CARDIAK
RICK
RIP2
RIPK2
UniProt:O43353 RIPK2
FYN
UniProt:P06241 FYN
JTK8
LYN
UniProt:P07948 LYN
CD45
PTPRC
UniProt:P08575 PTPRC
GILT
IFI30
IP30
UniProt:P13284 IFI30
CTSS
UniProt:P25774 CTSS
COT
ESTF
MAP3K8
UniProt:P41279 MAP3K8
BLK
UniProt:P51451 BLK
AGMX1
ATK
BPK
BTK
UniProt:Q06187 BTK
INPP5D
SHIP
SHIP1
UniProt:Q92835 INPP5D
LGMN
PRSC1
UniProt:Q99538 LGMN
Calcium binds calmodulin
Interaction of Csk with PAG
Inactivation of Lck by Csk
Dephosphorylation of Lck-pY505 by CD45
Activation of Lck
Phosphorylation of ITAM motifs in CD3 complexes
Recruitment of ZAP-70 to phosphorylated ITAMs
Phosphorylation of ZAP-70 by Lck
Activation of ZAP-70
Phosphorylation of TBSMs in LAT
Recruitment of Gads to LAT
Recruitment of SLP-76 to Gads
Phosphorylation of SLP-76
Recruitment of ITK to SLP-76
Recruitment of PLC-gamma1 to SLP-76
Recruitment of PLC-gamma1 to LAT
Phosphorylation of PLC-gamma1
Disassociation of PLC-gamma1 from LAT
Disassociation of PLC-gamma1 from SLP-76
Translocation of PLC-gamma1 to PIP2
PLC-gamma1 hydrolyses PIP2
p-SLP-76 binds ADAP
p-SLP-76:ADAP binds Ena/VASP
p-SLP-76 binds NCK
NCK binds PAK
NCK recruits WASP
Recruitment of PI3K to plasmamembrane
PI3K phosphorylates PIP2 to PIP3
Hydrolysis of PIP3 to PI(3,4)P2
Hydrolysis of PIP3 to PIP2
Translocation of PDK1 to Plasma membrane
Translocation of PKC theta to plasma membrane
Change of PKC theta conformation
Phosphorylation of PKC theta
Translocation of CARMA1 to Plasma membrane
Phosphorylation of CARMA1
Oligomerization of CARMA1
Interaction of Bcl10 to CARMA1
Phosphorylation of Bcl10
Oligomerization of Bcl10
Interaction and oligomerization of MALT1 to Bcl10
Translocation of TRAF6 to CBM complex
Auto-ubiquitination of TRAF6
Activation of TAK1-TAB2 complex
Activation of IKK complex
Ubiquitination of NEMO by TRAF6
Activation of NF-kB complex
CD28 homodimer binds B7-1 homodimer
CD28 homodimer binds B7-2 monomer
Phosphorylation of CD28
Gads binds CD28
PI3K binds CD28
CD28 bound PI3K phosphorylates PIP2 to PIP3
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
AKT interacts and phosphorylates Cot
p-S400-Cot phosphorylates NIK
Grb2 binds CD28
Translocation of Vav1 to CD28
Activation of Vav1
Activation of Rac1 by pVav1
Activation of Cdc42 by pVav1
Activation of PAK by Rac1 and Cdc42
PP2A binds CTLA4 homodimer
CTLA-4 binds B7-1/B7-2
Phosphorylation of CTLA-4
SHP2 phosphatase binds CTLA-4
Dephosphorylation of AKT by PP2A
ICOS binds ICOSL/B7-H2
PI3K binds ICOS
PD-1 binds B7DC and B7H1
Phosphorylation of PD-1
Interaction of SHP-1 or SHP-2 with phospho PD-1
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
BTLA interacts with HVEM
SHP-1 and SHP-2 bind pBTLA
Grb2 binds pBTLA
The Immunoglobulin of the B Cell Receptor Binds Antigen
The Immunoglobulin of the BCR Binds Antigen
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
Recruitment of SYK to the Activated B Cell Receptor
Recruitment of SYK to the Activated BCR
Autophosphorylation of SYK at the Activated B Cell Receptor
Autophosphorylation of SYK at the Activated BCR
Activated SYK Phosphorylates BLNK (SLP65)
Assembly of Signalosomes at the Activated B Cell Receptor
Assembly of Signalosomes at the Activated BCR
BCAP Signalosome Generates PIP3
CD19 Signalosome Generates PIP3
BLNK (SLP-65) Signalosome Generates Diacylglycerol and Inositol-1,4,5-trisphosphate
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
