5117795 58 This gene is one of several nuclear pore complex interacting protein (NPIP) gene copies that are present on chromosome 16. There are no full-length transcripts derived from this gene copy in support of this CCDS representation, and thus its exon combination is inferred based on paralogous transcript alignments, e.g., the mRNA AF132984.1. 5115529 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5115530 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5115535 58 This CCDS ID represents the most abundant of the shorter human BAG1 isoforms, known as BAG-1S or p36 or p33, as described in the literature, including PMIDs 9396724, 9679980, 9747877 and 17662274. This isoform initiates translation at a downstream AUG start codon. Alternative translation initiation at other AUG start codons produces additional isoforms, known as BAG-1M or p46, and p29. In addition, alternative translation initiation from an upstream non-AUG (CUG) start codon results in the longest human BAG1 isoform, known as BAG-1L or p50. The longest isoform is represented by CCDS 35004.1. Evidence in PMIDs 9747877 and 17662274 indicates that these isoforms have distinct subcellular distributions, which may contribute to the multifunctionality of the protein. 5113414 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data. 5113415 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data. 5113416 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data, and by conservation in primate species. 5113424 58 This CCDS ID was withdrawn because the reference genome contains an insertion in the CDS that results in a frameshift, and it cannot represent the correct protein. This insertion corresponds to the reference SNPs rs11338621 and rs66614253. 5113441 58 This variant represents the VMAT1delta15 variant described in PMID:16326835. There are no publicly available transcripts representing it, but it was cloned and characterized in the above publication. 5113450 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. The update uses a non-AUG (CUG) start codon, which is supported by strong conservation and ribosome profiling data for both the mouse and human orthologs (PMID:22927429). This update also adds an R3H domain to the protein N-terminus. 5113450 144 1 1 M 5113490 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5113491 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5113494 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5113536 58 The coding region has been updated to shorten the N-terminus to one that is supported by the reference genome allele (GRCh37 assembly). The previous representation used a polymorphic start codon that exists as ACG in the reference genome allele versus ATG in the alternate allele (also known as the T allele). This corresponds to the reference SNP rs2294008. Some individuals contain the reference genome allele, while others contain the T allele. Data in PMIDs 18488030, 19554573, 19582881 and 19648920 indicate that the T allele may be a risk allele for gastric and bladder cancers. It is also associated with decreased promoter activity (PMIDs 18488030 and 19648920). The current update results in a protein that is 9 aa shorter at the N-terminus. 5113556 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5113566 58 The coding region has been updated to shorten the N-terminus to one that is supported by conservation data. 5113570 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5113597 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5113603 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5113604 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5113655 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5113667 58 The coding region has been updated to include three additional 30-nt repeat segments in the variable repeat region of this VCX/Y family member. This update represents the number of repeats encoded by the reference genome (GRCh37) allele. 5113672 58 The coding region has been updated to extend the N-terminus, and to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5113675 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5113700 58 The coding region has been updated to shorten the N-terminus to one that is more supported by publication data. This transcript includes two transcription start sites, where the XAGE-1a variant is derived from the 5'-most start site, and the XAGE-1b variant is derived from the downstream start site. Experimental evidence in PMIDs 12479262 and 17335148 shows that both the XAGE-1a and XAGE-1b variants use the downstream translation initiation codon, as represented in this update. 5113704 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5113717 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript and protein data. 5113735 58 This CCDS represents the AIFsh2 isoform described in PMID:16644725. The transcript is a candidate for nonsense-mediated mRNA decay (NMD), but the protein is represented based on evidence for the endogenous protein in PMID:16644725. 5113746 58 This CCDS ID was withdrawn because currently there is insufficient support for the transcript and the protein. 5113772 58 The coding region has been updated to extend the N-terminus to one that is more supported by paralogous data. 5113818 12 62 62 U 5113914 58 The coding region has been scaled back at the 5' end to begin from a start codon that is better supported by conservation data. 5114011 58 This CCDS representation is supported by the mRNAs AY674051.1 and AY040091.1. The transcript is a candidate for nonsense-mediated mRNA decay (NMD); however, the protein is represented based on demonstration of the endogenous protein in mouse tissues in PMID:15252030, and because there are no non-NMD transcripts that can encode this protein in either human and mouse. 5114058 58 The coding region has been updated to represent an alternative splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript data and by conservation in primates. 5114180 58 This CCDS represents a TPI variant that uses an upstream promoter compared to the CCDS8566.1 representation. Data in PMIDs 4022011, 2925688, 2243103 and 10575546 support the presence of the internal promoter used by the CCDS8566.1 variant. The use of the upstream promoter is supported by human transcript data, including M10036.1, AL517115.3 and DB444195.1, as well as homologous transcripts. This longer transcript also uses an upstream start codon, resulting in an isoform that is 37 aa longer at the N-terminus compared to the CCDS8566.1 isoform. The sequence encoding the longer N-terminus is conserved in most mammalian species. 5109630 12 667 667 U 5109654 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5109671 12 49 49 U 5109687 58 This coding region is updated to represent an alternative splicing pattern that is more supported by RNA-seq data. This CCDS representation has an inferred exon combination due to a lack of full-length transcript support. 5109701 58 The coding region has been updated to represent an alternative splice pattern that is more supported by the available transcript and conservation data. The update extends a CUB domain and adds a SEA domain to the protein. 5109706 144 1 1 M 5109746 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5109749 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. The previous representation lacked full-length support, and the transcript would have been a candidate for nonsense-mediated mRNA decay (NMD). 5109813 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5109816 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript, conservation and publication data (PMIDs 9211900 and 11481476). 5109827 12 300 300 U 5109827 12 318 318 U 5109827 12 330 330 U 5109827 12 345 345 U 5109827 12 352 352 U 5109827 12 367 367 U 5109827 12 369 369 U 5109827 12 376 376 U 5109827 12 378 378 U 5109827 12 59 59 U 5109869 58 The coding region has been updated to represent an alternate 3' splice pattern that is more supported by the available transcript data. 5109879 144 1 1 M 5109892 12 73 73 U 5109912 58 The coding region has been updated to represent an alternative splicing pattern, and to extend the N-terminus to one that is better supported by the available transcript data. The annotated translational start codon is specific to human, but it has a strong Kozak signal and is thus likely to be used. An alternative and better conserved start codon, which also has a strong Kozak signal, exists further downstream; initiation from that start codon would result in a protein that is 2 aa shorter at the N-terminus. No experimental evidence exists to indicate which start codon is preferentially used in vivo. 5109918 12 73 73 U 5109921 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data, resulting in a longer protein with an extended N-terminal KRAB domain. 5109932 58 The coding region has been updated to represent an alternative splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript and publication data. 5109944 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available conservation and publication data. The start codon selected in the previous representation occurred very close to the transcription start/cap site, and is therefore unlikely to be used by the ribosome. 5109945 58 The coding region has been updated to shorten the N-terminus by 68 aa based on available publication data. The previously represented start codon has a weak Kozak signal and occurs only 6 nts downstream of the transcription start site, so it is unlikely to be used by the ribosome. It should also be noted that there are no publicly available full-length transcripts representing this variant. It is supported by data in PMID:9434946, where the splice junctions for this variant (referred to as OSF2/CBFA1b) were determined and the transcription start site was mapped. 5109965 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript, conservation and publication data. 5109982 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5110024 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation data. 5110025 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation data. 5110042 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110069 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5110100 58 The coding region has been updated to add two internal 6-nt sequences that were included in the update of the GRCh37 reference genome assembly to the GRCh38 assembly. The update results in a protein that is 4 aa longer. 5110128 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5110141 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110154 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. The update is supported by the mRNA AK295831.1, whereas the CDS of the previous representation was supported by BC034293.1, but that mRNA contains alternative 3' exon structure and would be subject to nonsense-mediated mRNA decay (NMD). 5110163 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and homology data. The previous representation was a candidate for nonsense-mediated mRNA decay (NMD). 5110170 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5110204 144 1 1 M 5110240 58 SSXB4 is identical to SSX4 as it produces the same protein product. This protein is likey to be functional despite arising from a duplication, therefore this CCDS has been retained. 5110248 58 This CCDS representation is supported by the mRNA accession BC069470.1, which has its best hit to this GAGE family member. 5110291 58 This CCDS ID represents the protein described in PMIDs: 12724276 and 12207887. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 12724276. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the more centromeric copy within the palindrome. 5110292 58 This CCDS ID represents the protein described in PMIDs: 12724276 and 12207887. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 12724276. Three identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the more telomeric copy within the palindrome 5110295 58 The coding region has been updated to represent an alternative 5' splicing pattern, resulting in an extended N-terminus that is better supported by the available transcript data, and by conservation in other primates. 5110303 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110309 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. There are no full-length transcripts representing this update in human, but it is supported by homologous proteins, including mouse NP_001020277.1 (CCDS18964.1) and zebrafish NP_001103936.1. 5110343 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5110360 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcripts and conservation data. 5110370 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110373 58 The coding region has been updated to scale back the N-terminus to one that is more supported by the available transcript data and by conservation across mammals. 5110378 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5110384 58 This CCDS representation uses a downstream start codon but includes a potential upstream start codon that would result in a protein that is 18 aa longer at the N-terminus. However, the upstream start codon has a weak Kozak signal, the vast majority of transcripts from human and homologous species start downstream of it, and data in PMID:19413330 indicate that the N-terminus begins at an N-alpha acetylated Ala-2 residue (nASIMEGPLSK...) following cleavage of the initiating Met-1 derived from the second start codon. The second start codon is therefore represented in this CCDS. 5110387 58 This CCDS ID represents a variant of the SCP2 locus that uses a downstream promoter, known as the SCP2 promoter. This promoter initiates transcription in an internal exon compared to the longer CCDS572.1 variant, which uses the upstream SCPx promoter. Data in PMIDs 7654720, 7698762 and 14563822, as well as chromatin regulatory features (including Ensembl ENSR00000282553 and ENSR00000282554), support the presence of an active downstream SCP2 promoter. 5110388 58 This CCDS ID represents a variant of the SCP2 locus that uses a downstream promoter, known as the SCP2 promoter. This promoter initiates transcription in an internal exon compared to the longer CCDS572.1 variant, which uses the upstream SCPx promoter. Data in PMIDs 7654720, 7698762 and 14563822, as well as chromatin regulatory features (including Ensembl ENSR00000282553 and ENSR00000282554), support the presence of an active downstream SCP2 promoter. 5110392 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. There are no full-length transcripts representing this update, but it is supported by a combination of partial human transcript alignments and homologous mouse transcript alignments. The update completes a UBA domain (Pfam prediction) in the protein. 5110407 58 This CCDS was updated to remove two 5' prime exons from the transcript because they are not considered to be a part of this gene. The updated protein is shorter at the N-terminus by 15 amino acid residues. 5110445 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110504 58 The coding region has been updated to represent a better supported splicing pattern and to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5110510 58 This CCDS representation uses the 5'-most in-frame start codon found in the transcript. It should be noted that this start codon has a weak Kozak signal, and its conservation is restricted to primate species, squirrel, rock hyrax and armadillo. Two better conserved potential start codons with stronger Kozak signals are located two and five codons downstream, respectively. It is possible that leaky scanning by ribosomes would allow one of the downstream start codons to be used some of the time. There is no experimental evidence indicating which start codon is preferentially used in vivo. 5110535 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5110537 58 This CCDS representation uses the 5'-most in-frame translational start codon, as supported by aligning transcript data. It should be noted that this start codon is restricted to higher primate species and is not conserved in other mammals. Lower species use a much better conserved downstream start codon, resulting in a protein that is 142 aa shorter at the N-terminus. It is possible that occasional leaky scanning past the upstream start codon by ribosomes, or alternatively, the presence of a downstream promoter, would sometimes allow use of the downstream start codon in humans. There is no experimental evidence indicating which start codon is preferentially used in vivo. 5110549 58 The coding region has been updated to start at a downstream alternate in-frame start codon that is supported by conservation data. 5110550 58 The coding region has been updated to start at a downstream alternate in-frame start codon that is supported by conservation data. 5110570 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110573 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. This updated representation lacks full-length transcript support and it therefore has an inferred exon combination; the inferred structure is supported by a combination of tiled EST alignments and RNA-Seq data, and by homologous transcript alignments. 5110591 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript, conservation and publication data. 5110595 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. There are no publicly available full-length transcripts representing this CCDS, but it is supported by the E-26 cDNA described in PMID:1698771. 5110596 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110597 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. There are no publicly available full-length transcripts representing this CCDS, but it is supported by the E-12 cDNA described in PMID:1698771. 5110598 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110599 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. There are no publicly available full-length transcripts representing this CCDS, but it is supported by the E-3 cDNA described in PMID:1698771. 5110614 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110660 58 This CCDS ID represents the protein described in PMID: 17572408. The full-length exon combination of this transcript is based on a combination of mouse (AK220482.1) and human (AK126964.1) partial transcripts. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5110677 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript data. There are no full-length transcripts representing this CCDS, likely due to its large size, but it is supported by partial transcripts that tile across this locus. The large central 10.9 kb exon contains several 87-nt tandem repeats, as described in the literature, including PMIDs 7916618, 9013550, 9804771 and 11713095. 5110695 58 The coding region has been updated to represent an alternatve splice site that is more supported by the available transcript and protein data. 5110696 144 1 1 M 5110697 58 This CCDS representation uses a downstream AUG start codon compared to CCDS44539.1. It is supported by the mRNA AK127209.1, which lacks the exon containing the alternative non-AUG (CUG) start codon described in PMID:10321731. 5110698 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation data. 5110699 58 The coding region has been updated to represent an alternative intronless transcript structure that is more supported by the available data. 5110716 58 The coding region has been updated to start at a non-AUG translation start codon that is supported by a publication and protein conservation. 5110716 144 1 1 M 5110717 58 The coding region has been updated to start at a non-AUG translation start codon that is supported by a publication and protein conservation. 5110717 144 1 1 M 5110720 58 The coding region has been updated to extend the N-terminus and this extension is supported by transcript data. 5110724 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5110733 58 The coding region has been updated to represent an alternative splice site, and to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5110749 58 This CCDS ID was withdrawn because there are no full-length transcripts representing it, and the exon combination of the gene is unclear. 5110752 12 44 44 U 5110777 58 This CCDS ID represents the protein described in PMID: 16971948. This transcript is supported by AB209915.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 16971948. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5110787 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5110825 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and homology data. 5110921 58 The coding region has been updated to include an additional short exon that is more supported by the available transcript and publication data. 5110949 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110972 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110976 58 The full-length exon combination of this CCDS representation is inferred. It is mostly supported by the mRNA AF010403.1, but with correction of a gap in exon 10-11, supported by the mRNA AF010404.1, and by EST, RNA-Seq and orthologous transcript alignments. 5110982 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110996 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5110997 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5111026 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5111093 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5111098 58 This CCDS ID was withdrawn because the CDS was partial, and there is insufficient transcript or protein evidence to predict its full-length nature. 5111105 144 1 1 M 5111108 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data or publications. 5111153 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5111172 58 This CCDS ID was withdrawn because the CDS was partial, and there is insufficient transcript or protein evidence to predict its full-length nature. 5111175 58 The coding region has been updated to annotate a downstream in-frame AUG. The downstream AUG is predicted to encode a signal peptide which is expected for this GPI-anchored protein. PMID: 23358245 shows evidence that the ortholog of this protein mouse is processed through the ER and would likely require a signal peptide. The upstream in-frame AUG is likely bypassed by leaky scanning to allow for translation from the downstream AUG. 5111204 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5111213 12 133 133 U 5111213 12 266 266 U 5111219 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. The update adds an additional transmembrane domain to the protein. 5111222 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. 5111233 58 The coding region has been updated to represent an alternative splice site in the terminal exon that is more supported by the available transcript and protein data. 5111238 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript and protein data. 5111240 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5111244 58 The coding region has been updated to correct several errors that were present versus the GRCh38 reference genome assembly. 5111274 58 The coding region has been updated to trim the N-terminus to one that is more supported by available transcript data, CAGE data and conservation data. 5111353 58 The coding region has been updated to correct several errors that were present versus the GRCh38 reference genome assembly. 5111375 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5111396 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5111414 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript data. This update is supported by mRNA accession EF471398.2 and by data in PMID:19737927. 5111427 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available protein and publication data. The previously represented N-terminus was over-extended, which eliminated an N-terminal signal peptide that is present in the update. 5111428 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available protein and publication data. The previously represented N-terminus was over-extended, which eliminated an N-terminal signal peptide that is present in the update. 5111460 58 This gene lacks full-length transcript support, and therefore this CCDS representation has an inferred exon combination based on partial transcript and RNA-seq alignments. 5111501 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. 5111535 58 The coding region has been updated to represent an alternative 3' splicing pattern, resulting in an alternative C-terminus that is more supported by the available transcript and homology data. 5111569 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data, and by conservation in other higher primate species. 5111580 58 This CCDS ID represents the p53gamma isoform described in PMIDs: 16131611, 16601753 and 18289041. This variant is supported by the transcript DQ186649.1. It should be noted that this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because other similar isoforms derived from NMD transcripts were detected endogenously in PMID:16131611. In addition, experiments in PMID:17694537 indicate that this gene may be somewhat less sensitive to NMD. A contributing factor is the presence of a ubiquitination domain in the C-terminus of the full-length protein, which makes the protein less stable under non-stress conditions. C-terminally truncated proteins that lack the ubiquitination domain, such as this isoform, are therefore more stable. NMD inhibition experiments in the same study show that the majority of NMD transcripts do indeed undergo NMD, but some low level of NMD escape, combined with the increased stability of C-terminally truncated isoforms, allows for the expression of such isoforms. 5111581 58 This CCDS ID represents the p53beta isoform described in PMIDs: 16131611, 16601753 and 18289041. This variant is supported by the transcript DQ186648.1. It should be noted that this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID:16131611 using an antibody specific for the distinct C-terminus of this isoform. In addition, experiments in PMID:17694537 indicate that this gene may be somewhat less sensitive to NMD. A contributing factor is the presence of a ubiquitination domain in the C-terminus of the full-length protein, which makes the protein less stable under non-stress conditions. C-terminally truncated proteins that lack the ubiquitination domain, such as this isoform, are therefore more stable. NMD inhibition experiments in the same study show that the majority of NMD transcripts do indeed undergo NMD, but some low level of NMD escape, combined with the increased stability of C-terminally truncated isoforms, allows for the expression of such isoforms. 5111603 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data, and by the allele represented in the GRCh38 reference genome assembly. 5111661 58 The coding region has been updated to represent an alternative 3' splicing pattern that is more supported by the available transcript data. There are no full-length transcripts representing this update, but it is supported by partial transcript data and by data in homologs, including mouse NM_001127576.1. 