CARDIAK
label: RICK
label: RIP2
label: RIPK2
label: UNQ277/PRO314/PRO34092
label: UniProt:O43353 RIPK2

FYN
label: UniProt:P06241 FYN

JTK8
label: LYN
label: UniProt:P07948 LYN

CD45
label: PTPRC
label: UniProt:P08575 PTPRC

GILT
label: IFI30
label: IP30
label: UniProt:P13284 IFI30

CTSS
label: UniProt:P25774 CTSS

COT
label: ESTF
label: MAP3K8
label: UniProt:P41279 MAP3K8

BLK
label: UniProt:P51451 BLK

AGMX1
label: ATK
label: BPK
label: BTK
label: UniProt:Q06187 BTK

INPP5D
label: SHIP
label: SHIP1
label: UniProt:Q92835 INPP5D

LGMN
label: PRSC1
label: UniProt:Q99538 LGMN

Calcium binds calmodulin
type: GO_0003674
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: BiochemicalReaction1287
directly activates: BiochemicalReaction1292
directly activates: BiochemicalReaction1296
directly activates: BiochemicalReaction1298
directly activates: BiochemicalReaction1324
directly activates: BiochemicalReaction243
directly activates: BiochemicalReaction4415
directly activates: BiochemicalReaction5368
directly activates: Catalysis453
directly activates: Control94
directly activates: Control95
directly activates: Modulation7
directly activates: Modulation8
directly activates: Pathway336

Interaction of Csk with PAG
type: GO_0003674
BFO_0000050: Phosphorylation of CD3 and TCR zeta chains
directly activates: Inactivation of Lck by Csk
directly activates: Catalysis226

Inactivation of Lck by Csk
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Phosphorylation of CD3 and TCR zeta chains
directly activates: Dephosphorylation of Lck-pY505 by CD45
directly activates: Catalysis227

Dephosphorylation of Lck-pY505 by CD45
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: CD45
type: Restriction
  on property: enabled by
  some values from: CD45
type: Restriction
  on property: enabled by
  some values from: CD45
type: Restriction
  on property: enabled by
  some values from: CD45
type: GO_0004725
BFO_0000050: Phosphorylation of CD3 and TCR zeta chains
directly activates: Activation of Lck
directly activates: Catalysis228

Activation of Lck
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Phosphorylation of CD3 and TCR zeta chains
directly activates: Phosphorylation of ITAM motifs in CD3 complexes
directly activates: Catalysis229

Phosphorylation of ITAM motifs in CD3 complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Phosphorylation of CD3 and TCR zeta chains
directly activates: Recruitment of ZAP-70 to phosphorylated ITAMs
directly activates: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
directly activates: Catalysis260

Recruitment of ZAP-70 to phosphorylated ITAMs
type: GO_0003674
BFO_0000050: Translocation of ZAP-70 to Immunological synapse
directly activates: Phosphorylation of ZAP-70 by Lck
directly activates: Catalysis230

Phosphorylation of ZAP-70 by Lck
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Translocation of ZAP-70 to Immunological synapse
directly activates: Activation of ZAP-70
directly activates: Catalysis231

Activation of ZAP-70
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Translocation of ZAP-70 to Immunological synapse
directly activates: Phosphorylation of TBSMs in LAT
directly activates: Catalysis232

Phosphorylation of TBSMs in LAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Generation of second messenger molecules
directly activates: Recruitment of Gads to LAT
directly activates: Recruitment of PLC-gamma1 to LAT

Recruitment of Gads to LAT
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Recruitment of SLP-76 to Gads

Recruitment of SLP-76 to Gads
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Phosphorylation of SLP-76
directly activates: Catalysis233

Phosphorylation of SLP-76
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Generation of second messenger molecules
directly activates: Recruitment of ITK to SLP-76
directly activates: Recruitment of PLC-gamma1 to SLP-76
directly activates: p-SLP-76 binds ADAP

Recruitment of ITK to SLP-76
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Phosphorylation of PLC-gamma1
directly activates: Catalysis234

Recruitment of PLC-gamma1 to SLP-76
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Phosphorylation of PLC-gamma1
directly activates: Catalysis234

Recruitment of PLC-gamma1 to LAT
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Phosphorylation of PLC-gamma1
directly activates: Catalysis234

Phosphorylation of PLC-gamma1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Generation of second messenger molecules
directly activates: Disassociation of PLC-gamma1 from LAT
directly activates: Disassociation of PLC-gamma1 from SLP-76
directly activates: Translocation of PLC-gamma1 to PIP2

Disassociation of PLC-gamma1 from LAT
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Translocation of PLC-gamma1 to PIP2

Disassociation of PLC-gamma1 from SLP-76
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: Translocation of PLC-gamma1 to PIP2

Translocation of PLC-gamma1 to PIP2
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: PLC-gamma1 hydrolyses PIP2
directly activates: Catalysis235

