GO_0008150

Cross-presentation of particulate exogenous antigens (phagosomes)
type: GO_0008150
BFO_0000050: Antigen processing-Cross presentation

ER-Phagosome pathway
type: GO_0008150
BFO_0000050: Antigen processing-Cross presentation

Endosomal/Vacuolar pathway
type: GO_0008150
BFO_0000050: Antigen processing-Cross presentation

Cross-presentation of soluble exogenous antigens (endosomes)
type: GO_0008150
BFO_0000050: Antigen processing-Cross presentation