5111664 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5111667 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5111679 58 Experimental evidence (N-terminal protein sequencing; PubMed ID 10978616) shows a peptide starting at Pro-46, suggesting that the downstream ATG (coding for Met-45) is used. 5111734 58 The coding region has been updated to remove an unsupported 5' exon, resulting in a shorter N-terminus that is more supported by the available transcript and protein data. 5111735 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5111736 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5111819 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data and publications. There are no publicly available human transcripts that include the extended region. However, the update is supported by homologous transcript data and is consistent with the full-length 190 kDa human isoform described in the literature. This 190 kDa product, known as PHLPP1beta, has been detected in several studies, including PMIDs 17386267, 19079341, 20089132, 20819118 and 20861921. 5111858 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5111863 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5111873 58 The coding region has been updated to start at a downstream start codon that is supported by conservation data. 5111881 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript and protein data. 5111887 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5111910 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5111922 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data or publications. 5111923 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5111933 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and homology data. There is currently no transcript or protein data supporting the use of the upstream start codon. 5111969 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5111997 58 This CCDS representation has an inferred exon combination due to a lack of full-length human transcript support for this gene. The represented two-exon structure is supported by orthologous mouse transcript alignments, and by partial human transcript data for the 3' exon. 5112005 58 The 5'-most start codon based on available transcript data is represented in this CCDS. It should be noted that a possible upstream start codon, which is moderately well-conserved, is present. The use of this upstream start codon would result in a protein that is 15 aa longer at the N-terminus. However, other than AK297891.1, which is a read-through transcript from the upstream ZNF576 locus, there are no human or homologous transcripts supporting extension to this upstream start codon. The 15 aa extension is therefore not included in this CCDS representation. 5112027 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5112040 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. This gene lacks full-length human transcript support, and therefore the exon combination represented in this CCDS ID is inferred; it is supported by tiled partial transcript alignments and by homologous transcript alignments. 5112131 12 387 387 U 5112150 144 1 1 M 5112151 58 The coding region has been updated to represent an alternative 3' splicing pattern that is more supported by the available transcript data. It should be noted that there are no full-length transcripts representing this CCDS; it is supported by partial transcripts that tile across this locus, and by conservation data. 5112212 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript, protein and homology data. 5112214 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5112218 58 This CCDS representation lacks publicly available full-length transcript support. Its exon combination is based on mRNA annotation on DNA accession AF064205.1 (AAD55812.1 product) from PMID:9799602. 5112235 58 The coding region has been updated to extend the N-terminus and represent the 5'-most in-frame start codon. This start codon is not conserved in any other species. Two alternative downstream start codons, which are more widely conserved, also exist. It is possible that leaky scanning by ribosomes would allow the downstream start codons to be used, at least some of the time. Use of the downstream start codons would result in a protein that is either 26 aa or 32 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5112310 144 1 1 M 5112373 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data, and by most available haplotypic data, including that represented in the GRCh38 primary reference assembly allele. 5112377 58 This CCDS representation is supported by the mRNA AK295564.1. It contains an alternative 5' exon compared to other variants at this locus, as represented by CCDS2460.1 and CCDS46526.1. It should be noted that the annotated start codon in this CCDS has a weak Kozak signal and is only conserved among primate species. It is possible that leaky scanning by ribosomes could occur to allow a downstream start codon to be used at least some of the time. The downstream start codon has a stronger Kozak signal and is much better conserved, and it would result in a protein that is 12 aa shorter at the N-terminus. There is no experimental evidence indicating which start codon is preferentially used by this variant in vivo. Signal peptides can be predicted for both the longer and shorter N-termini (cleavage following aa 31 or aa 19, respectively), but it should be noted that the probability of signal peptide occurrence is reduced for the longer N-terminus, as predicted by SignalP 3.0 and Phobius. It is unknown if a signal peptide is cleaved from the longer protein in vivo. 5112396 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5112403 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5112439 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5112489 58 This CCDS representation has been updated to correct a frameshifted segment in the 3' coding region, supported by transcript and orthologous alignments, and by the update of the GRCh37 reference genome assembly to the GRCh38 assembly. 5112521 144 1 1 M 5112547 58 The coding region has been updated to represent alternative splice sites that are more supported by the available transcript and protein data. These alternative splice sites (nts 3484-3485 of NM_001099952.2) represent a non-canonical GA-AG donor-acceptor pair, but are well-supported by all available human transcripts, and by homologous transcripts in mouse, rat and cow. 5112550 58 This CCDS represents a variant of the ARPC4 locus, and is supported by EST data, including BI768875.1, BQ688329.1, BU161393.1 and BG938423.1. A variant encoding a longer protein is represented by CCDS43047.1. 5112570 58 This coding region is updated to represent a better supported splice structure based on transcript data and to correct a single base deletion which existed in the previous version as a result of a reference genome assembly error. 5112593 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available conservation data. The update adds TPR (Tetratricopeptide) repeats and ankyrin domains to the protein. 5112605 58 This CCDS representation is supported by the splicing pattern of BC143332.1. It should be noted that this mRNA is 5' partial and does not encode the first 4 aa of the protein. Therefore, this representation includes a 5' extension based on other transcript data at this locus. This extension completes an N-terminal KRAB box, as found in many other zinc finger proteins. 5112606 58 This CCDS representation is supported by the splicing pattern of BC143304.1. It should be noted that this mRNA is 5' partial and does not encode the first 4 aa of the protein. Therefore, this representation includes a 5' extension based on other transcript data at this locus. This extension completes an N-terminal KRAB box, as found in many other zinc finger proteins. 5112607 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5112632 58 The coding region has been updated to shorten the N-terminus, using a downstream start codon that is better supported by conservation data, and is supported by ribosome profiling data. 5112651 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. The update adds an ankyrin repeat (Pfam) and completes another in the protein. This update is supported by AL832472.1, which contains a non-canonical splice donor-acceptor pair (either GT-TA or TT-AG depending on alignment method) at the exon 3-4 splice junction. The non-canonical donor-acceptor pair is supported by homologous transcripts in cow, macaque, mouse and rat. 5112655 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5112659 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5112663 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5112716 12 49 49 U 5112744 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript data. This CCDS representation is based on the splicing pattern of the mRNA D12686.1, but corrections have been made to correct several mismatches and frameshifting indels in that mRNA compared to the reference genome sequence. This variant uses an alternative downstream promoter, known as the gamma promoter. Experimental evidence in PMID:16982693 shows that this promoter is active, although it is used much less frequently than the upstream alpha or beta promoters. PMID:15755734 also provides support for a variant that is derived from the downstream gamma promoter. 5112770 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data. The updated representation includes a predicted N-terminal signal peptide. 5112792 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. This CCDS ID represents a short variant from this locus; the full-length variant is represented by CCDS47026.1. 5112846 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and publication (PMID:15153069) data, and by conservation in higher primate species. 5112889 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5112939 58 This CCDS ID represents the protein described in PMIDs: 10053003, 16737835 and 9889283. This transcript is supported by BC095417.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 10053003 and 16737835. 5112943 58 This CCDS ID represents the gp130-RAPS isoform described in PMIDs: 10880057 and 16646038. This variant is supported by the transcript AB015706.1. It should be noted that this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID:10880057 using an antibody specific for the distinct C-terminus of this isoform. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this isoform. 5112945 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5112963 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5112965 58 The exon combination of this CCDS representation is inferred based on available partial human transcript alignments and homology data. 5112971 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5112984 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. It should be noted that the start codon of this representation is conserved only in higher primate species. It has a weak Kozak signal, and it is therefore possible that leaky scanning by ribosomes may occur some of the time, which may allow the use of a better conserved downstream start codon. The use of the latter would result in a protein that is 2 aa shorter at the N-terminus. There is no experimental evidence indicating which start codon is preferentially used in vivo. 5112992 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5113007 58 A downstream start codon is annotated for this CCDS representation because its use is more consistent with the presence of an N-terminal signal peptide in the protein, which is known to contain extracellular cadherin domains. However, it should be noted that an alternative upstream start codon exists, which would result in a protein that is 9 aa longer at the N-terminus and is less likely to contain a signal peptide. The upstream start codon has a weak Kozak signal, so it is possible that leaky scanning by ribosomes will allow the use of the downstream start codon. There is no experimental evidence indicating which start codon is used in vivo. 5113008 58 A downstream start codon is annotated for this CCDS representation because its use is more consistent with the presence of an N-terminal signal peptide in the protein, which is known to contain extracellular cadherin domains. However, it should be noted that an alternative upstream start codon exists, which would result in a protein that is 9 aa longer at the N-terminus and is less likely to contain a signal peptide. The upstream start codon has a weak Kozak signal, so it is possible that leaky scanning by ribosomes will allow the use of the downstream start codon. There is no experimental evidence indicating which start codon is used in vivo. 5113033 58 The coding region has been updated to represent an alternate CDS that is more supported by available conservation data, cross-species protein homology, and publications. 5113065 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5113073 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data, and by the reference genome allele (GRCh37 assembly). It should be noted that the updated start codon is polymorphic, where some transcripts contain ATC versus ATG in the reference genome allele. This corresponds to the reference SNP rs705441. The previously represented downstream start codon is likely to be used in transcripts derived from the ATC allele, resulting in a protein that is 27 aa shorter at the N-terminus. 5113105 58 The coding region has been updated to represent an alternative splicing pattern that is more likely to be protein-coding. The previous representation was a candidate for nonsense-mediated mRNA decay (NMD). 5113108 144 1 1 M 5113108 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available transcript data and publication evidence. The update uses a non-AUG (CUG) start codon, which was shown to be the predominant start codon in studies in PMID:19489092. The transcript also has two other potential start codons, which are used less frequently: an upstream and polymorphic AUG start codon, which can produce a 265 aa isoform, and a downstream AUG start codon, which can produce a 164 aa isoform. The upstream AUG is not present in the GRCh37 primary assembly, where it appears as AGG versus AUG. This is a valid polymorphism (reference SNP 3130932), as described in PMIDs 1408763 and 19489092. This polymorphic start codon has a weak Kozak signal, and therefore in AUG-containing alleles, leaky scanning by ribosomes may occur to allow preferential initiation at the downstream CUG start codon. The isoform derived from the CUG start codon is the only one detected endogenously in studies in PMID:19489092. 5113121 144 1 1 M 5113138 58 This CCDS representation starts at an upstream non-AUG (CUG) translation start codon that is supported by conservation data and experimental evidence, including that in PMIDs:11352659, 11563986 and 11731620. Most of the publicly available long mRNAs at this locus do not extend far enough 5' to include the CUG start codon, including AF430806.1 which supports this variant. However, BC058855.1, several unspliced partial transcripts and the aforementioned publications all support transcription initiation further upstream. Hence, this CCDS representation includes the extended 5' CDS. Alternative translation initiation from a downstream AUG codon (Met-181), which results in a shorter isoform with a predicted signal peptide, has also been shown for this gene. The shorter isoform encoded by this variant is represented by CCDS 55013.1. 5113138 144 1 1 M 5113139 58 This CCDS representation starts at an upstream non-AUG (CUG) translation start codon that is supported by conservation data and experimental evidence, including that in PMIDs:11352659, 11563986 and 11731620. Most of the publicly available long mRNAs at this locus do not extend far enough 5' to include the CUG start codon, including AJ010438.1 which supports this variant. However, BC058855.1, several unspliced partial transcripts and the aforementioned publications all support transcription initiation further upstream. Hence, this CCDS representation includes the extended 5' CDS. Alternative translation initiation from a downstream AUG codon (Met-181), which results in a shorter isoform with a predicted signal peptide, has also been shown for this gene. The shorter isoform encoded by this variant is represented by CCDS 55008.1. 5113139 144 1 1 M 5113140 58 This CCDS representation starts at an upstream non-AUG (CUG) translation start codon that is supported by conservation data and experimental evidence, including that in PMIDs:11352659, 11563986 and 11731620. Most of the publicly available long mRNAs at this locus do not extend far enough 5' to include the CUG start codon, including BC065522.1 which supports this variant. However, BC058855.1, several unspliced partial transcripts and the aforementioned publications all support transcription initiation further upstream. Hence, this CCDS representation includes the extended 5' CDS. Alternative translation initiation from a downstream AUG codon (Met-181), which results in a shorter isoform with a predicted signal peptide, has also been shown for this gene. The shorter isoform encoded by this variant is represented by CCDS 55014.1. 5113140 144 1 1 M 5113141 58 This CCDS representation starts at an upstream non-AUG (CUG) translation start codon that is supported by conservation data and experimental evidence, including that in PMIDs:11352659, 11563986 and 11731620. Most of the publicly available long mRNAs at this locus do not extend far enough 5' to include the CUG start codon, including AF091352.1 which supports this variant. However, BC058855.1, several unspliced partial transcripts and the aforementioned publications all support transcription initiation further upstream. Hence, this CCDS representation includes the extended 5' CDS. Alternative translation initiation from a downstream AUG codon (Met-181), which results in a shorter isoform with a predicted signal peptide, has also been shown for this gene. The shorter isoform encoded by this variant is represented by CCDS 55011.1. 5113141 144 1 1 M 5113166 58 The coding region has been updated to extend the N-terminus, and to represent an alternative splicing pattern that is more supported by the available transcript data. 5113214 58 The coding region has been updated to represent an alternative 3' splicing pattern, resulting in an extended C-terminus that is more supported by the available transcript data. 5113220 58 The coding region was updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5113242 144 1 1 M 5113273 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available data and transcripts. 5113324 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and homology data. It should be noted that there are no full-length human transcripts spanning the first exon of this update, but it is supported by tiled EST data and by mouse mRNA EF535989.1. 5092474 58 The coding region has been updated to start at a downstream alternate in-frame start codon that is supported by conservation data. 5092504 58 This CCDS represents the transcript derived from the downstream promoter of this gene. Studies in both PMIDs 10631117 and 11978970 support the presence of the downstream promoter, as do the 5' extents of several human and homologous transcripts. PMID:11978970 also provides evidence for an upstream promoter; the transcript derived from the upstream promoter would encode a protein that is 60 aa longer at the N-terminus. 5092507 58 The coding region has been updated to include an additional internal exon, and thereby to represent a splice pattern that is better supported by the available transcript and homology data. 5092543 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5092544 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5092591 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5092615 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data and by conservation in higher primates. 5092625 58 The coding region has been updated to represent alternative splice sites that are more supported by the available transcript and protein data. 5092632 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5092670 58 The coding region has been updated to represent an alternative splicing pattern that is better supported by the available transcript and protein data. 5092747 58 The coding region has been scaled back at the 5' end to begin from a start codon that is better supported by conservation data. 5092750 58 The coding region has been updated to shorten the 5' CDS to one that is more supported by available transcript and conservation data. 5092796 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5092956 58 This CCDS representation uses the 5'-most in-frame start codon. While this start codon is well-conserved, it should be noted that other than human and chimp, all other species have indels that follow this start codon. Other primates and rodents have frameshifting indels, and thus cannot use this start codon. However, some mammalian species, including cow, pig and dog, contain additional compensating indels that bring them back in frame; these species could therefore use the start codon represented in this CCDS. An alternative downstream start codon, which is more widely conserved and has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 39 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5093062 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. 5093117 58 The coding region has been updated to represent an alternative 5' splicing pattern, which results in an extended N-terminus that is more supported by available conservation and protein data. The previous representation was based on the mRNA D42108.1, but this would be a nonsense-mediated mRNA decay (NMD) candidate if the homology-supported upstream AUG start codon (strong Kozak signal) was used, and it is thus unlikely that translation would initiate from the annotated downstream AUG (weaker Kozak signal). There are no full-length mRNAs representing the updated transcript in human, but the updated 5' end is supported by the partial human ESTs DA193701.1 and DB284706.1, and by the full-length rat transcript D45920.1. 5093131 58 This CCDS representation is based on AF422928.1 and U58143.1, and on data in PMID:11917123. This 479 aa isoform is also supported by homologous proteins, including pig NP_001026949.1, cow NP_001039435.1, mouse NP_033942.1, rat NP_071613.1 and chicken NP_989923.1. In addition, macaque AB172864.1 supports the full-length splice pattern. 5093172 58 The coding region has been updated to represent additional exon structure at the 3' end, supported by the transcripts AB058746.2, AK302830.1 and ESTs that tile across the locus. The update results in a significantly longer C-terminus that is better supported by cross-species protein homology, including mouse Q8BLN6.2. 5093240 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5093306 58 The coding region has been restored to the original sequence and begins from a better supported downstream start codon. 5093337 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5093358 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation and transcript data. The upstream AUG has a weak Kozak sequence while the downstream AUG has a strong Kozak sequence. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the downstream AUG codon while others start from the upstream one. 5093417 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. The update results in a completed Pyridoxal_deC domain that was truncated in the previous representation. 5093440 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. The upstream AUG start codon was annotated as the CDS start in the absence of experimental evidence or a community standard to suggest otherwise. The upstream AUG appears to be conserved only among primates and it has a weak Kozak sequence while the downstream AUG has a strong Kozak sequence. Due to leaky scanning by ribosomes, some ribosomes may initiate translation from the downstream AUG while others initiate from the upstream AUG codon. 5093511 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data. 5093512 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. There are no full-length mRNAs containing the extended 5' end, but this is supported by overlapping transcripts, including AK131371.1, DA800082.1 and DA093958.1, and by homologous ESTs in mouse (BE953532.1, AA764357.1 and BX523397.1). 5093522 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5093542 58 The coding region has been updated to shorten the N-terminus, using a start codon that is better supported by conservation data, ribosome profiling, and peptide data. 5093560 58 This CCDS ID represents the protein described in PMIDs: 10329005 and 9679147. This transcript is supported by AF052224.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMIDs: 9679147 and 19165527. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5093564 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. 5093568 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5093598 58 The coding region has been updated to represent an alternative splicing pattern that is better supported by the available transcript and protein data. 5093660 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5093674 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. 5093774 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. 5093801 58 The coding region has been updated to significantly extend the N-terminus to one that is more supported by the available transcript and conservation data. 5093816 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5093854 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data.The next downstream ATG (186 basepairs downstream) may also be used as the start codon, according to Edman degradation experiments in orthologous species. 5093898 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5093901 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5093925 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5093947 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5093964 58 This CCDS representation is supported by accession AF204159.1 and data in PMID:10766764. 5093999 58 The coding region has been updated to represent an alternative splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript and homology data. 5094037 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5094038 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5094043 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript data. 5094054 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. The update initiates translation at a CUG start codon that is very well-conserved and is in a strong Kozak signal context. This non-AUG start codon is supported by experimental evidence for the rat homolog in PMID:15635094. The update adds a predicted N-terminal signal peptide to the protein. 