PLC-gamma1 hydrolyses PIP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004435
BFO_0000050: Generation of second messenger molecules
directly activates: Recruitment of PI3K to plasmamembrane

p-SLP-76 binds ADAP
type: GO_0003674
BFO_0000050: Generation of second messenger molecules

p-SLP-76:ADAP binds Ena/VASP
type: GO_0003674
BFO_0000050: Generation of second messenger molecules

p-SLP-76 binds NCK
type: GO_0003674
BFO_0000050: Generation of second messenger molecules

NCK binds PAK
type: GO_0003674
BFO_0000050: Generation of second messenger molecules

NCK recruits WASP
type: GO_0003674
BFO_0000050: Generation of second messenger molecules
directly activates: BiochemicalReaction1226

Recruitment of PI3K to plasmamembrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: PI3K phosphorylates PIP2 to PIP3
directly activates: Catalysis236

PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: Downstream TCR signaling
directly activates: BiochemicalReaction2321
directly activates: Hydrolysis of PIP3 to PI(3,4)P2
directly activates: Hydrolysis of PIP3 to PIP2
directly activates: Translocation of PDK1 to Plasma membrane
directly activates: PIP3 recruits PDPK1 to the membrane
directly activates: PIP3 recruits AKT to the membrane
directly activates: Catalysis237
directly activates: Catalysis238
directly activates: Control158

Hydrolysis of PIP3 to PI(3,4)P2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: INPP5D
type: Restriction
  on property: enabled by
  some values from: INPP5D
type: Restriction
  on property: enabled by
  some values from: INPP5D
type: Restriction
  on property: enabled by
  some values from: INPP5D
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of PDK1 to Plasma membrane

Hydrolysis of PIP3 to PIP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Downstream TCR signaling

Translocation of PDK1 to Plasma membrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of PKC theta to plasma membrane

Translocation of PKC theta to plasma membrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Change of PKC theta conformation
directly activates: Catalysis239

Change of PKC theta conformation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Downstream TCR signaling
directly activates: Phosphorylation of PKC theta
directly activates: Catalysis240

Phosphorylation of PKC theta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of CARMA1 to Plasma membrane

Translocation of CARMA1 to Plasma membrane
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Phosphorylation of CARMA1
directly activates: Catalysis241

Phosphorylation of CARMA1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Oligomerization of CARMA1

Oligomerization of CARMA1
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Interaction of Bcl10 to CARMA1

Interaction of Bcl10 to CARMA1
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Phosphorylation of Bcl10
directly activates: Catalysis242

Phosphorylation of Bcl10
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CARDIAK
type: Restriction
  on property: enabled by
  some values from: CARDIAK
type: Restriction
  on property: enabled by
  some values from: CARDIAK
type: Restriction
  on property: enabled by
  some values from: CARDIAK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Oligomerization of Bcl10

Oligomerization of Bcl10
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Interaction and oligomerization of MALT1 to Bcl10

Interaction and oligomerization of MALT1 to Bcl10
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Translocation of TRAF6 to CBM complex

Translocation of TRAF6 to CBM complex
type: GO_0003674
BFO_0000050: Downstream TCR signaling
directly activates: Auto-ubiquitination of TRAF6
directly activates: Catalysis243

Auto-ubiquitination of TRAF6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004842
BFO_0000050: Downstream TCR signaling
directly activates: Activation of TAK1-TAB2 complex
directly activates: Catalysis244

Activation of TAK1-TAB2 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Activation of IKK complex
directly activates: Catalysis245

Activation of IKK complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: Ubiquitination of NEMO by TRAF6
directly activates: Catalysis246

Ubiquitination of NEMO by TRAF6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004842
BFO_0000050: Downstream TCR signaling
directly activates: Activation of NF-kB complex
directly activates: Catalysis247

Activation of NF-kB complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Downstream TCR signaling
directly activates: BiochemicalReaction1341
directly activates: BiochemicalReaction3896

CD28 homodimer binds B7-1 homodimer
type: GO_0003674
BFO_0000050: CD28 co-stimulation
directly activates: Phosphorylation of CD28
directly activates: Catalysis248

CD28 homodimer binds B7-2 monomer
type: GO_0003674
BFO_0000050: CD28 co-stimulation
directly activates: Phosphorylation of CD28
directly activates: Catalysis248

Phosphorylation of CD28
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: CD28 co-stimulation
directly activates: Gads binds CD28
directly activates: PI3K binds CD28
directly activates: Grb2 binds CD28

Gads binds CD28
type: GO_0003674
BFO_0000050: CD28 co-stimulation

PI3K binds CD28
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: CD28 bound PI3K phosphorylates PIP2 to PIP3
directly activates: Catalysis249

CD28 bound PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: BiochemicalReaction2321
directly activates: Translocation of PDK1 to Plasma membrane
directly activates: PIP3 recruits PDPK1 to the membrane
directly activates: PIP3 recruits AKT to the membrane
directly activates: Control158

