JNK1
MAPK8
PRKM8
SAPK1
SAPK1C
UniProt:P45983 MAPK8
Sequestration of BAD protein by 14-3-3
Activation of BAD by calcineurin
Translocation of activated BAD protein to mitochondria
BAD displaces tBID from BCL-2 sequestration
Translocation of NOXA to mitochondria
Translocation of PUMA protein to mitochondria
MAPK8 phosphorylates BCL2L11
Phosphorylation of BIM by JNK
Translocation of BIM to mitochondria
Phosphorylation of DLC2 by MAPK8
Translocation of BMF to mitochondria
AKT phosphorylates BAD
Activation of BH3-only proteins
Activation of BAD and translocation to mitochondria
Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
Transactivation of NOXA by p53
Transactivation of NOXA by E2F1
Transactivation of PUMA by p53
Transactivation of PUMA by E2F1