Release of calcium from intracellular stores by IP3 receptor activation
Oligomerization of STIM1
STIM1 activation of CRAC
Formation of STIM1:TRPC1 Complex
STIM1 Binds TRPC1
Calcium influx via CRAC
Calcium Influx via TRPC1
Activation of Protein Kinase C beta (PKC-beta)
Phosphorylation of CARMA1 in B Cells
CARMA1 Recruits MALT1 and BCL10 to Form CBM Complex
Formation of CBM Complex
CARMA1:BCL10:MALT1 Complex Recruits TAK1 and IKK
TAK1 Associated with the CBM Complex Phosphorylates IKKbeta
Phosphorylation of I-kappaB by Activated IKK (B cell)
SCF with beta-TrCP1 or beta-TrCP2 Binds NF-kappaB;phospho-IkB
Ubiquitination of IkB by SCF-beta-TrCP
Degradation of Ubiquitinated IkB (B cell)
Translocation of NF-kappaB from the Cytosol to the Nucleus
Activation of RasGRP1 and RasGRP3 by Recruitment to the Membrane and Phosphorylation
Activation of RAS by RasGRP1 and RasGRP3
AKT phosphorylates BAD
AKT phosphorylates GSK3
AKT phosphorylates caspase-9
AKT phosphorylates MDM2
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates AKT1S1 (PRAS40)
AKT translocates to the nucleus
AKT phosphorylates CREB1
AKT can phosphorylate forkhead box transcription factors
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
PTEN dephosphorylates PIP3
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
PHLPP dephosphorylates S473 in AKT
PDPK1 binds PIP2
MIR26A microRNAs bind PTEN mRNA
PTEN mRNA translation negatively regulated by microRNAs
E1 mediated ubiquitin activation
Transfer of ubiquitin from E1 to E2
Interaction of E3 with substrate and E2-Ub complex
Transfer of Ub from E2 to substrate and release of E2
Polyubiquitination of substrate
Release of E3 from polyubiquitinated substrate
Proteasomal cleavage of substrate
Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
Binding of newly synthesized MHC class I heavy chain (HC) with calnexin
Interaction of Erp57 with MHC class I HC
Interaction of beta-2-microglobulin (B2M) chain with class I HC
Formation of peptide loading complex (PLC)
Transport of Antigen peptide in to ER
Trimming of peptides in ER
Loading of antigenic peptides on to class I MHC
Transport of MHC heterotrimer to ER exit site
Capturing cargo and formation of prebudding complex
Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle
Budding of COPII coated vesicle
Disassembly of COPII coated vesicle
Journey of cargo through Golgi complex
Expression of peptide bound class I MHC on cell surface
Interaction of particulate antigens with dendritic cell receptors
Engulfment of particulate antigen into phagocytic vesicle
Maturation of phagosome into phagolysosome
Alkalization of the phagosomal lumen by NOX2
Partial proteolysis of antigen in phagolysosomes
Escape of antigens from phagosome to cytosol
Egress of internalized antigen to the cytosol via sec61
Translocation of antigenic peptides back to phagosomes via TAP
Peptide loading on MHC class I in phagosome
Export of peptide loaded MHC class I complex to PM
Antigen processing by cathepsin S in endosoytic vesicle
Trimming of peptides by IRAP in endocytic vesicles
Loading of antigen peptide onto MHC class I molecule
Translocation of peptide bound MHC class I complex to cell surface
Interaction of exogenous soluble antigen with its corresponding receptor
Internalization of receptor bound antigen into clathrin coted vesicles
Movement of clathrin coated vesicles into early endosome