5094054 144 1 1 M 5094085 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5094086 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. There are no human transcripts supporting this extension, but it is supported by data in homologs, including mouse NP_001001985.3 (CCDS19210.1) and zebrafish NP_001077308.1. 5094125 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. There are no human full-length transcripts representing this exon combination, but it is supported by the tiled ESTs BX395637.2, BX371487.2, BX348769.2 and BX395636.2 from the same clone, which were used to construct Genoscope accession CR604280.1. The updated N-terminus is also supported by homologous mouse transcripts. 5094134 58 The coding region has been updated to extend the C-terminus following the addition of several exons at the 3' end. There are no full-length transcripts representing the update, but partial transcripts do span its length in both human and the mouse ortholog. The updated sequence includes a large exon 10 that has no single transcript spanning its full extent. Nonetheless, BX648206.1 covers most of this exon, as does AB037748.2, which is spliced to the 3' neighboring exons. AF528529.1 and AK090534.1 are spliced to the 5' neighboring exons, supported by orangutan CR860680.1. Several tiled transcripts also span this exon in mouse, including AK140021.1, AF013969.1 and AK122495.1. Some transcripts appear to have polyA tails and terminate in this large exon, e.g., BX648206.1, AK025965.1 and AF528529.1, but on closer inspection, it appears that these may be priming off internal 'A' nucleotides in exon 10, and they do not have polyA signals. The open reading frame represented in the update also shows good conservation in models from other species, including macaque XP_001098928.1, dog XP_536235.2, cow XP_585315.3, chicken XP_420784.2, and rat XP_001060944.1. It is also of note that the genomic alignments between these species show insertions/deletions in the region of exon 10 that are always in multiples of three, or else they are compensated in order to restore the reading frame. This is a strong signature of a protein-coding region and provides good supporting evidence for the validity of this exon/intron structure. 5094153 58 The coding region has been updated to represent an alternative splicing pattern in the 5' CDS, resulting in an extended protein N-terminus that is more supported by the available transcript and protein data. 5094160 58 The coding region has been updated to shorten the N-terminus to one that is more supported by data in PMID:1146333. This publication shows that a non-AUG translation initiation codon is used exclusively. The UUG start codon annotated in the update is conserved as an AUG in rat and mouse. An upstream in-frame putative AUG start codon exists in the transcript, which would result in a protein that is 87 aa longer at the N-terminus, but the studies in PMID:1146333 do not support usage of this. In addition, a signal peptide is predicted only if the downstream start codon is used, and the same publication performed N-terminal sequencing of the mature protein to confirm the signal peptide cleavage. 5094160 144 1 1 M 5094181 58 The coding region has been updated to represent an alternate exon that is more supported by the available transcript and protein data. 5094259 58 This CCDS ID represents the human ortholog of the protein described in PMIDs: 19208547 and 19271754. This transcript is supported by AK057459.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in mouse and rat (PMIDs: 19208547 and 19271754, respectively). It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5094298 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. Two possible start codons are present in this update, with the downstream AUG codon have a stronger Kozak signal. The upstream AUG codon, as represented in this update, is conserved in several mammalian species, but not in mouse or dog, whereas the downstream AUG is more widely conserved. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 1 aa shorter at the N-terminus. 5094380 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5094398 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5094403 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. The update adds a predicted N-terminal signal peptide to the protein. 5094449 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by transcript and conservation data. 5094490 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5094492 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data, and to include an alternative splice acceptor site at exon 12 based on the splice pattern of BC131505.1, which is the longest transcript available for this locus. The majority of human transcripts, including AK092270.1 and BC044932.1, include an extra 3 nts in exon 12 due to alternative splicing, and would encode an additional alanine residue at position 354 of the protein, but all of these transcripts are partial. 5094554 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5094575 58 The coding region has been updated to extend the N-terminus to one that is more supported by conservation. 5094742 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5094766 58 The coding region has been updated to significantly extend the N-terminus based on available transcript and homology data. The update adds two BRCT (breast cancer carboxy-terminal) domains to the protein. 5094812 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. The previously represented start codon has a very weak Kozak signal and the N-terminal extension is poorly conserved, even among other higher primate species. It is likely that the ribosome will bypass the upstream start codon due to leaky scanning, and thus, the downstream start codon, which has a strong Kozak signal and is very well-conserved, will be used. 5094827 58 The coding region has been updated to extend the N-terminus to an upstream in-frame ATG. The update adds an N-terminal transit peptide, which is necessary for mitochondrial localization, and is consistent with the known gene function in lysine catabolism (which occurs in the mitochondrion). The transcript includes three potential translational start codons, all of which have weak Kozak signals. Ribosomal leaky scanning may result in the use of all three start codons, and a mitochondrial transit peptide can be predicted for the N-terminus arising from use of either the first or second initiation site. The second start codon is represented for this CCDS protein because the predicted transit peptide is scored as more probable, and the second ATG is more strongly conserved. This representation of the mitochondrial isoform is consistent with published reports (see PMIDs: 19885858 and 20207735). 5094836 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5094877 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates. An alternative downstream start codon, which is more widely conserved and has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 12 aa shorter at the N-terminus. Both the longer and shorter proteins have N-terminal signal peptides, as predicted by SignalP 3.0. There is no experimental evidence showing which start codon is preferentially used in vivo. 5094968 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5095035 58 The coding region has been updated to shorten the N-terminus to one that is better supported by available ribosome profiling data. The presence of a signal peptide in the shortened CDS is consistent with other members of the C1QTNF family. 5095080 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. The update is based on the coding sequence of BC066980.1, which lacks an exon in the 5' coding region. A longer variant containing this exon, as represented in SwissProt Q8NDZ2.1, may also be possible, but this has no full-length transcript support to enable current CCDS representation. 5095159 58 The coding region has been updated to represent an alternative 5' splice pattern, resulting in an different protein N-terminus that is more supported by the available transcript and homology data. 5095167 58 The coding region has been updated to represent an alternative splice pattern that is more supported by the available transcript and protein data. 5095182 58 A downstream start codon is used for this CCDS representation based on sequencing of the purified protein in PMID:3063603, which shows that the second in-frame start codon is used. An upstream start codon exists and would result in a protein that is 2 aa longer at the N-terminus, but there is currently no evidence for this longer protein. 5095244 58 This CCDS ID represents the longest isoform encoded by the HFE gene. This isoform contains both a Class I Histocompatibility antigen (MHC_I) and an Immunoglobulin constant region (IGc) domain. 5095245 58 This CCDS ID represents a variant of the HFE gene that lacks an internal coding exon compared to the longest variant, which is represented by CCDS4578.1. This results in an isoform that includes the Immunoglobulin constant region (IGc) domain but lacks a portion of the Class I Histocompatibility antigen (MHC_I) domain. 5095246 58 This CCDS ID represents a variant of the HFE gene that lacks an internal coding exon compared to the longest variant, which is represented by CCDS4578.1. This results in an isoform that includes the Immunoglobulin constant region (IGc) domain but lacks a portion of the Class I Histocompatibility antigen (MHC_I) domain. 5095247 58 This CCDS ID represents a variant of the HFE gene that lacks two internal coding exons compared to the longest variant, which is represented by CCDS4578.1. This results in an isoform that lacks the entire Class I Histocompatibility antigen (MHC_I) domain, but the Immunoglobulin constant region (IGc) domain is included. 5095248 58 This CCDS ID represents a variant of the HFE gene that lacks three internal coding exons compared to the longest variant, which is represented by CCDS4578.1. This results in an isoform that lacks both the Class I Histocompatibility antigen (MHC_I) and Immunoglobulin constant region (IGc) domains. 5095277 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5095342 58 The coding region has been updated to represent a longer and distinct C-terminus that is better supported by available transcript and homology data. 5095343 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. The previous representation appeared to be partial on the 5' end. 5095351 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. The extended 5' CDS lacks transcript support in human, but is supported by transcript data in mouse (AK131887.1, AK164929.1, BC150798.1 and four ESTs). The human and mouse splice sites are conserved. In addition, the human sequence includes an additional tandem repeat region in the second exon, which makes it longer than the equivalent exon in mouse. 5095363 58 The coding region has been updated to represent an alternative 3' splicing pattern that is more supported by the available transcript data. 5095440 58 This coding region is updated to annotate a different coding sequence, which is shorter and reflects the use of an alternate start codon that is better supported by conservation and ribosome profiling. 5095501 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available homology data. The shorter protein contains a predicted signal peptide sequence that is not present in the longer protein. 5095519 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5095551 58 The coding region has been updated to start at an upstream non-AUG (CUG) translation start codon that is supported by conservation data and experimental evidence, including that in PMIDs:11352659, 11563986 and 11731620. Most of the publicly available long mRNAs at this locus do not extend far enough 5' to include the CUG start codon, including M27281.1 which supports this variant. However, BC058855.1, several unspliced partial transcripts and the aforementioned publications all support transcription initiation further upstream. Hence, this CCDS representation includes the extended 5' CDS. Alternative translation initiation from a downstream AUG codon (Met-181), which results in a shorter isoform with a predicted signal peptide, has also been shown for this gene. The shorter isoform encoded by this variant is represented by CCDS 55009.1. 5095551 144 1 1 M 5095572 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data. The updated start codon is found only in primates and it has a weak Kozak signal. It is possible that ribosomal leaky scanning may sometimes allow the better conserved downstream start codon to be used. There is no experimental evidence to indicate which start codon is preferentially used in vivo. 5095582 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5095656 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and conservation data. This update is also supported by data in PMID:15620723. 5095659 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5095660 58 The coding region has been updated to shorten the protein N-terminus to one that is more supported by the available transcript and conservation data. The updated protein contains a predicted N-terminal signal peptide, which is consistent with its biological function as a subunit of the GABA receptor complex. 5095694 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5095720 58 The coding region has been updated to start at a downstream alternate, in-frame start codon that is supported by conservation data. 5095775 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5095783 58 The coding region has been updated to extend the N-terminus based on the presence of an upstream translation start codon that is conserved in several species. A possible downstream start codon would reduce the protein length by 52 aa. The downstream start codon is referred to in PMID:2211644. No experimental evidence exists regarding which start codon is used. 5095824 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5095863 58 The coding region has been updated to represent an alternative splice junction that is more supported by the available transcript data. 5095893 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5095925 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5095926 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5095990 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5096022 58 The coding region has been updated to extend the N-terminus based on the presence of an upstream translation start codon that is well-conserved across vertebrate species. An alternative downstream start codon, which has been represented historically and is consistent with that used by other HOX gene family members, would reduce the protein length by 17 aa. No experimental evidence exists regarding which start codon is preferentially used. 5096065 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript data, and by conservation across several species, including fish and amphibians which have greater evolutionary distance. 5096133 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation data. 5096171 58 The coding region has been updated to represent an alternate splice pattern, resulting in an alternate and longer C-terminus that is better supported by available transcript and conservation data. 5096183 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primate species. This starting position is most commonly referred to in the literature, and the numbering system used to describe disease-associated mutations is based on this protein start. This includes data in the P450 oxidoreductase (POR) allele nomenclature locus-specific database, and the Human Gene Mutation Database (HGMD). This start codon is restricted to higher primate species, and it has a weak Kozak signal. However, it should be noted that an alternative downstream start codon, which has a strong Kozak signal and is much more widely conserved, is also present. The use of this downstream start codon would result in a protein that is 3 aa shorter at the N-terminus. Protein sequencing in PMID:2513880 indicates that this is the preferred start codon in vivo. It is therefore possible that the ribosome will initiate at the upstream start codon only a small fraction of the time (if at all), while leaky scanning will allow the downstream start codon to be used predominantly. 5096207 58 This CCDS ID represents variant C of the ABCB4 gene, which is based on experimental evidence described in PMID:2892668. 5096279 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates, dog and horse. An alternative downstream start codon also exists, and would result in a protein that is 3 aa shorter at the N-terminus. Both the longer and shorter N-termini have predicted signal peptides according to SignalP 3.0. There is no experimental evidence showing which start codon is preferentially used in vivo. 5096298 58 The coding region has been updated to represent an alternative transcript variant that is more supported by the available transcript data. 5096358 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5096411 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. Two possible start codons are present in this update, with both start codons having moderately weak Kozak signals. The upstream AUG codon, as represented in this update, is specific to higher primate species, while the downstream AUG is more widely conserved. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 2 aa shorter at the N-terminus. 5096429 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript data. 5096431 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5096448 58 The coding region has been updated to shorten the N-terminus to one that is better supported by available conservation data and peptide data. This CCDS represents use of a downstream start codon, shortening the protein by a single amino acid. 5096449 58 The coding region has been updated to shorten the N-terminus to one that is better supported by available conservation data and peptide data. This CCDS represents use of a downstream start codon, shortening the protein by a single amino acid. 5096466 58 The coding region has been updated to include an additional codon based on a 3-nt insertion that is present in the GRCh38 reference genome sequence. 5096467 144 1 1 M 5096467 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript, conservation and publication evidence. The update uses a non-AUG (ACG) start codon, supported by data in PMID:23612980. 5096469 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. 5096510 58 The coding region has been updated to represent an alternative splice pattern that is more supported by the available transcript and protein data. 5096572 58 The coding region has been updated to represent an alternative splicing pattern at the 3' end, resulting in an alternative protein C-terminus that is more supported by the available transcript and protein data. 5096610 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data. The extended N-terminus appears to be restricted to higher primate species. 5096615 58 This CCDS representation uses a downstream AUG start codon. This start codon has a strong Kozak signal and is restricted to human. An upstream start codon, which has a weak Kozak signal and is conserved in some other primates, is also present. The use of the upstream start codon would result in a protein that is 40 aa longer at the N-terminus. However, this would eliminate a signal peptide that is predicted for the shorter but not the longer N-terminus. PMID:9242611 shows experimental evidence for cleavage of a signal peptide following aa 25 from the downstream start, and this is also confirmed in PMID:15340161. Therefore, the downstream start codon is represented for this CCDS. 5096669 58 The coding region has been updated to represent an alternative 5' splice pattern that is more supported by the available transcript and protein data. 5096673 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. It should be noted that an upstream ORF (uORF), which has a strong Kozak signal and encodes 2 aa, overlaps the updated start codon by 1 nt. This uORF may inhibit the use of the upstream start codon, and therefore allow the downstream start codon to be used via a reinitiation shunt mechanism. Alternatively, low level leaky scanning past the uORF start, or translation reinitiation due to the minimal overlap, may allow the upstream start codon to be used. There is no experimental evidence indicating which start codon is preferentially used in vivo. 5096707 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5096764 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and primate conservation data. Two possible start codons are present in this update, with the downstream start codon having a stronger Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 1 aa shorter at the N-terminus. 5096767 58 The coding region has been updated to represent an alternate splice pattern, resulting in an N-terminal extension and a longer and different C-terminus that is more supported by the available transcript and protein data. The update completes a predicted C-terminal MCM (minichromosome maintenance proteins) domain. 5096772 58 The coding region has been updated to represent an alternative 5' splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript and conservation data. 5096822 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5096827 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation and transcript data. 5096843 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5096870 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5096882 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5096924 144 1 1 M 5096933 58 This CCDS represents a 276 aa protein that is encoded by NM_001045556.2, which is based on BX648382.1 and several locally supporting ESTs. However, it should be noted that NM_001045556.2 contains an upstream translation start codon at nts 504-506, as used in the NM_001045557.2 variant which encodes a 293 aa protein. The use of this upstream start codon in NM_001045556.2 would result in only a 15 aa ORF with a stop codon in the second exon. The short length of this upstream ORF may allow escape from nonsense-mediated mRNA decay (NMD) and translation reinitiation at the downstream start codon (nts 833-835) to encode the represented 276 aa protein, or alternatively, the weak Kozak signal at the upstream start codon may enable leaky scanning by the translation machinery and subsequent use of the downstream start codon. The 276 aa protein is consistent with reports in the literature, including PMIDs:7543898, 8825655 and 9660183. Variants encoding both the longer and shorter isoforms are also present in mouse (NM_001029841.3 and NM_009192.2, respectively). 5096947 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available conservation data. The updated protein has a predicted signal peptide, which was eliminated in the longer N-terminus of the previous representation. 5096957 58 This CCDS represents the shorter LY6H isoform. NM_002347.4 is based on an alternative 5' end, as found in the ESTs DB471677.1, BP347868.1 and EB385547.1. Other alternative 5' ends exist, as in AK314139.1, BC028894.1, AB012293.1 and BC030192.1, and these contain an upstream in-frame translation start codon which results in an isoform that is 21 aa longer at the N-terminus. The upstream start codon has a weaker Kozak signal than the downstream start codon, so these variants may also produce the shorter isoform, as suggested in PMID:9799603. 5096958 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5096963 58 The coding region has been updated to extend the N-terminus and to represent an alternate C-terminus that is more supported by the available transcript and protein data. The update is described in PMID:17604275. 5096966 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5096967 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5096973 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. The extension adds an N-terminal coiled-coil region to the protein. 5096999 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5097029 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5097034 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data. 5097046 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. The exon combination of this CCDS representation is inferred due to a lack of full-length human transcript data, but it is supported by tiled partial transcripts, and by homology data. 5097060 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. Two possible start codons are present in this update, with the downstream start codon having a stronger Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 1 aa shorter at the N-terminus. 5097066 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and publication data. The previously represented upstream start codon, although moderately well-conserved, occurs more 5' of the vast majority of transcripts and the major transcription start site mapped in PMID:7541708; this upstream start codon may be used rarely if at all, and there is currently no experimental evidence for its use. It should also be noted that this transcript variant, which encodes the p14ARF isoform, is a candidate for nonsense-mediated mRNA decay (NMD). However, this is a well-characterized isoform with homology support, and several studies, including PMIDs 9724636, 18004878, 18583933, 19115249 and 12082609, show in vivo evidence for this isoform. This transcript can therefore escape NMD at least some of the time. In PMID:20212158, it is speculated that the relatively long dual coding region shared with the p16INK4a variant (CCDS6510.1), and the resulting disordered protein structure encoded by that region, may aid in NMD escape. 5097143 58 This olfactory receptor gene is a segregating pseudogene (PMID:22908908), where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele that is predicted to be non-functional. This CCDS is being retained because the Classifier for Olfactory Receptor Pseudogenes (CORP) predicts the reference genome allele to be functional. 5097165 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5097291 58 The coding region has been updated to shorten the N-terminus, using a downstream start codon, to one that is more supported by available conservation data. 5097297 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript data. 5097302 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5097325 58 The coding region has been updated to start at an alternate in-frame start codon that is supported by conservation data or a publication. PMID:3463993 suggests that the downstream AUG codon is the translation start site from evidence provided by N-terminal sequencing of the human protein. Although this may be the dominant translation start site, it is possible that some translation also occurs from the upstream AUG which is 27 nt upstream of the annotated start for this CCDS. The upstream AUG is in a weak Kozak context so a possible mechanism is that leaky scanning by ribosomes occurs so that, in most cases, ribosomes continue scanning and use the downstream AUG as the translation initiation site. 5097389 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5097392 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5097417 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5097422 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology support. 