PIP3 recruits PDPK1 to the membrane
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling
BFO_0000050: PIP3 activates AKT signaling

PIP3 recruits AKT to the membrane
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling
BFO_0000050: PIP3 activates AKT signaling

TORC2 (mTOR) phosphorylates AKT at S473
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: CD28 dependent PI3K/Akt signaling
BFO_0000050: PIP3 activates AKT signaling
directly activates: AKT interacts and phosphorylates Cot
directly activates: AKT phosphorylates BAD
directly activates: AKT phosphorylates GSK3
directly activates: AKT phosphorylates caspase-9
directly activates: AKT phosphorylates MDM2
directly activates: AKT phosphorylates IKKalpha
directly activates: AKT phosphorylates p21Cip1 and p27Kip1
directly activates: AKT phosphorylates TSC2, inhibiting it
directly activates: AKT phosphorylates AKT1S1 (PRAS40)
directly activates: Catalysis252
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

AKT binds PDPK1
type: GO_0003674
BFO_0000050: CD28 dependent PI3K/Akt signaling
BFO_0000050: PIP3 activates AKT signaling

PDPK1 phosphorylates AKT at T308
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: CD28 dependent PI3K/Akt signaling
BFO_0000050: PIP3 activates AKT signaling
directly activates: AKT phosphorylates BAD
directly activates: AKT phosphorylates GSK3
directly activates: AKT phosphorylates caspase-9
directly activates: AKT phosphorylates MDM2
directly activates: AKT phosphorylates IKKalpha
directly activates: AKT phosphorylates p21Cip1 and p27Kip1
directly activates: AKT phosphorylates TSC2, inhibiting it
directly activates: AKT phosphorylates AKT1S1 (PRAS40)
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

AKT interacts and phosphorylates Cot
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: CD28 dependent PI3K/Akt signaling
directly activates: p-S400-Cot phosphorylates NIK
directly activates: Catalysis253

p-S400-Cot phosphorylates NIK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004709
BFO_0000050: CD28 dependent PI3K/Akt signaling

Grb2 binds CD28
type: GO_0003674
BFO_0000050: CD28 dependent Vav1 pathway
directly activates: Translocation of Vav1 to CD28

Translocation of Vav1 to CD28
type: GO_0003674
BFO_0000050: CD28 dependent Vav1 pathway
directly activates: Activation of Vav1
directly activates: Catalysis254

Activation of Vav1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: Restriction
  on property: enabled by
  some values from: FYN
type: GO_0004713
BFO_0000050: CD28 dependent Vav1 pathway
directly activates: Activation of Rac1 by pVav1
directly activates: Activation of Cdc42 by pVav1
directly activates: Catalysis255
directly activates: Catalysis256

Activation of Rac1 by pVav1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: CD28 dependent Vav1 pathway
directly activates: Activation of PAK by Rac1 and Cdc42

Activation of Cdc42 by pVav1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: CD28 dependent Vav1 pathway
directly activates: Activation of PAK by Rac1 and Cdc42

Activation of PAK by Rac1 and Cdc42
type: GO_0003674
BFO_0000050: CD28 dependent Vav1 pathway

PP2A binds CTLA4 homodimer
type: GO_0003674
BFO_0000050: CTLA4 inhibitory signaling
directly activates: CTLA-4 binds B7-1/B7-2

CTLA-4 binds B7-1/B7-2
type: GO_0003674
BFO_0000050: CTLA4 inhibitory signaling
directly activates: Phosphorylation of CTLA-4
directly activates: Catalysis257

Phosphorylation of CTLA-4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: CTLA4 inhibitory signaling
directly activates: SHP2 phosphatase binds CTLA-4
directly activates: Dephosphorylation of AKT by PP2A
directly activates: Catalysis258

SHP2 phosphatase binds CTLA-4
type: GO_0003674
BFO_0000050: CTLA4 inhibitory signaling

Dephosphorylation of AKT by PP2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008195
BFO_0000050: CTLA4 inhibitory signaling

ICOS binds ICOSL/B7-H2
type: GO_0003674
BFO_0000050: Costimulation by the CD28 family

PI3K binds ICOS
type: GO_0003674
BFO_0000050: Costimulation by the CD28 family

PD-1 binds B7DC and B7H1
type: GO_0003674
BFO_0000050: PD-1 signaling
directly activates: Phosphorylation of PD-1
directly activates: Catalysis259

Phosphorylation of PD-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: PD-1 signaling
directly activates: Interaction of SHP-1 or SHP-2 with phospho PD-1

Interaction of SHP-1 or SHP-2 with phospho PD-1
type: GO_0003674
BFO_0000050: PD-1 signaling
directly activates: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
directly activates: Catalysis260

Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004725
BFO_0000050: PD-1 signaling

BTLA interacts with HVEM
type: GO_0003674
BFO_0000050: Costimulation by the CD28 family

SHP-1 and SHP-2 bind pBTLA
type: GO_0003674
BFO_0000050: Costimulation by the CD28 family

