JNK1
label: MAPK8
label: PRKM8
label: SAPK1
label: SAPK1C
label: UniProt:P45983 MAPK8

Sequestration of BAD protein by 14-3-3
type: GO_0003674
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: Activation of BAD by calcineurin
directly activates: Catalysis3110

Activation of BAD by calcineurin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008597
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: Translocation of activated BAD protein to mitochondria

Translocation of activated BAD protein to mitochondria
type: GO_0001844
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: BAD displaces tBID from BCL-2 sequestration

BAD displaces tBID from BCL-2 sequestration
type: GO_0003674
BFO_0000050: Activation of BAD and translocation to mitochondria

Translocation of NOXA to mitochondria
type: GO_0001844
BFO_0000050: Activation of NOXA and translocation to mitochondria

Translocation of PUMA protein to mitochondria
type: GO_0001844
BFO_0000050: Activation of PUMA and translocation to mitochondria

MAPK8 phosphorylates BCL2L11
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: JNK1
type: GO_0016301
BFO_0000050: Activation of BIM and translocation to mitochondria
label: Phosphorylation of BIM by JNK

Translocation of BIM to mitochondria
type: GO_0001844
BFO_0000050: Activation of BIM and translocation to mitochondria

Phosphorylation of DLC2 by MAPK8
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: enabled by
  some values from: JNK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Activation of BMF and translocation to mitochondria

Translocation of BMF to mitochondria
type: GO_0001844
BFO_0000050: Activation of BMF and translocation to mitochondria

AKT phosphorylates BAD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Activation of BAD and translocation to mitochondria
directly activates: Sequestration of BAD protein by 14-3-3

Activation of BH3-only proteins
type: GO_0008150

Activation of BAD and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of NOXA and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of PUMA and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of BIM and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Activation of BMF and translocation to mitochondria
type: GO_0008150
BFO_0000050: Activation of BH3-only proteins

Transactivation of NOXA by p53
type: GO_0003674
BFO_0000050: Activation of NOXA and translocation to mitochondria
directly activates: Translocation of NOXA to mitochondria

Transactivation of NOXA by E2F1
type: GO_0003674
BFO_0000050: Activation of NOXA and translocation to mitochondria
directly activates: Translocation of NOXA to mitochondria

Transactivation of PUMA by p53
type: GO_0003674
BFO_0000050: Activation of PUMA and translocation to mitochondria
directly activates: Translocation of PUMA protein to mitochondria

Transactivation of PUMA by E2F1
type: GO_0003674
BFO_0000050: Activation of PUMA and translocation to mitochondria
directly activates: Translocation of PUMA protein to mitochondria