5097510 58 The coding region has been updated to represent an alternate splice pattern based on BC009979.1 and BC017353.1. The update results in an alternate protein C-terminus, and a longer N-terminus that is more supported by the available transcript and homologous protein data. 5097536 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5097537 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. 5097548 144 1 1 M 5097548 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. The update uses a non-AUG (CUG) start codon, supported by data in PMID:26010750. 5097558 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5097560 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5097561 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5097583 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5097645 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. Two possible start codons are present in this update, with the downstream start codon having a stronger Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 1 aa shorter at the N-terminus. The shorter protein is described in the literature (PMIDs 12056806, 15793564 and 17347647). 5097668 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5097692 58 The coding region has been updated to extend the N-terminus to one that is supported by available conservation and CAGE data. 5097702 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. The N-terminal extension completes a KRAB domain that was truncated in the previous representation. 5097723 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. The update adds a predicted N-terminal signal peptide to the protein. 5097797 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5097876 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5097911 58 The coding region has been updated to represent an alternative splice pattern, resulting in an extended N-terminus and an alternative and longer C-terminus that is more supported by the available transcript and protein data. 5098008 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. Two possible start codons are present in this update. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 1 aa shorter at the N-terminus. 5098026 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5098030 58 The coding region has been updated to include an alternative exon that is more supported by the available transcript and protein data. The update completes the helix-loop-helix dimerization domain, which was previously truncated. 5098035 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. Two possible start codons are present in this update, with each having a weak Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 15 aa shorter at the N-terminus. The literature, including PMIDs 2823383, 2568356, 1354394 and 1678390, assumes the use of the downstream start codon based on initial cloning reports, but there is no experimental evidence indicating which start codon is preferentially used in vivo. 5098055 58 The coding region has been updated to represent an alternative 3' splicing pattern that is more supported by the available transcript and protein data. 5098083 58 A downstream AUG translation start codon is selected for this CCDS representation based on a strong community standard for its use, and on a higher probability of a signal peptide being present in the protein N-terminus. The use of an alternative upstream AUG start codon would result in a protein that is 19 aa longer at the N-terminus. The upstream AUG has a weak Kozak signal while the downstream AUG has a strong Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the downstream AUG codon while others start from the upstream AUG. The presence of multiple upstream ORFs suggests that a combination of leaky scanning and translational reinitiation may be necessary to achieve translation of the annotated ORF. 5098114 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. The update adds a Forkhead domain to the protein. 5098119 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5098122 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data, and by conservation in some primates. 5098161 58 No human mRNA or EST accessions have been deposited in public databases to support this CCDS, but the gene, transcript and protein have been well-characterized in the literature, e.g., PMIDs:2315322, 12160732, 15706223 and 16888198. Secretin proteins in other species also support this CCDS. 5098178 58 The coding region has been updated to represent an alternative 3' splice pattern, resulting in a longer and distinct C-terminus that is better supported by available transcript and homology data. The update adds two C2 domains (Ca2+-dependent membrane-targeting modules), which are hallmarks of synaptotagmin proteins. 5098246 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5098257 58 The coding region has been updated to start at a non-AUG translation start codon that is supported by PubMedID: 1851669 and protein conservation. The update results in a 15 aa N-terminal extension of the encoded protein. 5098257 144 1 1 M 5098318 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in other species. An alternative downstream start codon, which has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 1 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5098322 58 The coding region has been updated to start at a non-AUG translation start codon that is supported by a publication and protein conservation. 5098322 144 1 1 M 5098330 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5098332 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5098355 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5098387 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. 5098405 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5098443 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data with the same 5' splice pattern. The protein with the shorter N-terminus is encoded by a variant with an alternative 5' splice pattern, as in NM_001136040.2. 5098448 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5098458 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by transcript and conservation data. 5098488 58 The coding region has been updated to represent an alternative 5' end, resulting in an extended N-terminus that is more supported by available transcript data. 5098558 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5098646 58 The coding region has been updated to represent an alternative 5' splice pattern that is more supported by the available transcript and protein data. 5098647 58 The coding region has been updated to represent an alternative 5' splice pattern, resulting in the extension of the N-terminus to one that is better supported by available transcript and homology data. The update completes the N-terminal Fes/CIP4 homology domain. 5098695 58 The coding region has been updated to represent an alternative splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript and conservation data. 5098737 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5098738 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5098752 58 The coding region has been updated to a different splice variant that extends the N-terminus to represent a splice variant that is more supported by available conservation data and publications. The upstream AUG in this variant has a relatively stronger AUG codon for translation initiation. This update is based on the full-length CDS of DQ228672.1 (note that its first 7 nts represent the end of exon 1) and on evidence for this variant in PMID:16893518 (Casp-5/a). 5098760 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5098761 58 The coding region has been updated to represent an alternative splice pattern, resulting in a longer C-terminus that is more supported by the available transcript and protein data. The update extends a predicted alkylated DNA repair protein domain and adds a C-terminal S-adenosylmethionine-dependent methyltransferase domain to the protein. 5098780 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5098788 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5098789 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5098802 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation and protein data. 5098807 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by transcript data. 5098868 58 The coding region has been updated to represent an alternative 5' splice pattern, resulting in the extension of the N-terminus to one that is better supported by available transcript and homology data. 5098896 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5098908 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data. 5098918 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5098936 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5098962 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5098976 58 This CCDS represents a TPI variant that uses an internal promoter compared to the CCDS53740.1 representation. Data in PMIDs 4022011, 2925688, 2243103 and 10575546 support the presence of the internal promoter used by this variant. The resulting isoform is 37 aa shorter at the N-terminus compared to the CCDS53740.1 isoform. N-terminal sequencing in PMIDs 9150946 and 9150948 supports the existence of the shorter isoform in vivo. 5099047 58 This CCDS ID is based on AF281255.1. This transcript appears to be a nonsense-mediated mRNA decay (NMD) candidate; however, there are publications describing this transcript and its encoded protein (Guo et al, 2001, PMID 11054413; Liu et al, 2008, PMID 18006276) so this CCDS ID has been retained. 5099131 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5099149 58 This CCDS ID has been updated to represent an alternative coding region that is better supported by available protein and publication (PMID:18418376) data. 5099150 58 The coding region has been updated to represent an alternative 5' splice pattern, resulting in a longer N-terminus that is better supported by available transcript and homology data. 5099202 58 The coding region has been updated to shorten the N-terminus of the encoded protein to one that is more supported by conservation data. 5099237 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5099274 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. The update adds a predicted signal peptide to the protein. 5099276 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. The updated start codon is only conserved among primates, but it has a strong Kozak signal and is therefore expected to be used when encountered by the ribosome. 5099299 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. Two possible start codons are present in this update, with the downstream start codon having a stronger Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 1 aa shorter at the N-terminus. 5099342 58 The coding region has been updated to remove an unsupported internal exon, and thereby to represent a splice pattern that is better supported by the available transcript and homology data. 5099467 58 The coding region has been updated to represent an alternative splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript and conservation data. 5099476 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5099499 58 The coding region has been updated to represent an alternative 5' splice pattern, resulting in an N-terminus extension that is better supported by available transcript and conservation data. 5099515 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. It should be noted that there is limited transcript evidence extending to the start codon of the update (human DB003237.1 and DA484190.1, macaque CJ446700), which is present in a CpG island. An alternative downstream in-frame start codon codon also exists, with both start codons having weak Kozak signals. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 34 aa shorter at the N-terminus. 5099518 58 The coding region has been updated to represent an alternative 5' splice pattern, resulting in a longer N-terminus that is better supported by available transcript and homology data. The update completes the N-terminal Rad9 domain, which was previously truncated. 5099548 58 This CCDS ID represents the protein described in PMID: 9130713 and 9228060. This transcript is supported by BF510077.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously PMID: 18008329. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5099550 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data. It should be noted that the upstream start codon used in the previous representation is poorly conserved, and is not present in the vast majority of transcripts. 5099604 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. The updated CCDS representation lacks full-length transcript support and thus has an inferred exon combination, supported by tiled partial transcript alignments and homologous transcripts. 5099616 58 The coding region has been updated to represent to extend the 5' and 3' ends supported by the available transcript, paralog protein and conservation data. The update includes additional protein domains and it can be constructed by tiling human mRNAs and ESTs. There is currently no full-length mRNA to support the update. The translation initiation start site of the update has a strong Kozak sequence and it appears to be primate-specific. There are also more upstream in-frame AUG codons that show conservation among more mammmals and which could extend the encoded protein by a further 61 aa at the N-terminus . However, there is currently no transcript or protein evidence to support that extension. 5099652 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5099683 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5099791 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5099795 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation data. 5099804 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data or publications. 5099849 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5099871 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5099876 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5099915 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data or publications. 5099935 144 1 1 M 5099936 144 1 1 M 5099947 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in other species. An alternative downstream start codon, which is specific to human and has a slightly stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 2 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5099960 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation or experimental data. 5099966 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5100010 58 This CCDS ID represents the shorter isoform encoded by the TRAPPC6B gene. Although this protein lacks a segment of the predicted TRAPP_Bet3 domain compared to the longer isoform (represented by CCDS41947.1), there are several transcripts supporting this shorter variant, and there is no experimental evidence indicating that this variant does not encode a protein. 5100049 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available proteomics data. 5100112 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5100150 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5100157 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. 5100159 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5100168 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5100184 58 The coding region has been updated to represent an alternative transcript variant that is more likely to be protein-coding. The previous representation was a candidate for nonsense-mediated mRNA decay (NMD). 5100224 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available conservation and protein data. The previously represented start codon is overlapped by an upstream ORF, which is predicted to prevent its use, but would allow the use of the updated start codon. 5100230 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data or publications. 5100232 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5100292 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5100301 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5100305 58 The coding region has been updated to add additional internal exons based on transcript and homology support, and to extend the N-terminus to one that is more supported by available transcript and conservation data. The update adds a DEAD/DEAH box helicase domain in addition to the Helicase conserved C-terminal domain and a Tudor domain. 5100319 58 The coding region has been updated to represent an alternative splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript and protein data. 5100363 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5100376 58 The coding region has been updated to trim the N-terminus to one that is more supported by available transcript data, CAGE data and conservation data. 5100423 58 The coding region has been updated to extend both the N- and C-termini based on available transcript data. The update is based on the splice pattern of AK096267.1, a full-length mRNA. The same protein is described in PMID:11095946, but the published sequence is over-extended by 57 aa at the N-terminus due to the presence of an uncorrected 5' mismatch compared to the reference genome sequence. 5100477 58 The coding region has been updated to extend the N-terminus based on the presence of an upstream translation start codon, which is conserved in human and Rhesus macaque. A possible downstream start codon, which shows better cross-species conservation, would shorten the protein by 121 aa. The shorter protein is described in the literature, including PMID:7954800. No experimental evidence exists to show which start codon is used in vivo. 5100490 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5100516 58 The coding region has been updated to represent an alternative 5' splice pattern, resulting in a longer and distinct N-terminus that is better supported by available transcript and homology data. The update adds an epidermal growth factor-like domain and a predicted signal peptide to the protein. 5100526 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. The previous representation was a candidate for nonsense-mediated mRNA decay (NMD). 5100535 58 This CCDS ID represents a variant of the RPLP1 gene that is based on a splice pattern found in several ESTs, including BM768334.1, BM508180.1, EL948616.1 and AJ713466.1. 5100539 58 The coding region has been updated to include additional 5' exons and to extend the N-terminus to one that is more supported by available transcript and conservation data. The update adds an additional TSP1 (Thrombospondin type 1 repeats) domain and an Adam_spacer 1 domain to the protein. 5100598 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5100624 58 The coding region has been updated to represent an alternative splice pattern that is more supported by the available transcript and protein data. The update extends the BAR domain in the protein. 5100724 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation and homologous transcript data. 5100733 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. The update adds an RBA2_OBF_family superfamily domain to the protein. 5100741 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5100774 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5100834 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and homology data. It should be noted that the updated structure lacks full-length human transcript support, but it is supported by consistently spliced partial transcripts and by homologous transcript alignments 5100881 58 The coding region has been updated to represent an alternative splice pattern that is more supported by the available transcript and protein data. 5100951 58 The coding region has been updated to extend the N-terminus based on the presence of an upstream translation start codon, which is supported by available transcript and conservation data. 5100953 58 The coding region has been updated to shorten the N-terminus, using a downstream start codon that is better supported by available peptide data and ribosome profiling data. 5100963 58 The coding region has been updated to add an additional internal exon and to extend the N-terminus to one that is more supported by available transcript and conservation data. The N-terminal extension adds a HSA domain (found in DNA binding proteins and often associated with helicases) to the DEXDc, HELICc and AT_hook domains that are also found in this protein, and this is consistent with the function of this protein as a DNA helicase. 5101068 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available protein and publication data. 5101085 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. 5101092 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5101101 58 This CCDS was updated to trim the coding region at the 5' end, which shortens the N-terminus of the protein by 86 amino acid residues. The update is supported by conservation data. 5101115 58 The coding region has been updated to start at an alternate start codon that is better supported by conservation data. 5101137 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5101138 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates. An alternative downstream start codon, which is more widely conserved, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 4 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5101181 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5101333 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5101378 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5101418 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript, conservation and protein localization data. 5101422 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5101423 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5101442 58 The coding region has been updated to represent an alternative splice site in the 3' coding region that is more supported by the available transcript data. 5101472 58 This CCDS ID was withdrawn because the region of the genome (NCBI Build 36) corresponding to the 5' coding region of this gene contains several mismatches and deletions, and thus, the correct protein cannot be derived from the current assembly. A new CCDS ID is expected for this gene when improved genomic sequence becomes available in a future build. 5101523 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. The 5' exon structure of this update is inferred from orthologous transcript alignments. 5101558 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available full-length transcript data. 5101592 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5101597 58 The coding region has been updated to start at an alternate in-frame start codon that is more supported by conservation data. 5101642 58 The coding region has been updated to represent an alternative 5' splicing pattern, resulting in an N-terminal extension that is more supported by the available transcript and conservation data. There are no full-length transcripts representing this update in human, but it is supported by partial ESTs, including CN393115.1, DN602074.1, CX762257.1, CX762257.1, BF529786.1 and CX754238.1. This update is also supported by protein homology to mouse NP_001096120.1 and rat NP_001007724.2. 5101684 58 The coding region has been updated to represent an alternative splice variant that is more supported by the available transcript and protein data. The update is supported by U64805.1, a full-length mRNA. This CCDS previously represented the delta(9-11) variant that is only partially described by RT-PCR analyses in PMIDs 7545954 and 9115959. However, its full-length exon combination is unknown, and thus the update was made based on a known full-length variant. 5101685 58 The coding region has been updated to represent an alternative splice variant that is more supported by the available transcript and protein data. The update is supported by BC072418.1, a full-length mRNA. This CCDS previously represented the delta(14-17) variant that is only partially described by RT-PCR analysis in PMID:9115959. However, its full-length exon combination is unknown, and thus the update was made based on a known full-length variant. 5101686 58 The coding region has been updated to represent an alternative splice variant that is more supported by the available transcript and protein data. The update is supported by BC115037.1. This CCDS previously represented the delta(14-18) variant that is only partially described by RT-PCR analysis in PMID:9115959. However, its full-length exon combination is unknown, and thus the update was made based on a known full-length variant. 5101687 58 The coding region has been updated to represent an alternative splice variant that is more supported by the available transcript and protein data. The update is supported by BC115036.1 and BC115038.1. This CCDS previously represented the delta(2-10) variant that is only supported by BC106746.1, a partial mRNA, and by RT-PCR analysis from breast cancer tissues in PMID:9115959. However, its full-length exon combination is unknown, and thus the update was made based on a known full-length variant. 5101763 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5101778 58 The coding region has been updated to scale back the N-terminus to one that is more supported by the available transcript data and by conservation across mammals. 5101849 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5101914 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5101915 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data and paralogous family members. The update has a predicted N-terminal signal peptide, which is consistent with functional support for the protein (e.g., PMIDs 16920917, 19359216). 5101917 58 This CCDS representation contains an upstream in-frame start codon that could result in a longer protein N-terminus. However, a downstream start codon is annotated because use of the upstream start codon would eliminate an N-terminal signal peptide, whose presence is consistent with functional support for CD300 family members (e.g., PMIDs 16920917, 19359216). 5101947 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5101954 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. Two possible start codons are present in this update, with the downstream start codon having a stronger Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 1 aa shorter at the N-terminus. 