Grb2 binds pBTLA
type: GO_0003674
BFO_0000050: Costimulation by the CD28 family

The Immunoglobulin of the B Cell Receptor Binds Antigen
type: GO_0003674
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
directly activates: Catalysis261
directly activates: Catalysis262
directly activates: Catalysis263
label: The Immunoglobulin of the BCR Binds Antigen

Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Recruitment of SYK to the Activated B Cell Receptor

Recruitment of SYK to the Activated B Cell Receptor
type: GO_0003674
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Autophosphorylation of SYK at the Activated B Cell Receptor
directly activates: Catalysis264
label: Recruitment of SYK to the Activated BCR

Autophosphorylation of SYK at the Activated B Cell Receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Activated SYK Phosphorylates BLNK (SLP65)
directly activates: Catalysis265
label: Autophosphorylation of SYK at the Activated BCR

Activated SYK Phosphorylates BLNK (SLP65)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Assembly of Signalosomes at the Activated B Cell Receptor
directly activates: Catalysis266
directly activates: Catalysis267
directly activates: Catalysis268

Assembly of Signalosomes at the Activated B Cell Receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: AGMX1
type: Restriction
  on property: enabled by
  some values from: AGMX1
type: Restriction
  on property: enabled by
  some values from: AGMX1
type: Restriction
  on property: enabled by
  some values from: AGMX1
type: GO_0004713
type: GO_0046934
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: BCAP Signalosome Generates PIP3
directly activates: CD19 Signalosome Generates PIP3
directly activates: BLNK (SLP-65) Signalosome Generates Diacylglycerol and Inositol-1,4,5-trisphosphate
directly activates: Catalysis269
directly activates: Catalysis270
directly activates: Catalysis271
label: Assembly of Signalosomes at the Activated BCR

BCAP Signalosome Generates PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0035004
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: BiochemicalReaction2321
directly activates: PIP3 recruits PDPK1 to the membrane
directly activates: PIP3 recruits AKT to the membrane
directly activates: Control158

CD19 Signalosome Generates PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: BiochemicalReaction2321
directly activates: PIP3 recruits PDPK1 to the membrane
directly activates: PIP3 recruits AKT to the membrane
directly activates: Control158

BLNK (SLP-65) Signalosome Generates Diacylglycerol and Inositol-1,4,5-trisphosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004629
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
directly activates: Activation of Protein Kinase C beta (PKC-beta)
directly activates: Activation of RasGRP1 and RasGRP3 by Recruitment to the Membrane and Phosphorylation

IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
type: GO_0003674
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Release of calcium from intracellular stores by IP3 receptor activation
directly activates: Catalysis272
directly activates: Control50

Release of calcium from intracellular stores by IP3 receptor activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0005261
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Calcium binds calmodulin
directly activates: BiochemicalReaction5350
directly activates: Oligomerization of STIM1
directly activates: Activation of Protein Kinase C beta (PKC-beta)
directly activates: Catalysis2575
directly activates: Catalysis273
directly activates: Control428
directly activates: Control429
directly activates: Control430
directly activates: Control431
directly activates: Pathway1104

Oligomerization of STIM1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0005261
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: STIM1 activation of CRAC
directly activates: Formation of STIM1:TRPC1 Complex

STIM1 activation of CRAC
type: GO_0003674
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Calcium influx via CRAC
directly activates: Catalysis274

Formation of STIM1:TRPC1 Complex
type: GO_0003674
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Calcium Influx via TRPC1
directly activates: Catalysis275
label: STIM1 Binds TRPC1

Calcium influx via CRAC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015279
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Calcium binds calmodulin
directly activates: Activation of Protein Kinase C beta (PKC-beta)

Calcium Influx via TRPC1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0005261
BFO_0000050: Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
directly activates: Calcium binds calmodulin

Activation of Protein Kinase C beta (PKC-beta)
type: GO_0003674
BFO_0000050: Activation of NF-kappaB in B Cells
directly activates: Phosphorylation of CARMA1 in B Cells
directly activates: Catalysis276

Phosphorylation of CARMA1 in B Cells
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Activation of NF-kappaB in B Cells
directly activates: CARMA1 Recruits MALT1 and BCL10 to Form CBM Complex

CARMA1 Recruits MALT1 and BCL10 to Form CBM Complex
type: GO_0003674
BFO_0000050: Activation of NF-kappaB in B Cells
directly activates: CARMA1:BCL10:MALT1 Complex Recruits TAK1 and IKK
label: Formation of CBM Complex

CARMA1:BCL10:MALT1 Complex Recruits TAK1 and IKK
type: GO_0003674
BFO_0000050: Activation of NF-kappaB in B Cells
directly activates: TAK1 Associated with the CBM Complex Phosphorylates IKKbeta
directly activates: Catalysis277

TAK1 Associated with the CBM Complex Phosphorylates IKKbeta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Activation of NF-kappaB in B Cells
directly activates: Phosphorylation of I-kappaB by Activated IKK (B cell)
directly activates: Catalysis278

