Spontaneous hydrolysis of C3 thioester
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor B binds to C3(H2O)

Factor B binds to C3(H2O)
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor D cleaves C3(H2O)-bound Factor B
directly activates: Catalysis385

Factor D cleaves C3(H2O)-bound Factor B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: C3(H2O):Factor Bb cleaves C3 to C3b and C3a
directly activates: BiochemicalReaction1035
directly activates: BiochemicalReaction1043
directly activates: BiochemicalReaction1048
directly activates: Catalysis386
directly activates: Control77

C3(H2O):Factor Bb cleaves C3 to C3b and C3a
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: C3b binds to cell surface

C3b binds to cell surface
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor B binds to surface-associated C3b
directly activates: BiochemicalReaction1034
directly activates: Control76

Factor B binds to surface-associated C3b
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Factor D cleaves C3b-bound Factor B
directly activates: Catalysis387

Factor D cleaves C3b-bound Factor B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: Properdin stabilizes C3b:Bb bound to cell surfaces
directly activates: BiochemicalReaction1035
directly activates: BiochemicalReaction1043
directly activates: BiochemicalReaction1048
directly activates: Control77

Properdin stabilizes C3b:Bb bound to cell surfaces
type: GO_0003674
BFO_0000050: Alternative complement activation
directly activates: Formation of alternative pathway C5 convertase
directly activates: BiochemicalReaction1028
directly activates: BiochemicalReaction1031
directly activates: Catalysis388
directly activates: Catalysis389

Formation of alternative pathway C5 convertase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Alternative complement activation
directly activates: BiochemicalReaction1028
directly activates: BiochemicalReaction1030
directly activates: BiochemicalReaction1031
directly activates: Catalysis389
directly activates: Catalysis390

Alternative complement activation
type: GO_0008150