5101957 58 The coding region has been updated to represent an alternate 5' splice pattern, which results in an extension of the N-terminus to one that is more supported by available transcript and conservation data. 5102046 58 The coding region has been updated to represent an alternative 3' splice pattern, resulting in a longer and distinct C-terminus that is better supported by available transcript and homology data. In addition to the three MBT repeats and the C2HC type zinc finger domain included in this protein, the update adds a SAM_1 (Sterile alpha motif) domain, which is a widespread domain in signaling and nuclear proteins. 5102085 58 This CCDS representation is supported by protein evidence in PMIDs 11820818 and 16139264. 5102086 58 This CCDS representation is supported by protein evidence in PMIDs 11820818 and 16139264. 5102125 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5102128 58 The coding region has been updated to include additional exons at both the 5' and 3' ends, resulting in an extension of both the N- and C-termini. There are no full-length human transcripts representing this gene, but the update is supported by available overlapping partial transcripts, by conservation data, and by data included in PMID:17549423. 5102131 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available RNA-seq and orthology data. This CCDS representation has an inferred exon combination due to a lack of full-length transcript support for this gene. 5102195 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. 5102252 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data and by conservation in primates. 5102255 58 The coding region has been updated to represent an alternative coding sequence that is more supported by homology data. The updated CDS occurs upstream of the previous CDS, and the protein encoded by the update has a predicted signal peptide and two predicted transmembrane domains. 5102257 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5102271 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data and by conservation in other primates. 5102284 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript, publication and conservation data. 5102347 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5102370 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5102405 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. The update adds an N-terminal KRAB box domain to the protein. 5102412 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5102430 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5102453 58 The coding region has been updated to represent an alternative splice pattern and to extend the N-terminus to one that is more supported by available transcript and paralogous protein data. The update adds an N-terminal KRAB box to the protein. 5102456 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5102487 58 The coding region has been updated to start at an alternate in-frame start codon that is more supported by conservation data. 5102541 58 The coding region has been scaled back at the 5' end to begin from a start codon that is better supported by conservation data. 5102588 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript, conservation and publication data. 5102692 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. The update adds a predicted signal peptide to the protein. 5102711 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5102726 58 The coding region has been updated to represent an alternative transcript variant that is more likely to be protein-coding, resulting in a protein that contains a longer cyclin domain and an extended C-terminus. The previous representation was a candidate for nonsense-mediated mRNA decay (NMD). 5102857 58 The coding region has been updated to extend the N-terminus to one that is more supported by available homology data. There are no full-length transcripts representing the splice pattern of this update in human, but it is supported by human ESTs that tile across the gene, by the mouse ortholog NM_001081655.1 (CCDS39788.1), and by experimental data in PMID:18538736. 5102879 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5102881 58 The coding region has been updated to represent an alternate splice form that is more supported by the available transcript and protein data. The translation initiation AUG codon of the update has a strong Kozak sequence. Currently, BC007730.2 is the only valid full-length mRNA. Several transcripts indicate that another variant with a longer 5' end exists, but none of the representative mRNAs are valid due to incomplete processing and/or non-consensus splice sites elsewhere. 5102912 58 The coding region has been updated to represent an alternative transcript variant that is more likely to be protein-coding. The previous representation was a candidate for nonsense-mediated mRNA decay (NMD). 5102954 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. Three possible start codons are present in this update, with each having a weak Kozak signal. This update starts at the second start codon. The use of the 5'-most start codon would extend the protein N-terminus by 24 aa, but it is not represented because it would eliminate a predicted N-terminal signal peptide, and there is only one supporting transcript (AF337818.1) that extends that far 5'. The use of the third start codon would result in a protein that is 12 aa shorter at the N-terminus. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others may start from either of the downstream AUG codons. 5102969 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript data. 5102997 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology support. 5102998 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology support. 5102999 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology support. 5103005 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. 5103013 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. Two possible start codons are present in this update, with the downstream AUG codon have a stronger Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 19 aa shorter at the N-terminus. 5103027 58 This CCDS representation lacks publicly available transcript support. The represented exon combination is supported by RT-PCR data in PMID:11170751 and by RNA-Seq data from the ENCODE project. 5103109 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data and by conservation in primates. 5103111 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. The update results in an extension of the N-terminal KRAB box in the protein. 5103119 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5103170 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data, homology with mouse NP_899085.3 and the publication, PMID:19756140. 5103283 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. There are no transcripts representing the 5' exon of the update in human, but the 5' end can be inferred from cross-species conservation and homologous transcripts in mouse, including NM_008780.2 (CCDS16835), AK134066.1 and AB080656.1. 5103302 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available conservation and protein data, and by publications. 5103346 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data, and by data in PMID:12887310. 5103382 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5103520 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available full-length transcript data. The previous representation lacked full-length support. 5103557 58 The coding region has been updated to shorten the N-terminus based on the presence of a downstream start codon that shows good cross-species conservation, and for consistency with that used by other family members, including the genes encoding the human melanocortin 4 and melanocortin 5 receptors. The use of an alternative upstream start codon, which is specific to primate species, would increase the protein length from 323 aa to 360 aa. This longer protein is referred to in the literature, including PMIDs:15292330 and 8463333. Experimental data in PMIDs:8957262 and 9237634 indicate that deletion of the N-terminus does not affect the function of the protein, but there is no conclusive evidence indicating which start codon is preferentially used in vivo. 5103577 58 This CCDS ID represents the protein described in PMIDs: 20443919 and 19412439. This transcript is supported by AF106697.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in in cow in PMIDs: 9111083 and 10729789. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5103579 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5103632 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5103762 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. 5103763 58 This CCDS ID represents a splice variant of the C2CD2 gene, compared to the longer variant which is represented by CCDS42933.1. The splice pattern of this shorter variant is supported by AL833323.1. This variant contains an alternative 5' end, which is also supported by BM051485.1, and it lacks the first two coding exons found in the longer variant, resulting in the use of an in-frame downstream translation start codon compared to the longer variant. This shorter variant is considered to be protein-coding in the absence of evidence suggesting otherwise. 5103835 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5103851 58 The coding region has been updated to represent an alternative protein C-terminus as encoded by the GRCh38 reference genome assembly, and supported by the available transcript and conservation data. 5103873 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript data. 5103884 58 The coding region has been updated to represent an alternative splice pattern that is more supported by the available transcript data. The update is based on the splice pattern of BU739625.1 and BM713608.1, and is supported by the Swiss-Prot representation, Q8WYQ4.1. 5103901 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5103917 58 The coding region has been updated to represent an alternative splicing pattern that is better supported by the available full-length transcript data. 5103920 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5103961 58 The coding region has been updated to represent an alternate exon or splice site that is more supported by the available transcript and protein data. Conservation among mammals supports the exons of this splice variant and the update is also supported by the mRNA, CT841517.1, with additional 5' exons supported by overlapping human ESTs. 5103998 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5104059 58 NM_020831.4 is set to be removed from CCDS14003.1 in the next CCDS release. It has been updated to NM_020831.5 following an extension of the 5' CDS that reflects the use of a GUG start codon. The updated protein is longer at the N-terminus by 100 amino acid residues. The CDS of NM_001282660.1 remains unchanged. 5104118 58 This CCDS ID was withdrawn because the genome contains a deletion and cannot represent the correct protein. All the transcripts at this locus contain an insertion relative to the genome and therefore the transcripts and the genome represent different alleles. 5104124 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5104140 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5104142 58 The coding region has been updated to represent an alternative splicing pattern at the 5' end, resulting in a longer protein N-terminus that is more supported by the available transcript and conservation data. 5104146 58 The coding region has been updated to start at an alternate in-frame start codon that is more supported by conservation data. 5104149 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data. The updated start codon appears to be restricted to primate species, and it has a weak Kozak signal. It is possible that ribosomal leaky scanning may allow the better conserved downstream start codon to be used some of the time. There is no experimental evidence indicating which start codon is preferentially used in vivo. 5104177 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data and publications. The update is in accordance with the representations of both the Retina International Mutations of the OA1 Gene Database, and the Albinism Database. The previous representation used an upstream in-frame start codon that resulted in a 20 aa longer N-terminus. According to the ribosome scanning model of translation, the weak Kozak signal of the upstream start codon would make it subject to leaky scanning, and thus the downstream start codon, which has a stronger Kozak signal, would be used. However, there is no experimental evidence showing which start codon is used in vivo. Thus, the use of the upstream start codon, at least some of the time, cannot be ruled out. 5104399 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5104405 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5104433 58 The exon combination of this CCDS representation lacks full-length support from transcripts deposited in INSDC databases, but it is supported by mRNA annotation on DNA accession AY623109.1. 5104436 58 The coding region has been updated to start at a downstream alternate in-frame start codon that is supported by conservation data. 5104444 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available transcript and protein data. 5104454 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. Two possible start codons are present in this update. The upstream AUG has a weak Kozak sequence, while the downstream AUG has a strong Kozak sequence. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the downstream AUG codon while others start from the upstream AUG. Translation initiation from the downstream AUG would result in a protein that is 32 aa shorter at the N-terminus. 5104491 58 The coding region has been updated to represent a downstream start codon that is more supported by the available conservation data. The upstream start codon annotated in the previous representation is unlikely to be used due to the presence of an upstream ORF that overlaps it. 5104498 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by transcript and conservation data. 5104538 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5104539 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5104666 58 The coding region has been updated to represent the sequence of the GRCh38 reference genome assembly, which results in eight non-synonymous substitutions in the coding region. 5104715 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5104770 58 This CCDS ID represents the protein described in PMIDs: 12724276 and 12207887. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 12724276. Three identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region. 5104782 58 This CCDS represents the L2betaA isoform of the cyclin L2 locus, as described in PMID:18216018. The transcript is supported by BC016333.1, which is processed at an internal polyA site compared to other transcripts at this locus. The mRNA AK074112.1 also contains the same CDS. However, because the latter mRNA has additional 3' exon structure and the stop codon is present in an internal exon, that transcript is expected to be subject to nonsense-mediated mRNA decay (NMD), whereas transcripts processed at the internal polyA site are predicted to be translated. 5104786 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5104792 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5104862 58 The coding region has been updated to represent an alternative and longer transcript variant, resulting in an extended N-terminus that is more supported by available transcript and conservation data. 5104876 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5104883 58 The coding region has been updated to scale back the N-terminus to one that is more supported by the available transcript data and by conservation across mammals. 5104887 58 The coding region has been updated to extend the N-terminus and to represent an alternate splice pattern that is more supported by the available transcript and homology data. 5104893 58 This CCDS ID represents a variant of the SCP2 locus that uses a downstream promoter, known as the SCP2 promoter. This promoter initiates transcription in an internal exon compared to the longer CCDS572.1 variant, which uses the upstream SCPx promoter. Data in PMIDs 7654720, 7698762 and 14563822, as well as chromatin regulatory features (including Ensembl ENSR00000282553 and ENSR00000282554), support the presence of an active downstream SCP2 promoter. 5104921 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5105015 58 The coding region has been updated to shorten the N-terminus to one that is more supported by other olfactory receptors (ORs), and by the representation in The Human Olfactory Data Explorer (HORDE) database, entry #42-401. This OR gene lacks transcript support, possibly because OR genes are expressed in only a very small fraction of olfactory neurons, and thus, transcript evidence may be difficult to detect for all functional genes. 5105122 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5105207 58 This CCDS ID was withdrawn because the genome contains an insertion and cannot represent the correct protein. 5105230 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5105284 58 The coding region has been updated to represent an alternative splice pattern that is more supported by the available transcript and protein data. The update results in an extended protein N-terminus and in the presence of an additional internal segment. A downstream AUG translation start codon is selected for the update based on better conservation support, and on a higher probability of an N-terminal signal peptide being present in the resulting protein. Data in PMID:16357211 suggest that the protein is secreted. The use of an alternative upstream AUG start codon would result in a protein that is 18 aa longer at the N-terminus. Translation from the annotated downstream start codon is likely to occur via leaky scanning. 5105295 58 The coding region has been updated to extend the N-terminus and this extension is supported by conservation data. 5105318 58 A downstream AUG translation start codon is selected for this CCDS representation based on a strong community standard for its use, and on a higher probability of a signal peptide being present in the protein N-terminus. The use of an alternative upstream AUG start codon would result in a protein that is 19 aa longer at the N-terminus. The upstream AUG has a weak Kozak signal while the downstream AUG has a strong Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the downstream AUG codon while others start from the upstream AUG. The presence of multiple upstream ORFs suggests that a combination of leaky scanning and translational reinitiation may be necessary to achieve translation of the annotated ORF. 5105335 58 The 3' coding region has been updated to correct a 1 nt deletion versus the GRCh37 reference genome sequence, which results in a shorter protein C-terminus that is better supported by the available transcript and protein data. 5105337 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5105360 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. Two possible start codons are present in this update, with the downstream start codon having a stronger Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 1 aa shorter at the N-terminus. 5105362 58 The coding region has been updated to start at an alternate in-frame start codon that is supported by conservation data. 5105364 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5105396 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5105401 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5105406 58 This olfactory receptor gene is a segregating pseudogene (PMID:22908908), where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele that is predicted to be non-functional. This CCDS is being retained because the Classifier for Olfactory Receptor Pseudogenes (CORP) predicts the reference genome allele to be functional. 5105419 144 1 1 M 5105428 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. Additionally, this CCDS representation has an inferred exon combination due to a lack of full-length transcript support for this gene. 5105467 58 This olfactory receptor gene is a segregating pseudogene (PMID:22908908), where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele that is predicted to be non-functional. This CCDS is being retained because the Classifier for Olfactory Receptor Pseudogenes (CORP) predicts the reference genome allele to be functional. 5105469 58 The coding region has been updated to start at an alternate in-frame start codon that is supported by conservation data. 5105476 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5105508 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates. Two alternative downstream start codons also exist, each with stronger Kozak signals and the second being most widely conserved. It is possible that leaky scanning by ribosomes would allow either of the downstream start codons to be used, at least some of the time. The use of a downstream start codon would result in a protein that is 25 aa or 30 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5105509 58 This olfactory receptor gene is a segregating pseudogene (PMID:22908908), where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele that is predicted to be non-functional. This CCDS is being retained because the Classifier for Olfactory Receptor Pseudogenes (CORP) predicts the reference genome allele to be functional. 5105574 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5105610 58 The coding region has been updated to extend the N-terminus and this extension is supported by conservation data. 5105642 58 This olfactory receptor gene is a segregating pseudogene (PMID:22908908), where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele that is predicted to be non-functional. This CCDS is being retained because the Classifier for Olfactory Receptor Pseudogenes (CORP) predicts the reference genome allele to be functional. 5105644 58 The coding region has been updated to start at an downstream in-frame start codon that is supported by conservation data. 5105657 144 1 1 M 5105658 144 1 1 M 5105696 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available conservation and protein data. 5105704 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5105709 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5105731 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data. 5105780 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. Two possible start codons are present in this update, with the downstream start codon having a stronger Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 1 aa shorter at the N-terminus. 5105781 58 The coding region has been updated to represent alternative exon structure that is more supported by the available transcript data. 5105804 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5105809 58 The coding region has been updated to represent an alternative splice variant that is more supported by the available full-length transcript data. 5105855 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5105859 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data or publications. 5105893 58 The coding region has been scaled back at the 5' end to begin from a start codon that is better supported by conservation data. 5105922 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5105927 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5105941 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5105948 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data and the prediction of a signal peptide. 5105956 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5106010 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data or publications. The longer protein encoded by this updated coding region is consistent with the Rtf1 Plus3 domain shown in PMID:18184592 (Figure 1). The translation start AUG codon in the update has a weak Kozak sequence, while a downstream AUG (amino acid 41) has a stronger Kozak sequence so it is possible that sometimes ribosomes may start translation at the downstream AUG due to leaky scanning. 5106068 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data or publications. 5106088 58 The coding region has been updated to extend the N-terminus to one that is more supported by available homology data. The update adds a pleckstrin homology (PH) domain to the protein. 5106095 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5106106 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data, by partial human transcript data, and by transcript data in homologs. The update adds an N-terminal kinesin domain to the protein. 5106159 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5106165 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available protein and conservation data. The shorter protein has a predicted N-terminal signal peptide, which is compatible with functional data for the protein. 5106178 58 This CCDS was updated to trim the coding region at the 5' end, which reduces the protein size to 86aa. The update is supported by conservation and proteomics data. 5106182 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5106243 58 The coding region has been updated to represent a downstream AUG translational start codon, which results in a protein that is 42 aa shorter at the N-terminus. An upstream CUG start codon was used in the previous CCDS representation. While data in PMIDs 8208557 and 11006117 suggest that the CUG start codon might possibly be used, there is currently insufficient conclusive evidence showing that it is used in vivo. 5106246 58 The coding region has been updated to remove a 30-nt insert that is absent in the GRCh37 reference genome assembly. The CDS of this locus includes a tandem repeat sequence that is present 17 times in the reference genome assembly; the removed 30-nt insert corresponds to an additional repeat. Transcript data indicate that alleles contain variable copy numbers of this tandem repeat. 5106326 58 The coding region has been updated to represent an alternative splicing pattern that can be produced by the allele represented by primary chromosome 17 of the GRCh38 reference genome assembly. 5106329 58 The coding region has been updated to extend the N-terminus and this extension is supported by conservation data. 5106354 58 This CCDS represents a short variant at the 5' end of a much longer ARHGAP27 gene. The protein includes an SH3 domain. 5106361 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5106377 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5106419 58 The coding region has been updated to represent an alternate splice site that is more supported by the available transcript and protein data. 5106427 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. 