Phosphorylation of I-kappaB by Activated IKK (B cell)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Activation of NF-kappaB in B Cells
directly activates: SCF with beta-TrCP1 or beta-TrCP2 Binds NF-kappaB;phospho-IkB

SCF with beta-TrCP1 or beta-TrCP2 Binds NF-kappaB;phospho-IkB
type: GO_0003674
BFO_0000050: Activation of NF-kappaB in B Cells
directly activates: Ubiquitination of IkB by SCF-beta-TrCP

Ubiquitination of IkB by SCF-beta-TrCP
type: GO_0003674
BFO_0000050: Activation of NF-kappaB in B Cells
directly activates: Degradation of Ubiquitinated IkB (B cell)
directly activates: Catalysis279

Degradation of Ubiquitinated IkB (B cell)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Activation of NF-kappaB in B Cells
directly activates: Translocation of NF-kappaB from the Cytosol to the Nucleus

Translocation of NF-kappaB from the Cytosol to the Nucleus
type: GO_0003674
BFO_0000050: Activation of NF-kappaB in B Cells

Activation of RasGRP1 and RasGRP3 by Recruitment to the Membrane and Phosphorylation
type: GO_0003674
BFO_0000050: Activation of RAS in B Cells
directly activates: Activation of RAS by RasGRP1 and RasGRP3
directly activates: Catalysis280

Activation of RAS by RasGRP1 and RasGRP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Activation of RAS in B Cells
directly activates: BiochemicalReaction1275

PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: PIP3 activates AKT signaling

AKT phosphorylates BAD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol
directly activates: BiochemicalReaction6004

AKT phosphorylates GSK3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates caspase-9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates MDM2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates IKKalpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates p21Cip1 and p27Kip1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates TSC2, inhibiting it
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates AKT1S1 (PRAS40)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT translocates to the nucleus
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling
directly activates: AKT phosphorylates CREB1
directly activates: AKT can phosphorylate forkhead box transcription factors
directly activates: AKT can phosphorylate RSK
directly activates: AKT can phosphorylate NR4A1 (NUR77)
directly activates: Catalysis290
directly activates: Catalysis291
directly activates: Catalysis292
directly activates: Catalysis293

AKT phosphorylates CREB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate forkhead box transcription factors
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate RSK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate NR4A1 (NUR77)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

PTEN dephosphorylates PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Negative regulation of the PI3K/AKT network
directly activates: BiochemicalReaction3944
directly activates: Catalysis1796

THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
type: GO_0003674
BFO_0000050: Negative regulation of the PI3K/AKT network

PHLPP dephosphorylates S473 in AKT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: Negative regulation of the PI3K/AKT network

PDPK1 binds PIP2
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling
directly activates: BiochemicalReaction3238

MIR26A microRNAs bind PTEN mRNA
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PTEN mRNA translation negatively regulated by microRNAs
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

E1 mediated ubiquitin activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Antigen processing: Ubiquitination & Proteasome degradation
directly activates: Transfer of ubiquitin from E1 to E2
directly activates: Catalysis297

Transfer of ubiquitin from E1 to E2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0043130
BFO_0000050: Antigen processing: Ubiquitination & Proteasome degradation
directly activates: Interaction of E3 with substrate and E2-Ub complex

Interaction of E3 with substrate and E2-Ub complex
type: GO_0003674
BFO_0000050: Antigen processing: Ubiquitination & Proteasome degradation
directly activates: Transfer of Ub from E2 to substrate and release of E2
directly activates: Catalysis298

Transfer of Ub from E2 to substrate and release of E2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Antigen processing: Ubiquitination & Proteasome degradation
directly activates: Polyubiquitination of substrate
directly activates: Catalysis299

Polyubiquitination of substrate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Antigen processing: Ubiquitination & Proteasome degradation
directly activates: Release of E3 from polyubiquitinated substrate

Release of E3 from polyubiquitinated substrate
type: GO_0003674
BFO_0000050: Antigen processing: Ubiquitination & Proteasome degradation
directly activates: Proteasomal cleavage of substrate
directly activates: Catalysis300

Proteasomal cleavage of substrate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Antigen processing: Ubiquitination & Proteasome degradation
directly activates: Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
directly activates: Catalysis301

Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004177
BFO_0000050: Antigen processing: Ubiquitination & Proteasome degradation
directly activates: Transport of Antigen peptide in to ER
directly activates: Catalysis302

Binding of newly synthesized MHC class I heavy chain (HC) with calnexin
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Interaction of Erp57 with MHC class I HC

Interaction of Erp57 with MHC class I HC
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Interaction of beta-2-microglobulin (B2M) chain with class I HC

Interaction of beta-2-microglobulin (B2M) chain with class I HC
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Formation of peptide loading complex (PLC)

Formation of peptide loading complex (PLC)
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Transport of Antigen peptide in to ER
directly activates: Catalysis302