Exogenous soluble antigen targeted to more stable early endosome
Egress of internalized antigen into cytosol from early endosome
Proteasomal clevage of exogenous antigen
Formation of MHC II alpha beta heterodimer
Interaction of invariant chain trimer and MHC II alpha beta dimer
Formation of nonameric complex
Formation of COPII vesicle
Fusion of COPII vesicle with Golgi complex
Translocation of MHC II:Ii complex to TGN
Transport of MHC II:Ii complex along Golgi to TGN
TGN-lysosomal vesicle coat assembly
Translocation of TGN-lysosome vesicle to lysosome
TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome
Transport of MHC II:Ii complex to plasma membrane
Insertion of MHC II:Ii complex in to the plasma membrane
Recruitment of clathrin coated vesicle by Ii
Internalization of MHC II:Ii clathrin coated vesicle
Uncoating of clathrin-coated vesicles and fusion with endosomes
Trafficking of nonameric complex in the endocytic pathway
Initial proteolyis of Ii by aspartic proteases to lip22
Cleavage of lip22 to lip10
Generation of CLIP from lip10
Disassociation of CLIP from MHC II
MHC class II antigen internalization
Reduction of disulphide bonds in MHC II antigens
MHC class II antigen processing
Loading of antigenic peptides
Transport of antigen loaded MHC II molecules to surface
VCAM-1interacts with VLA-4
TCR complex interacts with peptide antigen-presenting MHC Class I
KIR2DL2/3 interacting with HLA-C group 1 (Cw4)
NKG2D homodimer interacting with ligands
CD96 binds PVR
MADCAM interacts with Integrin alpha4beta7
LILRs interact with MHC Class I
Ligands bind L-selectin
ICAMs 1-4 bind to Integrin LFA-1
KLRC1:KLRD1 heterodimer interacts with HLA-E
Epithelial cadherin binds to KLRG1
CRTAM binds to NECL2
PVR binds CD226
Nectin 2 binds CD226
CD200 binds to CD200R
MHC Class I interacts with CD160
Fc gamma receptors interact with antigen-bound IgG
CD40 interacting with CD40L
CXADR binds to AMICA1
C3d-complexed antigen binds to complement receptor
KIR2DL1 interacting with HLA-C group 2 (Cw3)
KIR3DL1 interacting with HLA Bw4
KIR3DL2 interacting with HLA-A3
KIR2DL4 interacting with HLA-G
KIR2DS1 interacting with HLA-C group 2 (Cw4)
KIR2DS2 interacting with HLA-C group 1 (Cw3)
PKA/PKG phosphorylate Rap1GAP2
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
Activation of EPACs by cAMP
Activation of Rap1 by membrane-associated GEFs
Activation of Rap1 by cytosolic GEFs
Rap1 signal termination by Rap1GAPs
Rap1 sequesters Raf1 to inhibit ERK cascade
Adaptive Immune System
TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
Downstream TCR signaling
Costimulation by the CD28 family
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
B Cell Activation
Signaling by the B Cell Receptor (BCR)
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
Downstream Signaling Events Of B Cell Receptor (BCR)
Activation of NF-kappaB in B Cells
Activation of RAS in B Cells
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
Class I MHC mediated antigen processing & presentation
Antigen processing: Ubiquitination & Proteasome degradation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Cross-presentation of particulate exogenous antigens (phagosomes)
ER-Phagosome pathway
Endosomal/Vacuolar pathway
Cross-presentation of soluble exogenous antigens (endosomes)
MHC class II antigen presentation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Rap1 signalling