5106430 58 The coding region has been updated to represent an alternative 5' splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript and protein data. 5106433 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. The updated start codon is conserved in higher primate species. It is also possible that leaky scanning by ribosomes may sometimes allow the use of the downstream start codon, which is better conserved across mammalian species. This would result in a protein that is 7 aa shorter at the N-terminus. It is unclear which start codon is preferentially used in vivo. 5106435 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript, conservation and publication (PMID:18429952) data. 5106449 58 The coding region has been updated to extend the N-terminus to one that is supported by available transcript data. 5106451 58 The coding region has been updated to represent an alternative splicing pattern, and includes an N-terminal extension that is more supported by the available transcript data. There are no full-length transcripts representing this update in human, but it is supported by partial transcript alignments and by homology data in mouse. 5106465 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data and by conservation in primates. 5106472 58 The coding region has been updated to represent an alternative 3' splice pattern, resulting in a longer and distinct C-terminus that is better supported by available transcript and homology data. 5106510 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5106526 58 The coding region has been updated to represent an alternate splice pattern that is more supported by conservation data. 5106532 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5106562 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5106584 58 The coding region has been updated to represent an alternative 5' splice pattern, resulting in a longer and distinct N-terminus that is better supported by available transcript and homology data. The update adds two additional transmembrane domains (TMHMMv2.0) to the protein. 5106599 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5106615 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. Two possible start codons are present in this update, with the downstream start codon having a stronger Kozak signal. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the upstream AUG codon while others start from the downstream AUG. Translation initiation from the downstream AUG would result in a protein that is 27 aa shorter at the N-terminus. 5106626 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5106628 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5106631 58 The coding region has been updated to extend the N-terminus to one that is supported by available conservation data and transcripts. The upstream AUG at the start of the update has a strong Kozak sequence and shows moderate conservation while the downstream AUG has a weaker Kozak sequence. The N-terminal extension completes a truncated KRAB box domain. 5106692 58 The coding region has been updated to represent an alternative 5' splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript and protein data. The update adds a KRAB domain to the protein 5106700 144 1 1 M 5106709 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data and by conservation in some primates. 5106729 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5106740 58 There is only one full-length mRNA, AY358172.1, that supports this CCDS splice variant although it is different at the 3' end. The 3' end of AY358172.1 would cause it to be an NMD candidate. The 3' end is supported by BC043211.1, AK122995.1 and AY358214.1 although these have extra internal exons that are not in the RefSeq. Mouse ESTs, BB730166.1 and BB728829.1, support the 3' end. Human ESTs, BI559800.1, DC308501.1, and BX118758.1, show support for some splice sites but also include additional exons. The protein encoded by this CCDS contains intact PFAM Latrophilin/CL-1-like GPS (GPS) and the 7 transmembrane receptor (Secretin family) (7tm_2) domains. Given the current evidence at this locus, this is the best variant that can be represented; this could change with future transcript evidence. It seems that a combination of AY358172.1 5' and 3' ends and the inclusion of the extra AY140955.1 exons in the middle could also create a valid splice variant but there is not enough evidence for this at this time. 5106742 58 The coding region has been updated to include an additional segment in the 3' coding region. This region corresponds to a tandem repeat encoding a 17 aa segment, which is present 4.4 times in the reference genome sequence. These tandem repeats are described in PMID:8968090. It should be noted that the majority of available transcript data represent an allele lacking one of these repeats, whereas this update represents the number of repeats found in the reference genome sequence. 5106754 58 The coding region has been updated to represent an alternate internal splice site that is more supported by the available transcript and protein data. 5106755 58 The coding region has been updated to represent an alternate internal splice site that is more supported by the available transcript and protein data. 5106762 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data and protein homology and there is no experimental evidence to show which translation start site is preferred. The translation initiation codon is well-conserved among mammals but it has a weak Kozak sequence whereas the downstream AUG has a strong Kozak sequence. Due to leaky scanning, although some ribosomes may initiate translation at the upstream AUG, other ribosomes may skip this AUG codon and initiate at the downstream AUG. 5106782 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript and protein data. 5106787 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5106808 58 This CCDS representation is based on AB083211.1 and is supported by data in PMID:14985102. This publication also shows the existence of this variant in mouse, as well as the presence of this truncated isoform in various mouse tissues in vivo. 5106817 58 This CCDS representation does not have any full-length human transcript support, but it is supported by overlapping partial transcript evidence, including AF432211.1, AK090813.1, AK308707.1, and several tiled ESTs. This representation is also supported by studies in PMID:18946081, which functionally characterizes this protein, and by homology support in mouse (NP_081651.2, CCDS23859.1) and rat (NP_001101103.1). PMID:18243103 also describes a partial crystal structure for this protein. 5106825 58 The coding region has been updated to represent an alternative splicing pattern, resulting in a longer protein N-terminus that is more supported by the available protein data. It should be noted that the exon combination of the update lacks full-length transcript support in human. None of the currently available human mRNAs can encode the supported full-length protein. Therefore, the exon combination of the update is inferred from alignment of the mouse mRNA, EF632061.1. This is consistent with the orthologous mouse CCDS representation, CCDS48340.1. 5106867 58 This CCDS ID represents the TTN novex-3 isoform, which has a novel and shorter C-terminus compared to longer isoforms. This isoform is supported by data in PMID:11717165, but it should be noted that the evidence for the transcript is partial on the 5' end, and thus this CCDS representation has an inferred exon combination. 5106869 58 The coding region has been updated to start at an alternate in-frame start codon that is more supported by conservation data. 5106878 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5106882 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5106888 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. There are no human transcripts extending across the entire exon 1 of this representation, possibly because of cloning or sequencing difficulties over this highly GC-rich sequence, but it is supported by mouse NM_001037725.2 (CCDS14986.1) and AK154812.1, as well as by a few human transcripts that partially represent this exon (including AI523857.1, BF513253.1, AW015381.1). 5106925 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available full-length transcript data. The previous representation, although partially supported by data in PMID:1689238, lacked full-length support. 5106926 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available full-length transcript data. The previous representation lacked full-length support. 5106957 58 This CCDS, which is supported by the mRNAs AK026432.1, BC108930.1 and others, represents a long human HCK isoform, known as p61HCK, as described in PMIDs 1875927 and 7791757. This isoform initiates translation from a non-AUG (CUG) start codon that is well-conserved and present in a strong Kozak signal context. Alternative translation initiation from a downstream AUG start codon produces an isoform that is 21 aa shorter at the N-terminus. The shorter isoform, which is known as p59HCK, is represented by CCDS 54455.1. These isoforms exhibit distinct subcellular distributions, as indicated in PMID:7791757. 5106957 144 1 1 M 5106961 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript and protein data. 5106987 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data and by conservation in primates. 5106997 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5107005 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5107006 58 The coding region has been updated to represent an alternative splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript and conservation data. 5107022 58 The coding region has been updated to shorten the N-terminus by 36 aa to one that is more supported by the available protein data. Use of the previously represented upstream start codon eliminates an N-terminal signal peptide, whose presence is consistent with publication data showing this to be a secreted protein. Both the upstream and the downstream start codons have weak Kozak signals and are restricted to primate species. The existence of another alternative downstream start codon, which has a strong Kozak signal and is much more widely conserved, should also be noted. It is possible that leaky scanning by ribosomes may allow this alternative start codon to be used some of the time. This would result in a protein that is 21 aa shorter at the N-terminus. There is no experimental evidence indicating which start codon is preferentially used in vivo. 5107047 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data. The annotated start codon appears to be specific for higher primate species. It is possible that leaky scanning by ribosomes may sometimes allow the use of the better conserved downstream start codon, which has a stronger Kozak signal. The use of the downstream start codon would result in a protein that is 37 aa shorter at the N-terminus. It is unclear which start codon is preferentially used in vivo. 5107048 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. The previous representation lacked full-length transcript support. 5107050 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5107064 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5107077 144 1 1 M 5107078 144 1 1 M 5107081 58 This CCDS representation is based on X83705.1. Although this mRNA accession lacks the final two exons, data in PMID:7659502 support the full-length nature of the transcript, and also the presence of a functional promoter at the 5' end. 5107087 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates, cow and dog. An alternative downstream start codon, which is more widely conserved and has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 26 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5107158 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5107159 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. The upstream AUG has a weak Kozak sequence while the downstream AUG has a strong Kozak sequence. Due to leaky scanning by ribosomes, it is possible that some ribosomes may initiate translation from the downstream AUG codon while others start from the upstream one. 5107166 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data or publications. 5107167 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5107170 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5107171 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. This CCDS ID represents a 5' end variant that is supported by human BC047509.1 and CF994722.1, and by orangutan CR857607.1. The encoded isoform has a shorter N-terminus compared to the isoform encoded by NM_001141947.1. 5107193 58 This olfactory receptor gene is a segregating pseudogene (PMID:22908908), where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele that is predicted to be non-functional. This CCDS is being retained because the Classifier for Olfactory Receptor Pseudogenes (CORP) predicts the reference genome allele to be functional. 5107224 58 This CCDS ID was withdrawn because the GRCh37.1 reference assembly contains a deletion and cannot encode the supported protein. 5107229 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available conservation data and protein homology data in mouse. The update adds a predicted signal peptide to the protein. 5107254 58 The coding region has been updated to start at an alternate start codon that is more supported by available transcripts and conservation data. 5107256 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5107262 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. 5107290 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5107318 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5107366 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates. An alternative downstream start codon, which is more widely conserved and has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 12 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5107385 144 1 1 M 5107399 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5107423 58 This CCDS representation is supported by transcript data, including the mRNAs BC088357.1 and AK313221.1. The 5'-most in-frame translational start codon is annotated, but it should be noted that this start codon is specific to primate species. This start codon also has a weak Kozak signal, and thus it is possible that leaky scanning by the ribosome will sometimes occur to allow initiation at a downstream start codon. The downstream start codon has a stronger Kozak signal and is much more widely conserved. Translation from the downstream start codon would result in a protein that is 11 aa shorter at the N-terminus. An alternative 5' end variant that encodes the shorter protein is represented by CCDS3831.1. 5107435 58 The coding region has been updated to represent an exon combination that is more supported by available data. The earlier representation (NM_052909.3) was partial at the 5' end. 5107437 58 The coding region has been updated to represent an alternative 5' splicing pattern, resulting in a longer protein N-terminus that is better supported by the available transcript and conservation data. 5107438 58 The coding region has been updated to represent an alternative splicing pattern that is better supported by the available full-length transcript data. 5107453 58 The coding region has been updated to significantly extend the N-terminus to one that is more supported by available transcript and conservation data. 5107547 58 This CCDS ID was withdrawn because there are no full-length transcripts representing it, and the exon combination of the variant is unclear. 5107572 58 This CCDS is supported by the mRNA AF155097.1. This mRNA has several mismatches versus the reference genome sequence at this location, and it is unclear if it is derived from this gene (FAM153A) or the similar FAM153B family member (CCDS 43401). 5107610 58 This olfactory receptor gene is a segregating pseudogene (PMID:22908908), where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele that is predicted to be non-functional. This CCDS is being retained because the Classifier for Olfactory Receptor Pseudogenes (CORP) predicts the reference genome allele to be functional. 5107640 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. 5107646 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5107660 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5107661 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5107664 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5107685 144 1 1 M 5107685 58 This CCDS representation starts at an upstream non-AUG (CUG) translation start codon that is supported by conservation data and experimental evidence, including that in PMIDs:11352659, 11563986 and 11731620. Most of the publicly available long mRNAs at this locus do not extend far enough 5' to include the CUG start codon, including S85192.1 which supports this variant. However, BC058855.1, several unspliced partial transcripts and the aforementioned publications all support transcription initiation further upstream. Hence, this CCDS representation includes the extended 5' CDS. Alternative translation initiation from a downstream AUG codon (Met-181), which results in a shorter isoform with a predicted signal peptide, has also been shown for this gene. The shorter isoform encoded by this variant is represented by CCDS 55010.1. 5107686 144 1 1 M 5107686 58 This CCDS representation starts at an upstream non-AUG (CUG) translation start codon that is supported by conservation data and experimental evidence, including that in PMIDs:11352659, 11563986 and 11731620. This transcript variant is supported by the full-length mRNA BC058855.1. Alternative translation initiation from a downstream AUG codon (Met-181), which results in a shorter isoform with a predicted signal peptide, has also been shown for this gene. The shorter isoform encoded by this variant is represented by CCDS 55012.1. 5107710 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data. The update adds a putative transmembrane domain to the protein. It should be noted that the start codon used in this update is restricted to higher primate species. This start codon has a weak Kozak signal, so it is possible that leaky scanning by ribosomes may occur some of the time, thus allowing the better conserved downstream start codon to be used, resulting in a protein that is 32 aa shorter at the N-terminus. No experimental evidence exists to show which start codon is used in vivo. 5107718 58 The exon combination of this CCDS representation lacks full-length human transcript support, but it is supported by partial human transcript alignments and by full-length orthologous transcripts, e.g., mouse BC150998.1 or BC151006.1. 5107799 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5107804 58 The coding region has been updated to start at a downstream in-frame start codon that is more supported by conservation data. 5107821 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5107824 58 The coding region has been updated to represent an alternative splicing pattern, which results in an extended N-terminus that is more supported by the available transcript and protein data. The update adds an N-terminal KRAB domain to the protein. 5107838 58 The coding region has been updated to represent an alternative splicing pattern that is more likely to encode a protein, and is supported by the available transcript data. The previous representation contained upstream ORFs that are likely to inhibit the translation of the protein. 5107868 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data. 5107880 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5107885 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein homology data. 5107901 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and homology data. The previous representation lacked full-length support. 5107920 58 The coding region has been updated to start at a downstream, alternate, in-frame start codon that is supported by conservation data. 5107979 58 The coding region has been updated to start at an alternate start codon and to represent an exon combination that is more supported by the available data. The earlier representation (NM_172059.3) was partial at the 5' end. 5107988 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5108000 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5108012 58 This CCDS ID represents the protein described in PMIDs: 10970730 and 17466953. This transcript is supported by BC075802.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously PMID: 17466953. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5108019 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5108025 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5108028 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5108037 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5108054 144 1 1 M 5108054 58 This CCDS ID represents the longest human BAG1 isoform, known as BAG-1L or p50, as described in the literature, including PMIDs 9396724, 9679980, 9747877 and 17662274. This isoform initiates translation at a non-AUG (CUG) start codon that is well-conserved and present in a strong Kozak signal context. Alternative translation initiation at downstream AUG start codons produces three additional isoforms with shorter N-termini, known as BAG-1M or p46, BAG-1S or p36 (also known as p33), and p29. The most abundant of the shorter isoforms, BAG-1S, is represented by CCDS 55301.1. Evidence in PMIDs 9747877 and 17662274 indicates that these isoforms have distinct subcellular distributions, which may contribute to the multifunctionality of the protein. 5108068 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the human reference genome sequence and by available conservation data. The reference genome contains a polymorphism that changes the previously represented ATG start codon to ATT; hence the next downstream AUG is represented in the update. This polymorphism is represented in the Reference SNP, rs2490582. The reference genome polymorphism results in a protein that is 7 aa shorter at the N-terminus, and is supported by homologous proteins. It is also possible that leaky scanning by ribosomes would permit translation initiation from the downstream AUG in alleles containing the upstream AUG. 5108070 58 The coding region has been updated to represent an alternative 5' splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript and protein data. 5108077 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5108088 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5108092 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5108099 58 This CCDS ID is based on a transcript that is a candidate for nonsense-mediated decay (NMD); however, the protein is supported by experimental evidence (PMID 7737358, 12747772) and by protein homology. 5108130 58 The coding region has been updated to start at an alternate in-frame start codon that is supported by conservation data. 5108133 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available protein data. This olfactory receptor (OR) gene lacks transcript support, possibly because OR genes are expressed in only a very small fraction of olfactory neurons, and thus, transcript evidence may be difficult to detect for all functional genes. The updated representation is consistent with that of The Human Olfactory Data Explorer (HORDE) database, entry #42-805. 5131697 535 ENSP00000337889.2 5154718 535 ENSP00000370521.3 5146439 535 ENSP00000330475.5 5197265 535 ENSP00000254722.4 5154080 535 ENSP00000475168.1 5217271 535 ENSP00000261180.5 5132721 535 ENSP00000354676.4 5222919 535 ENSP00000320089.3 5218249 535 ENSP00000388723.2 5128914 535 ENSP00000496416.1 5194281 535 ENSP00000384398.3 5129531 535 ENSP00000377517.4 5231602 535 ENSP00000347686.4 5264107 535 ENSP00000295897.4 5255102 535 ENSP00000295453.3 5149347 535 ENSP00000514123.1 5127016 535 ENSP00000326240.4 5248009 535 ENSP00000261254.3 5134540 535 ENSP00000342077.4 5176672 535 ENSP00000340761.7 5259349 535 ENSP00000308450.5 5234920 535 ENSP00000377381.2 5224234 535 ENSP00000378418.2 5236706 535 ENSP00000507809.1 5142449 535 ENSP00000388293.2 5131217 535 ENSP00000493076.1 5225360 535 ENSP00000369604.2 5209650 535 ENSP00000375070.6 5254617 535 ENSP00000401980.2 5160330 535 ENSP00000220940.1 5142722 535 ENSP00000468656.1 5231552 535 ENSP00000346659.3 5168468 535 ENSP00000402723.1 5117299 58 The coding region was updated to make it identical to the current human reference genome sequence. 5115635 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5115686 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5115763 58 The coding region has been updated to start at a downstream in-frame start codon that has better support from conservation data. 5115764 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. 5116079 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5116451 58 The coding region has been updated to shorten the N-terminus based on the use of a downstream in-frame start codon, which is more supported by the available transcript and conservation data. There is a higher probability of an N-terminal transit peptide being present in the updated protein. 5116941 12 460 460 U 5117052 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5117141 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data, and by conservation in primates. 5117269 58 The expression of the protein represented in this CCDS ID is auto-regulated by polyamine-enhanced translational frameshifting. During translation, a +1 frameshift occurs following codon 68, just preceding a termination codon, thereby enabling translation of the remaining portion of the protein (aa 69-228) in a different reading frame, as experimentally shown for the conserved rat ortholog (PMID:7813017). 5114628 12 273 273 U 5114769 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data. 5114254 12 648 648 U 5114255 12 550 550 U 5114257 12 498 498 U 5114276 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5114309 58 This CCDS ID represents the protein described in PMIDs: 12364586 and 14966479. This transcript is supported by AY170469.2. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 18544534. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5114343 58 The coding region has been updated to shorten the N-terminus, annotating a downstream start codon, to one that is more supported by available conservation data. 5114387 12 188 188 U 5114465 58 The coding region has been updated to include an additional segment in the coding region. This region corresponds to a tandem repeat encoding a 13 aa segment, which is present 3 times in the reference genome sequence. These tandem repeats are described in PMID:1577776. It should be noted that the majority of available transcript data represent an allele lacking one or more of these repeats, whereas this update represents the number of repeats found in the reference genome sequence. 5114544 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data, and by the number of 5' repeat motifs that are present in the GRCh38 reference genome assembly allele. 