Transport of Antigen peptide in to ER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0015433
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Trimming of peptides in ER
directly activates: Catalysis303

Trimming of peptides in ER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0004175
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Loading of antigenic peptides on to class I MHC

Loading of antigenic peptides on to class I MHC
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Transport of MHC heterotrimer to ER exit site

Transport of MHC heterotrimer to ER exit site
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Capturing cargo and formation of prebudding complex
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle

Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Budding of COPII coated vesicle

Budding of COPII coated vesicle
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Disassembly of COPII coated vesicle
directly activates: Catalysis304

Disassembly of COPII coated vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0012507
type: Restriction
  on property: BFO_0000066
  some values from: GO_0012507
type: Restriction
  on property: BFO_0000066
  some values from: GO_0012507
type: Restriction
  on property: BFO_0000066
  some values from: GO_0012507
type: GO_0003924
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Journey of cargo through Golgi complex

Journey of cargo through Golgi complex
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC
directly activates: Expression of peptide bound class I MHC on cell surface

Expression of peptide bound class I MHC on cell surface
type: GO_0003674
BFO_0000050: Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Interaction of particulate antigens with dendritic cell receptors
type: GO_0003674
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)
directly activates: Engulfment of particulate antigen into phagocytic vesicle

Engulfment of particulate antigen into phagocytic vesicle
type: GO_0003674
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)
directly activates: Maturation of phagosome into phagolysosome

Maturation of phagosome into phagolysosome
type: GO_0003674
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)

Alkalization of the phagosomal lumen by NOX2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: GO_0016175
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)

Partial proteolysis of antigen in phagolysosomes
type: GO_0003674
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)
directly activates: Escape of antigens from phagosome to cytosol
directly activates: Egress of internalized antigen to the cytosol via sec61
directly activates: Catalysis307

Escape of antigens from phagosome to cytosol
type: GO_0003674
BFO_0000050: Cross-presentation of particulate exogenous antigens (phagosomes)

Egress of internalized antigen to the cytosol via sec61
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: GO_0022857
BFO_0000050: ER-Phagosome pathway
directly activates: Proteasomal cleavage of substrate
directly activates: Catalysis308

Proteasomal cleavage of substrate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: ER-Phagosome pathway
directly activates: Translocation of antigenic peptides back to phagosomes via TAP
directly activates: Catalysis309

Translocation of antigenic peptides back to phagosomes via TAP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: Restriction
  on property: BFO_0000066
  some values from: GO_0030670
type: GO_0015433
BFO_0000050: ER-Phagosome pathway
directly activates: Peptide loading on MHC class I in phagosome

Peptide loading on MHC class I in phagosome
type: GO_0003674
BFO_0000050: ER-Phagosome pathway
directly activates: Export of peptide loaded MHC class I complex to PM

Export of peptide loaded MHC class I complex to PM
type: GO_0003674
BFO_0000050: ER-Phagosome pathway

Antigen processing by cathepsin S in endosoytic vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031905
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031905
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031905
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031905
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031905
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031905
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031905
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031905
type: Restriction
  on property: enabled by
  some values from: CTSS
type: Restriction
  on property: enabled by
  some values from: CTSS
type: Restriction
  on property: enabled by
  some values from: CTSS
type: Restriction
  on property: enabled by
  some values from: CTSS
type: Restriction
  on property: enabled by
  some values from: CTSS
type: Restriction
  on property: enabled by
  some values from: CTSS
type: Restriction
  on property: enabled by
  some values from: CTSS
type: Restriction
  on property: enabled by
  some values from: CTSS
type: GO_0004197
BFO_0000050: Endosomal/Vacuolar pathway
directly activates: Trimming of peptides by IRAP in endocytic vesicles
directly activates: Catalysis311

Trimming of peptides by IRAP in endocytic vesicles
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: GO_0004177
BFO_0000050: Endosomal/Vacuolar pathway
directly activates: Loading of antigen peptide onto MHC class I molecule

Loading of antigen peptide onto MHC class I molecule
type: GO_0003674
BFO_0000050: Endosomal/Vacuolar pathway
directly activates: Translocation of peptide bound MHC class I complex to cell surface

Translocation of peptide bound MHC class I complex to cell surface
type: GO_0003674
BFO_0000050: Endosomal/Vacuolar pathway

Interaction of exogenous soluble antigen with its corresponding receptor
type: GO_0003674
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)
directly activates: Internalization of receptor bound antigen into clathrin coted vesicles

Internalization of receptor bound antigen into clathrin coted vesicles
type: GO_0003674
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)
directly activates: Movement of clathrin coated vesicles into early endosome

Movement of clathrin coated vesicles into early endosome
type: GO_0006898
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)
directly activates: Exogenous soluble antigen targeted to more stable early endosome

Exogenous soluble antigen targeted to more stable early endosome
type: GO_0003674
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)
directly activates: Egress of internalized antigen into cytosol from early endosome

