CTSS
UniProt:P25774 CTSS
Interaction of particulate antigens with dendritic cell receptors
Engulfment of particulate antigen into phagocytic vesicle
Maturation of phagosome into phagolysosome
Alkalization of the phagosomal lumen by NOX2
Partial proteolysis of antigen in phagolysosomes
Escape of antigens from phagosome to cytosol
Egress of internalized antigen to the cytosol via sec61
Proteasomal cleavage of substrate
Translocation of antigenic peptides back to phagosomes via TAP
Peptide loading on MHC class I in phagosome
Export of peptide loaded MHC class I complex to PM
Antigen processing by cathepsin S in endosoytic vesicle
Trimming of peptides by IRAP in endocytic vesicles
Loading of antigen peptide onto MHC class I molecule
Translocation of peptide bound MHC class I complex to cell surface
Interaction of exogenous soluble antigen with its corresponding receptor
Internalization of receptor bound antigen into clathrin coted vesicles
Movement of clathrin coated vesicles into early endosome
Exogenous soluble antigen targeted to more stable early endosome
Egress of internalized antigen into cytosol from early endosome
Proteasomal clevage of exogenous antigen
Antigen processing-Cross presentation
Cross-presentation of particulate exogenous antigens (phagosomes)
ER-Phagosome pathway
Endosomal/Vacuolar pathway
Cross-presentation of soluble exogenous antigens (endosomes)