5090983 58 The coding region has been updated to represent an alternative splice pattern, resulting in an altered 3' coding region and an extended protein N-terminal that is better supported by available transcript and homology data. 5090993 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5091001 58 The coding region has been updated to represent an alternative CDS that is more likely to be translated based on the presence of an upstream and supported start codon, which is also used by the NM_022834.4 variant (CCDS27.1) at this locus. The updated representation contains a predicted N-terminal signal peptide. 5091013 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5091014 58 The coding region has been updated to start at a downstream in-frame start codon that has better support from conservation data. 5091024 58 This CCDS ID represents the protein described in PMIDs: 14595118 and 17267690. This protein is encoded by two different splice variants that are supported by AF175409.1 and AL049673.1. It should be noted that this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 14595118. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5091074 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation and functional data. The previous representation had an overextended N-terminus that lacked the expected signal peptide. 5091113 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. The update extends the Peptidase_C14 domain. 5091179 58 The coding region has been updated to represent an alternative 3' splice pattern, resulting in a shorter and distinct C-terminus that is better supported by available transcript and homology data. 5091188 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available transcript and conservation data. 5091201 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5091239 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5091281 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5091292 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5091304 58 The coding region has been updated to represent an alternative splice pattern that is more supported by the available transcript and protein data. 5091307 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5091309 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available protein, conservation and publication data. The updated CCDS representation uses a non-AUG (AUA) start codon. The human AUA start codon is conserved as AUG in most other mammals, and the use of this start codon results in a longer protein with an N-terminal signal peptide, consistent with experimental evidence showing that it is secreted (PMID:22237023). 5091309 144 1 1 M 5091312 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5091330 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data, and by data in PMID:14636996. 5091346 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data, and by data in PMID:16006562. 5091362 58 The coding region has been updated to start at a better supported upstream initiation codon, which is in a different reading frame, and to represent a protein that is more supported by available transcript and homology data. 5091386 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5091399 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. 5091404 58 The coding region has been updated to represent an alternative 3' splice pattern, resulting in a distinct C-terminus that is better supported by available transcript and homology data. 5091420 58 The coding region has been updated to extend the N-terminus, and to represent an alternative splicing pattern that that is more supported by the available transcript and homology data. 5091467 58 The coding region has been updated to scale back the N-terminus to one that is more supported by the available transcript data and by conservation across mammals. 5091469 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5091480 58 The coding region has been updated to represent an alternative 5' splice site, resulting in the extension of the N-terminus to one that is better supported by available transcript and homology data. 5091536 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and homology data. The update completes the FGGY_N, FGGY family of carbohydrate kinases, N-terminal domain, which was previously truncated. 5091551 58 This CCDS was updated to extend the coding region at the 5' end, which extends the N-terminus of the protein by 51aa. The update is supported by cross-species conservation data. 5091581 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data and by conservation in some primates. 5091631 58 This CCDS represents a retrogene of RBMX (RNA binding motif protein, X-linked), which is located on chromosome X. While all introns in the coding sequence have been processed out compared to the RBMX locus, the ORF is intact and there is specific evidence for transcription at this location. Studies in PMID:16201836 indicate that this locus is likely to be functional because the ORF has been preserved by purifying selection in all six Old World primates carrying this retrogene. Given that X chromosomal genes in mammals can generate a statistically significant excess of autosomal retrogenes relative to genes on other chromosomes (PMID:14739461), it is possible that this retrogene may be functional during male meiosis when X chromosomal genes are silenced or during haploid stages of spermatogenesis (PMID:16201836). In addition, it should be noted that this retrogene shares its first non-coding exon with the cysteine conjugate-beta lyase 2 (CCBL2) locus on chromosome 1, but the coding sequences are non-overlapping. 5091666 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5091667 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5091689 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5091712 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5091723 58 This CCDS representation uses a downstream in-frame AUG start codon, which is supported by homology and publication data. The use of the 5'-most in-frame AUG in the transcript would result in a 74 aa N-terminal extension, but this N-terminal extension is not conserved in other species, and it would eliminate an N-terminal signal peptide, which is known to be present based on experimental evidence (PMIDs 8262907, 3498652). 5091768 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5091775 58 This CCDS ID represents the protein described in PMIDs: 11437455 and 16111671. This variant is supported by AK056448.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 11437455. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5091780 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5091920 58 This CCDS representation uses a downstream AUG start codon. This start codon has a strong Kozak signal and is conserved among many organisms. An upstream start codon, which has a weak Kozak signal and is only found in humans, is also present. The use of the upstream start codon would result in a protein that is 18 aa longer at the N-terminus. PMID: 10882717 shows experimental evidence for translation from the downstream AUG. Therefore, the downstream start codon is represented for this CCDS. 5091923 58 The coding region has been updated to extend the N-terminus to one that is more supported by available proteomics data. 5091932 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5092041 58 The coding region has been updated to add additional internal exons and to extend the N-terminus to one that is more supported by available transcript and homology data. The update adds a CD80-like C2-set immunoglobulin domain, and completes a V-set domain that was previously truncated. 5092066 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5092097 58 The coding region has been updated to shorten the N-terminus to one that is more supported by current research community use. The updated start codon has a stronger Kozak signal and is better conserved across vertebrate species than the previously represented upstream start codon. There is no experimental evidence indicating which start codon is preferentially used in vivo. It is possible that the upstream start codon is used some of the time, whereas leaky scanning by ribosomes will permit use of the downstream start codon more of the time. Both the longer and shorter N-termini have predicted signal peptides (SignalP 3.0), but the signal peptide is 10 aa longer when the upstream start codon is used. 5221344 535 ENSP00000368100.4 5129588 535 ENSP00000269886.2 5264772 535 ENSP00000269209.6 5152904 535 ENSP00000398736.2 5259390 535 ENSP00000266085.5 5126871 535 ENSP00000266263.5 5136931 535 ENSP00000255198.2 5195923 535 ENSP00000247291.3 5218393 535 ENSP00000379823.3 5183945 535 ENSP00000222674.2 5181343 535 ENSP00000410024.2 5176409 535 ENSP00000264360.4 5150603 535 ENSP00000426911.2 5132253 535 ENSP00000363852.3 5215773 535 ENSP00000478901.1 5219903 535 ENSP00000264144.4 5183275 535 ENSP00000403644.2 5247454 535 ENSP00000343657.6 5182117 535 ENSP00000233099.5 5234577 535 ENSP00000357199.4 5271232 535 ENSP00000469689.2 5202036 535 ENSP00000374354.3 5260903 535 ENSP00000245458.7 5253759 535 ENSP00000262942.5 5148916 535 ENSP00000365510.3 5155840 535 ENSP00000378577.2 5226557 535 ENSP00000479775.2 5158198 535 ENSP00000417303.1 5148198 535 ENSP00000300976.3 5263090 535 ENSP00000350447.4 5209303 535 ENSP00000367965.2 5218304 535 ENSP00000341021.2 5250883 535 ENSP00000164227.5 5245122 535 ENSP00000403400.3 5218927 535 ENSP00000271843.4 5256978 535 ENSP00000307701.3 5179272 535 ENSP00000304762.5 5211902 535 ENSP00000357484.2 5251731 535 ENSP00000263932.2 5220032 535 ENSP00000296315.3 5185770 535 ENSP00000340546.4 5269189 535 ENSP00000381631.2 5207996 535 ENSP00000254803.2 5225210 535 ENSP00000350937.4 5220094 550 ENSP00000344521.3 5218348 535 ENSP00000468238.1 5242776 535 ENSP00000363241.5 5176001 535 ENSP00000253048.4 5245921 535 ENSP00000303149.2 5174060 550 ENSP00000449089.1 5249637 535 ENSP00000347012.5 5266785 535 ENSP00000392252.2 5228703 535 ENSP00000350198.2 5224926 535 ENSP00000306682.2 5150292 535 ENSP00000365016.3 5176423 535 ENSP00000249064.4 5236838 535 ENSP00000335255.3 5261636 535 ENSP00000252015.2 5270378 535 ENSP00000398089.1 5250499 535 ENSP00000404092.2 5152896 535 ENSP00000205214.6 5137718 535 ENSP00000275736.4 5182341 535 ENSP00000402446.4 5217882 535 ENSP00000261868.5 5198574 535 ENSP00000422464.1 5205074 535 ENSP00000318753.3 5251753 535 ENSP00000238112.3 5189579 535 ENSP00000369198.3 5177500 535 ENSP00000272907.7 5223971 535 ENSP00000261183.3 5151896 535 ENSP00000296577.4 5242004 535 ENSP00000331867.6 5171207 535 ENSP00000507487.1 5238737 535 ENSP00000262300.8 5237742 535 ENSP00000340841.5 5193093 535 ENSP00000298317.4 5162090 535 ENSP00000261226.4 5143989 535 ENSP00000322802.3 5164506 535 ENSP00000385632.4 5160847 535 ENSP00000296327.5 5192869 535 ENSP00000162391.3 5264016 535 ENSP00000345873.5 5229099 535 ENSP00000371018.5 5194298 535 ENSP00000419000.1 5241105 535 ENSP00000464645.1 5160203 535 ENSP00000355436.4 5197442 535 ENSP00000501053.1 5190205 535 ENSP00000262629.3 5268538 535 ENSP00000376472.3 5147243 535 ENSP00000315081.3 5197679 535 ENSP00000453129.1 5205676 535 ENSP00000369395.5 5204172 535 ENSP00000215793.7 5245425 535 ENSP00000360315.3 5155979 535 ENSP00000482439.1 5265764 535 ENSP00000264167.4 5266504 535 ENSP00000394936.2 5178067 535 ENSP00000234160.4 5247549 535 ENSP00000354615.4 5196392 535 ENSP00000495564.1 5170814 535 ENSP00000282903.5 5148754 535 ENSP00000389015.2 5200662 535 ENSP00000362550.4 5214194 535 ENSP00000366170.4 5197492 535 ENSP00000290417.2 5250821 535 ENSP00000256366.4 5137385 535 ENSP00000386830.1 5208955 535 ENSP00000497217.1 5247757 535 ENSP00000308597.6 5149847 535 ENSP00000377769.3 5261347 535 ENSP00000262374.5 5135951 535 ENSP00000481575.1 5239849 535 ENSP00000498483.1 5189937 535 ENSP00000469981.1 5157059 535 ENSP00000252137.6 5255879 535 ENSP00000248929.8 5204021 535 ENSP00000351166.6 5194353 535 ENSP00000512441.1 5233184 535 ENSP00000365473.3 5197955 535 ENSP00000218006.2 5169112 535 ENSP00000365152.4 5251847 535 ENSP00000350171.4 5188042 535 ENSP00000407837.2 5183411 535 ENSP00000447597.2 5150975 535 ENSP00000384141.3 5136182 535 ENSP00000420557.3 5190915 535 ENSP00000439378.1 5229889 535 ENSP00000287598.7 5244921 535 ENSP00000372035.4 5132553 535 ENSP00000340184.4 5186756 535 ENSP00000375922.3 5222340 535 ENSP00000225972.7 5208611 535 ENSP00000447931.1 5221578 535 ENSP00000333018.3 5267144 535 ENSP00000363283.2 5223993 535 ENSP00000285039.6 5229952 535 ENSP00000334938.3 5171743 535 ENSP00000194214.5 5245407 535 ENSP00000216252.3 5259967 535 ENSP00000431605.1 5266220 535 ENSP00000364742.3 5144733 535 ENSP00000326340.5 5252362 535 ENSP00000376278.1 5245156 535 ENSP00000249042.3 5208721 535 ENSP00000367384.4 5206428 535 ENSP00000367545.4 5167017 535 ENSP00000207457.3 5183338 535 ENSP00000261313.2 5183167 535 ENSP00000412031.2 5258721 535 ENSP00000237353.10 5248234 535 ENSP00000375093.2 5202492 535 ENSP00000345689.5 5265882 535 ENSP00000248879.2 5169790 535 ENSP00000357796.1 5184326 535 ENSP00000233969.2 5154765 535 ENSP00000350132.5 5134497 535 ENSP00000350005.2 5218251 535 ENSP00000242209.4 5177237 535 ENSP00000469886.1 5163210 535 ENSP00000475344.1 5215819 535 ENSP00000497409.1 5211936 535 ENSP00000291295.8 5154405 535 ENSP00000216807.6 5204166 535 ENSP00000493035.1 5135741 535 ENSP00000215832.7 5198756 535 ENSP00000255416.4 5246022 535 ENSP00000381104.2 5149260 535 ENSP00000455826.1 5251140 535 ENSP00000257549.4 5178940 535 ENSP00000400471.2 5235688 535 ENSP00000450482.1 5239992 535 ENSP00000423113.2 5157134 535 ENSP00000389513.2 5241068 535 ENSP00000263317.4 5217888 535 ENSP00000337446.5 5195821 535 ENSP00000264220.2 5237200 535 ENSP00000481684.1 5199854 535 ENSP00000354085.2 5262085 535 ENSP00000354991.3 5153672 535 ENSP00000221573.5 5189998 535 ENSP00000440374.2 5180334 535 ENSP00000309233.4 5202193 535 ENSP00000492896.1 5162651 535 ENSP00000344041.1 5142803 535 ENSP00000327758.4 5270282 535 ENSP00000239690.4 5139504 535 ENSP00000253799.2 5133625 535 ENSP00000301838.5 5203874 535 ENSP00000374409.3 5189893 535 ENSP00000301599.6 5267470 535 ENSP00000296666.9 5217453 535 ENSP00000356065.1 5154991 535 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ENSP00000393987.3 5179053 535 ENSP00000386398.1 5233716 535 ENSP00000346440.3 5269498 535 ENSP00000420176.1 5224283 535 ENSP00000357013.4 5197141 535 ENSP00000362760.3 5175167 535 ENSP00000377047.2 5254684 535 ENSP00000384625.3 5252514 535 ENSP00000286544.4 5259739 535 ENSP00000263620.2 5220571 535 ENSP00000296015.4 5193551 535 ENSP00000300417.6 5149787 535 ENSP00000281623.3 5268755 535 ENSP00000364003.4 5247110 535 ENSP00000492359.1 5251905 535 ENSP00000342222.7 5153637 535 ENSP00000316543.5 5251094 535 ENSP00000509504.1 5181793 535 ENSP00000370147.2 5160829 535 ENSP00000497050.1 5154994 535 ENSP00000370552.3 5223336 535 ENSP00000359691.4 5135940 535 ENSP00000509719.1 5168858 535 ENSP00000480291.1 5148465 535 ENSP00000338389.4 5134190 535 ENSP00000379412.1 5216406 535 ENSP00000463574.1 5130340 535 ENSP00000326272.3 5206355 535 ENSP00000357448.3 5216376 535 ENSP00000309945.11 5221469 535 ENSP00000331411.2 5166291 535 ENSP00000300648.6 5226883 535 ENSP00000473665.1 5176187 535 ENSP00000319217.1 5147618 535 ENSP00000357811.3 5127193 535 ENSP00000280560.8 5252110 535 ENSP00000430237.1 5203995 535 ENSP00000514106.1 5222893 535 ENSP00000407922.2 5131117 535 ENSP00000309524.5 5228416 535 ENSP00000368296.4 5267080 535 ENSP00000495418.1 5239723 535 ENSP00000364448.3 5262288 535 ENSP00000256649.4 5253294 535 ENSP00000319883.3 5148266 535 ENSP00000333142.3 5192160 535 ENSP00000310111.9 5252770 535 ENSP00000419361.1 5244549 535 ENSP00000361645.3 5258309 535 ENSP00000328940.5 5175826 535 ENSP00000493312.1 5179465 535 ENSP00000485316.2 5176167 535 ENSP00000452877.2 5227267 535 ENSP00000355237.2 5180633 535 ENSP00000354778.3 5167098 535 ENSP00000324005.4 5212633 535 ENSP00000359540.4 5160782 535 ENSP00000265404.2 5149674 535 ENSP00000308734.5 5205090 535 ENSP00000308051.6 5271121 535 ENSP00000344818.5 5151193 535 ENSP00000331211.5 5221889 535 ENSP00000393559.2 5161349 535 ENSP00000244573.4 5171830 535 ENSP00000386938.3 5260886 535 ENSP00000261530.7 5241759 535 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ENSP00000312649.5 5166522 535 ENSP00000268712.2 5197090 535 ENSP00000264828.3 5215607 535 ENSP00000331545.2 5223644 535 ENSP00000485586.2 5145971 535 ENSP00000215906.5 5177381 535 ENSP00000464391.1 5255391 535 ENSP00000509161.1 5246860 535 ENSP00000318641.2 5168162 535 ENSP00000214869.1 5251216 535 ENSP00000334974.2 5228880 535 ENSP00000375220.2 5158675 535 ENSP00000317128.4 5135175 535 ENSP00000315118.3 5151652 535 ENSP00000423673.1 5182369 535 ENSP00000267396.4 5267207 535 ENSP00000338481.3 5209791 535 ENSP00000040584.4 5179122 535 ENSP00000434727.2 5253557 535 ENSP00000350708.3 5195121 535 ENSP00000483595.2 5176762 535 ENSP00000257694.8 5218020 535 ENSP00000209875.4 5183612 535 ENSP00000272438.4 5189901 535 ENSP00000330338.4 5231181 535 ENSP00000327599.4 5239579 550 ENSP00000408489.2 5136810 535 ENSP00000498248.1 5255092 535 ENSP00000264047.2 5157380 535 ENSP00000477695.1 5167172 535 ENSP00000489944.1 5183115 535 ENSP00000357392.3 5224102 535 ENSP00000302100.3 5237428 535 ENSP00000361064.4 5254954 535 ENSP00000371835.3 5217619 535 ENSP00000256538.4 5128235 535 ENSP00000398017.2 5243747 535 ENSP00000423812.1 5143563 535 ENSP00000376800.3 5171074 535 ENSP00000249075.3 5141453 535 ENSP00000420854.1 5201744 535 ENSP00000369702.2 5190198 535 ENSP00000307004.4 5189772 535 ENSP00000463233.1 5252257 535 ENSP00000447879.1 5265994 535 ENSP00000494373.1 5231044 535 ENSP00000263921.3 5173487 535 ENSP00000503543.1 5202029 535 ENSP00000232501.3 5180524 535 ENSP00000482296.2 5147220 535 ENSP00000258390.7 5207294 535 ENSP00000330694.4 5223961 535 ENSP00000390809.1 5181520 535 ENSP00000480059.2 5131093 535 ENSP00000215885.3 5247935 535 ENSP00000412189.1 5181303 535 ENSP00000308279.5 5265746 535 ENSP00000311427.6 5189450 535 ENSP00000245479.2 5212517 535 ENSP00000350651.4 5263676 535 ENSP00000318559.6 5256237 535 ENSP00000353422.3 5184963 535 ENSP00000368688.4 5209629 535 ENSP00000386722.4 5197354 535 ENSP00000361486.3 5242551 535 ENSP00000276202.7 5259219 535 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ENSP00000385932.1 5190736 535 ENSP00000379678.1 5165653 535 ENSP00000355719.3 5228878 535 ENSP00000301488.4 5144961 535 ENSP00000432459.1 5192660 535 ENSP00000512868.1 5217639 535 ENSP00000389095.3 5254116 535 ENSP00000363654.3 5188934 535 ENSP00000417085.1 5236723 535 ENSP00000458772.1 5269852 535 ENSP00000251166.4 5263598 535 ENSP00000309463.4 5153921 535 ENSP00000234179.2 5199369 535 ENSP00000338509.4 5198588 535 ENSP00000310226.6 5151901 535 ENSP00000499779.1 5264777 535 ENSP00000268797.7 5156105 535 ENSP00000218008.3 5264002 535 ENSP00000409284.2 5271340 535 ENSP00000346155.6 5255541 535 ENSP00000295959.5 5200989 535 ENSP00000388387.1 5188732 535 ENSP00000386786.2 5150268 535 ENSP00000491174.1 5207885 535 ENSP00000357304.3 5180711 535 ENSP00000497523.1 5246816 535 ENSP00000331397.4 5149620 535 ENSP00000462664.1 5169999 535 ENSP00000376007.3 5174775 535 ENSP00000263863.5 5213488 535 ENSP00000451040.1 5165188 535 ENSP00000341597.4 5159433 535 ENSP00000354458.3 5190490 535 ENSP00000240922.2 5268012 535 ENSP00000411242.2 5174008 535 ENSP00000371272.2 5211479 535 ENSP00000261413.5 5207427 535 ENSP00000274606.4 5189058 535 ENSP00000264012.4 5271519 535 ENSP00000494310.1 5169170 535 ENSP00000353114.4 5200891 535 ENSP00000493121.1 5221773 550 ENSP00000387966.2 5175879 535 ENSP00000275016.2 5179830 535 ENSP00000308405.5 5145969 535 ENSP00000355241.2 5178851 535 ENSP00000337432.4 5263882 535 ENSP00000398266.2 5212277 535 ENSP00000262545.2 5149412 535 ENSP00000300853.3 5165591 535 ENSP00000361894.3 5196781 535 ENSP00000305595.4 5142291 535 ENSP00000367787.3 5219859 535 ENSP00000270225.6 5188524 535 ENSP00000377406.1 5235726 535 ENSP00000369274.4 5160696 535 ENSP00000430202.1 5217476 535 ENSP00000455106.1 5200736 535 ENSP00000519206.1 5172625 535 ENSP00000434995.1 5208604 535 ENSP00000360824.2 5129122 535 ENSP00000309477.5 5246795 535 ENSP00000471477.1 5153157 535 ENSP00000364945.2 5160706 535 ENSP00000306117.7 5169571 535 ENSP00000360644.5 5151967 535 ENSP00000308082.2 5205110 535 ENSP00000330341.2 5237449 535 ENSP00000434797.1 5213670 535 ENSP00000492311.2 5174940 535 ENSP00000422354.1 5150226 535 ENSP00000319281.3 5245097 535 ENSP00000349270.3 5146023 535 ENSP00000421191.1 5213652 535 ENSP00000445418.1 5211914 535 ENSP00000358921.4 5240231 535 ENSP00000286355.5 5218166 535 ENSP00000430236.1 5195618 535 ENSP00000261374.3 5223679 535 ENSP00000491507.1 5198941 535 ENSP00000434602.2 5249973 535 ENSP00000380460.3 5135188 535 ENSP00000267102.8 5219937 535 ENSP00000381250.3 5227437 535 ENSP00000300605.4 5235157 535 ENSP00000384421.1 5179720 535 ENSP00000309509.4 5241643 535 ENSP00000296511.5 5140470 535 ENSP00000363109.3 5152483 535 ENSP00000509996.1 5223927 535 ENSP00000380702.2 5221169 535 ENSP00000435096.1 5214696 535 ENSP00000344488.4 5258565 535 ENSP00000329918.4 5178744 535 ENSP00000259037.3 5207558 535 ENSP00000507692.1 5223435 535 ENSP00000351524.5 5180596 535 ENSP00000315950.5 5145726 535 ENSP00000486024.1 5174747 535 ENSP00000410470.2 5173932 535 ENSP00000250101.5 5245459 535 ENSP00000288135.6 5254874 535 ENSP00000310459.4 5163683 535 ENSP00000299295.2 5200544 535 ENSP00000245817.2 5175280 535 ENSP00000485306.1 5254705 535 ENSP00000276440.7 5200752 535 ENSP00000486058.1 5175796 535 ENSP00000326095.4 5140231 535 ENSP00000251089.3 5225423 535 ENSP00000496813.1 5198800 535 ENSP00000309142.7 5138530 535 ENSP00000358059.3 5231794 535 ENSP00000328062.6 5172942 535 ENSP00000310129.4 5161678 535 ENSP00000368245.3 5267235 535 ENSP00000314776.6 5183335 535 ENSP00000478258.1 5157847 535 ENSP00000363250.3 5235867 535 ENSP00000353557.4 5210227 535 ENSP00000356125.5 5208782 535 ENSP00000279281.3 5217357 535 ENSP00000273968.4 5144335 535 ENSP00000386412.1 5221949 535 ENSP00000364752.1 5255109 535 ENSP00000280800.3 5264305 535 ENSP00000298282.8 5129627 535 ENSP00000261507.6 5141235 535 ENSP00000497916.1 5199069 535 ENSP00000296233.3 5263495 535 ENSP00000393847.4 5257764 535 ENSP00000496129.1 5265707 535 ENSP00000270586.3 5199518 535 ENSP00000296292.3 5183393 535 ENSP00000385361.3 5179924 535 ENSP00000264031.2 5224656 535 ENSP00000378180.3 5197877 535 ENSP00000465157.1 5141918 535 ENSP00000300291.5 5201855 535 ENSP00000371230.3 5193896 535 ENSP00000360918.2 5269403 535 ENSP00000368511.3 5238528 535 ENSP00000262487.3 5213659 535 ENSP00000359224.4 5168789 535 ENSP00000429283.3 5250694 535 ENSP00000483662.1 5127881 535 ENSP00000312299.3 5152590 535 ENSP00000353094.7 5150504 535 ENSP00000364118.3 5238013 535 ENSP00000393597.2 5257858 535 ENSP00000308024.2 5174845 535 ENSP00000498582.2 5190154 535 ENSP00000262340.5 5257873 535 ENSP00000008527.5 5160089 535 ENSP00000377989.4 5264102 535 ENSP00000263867.4 5262415 535 ENSP00000216144.3 5220086 550 ENSP00000491796.1 5202007 535 ENSP00000481334.1 5225284 535 ENSP00000279068.5 5268719 535 ENSP00000357753.3 5150564 535 ENSP00000324375.5 5195342 535 ENSP00000507955.1 5257057 535 ENSP00000331849.3 5153224 535 ENSP00000334650.1 5234801 535 ENSP00000479106.2 5147732 535 ENSP00000301607.3 5270130 535 ENSP00000277120.3 5248920 535 ENSP00000348206.4 5160020 535 ENSP00000249330.2 5169363 535 ENSP00000216336.2 5178248 535 ENSP00000300896.3 5129253 535 ENSP00000348597.3 5161292 535 ENSP00000369947.3 5182981 535 ENSP00000263578.5 5195440 535 ENSP00000263773.5 5223079 535 ENSP00000332389.3 5231225 535 ENSP00000272133.3 5160053 535 ENSP00000173229.2 5199550 535 ENSP00000385610.3 5241088 535 ENSP00000262290.4 5243518 535 ENSP00000363822.3 5208909 535 ENSP00000359505.3 5238085 535 ENSP00000348933.4 5216598 535 ENSP00000356825.4 5195585 535 ENSP00000294973.6 5269686 535 ENSP00000434359.1 5134897 535 ENSP00000260810.5 5250604 535 ENSP00000299424.4 5136966 535 ENSP00000364493.3 5252447 535 ENSP00000301072.7 5169973 535 ENSP00000389445.1 5186047 535 ENSP00000422131.1 5156834 535 ENSP00000507927.1 5225624 535 ENSP00000252744.5 5179687 535 ENSP00000481358.1 5208907 535 ENSP00000412897.1 5251926 535 ENSP00000366829.3 5173016 535 ENSP00000419952.1 5160748 535 ENSP00000431083.1 5128090 535 ENSP00000004982.3 5253657 535 ENSP00000339695.5 5268566 535 ENSP00000323047.6 5238812 535 ENSP00000320401.2 5132891 535 ENSP00000359497.3 5191833 535 ENSP00000264824.3 5262624 535 ENSP00000305302.10 5258514 535 ENSP00000364586.2 5269061 535 ENSP00000400333.2 5259881 535 ENSP00000334276.5 5129297 535 ENSP00000494643.1 5134919 535 ENSP00000358715.3 5229447 535 ENSP00000299610.5 5179904 535 ENSP00000411851.2 5141088 535 ENSP00000252826.4 5252354 535 ENSP00000353472.6 5126769 535 ENSP00000261622.4 5181812 535 ENSP00000384523.3 5267885 535 ENSP00000250383.7 5268710 535 ENSP00000355028.3 5165345 535 ENSP00000302021.5 5135409 535 ENSP00000298717.3 5222966 535 ENSP00000292476.5 5171024 535 ENSP00000247005.5 5245642 535 ENSP00000356951.1 5178512 535 ENSP00000382675.2 5241573 535 ENSP00000348564.3 5235117 535 ENSP00000319255.6 5147875 535 ENSP00000329287.5 5196577 535 ENSP00000334876.5 5217265 535 ENSP00000266505.7 5184323 535 ENSP00000361338.3 5262769 535 ENSP00000357053.1 5202504 535 ENSP00000338034.5 5267365 535 ENSP00000264645.6 5254273 535 ENSP00000309262.9 5267679 535 ENSP00000257527.5 5169297 535 ENSP00000377977.2 5271398 535 ENSP00000305107.3 5157226 535 ENSP00000418669.3 5163223 535 ENSP00000387654.2 5153744 535 ENSP00000221283.4 5171996 535 ENSP00000508105.1 5150881 535 ENSP00000482946.1 5156123 535 ENSP00000456894.1 5226913 535 ENSP00000282753.1 5238872 535 ENSP00000254322.1 5192318 535 ENSP00000377505.1 5236937 535 ENSP00000364895.4 5198355 535 ENSP00000333547.5 5266671 535 ENSP00000312286.4 5195713 535 ENSP00000417314.1 5202388 535 ENSP00000349494.3 5165294 535 ENSP00000297056.6 5187854 535 ENSP00000296953.2 5230895 535 ENSP00000306276.4 5213792 535 ENSP00000279028.2 5230685 535 ENSP00000346403.3 5219344 535 ENSP00000483703.1 5207049 535 ENSP00000497102.1 5198023 535 ENSP00000339109.3 5187620 535 ENSP00000330432.5 5209086 535 ENSP00000508385.1 5240110 535 ENSP00000239587.5 5178852 535 ENSP00000379282.3 5234539 535 ENSP00000303015.7 5209740 535 ENSP00000265062.3 5216129 535 ENSP00000356280.3 5248846 535 ENSP00000260702.3 5144652 535 ENSP00000313854.5 5166375 535 ENSP00000377570.3 5217079 535 ENSP00000341538.4 5158187 535 ENSP00000307461.3 5250815 535 ENSP00000309597.3 5133845 535 ENSP00000320077.1 5204125 535 ENSP00000243914.3 5154575 535 ENSP00000346414.4 5218121 535 ENSP00000463922.1 5129020 535 ENSP00000493068.1 5145162 535 ENSP00000242375.3 5177424 535 ENSP00000455897.1 5194857 535 ENSP00000494957.1 5213542 535 ENSP00000352138.6 5205072 535 ENSP00000284885.3 5163292 535 ENSP00000424189.2 5269227 535 ENSP00000388841.3 5205610 535 ENSP00000334866.3 5158960 535 ENSP00000492990.1 5140930 535 ENSP00000301318.3 5198098 535 ENSP00000337797.5 5244782 535 ENSP00000365899.3 5202783 535 ENSP00000301050.2 5264011 535 ENSP00000267845.3 5194821 535 ENSP00000357425.4 5115427 58 The coding region has been updated to shorten the N-terminus to one that is better supported by available conservation data and peptide data. This CCDS represents use of a downstream start codon, shortening the protein by a single amino acid. 5114793 58 This CCDS, which is supported by the mRNAs AK289896.1 and BC113854.1, represents a long human HCK isoform, as described in PMIDs 1875927 and 7791757. This isoform initiates translation from a non-AUG (CUG) start codon that is well-conserved and present in a strong Kozak signal context. Alternative translation initiation from a downstream AUG start codon produces an isoform that is 21 aa shorter at the N-terminus. The shorter isoform encoded by this variant is represented by CCDS 54456.1. These isoforms exhibit distinct subcellular distributions, as indicated in PMID:7791757. 