Egress of internalized antigen into cytosol from early endosome
type: GO_0003674
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)
directly activates: Proteasomal clevage of exogenous antigen
directly activates: Catalysis312

Proteasomal clevage of exogenous antigen
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Cross-presentation of soluble exogenous antigens (endosomes)

Formation of MHC II alpha beta heterodimer
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Interaction of invariant chain trimer and MHC II alpha beta dimer

Interaction of invariant chain trimer and MHC II alpha beta dimer
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Formation of nonameric complex

Formation of nonameric complex
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Formation of COPII vesicle

Formation of COPII vesicle
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Fusion of COPII vesicle with Golgi complex
directly activates: Translocation of MHC II:Ii complex to TGN

Fusion of COPII vesicle with Golgi complex
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Translocation of MHC II:Ii complex to TGN

Translocation of MHC II:Ii complex to TGN
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: TGN-lysosomal vesicle coat assembly
directly activates: Transport of MHC II:Ii complex to plasma membrane
label: Transport of MHC II:Ii complex along Golgi to TGN

TGN-lysosomal vesicle coat assembly
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Translocation of TGN-lysosome vesicle to lysosome
directly activates: Catalysis313

Translocation of TGN-lysosome vesicle to lysosome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003924
BFO_0000050: MHC class II antigen presentation
directly activates: TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome

TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Initial proteolyis of Ii by aspartic proteases to lip22
directly activates: Catalysis315

Transport of MHC II:Ii complex to plasma membrane
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Insertion of MHC II:Ii complex in to the plasma membrane

Insertion of MHC II:Ii complex in to the plasma membrane
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Recruitment of clathrin coated vesicle by Ii

Recruitment of clathrin coated vesicle by Ii
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Internalization of MHC II:Ii clathrin coated vesicle
directly activates: Catalysis314

Internalization of MHC II:Ii clathrin coated vesicle
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003924
BFO_0000050: MHC class II antigen presentation
directly activates: Uncoating of clathrin-coated vesicles and fusion with endosomes

Uncoating of clathrin-coated vesicles and fusion with endosomes
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Trafficking of nonameric complex in the endocytic pathway

Trafficking of nonameric complex in the endocytic pathway
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Initial proteolyis of Ii by aspartic proteases to lip22
directly activates: Catalysis315

Initial proteolyis of Ii by aspartic proteases to lip22
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: LGMN
type: Restriction
  on property: enabled by
  some values from: LGMN
type: GO_0004197
BFO_0000050: MHC class II antigen presentation
directly activates: Cleavage of lip22 to lip10
directly activates: Catalysis316

Cleavage of lip22 to lip10
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004197
BFO_0000050: MHC class II antigen presentation
directly activates: Generation of CLIP from lip10
directly activates: Catalysis317

Generation of CLIP from lip10
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004197
BFO_0000050: MHC class II antigen presentation
directly activates: Disassociation of CLIP from MHC II

Disassociation of CLIP from MHC II
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Loading of antigenic peptides

MHC class II antigen internalization
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Reduction of disulphide bonds in MHC II antigens
directly activates: Catalysis318

Reduction of disulphide bonds in MHC II antigens
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: GILT
type: Restriction
  on property: enabled by
  some values from: GILT
type: GO_0016667
BFO_0000050: MHC class II antigen presentation
directly activates: MHC class II antigen processing
directly activates: Catalysis319

MHC class II antigen processing
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004197
BFO_0000050: MHC class II antigen presentation
directly activates: Loading of antigenic peptides

Loading of antigenic peptides
type: GO_0003674
BFO_0000050: MHC class II antigen presentation
directly activates: Transport of antigen loaded MHC II molecules to surface

Transport of antigen loaded MHC II molecules to surface
type: GO_0003674
BFO_0000050: MHC class II antigen presentation

VCAM-1interacts with VLA-4
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

TCR complex interacts with peptide antigen-presenting MHC Class I
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

KIR2DL2/3 interacting with HLA-C group 1 (Cw4)
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

NKG2D homodimer interacting with ligands
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

CD96 binds PVR
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

MADCAM interacts with Integrin alpha4beta7
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

LILRs interact with MHC Class I
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Ligands bind L-selectin
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

ICAMs 1-4 bind to Integrin LFA-1
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

KLRC1:KLRD1 heterodimer interacts with HLA-E
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Epithelial cadherin binds to KLRG1
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

CRTAM binds to NECL2
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

PVR binds CD226
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Nectin 2 binds CD226
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

CD200 binds to CD200R
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

MHC Class I interacts with CD160
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Fc gamma receptors interact with antigen-bound IgG
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

CD40 interacting with CD40L
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

CXADR binds to AMICA1
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

C3d-complexed antigen binds to complement receptor
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

KIR2DL1 interacting with HLA-C group 2 (Cw3)
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

KIR3DL1 interacting with HLA Bw4
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

KIR3DL2 interacting with HLA-A3
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

KIR2DL4 interacting with HLA-G
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

KIR2DS1 interacting with HLA-C group 2 (Cw4)
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

KIR2DS2 interacting with HLA-C group 1 (Cw3)
type: GO_0003674
BFO_0000050: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

PKA/PKG phosphorylate Rap1GAP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Rap1 signalling
directly activates: 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
directly activates: Control52

14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
type: GO_0003674
BFO_0000050: Rap1 signalling
directly activates: Rap1 signal termination by Rap1GAPs
directly activates: Catalysis323

Activation of EPACs by cAMP
type: GO_0003674
BFO_0000050: Rap1 signalling
directly activates: Activation of Rap1 by membrane-associated GEFs
directly activates: Catalysis321

Activation of Rap1 by membrane-associated GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Rap1 signalling
directly activates: BiochemicalReaction2324
directly activates: Rap1 signal termination by Rap1GAPs
directly activates: Rap1 sequesters Raf1 to inhibit ERK cascade
directly activates: Catalysis323

Activation of Rap1 by cytosolic GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: Rap1 signalling
directly activates: BiochemicalReaction2324
directly activates: Rap1 signal termination by Rap1GAPs
directly activates: Rap1 sequesters Raf1 to inhibit ERK cascade
directly activates: Catalysis323

Rap1 signal termination by Rap1GAPs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005096
BFO_0000050: Rap1 signalling

Rap1 sequesters Raf1 to inhibit ERK cascade
type: GO_0003674
BFO_0000050: Rap1 signalling

Adaptive Immune System
type: GO_0008150

TCR signaling
type: GO_0008150
BFO_0000050: Adaptive Immune System

Phosphorylation of CD3 and TCR zeta chains
type: GO_0008150
BFO_0000050: TCR signaling

Translocation of ZAP-70 to Immunological synapse
type: GO_0008150
BFO_0000050: TCR signaling

Generation of second messenger molecules
type: GO_0008150
BFO_0000050: TCR signaling

Downstream TCR signaling
type: GO_0008150
BFO_0000050: TCR signaling

Costimulation by the CD28 family
type: GO_0008150
BFO_0000050: Adaptive Immune System

CD28 co-stimulation
type: GO_0008150
BFO_0000050: Costimulation by the CD28 family

CD28 dependent PI3K/Akt signaling
type: GO_0008150
BFO_0000050: CD28 co-stimulation

CD28 dependent Vav1 pathway
type: GO_0008150
BFO_0000050: CD28 co-stimulation

CTLA4 inhibitory signaling
type: GO_0008150
BFO_0000050: Costimulation by the CD28 family

PD-1 signaling
type: GO_0008150
BFO_0000050: Costimulation by the CD28 family

B Cell Activation
type: GO_0008150
BFO_0000050: Adaptive Immune System
label: Signaling by the B Cell Receptor (BCR)

Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
type: GO_0008150
BFO_0000050: B Cell Activation

Downstream Signaling Events Of B Cell Receptor (BCR)
type: GO_0008150
BFO_0000050: B Cell Activation

Activation of NF-kappaB in B Cells
type: GO_0008150
BFO_0000050: Downstream Signaling Events Of B Cell Receptor (BCR)

Activation of RAS in B Cells
type: GO_0008150
BFO_0000050: Downstream Signaling Events Of B Cell Receptor (BCR)

PIP3 activates AKT signaling
type: GO_0008150
BFO_0000050: Downstream Signaling Events Of B Cell Receptor (BCR)

AKT phosphorylates targets in the cytosol
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

AKT phosphorylates targets in the nucleus
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

Negative regulation of the PI3K/AKT network
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

Class I MHC mediated antigen processing & presentation
type: GO_0008150
BFO_0000050: Adaptive Immune System

Antigen processing: Ubiquitination & Proteasome degradation
type: GO_0008150
BFO_0000050: Class I MHC mediated antigen processing & presentation

Antigen Presentation: Folding, assembly and peptide loading of class I MHC
type: GO_0008150
BFO_0000050: Class I MHC mediated antigen processing & presentation

Antigen processing-Cross presentation
type: GO_0008150
BFO_0000050: Class I MHC mediated antigen processing & presentation

Cross-presentation of particulate exogenous antigens (phagosomes)
type: GO_0008150
BFO_0000050: Antigen processing-Cross presentation

ER-Phagosome pathway
type: GO_0008150
BFO_0000050: Antigen processing-Cross presentation

Endosomal/Vacuolar pathway
type: GO_0008150
BFO_0000050: Antigen processing-Cross presentation

Cross-presentation of soluble exogenous antigens (endosomes)
type: GO_0008150
BFO_0000050: Antigen processing-Cross presentation

MHC class II antigen presentation
type: GO_0008150
BFO_0000050: Adaptive Immune System

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
type: GO_0008150
BFO_0000050: Adaptive Immune System

Rap1 signalling
type: GO_0008150
BFO_0000050: Adaptive Immune System