5114793 144 1 1 M 5114794 58 This CCDS, which is supported by the mRNAs AK026432.1, BC108930.1 and others, represents a short human HCK isoform, known as p59HCK, as described in PMID:7791757. This isoform initiates translation from a downstream AUG start codon. Alternative translation initiation from an upstream non-AUG (CUG) start codon, which is well-conserved and present in a strong Kozak signal context, produces an isoform that is 21 aa longer at the N-terminus. The longer isoform, which is known as p61HCK, is represented by CCDS 33460.1. These isoforms exhibit distinct subcellular localization, as indicated in PMID:7791757. 5114795 58 This CCDS, which is supported by the mRNAs AK289896.1 and BC113854.1, represents a short human HCK isoform, as described in PMID:7791757. This isoform initiates translation from a downstream AUG start codon. Alternative translation initiation from an upstream non-AUG (CUG) start codon, which is well-conserved and present in a strong Kozak signal context, produces an isoform that is 21 aa longer at the N-terminus. The longer isoform encoded by this variant is represented by CCDS 54453.1. These isoforms exhibit distinct subcellular localization, as indicated in PMID:7791757. 5113333 58 The coding region has been updated to represent an alternative splicing pattern, resulting in an extended N-terminus that is better supported by the available transcript data. 5113337 58 This CCDS ID was withdrawn because the gene is known to be polymorphic (e.g., PMID:17033959), and the reference genome allele contains a 1 nt insert and cannot encode the protein. 5113338 58 This CCDS ID was withdrawn because the gene is known to be polymorphic (e.g., PMID:17033959), and the reference genome allele contains a 1 nt insert and cannot encode the protein. 5113354 58 This CCDS representation is mostly supported by the long mRNA AB033044.1. However, it should be noted that AB033044.1 contains a chimeric 5' end and lacks the supported start codon for this gene. This CCDS representation therefore uses the expected start codon, with support from other human and homologous transcripts, including human BC030616.2 and several ESTs, mouse BY174440.1 and BY202771.1, and cow EV623524.1, DN286973.1 and AW654672.1. 5113368 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5113377 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5113384 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data that aligns specifically to this genomic location. There are no human full-length transcripts representing this exon combination, but it is supported by the tiled ESTs BX337599.2, BX350113.2 and BX337598.2 from the same clone, which were used to construct Genoscope accession CR607509.1. 5113392 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and publication data. The update is based on AM989468.1 whose 5' end was identified by 5' RACE in PMID: 18974108. The 5' CDS extension results in an additional 62 aa at the N-terminus of the encoded protein. 5113404 58 The coding region has been updated to extend the N-terminus, and to represent an alternative splicing pattern that is more supported by the available transcript data. It should be noted that the updated start codon is conserved only in higher primate species, but it is expected that these species will use this start codon at least some of the time. 5108136 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available protein data. This olfactory receptor (OR) gene lacks transcript support, possibly because OR genes are expressed in only a very small fraction of olfactory neurons, and thus, transcript evidence may be difficult to detect for all functional genes. The updated representation is consistent with that of The Human Olfactory Data Explorer (HORDE) database, entry #42-827. 5108170 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and homology data. 5108171 58 The coding region has been updated to represent an alternative splicing pattern and to extend the N-terminus based on available transcript and homology data. The 5' extension to the translation start codon of this update has no direct transcript support in human (14 nts are extended upstream of the 5'-most EST, AW448941.1), but it is supported by transcripts representing the mouse ortholog, and by conservation across several species. 5108201 58 This gene lacks full-length transcript support, and therefore this CCDS representation has an inferred exon combination based on partial transcript and RNA-seq alignments. 5108216 58 The coding region has been updated to represent an alternative 5' splice pattern, resulting in an extended N-terminus that is more supported by available transcript and conservation data. The update adds a predicted KRAB domain to the protein. 5108242 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript and homology data. 5108252 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5108253 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5108256 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript data. 5108271 58 The coding region has been updated to extend the N-terminus to one that is supported by available conservation. Mouse BC138009.1 and BC138011.1 support a longer 5' exon and 5' CDS which is conserved between human, mouse, and rat. There is currently no human transcript data to support the N-terminus extension. 5108333 58 The translation initiation codon selected for this CCDS representation has a strong Kozak signal, but it appears to be human-specific. A much better-conserved alternate start codon, which also has a strong Kozak signal, exists further downstream. Use of the downstream start codon would result in a protein that is 10 aa shorter at the N-terminus. No experimental evidence exists to indicate which start codon is used in vivo. 5108373 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. All transcripts that can encode this protein are candidates for nonsense-mediated mRNA decay (NMD), but in the absence of transcripts that are not NMD candidates, this representation is considered an NMD exception because the gene is believed to be protein-coding. 5108376 58 The coding region has been updated to extend the N-terminus based on the 5' splice pattern of AK296203.1, and on conservation support from other primate species. Alternative 5' end variants exist that would produce isoforms with shorter N-termini, with homology support from rat NP_058971.1 and mouse NP_036170.1, but currently these do not have full-length transcript support in human. 5108378 58 The coding region has been updated to begin from an alternative downstream start codon, which is better conserved. 5108382 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5108391 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5108394 58 The coding region has been updated to correct several errors that were present versus the GRCh38 reference genome assembly. 5108408 12 127 127 U 5108408 12 462 462 U 5108409 12 428 428 U 5108415 58 This CCDS ID represents the protein described in PMID: 16792503 and is supported by the mRNA BC069216.1. It should be noted that this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in mouse as shown in PMID: 16792503. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5108444 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5108447 58 This CCDS representation uses a downstream start codon but includes a potential upstream start codon that would result in a protein that is 18 aa longer at the N-terminus. However, the upstream start codon has a weak Kozak signal, the vast majority of transcripts from human and homologous species start downstream of it, and data in PMID:19413330 indicate that the N-terminus begins at an N-alpha acetylated Ala-2 residue (nASIMEGPLSK...) following cleavage of the initiating Met-1 derived from the second start codon. The second start codon is therefore represented in this CCDS. 5108448 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5108453 12 126 126 U 5108454 12 126 126 U 5108456 58 The coding region has been updated to represent an alternative splice variant that is supported by the full-length mRNA AK302446.1, and by the homologous rat and mouse proteins (NP_001094435.1 and NP_001119959.1, respectively). 5108467 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5108473 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. The updated protein is also described in PMID:11724789. 5108485 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5108508 58 This CCDS ID was withdrawn because the genome contains a 1 nt insertion and cannot represent the updated protein. The genome contains an extra 'C' at codon 424, which results in a frameshift and a protein with a different C-terminus compared to that encoded by AF193807.1, AY139092.1 and AY139093.1. Experimental evidence in PMID:18635543 indicates that residues downstream of aa 424 are important for phosphorylation of the 458 aa protein represented by the update, and this phosphorylation regulates both C-terminal anchorage to the membrane skeleton and the ammonium transport activity of the protein. The updated protein is supported by homologs in several mammalian species, including mouse NP_067350.2 (CCDS17466.1), rat NP_898877.1, dog NP_001003017.2, and pig NP_999161.1. It is possible that the additional 'C' in the reference genome sequence represents a valid polymorphism, but currently the representative SNPs (rs11303415 and rs60769529) have not been validated and no population diversity data exist for them. 5108529 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5108533 58 The coding region has been updated to represent an alternative splicing pattern that is better supported by the available transcript and protein data. 5108538 58 The coding region has been updated to represent an alternative splicing pattern, resulting in longer N- and C-termini that are more supported by the available transcript and protein data. 5108540 58 The coding region has been updated to represent an exon/intron structure that is more supported by the available transcript and protein data. The update is based on the human mRNA, BC063877.1, whose polyA site and signal confirm that it is complete at the 3' end. It is possible that there is a longer variant, as for mouse, but there is not enough transcript evidence to support it at this time. 5171437 535 ENSP00000310901.5 5132143 535 ENSP00000469417.1 5163466 535 ENSP00000335333.3 5256178 535 ENSP00000509436.1 5115283 58 This CCDS, which is supported by the mRNA S85192.1, represents a VEGFA isoform derived from an AUG start codon. Alternative translation initiation from multiple upstream non-AUG(CUG) codons is also possible for this gene, as indicated in PMIDs:11352659, 11563986 and 11731620. The longest isoform encoded by this variant, which is derived from the 5'-most CUG start codon, is represented by CCDS 34457.1. 5115284 58 This CCDS, which is supported by the mRNA AF091352.1, represents a VEGFA isoform derived from an AUG start codon. Alternative translation initiation from multiple upstream non-AUG(CUG) codons is also possible for this gene, as indicated in PMIDs:11352659, 11563986 and 11731620. The longest isoform encoded by this variant, which is derived from the 5'-most CUG start codon, is represented by CCDS 47435.1. 5115282 58 This CCDS, which is supported by the mRNA M27281.1, represents a VEGFA isoform derived from an AUG start codon. Alternative translation initiation from multiple upstream non-AUG(CUG) codons is also possible for this gene, as indicated in PMIDs:11352659, 11563986 and 11731620. The longest isoform encoded by this variant, which is derived from the 5'-most CUG start codon, is represented by CCDS 4907.2. 5108555 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5108599 58 The coding region has been updated to add an additional glycine residue in the protein C-terminal region, supported by the available transcript and conservation data. 5108619 58 The coding region has been updated to shorten the N-terminus to one that is supported by conservation data. 5108631 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5108639 144 1 1 M 5108645 58 The coding region has been updated to represent an alternative transcript variant that is more likely to be protein-coding. The previous representation was a candidate for nonsense-mediated mRNA decay (NMD). The update adds two FN3 and two IGcam domains to the C-terminus, which is better supported by paralogous proteins. 5108651 58 The coding region has been updated to extend the N-terminus and this extension is supported by conservation data. 5108670 58 This CCDS representation uses a downstream start codon, which is more consistent with the presence of an N-terminal signal peptide, and with experimental evidence for cleavage of this signal peptide in PMID:15340161. It should be noted that an alternative upstream start codon, which would result in a protein that is 38 aa longer at the N-terminus, also exists. However, the use of the upstream start codon would eliminate the signal peptide, and it has a weak Kozak signal, so it is likely that leaky scanning by ribosomes will allow the use of the downstream start codon. 5108749 58 The coding region has been updated to include an additional internal segment in exon 3 based on the allelic haplotype of the reference genome. Exon 3 of this gene contains several tandemly repeated sequences that vary in repeat copy number among different alleles, as described in PMIDs 2851479, 8422499 and 8554050. The reference genome allele is supported by DNA accession S80905.1. 5108757 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5108770 58 The coding region has been updated to represent an alternative splice pattern, and to extend the N- and C-termini based on available transcript and homologous protein data. There are no full-length mRNAs representing the update in human, but this can be constructed from tiled transcripts, including CN359946.1, CN359941.1 and BC033253.1, with support from the full-length mouse mRNA, BC110599.2. 5108775 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available transcript and conservation data. 5108820 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript data. The update adds an ATPase family associated with various cellular activities (AAA) domain to the protein. 5108829 58 The coding region has been updated to represent an alternative splice variant that is more supported by the available transcript data. 5108830 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5108854 58 The coding region has been updated to remove two codons that are not included in the GRCh38 reference genome allele. 5108858 58 This CCDS ID represents the protein described in PMIDs: 12364586 and 14966479. This transcript is supported by AY138546.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 18544534. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5108892 58 The coding region has been updated to scale back the N-terminus to one that is more supported by available conservation data. 5108897 58 This CCDS ID represents the longer isoform encoded by the TRAPPC6B gene. The shorter isoform is represented by CCDS9670.1. 5108910 12 40 40 U 5108913 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5108925 12 170 170 U 5108925 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5108989 12 95 95 U 5108991 144 1 1 M 5109025 12 60 60 U 5109040 58 The coding region has been updated to represent an alternative splicing pattern and to shorten to N-terminus to one that is more consistent with the available transcript and protein data. 5109046 58 This CCDS was updated to trim the coding region at the 5' end, which shortens the N-terminus of the protein by 86 amino acid residues. The update is supported by conservation data. 5109121 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates. An alternative downstream start codon, which is more widely conserved and has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 4 aa shorter at the N-terminus. Both the longer and shorter N-termini have predicted signal peptides according to SignalP 3.0. There is no experimental evidence showing which start codon is preferentially used in vivo. 5109164 58 The coding region has been updated to shorten the N-terminus to one that is more supported by the available protein and conservation data. 5109215 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in other vertebrates, including mouse, opossum, pig and zebrafish. An alternative downstream start codon, which has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 19 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5109220 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5109227 12 73 73 U 5109227 58 This CCDS ID represents a selenoprotein that is functionally sensitive to selenium levels (e.g., PMID:14642406). Position 73 of the protein is a selenocysteine residue, which is cotranslationally incorporated when a UGA codon, which is normally a stop codon, is recognized by a specific selenocysteyl-tRNA in conjunction with a stem-loop SECIS element in the 3' UTR. 5109310 58 This CCDS ID represents the BCAM transcript variant described in PMIDs 8781446 and 9192786. It encodes the C-terminally truncated 78 kDa isoform described in PMIDs 3810828 and 7777537. The transcript is a candidate for nonsense-mediated mRNA decay (NMD), but the protein is represented because this is the only currently available transcript variant that can encode the 78 kDa isoform. This isoform was detected by immunoblotting in PMID:3810828, and the authors of PMID:7777537 indicate that this isoform was not detected when C-terminal antibodies were used, but it was when antibodies from the region in common with the 85 kDa isoform (CCDS12644.1 representation) were used, thereby suggesting that this C-terminally truncated isoform is valid. 5109312 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5109321 58 The coding region was updated to make it identical to the current human reference genome sequence. 5109330 58 This CCDS representation lacks full-length transcript support that is specifically derived from the annotated location. The represented exon combination is inferred from a mixture of partial best hit transcript alignments and paralogous transcript alignments, e.g., from the related LILRA2 locus. 5109359 58 The coding region has been updated to represent an alternative splicing pattern, resulting in an extended protein N-terminus that is more supported by the available transcript and protein data. 5109387 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. 5109397 58 The coding region has been updated to remove a 3-nt insert (encoding Ser-310) that was present in the NCBI Build 36 reference genome assembly. This insert has been removed in the GRCh37 reference genome, and its absence is supported by transcript data. 5109403 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data that is specific for this location. It should be noted that two copies of this gene exist: RGPD1 (GeneID:400966), which is the more centromerically distal duplicate on the p arm of chromosome 2, and RGPD2 (this gene, GeneID:729857), which is more proximal to the centromere. 5109429 58 This CCDS representation uses the 5'-most in-frame start codon. While this start codon is well-conserved, it should be noted that other than human and chimp, all other species have indels that follow this start codon. Other primates and rodents have frameshifting indels, and thus cannot use this start codon. However, some mammalian species, including cow, pig and dog, contain additional compensating indels that bring them back in frame; these species could therefore use the start codon represented in this CCDS. An alternative downstream start codon, which is more widely conserved and has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 39 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5109465 58 This CCDS representation is based on U90273.1 and on full-length RT-PCR evidence from PMIDs 10831323 and 10556814. This variant also has homology support from cow AF539438.1, mouse U90270.1 and rat U90271.1. 5109475 58 The coding region was updated to make it identical to the current human reference genome sequence. 5109521 58 The coding region has been updated to represent an alternative splicing pattern that is better supported by the available full-length transcript data. 5109523 58 The coding region has been updated to shorten the N-terminus based on the use of a downstream in-frame start codon, which is supported by ribosome profiling and conservation data. 5109547 58 The coding region has been updated to correct an indel in the CDS, which results in a shorter protein C-terminus that is better supported by transcript and conservation data. 5109548 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5109592 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5109598 12 523 523 U 5109598 58 This CCDS ID represents the protein described in PMIDs: 9923614 and 10215850. This transcript is supported by AF106697.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 9923614. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5109610 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. 5109613 12 48 48 U 5109618 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data, and by conservation data in higher primate species. 5109620 58 This CCDS representation is supported by accession DQ778625.1. It includes an alternative splice acceptor for exon 10 compared to the variants represented by NM_014309.2 (CCDS13921.1) and NM_001082576.1 (CCDS46701.1). This is a non-canonical 'GG' splice acceptor site as compared to the 'AG' acceptor found in NM_014309.2 and NM_001082576.1, but the 'GG' splice acceptor is supported by 30 human transcripts and by transcripts in other species, including mouse (e.g., AK139555.1, AK077594.1, AK055213.1, AY659953.1, DQ017388.1 and several ESTs), rat (BC128766.1, BM388666.1), cow (BT026301.1 and several ESTs), pig (AK236515.1 and a few ESTs), sheep (EE755507.1, EE862219.1) and dog (CO666028.1, CO586266.1). 5128382 535 ENSP00000265773.5 5162759 535 ENSP00000286349.3 5150510 535 ENSP00000362181.5 5249968 535 ENSP00000273371.4 5193027 535 ENSP00000342215.3 5265792 535 ENSP00000350377.4 5204956 535 ENSP00000337180.5 5218259 535 ENSP00000368752.4 5214997 535 ENSP00000460172.2 5221314 535 ENSP00000359295.3 5239797 535 ENSP00000353343.1 5230608 535 ENSP00000288098.2 5250355 535 ENSP00000478691.2 5245726 535 ENSP00000300249.4 5208067 535 ENSP00000495563.1 5195179 535 ENSP00000215781.2 5160382 535 ENSP00000359434.3 5167266 535 ENSP00000342385.4 5209956 535 ENSP00000387297.1 5213036 535 ENSP00000265109.3 5177393 535 ENSP00000229758.3 5178714 535 ENSP00000290378.4 5167135 535 ENSP00000320247.5 5149514 535 ENSP00000298139.5 5236618 535 ENSP00000366378.2 5239142 535 ENSP00000468376.1 5129023 535 ENSP00000240306.3 5189877 535 ENSP00000262265.4 5210872 535 ENSP00000296543.4 5147056 535 ENSP00000273390.5 5188283 535 ENSP00000349732.3 5160235 535 ENSP00000516604.1 5149326 535 ENSP00000223641.4 5269107 535 ENSP00000368931.5 5192896 535 ENSP00000251642.3 5167814 535 ENSP00000358739.3 5243054 535 ENSP00000452007.1 5213891 535 ENSP00000507618.1 5251787 535 ENSP00000444642.2 5129444 535 ENSP00000320488.5 5229047 535 ENSP00000450544.1 5242164 535 ENSP00000288988.6 5171899 535 ENSP00000299767.4 5256504 535 ENSP00000320050.4 5212800 535 ENSP00000361527.1 5200923 535 ENSP00000261205.4 5178018 535 ENSP00000268489.5 5205438 535 ENSP00000342032.3 5168210 535 ENSP00000265310.1 5163706 535 ENSP00000267377.2 5191992 535 ENSP00000497510.1 5202884 535 ENSP00000344223.3 5141000 535 ENSP00000391774.2 5171928 535 ENSP00000462054.1 5252315 535 ENSP00000384387.2 5167966 535 ENSP00000438590.1 5244791 535 ENSP00000515970.1 5231017 535 ENSP00000406674.3 5202446 535 ENSP00000305918.6 5189359 535 ENSP00000436049.1 5162722 535 ENSP00000500082.3 5153226 535 ENSP00000360797.5 5223965 535 ENSP00000369927.3 5206356 535 ENSP00000277517.1 5141889 535 ENSP00000327386.6 5267482 535 ENSP00000308496.5 5267112 535 ENSP00000227868.4 5217835 535 ENSP00000384604.3 5232541 535 ENSP00000360398.3 5262911 535 ENSP00000483965.1 5213602 535 ENSP00000371923.3 5128690 535 ENSP00000357798.3 5269940 535 ENSP00000342026.5 5156970 535 ENSP00000417003.2 5176240 535 ENSP00000390126.2 5140523 535 ENSP00000335042.7 5153055 535 ENSP00000241416.7 5202468 535 ENSP00000302319.1 5171071 535 ENSP00000304903.3 5218665 535 ENSP00000426691.2 5240051 535 ENSP00000357754.3 5160681 535 ENSP00000330216.7 5259643 535 ENSP00000386143.4 5235777 535 ENSP00000415375.2 5208729 535 ENSP00000268459.3 5193971 535 ENSP00000261497.4 5225405 535 ENSP00000351740.2 5256562 535 ENSP00000295268.3 5192574 535 ENSP00000416968.2 5148668 535 ENSP00000362135.2 5162838 535 ENSP00000480186.2 5161406 535 ENSP00000242249.4 5136959 535 ENSP00000358563.5 5211906 535 ENSP00000305138.4 5203388 535 ENSP00000345468.5 5151016 535 ENSP00000360299.2 5197272 535 ENSP00000372335.4 5150497 535 ENSP00000486197.1 5210448 535 ENSP00000316909.4 5246892 535 ENSP00000274710.3 5199253 535 ENSP00000307449.4 5234831 535 ENSP00000462419.1 5245208 535 ENSP00000263666.4 5239529 535 ENSP00000453581.2 5247561 535 ENSP00000482431.2 5190491 535 ENSP00000307214.5 5143490 535 ENSP00000460475.1 5244344 535 ENSP00000302114.4 5239999 535 ENSP00000296682.4 5142874 535 ENSP00000386652.5 5206451 535 ENSP00000360961.4 5260825 535 ENSP00000376417.4 5208117 535 ENSP00000429993.2 5142862 535 ENSP00000295124.4 5227393 535 ENSP00000477486.1 5250622 535 ENSP00000260570.3 5144676 535 ENSP00000334983.5 5193436 535 ENSP00000339467.4 5257591 535 ENSP00000494141.2 5134484 535 ENSP00000342886.3 5252652 535 ENSP00000387393.3 5233883 535 ENSP00000258737.7 5211422 535 ENSP00000306010.6 5244663 535 ENSP00000373176.2 5209628 535 ENSP00000355780.3 5265011 535 ENSP00000361898.6 5256962 535 ENSP00000365838.1 5142223 535 ENSP00000384667.1 5167625 535 ENSP00000502607.1 5245150 535 ENSP00000240328.3 5225365 535 ENSP00000315931.3 5158573 535 ENSP00000335062.5 5145402 535 ENSP00000436541.2 5225754 535 ENSP00000265304.6 5201278 535 ENSP00000345347.5 5138704 535 ENSP00000296422.7 5168786 535 ENSP00000414376.2 5145221 535 ENSP00000334319.8 5256722 535 ENSP00000320378.7 5232096 535 ENSP00000272298.7 5127283 535 ENSP00000303424.2 5262885 535 ENSP00000322788.6 5237165 535 ENSP00000311505.6 5159579 535 ENSP00000292450.4 5259636 535 ENSP00000321070.5 5268528 535 ENSP00000216241.9 5137341 535 ENSP00000493283.1 5193188 535 ENSP00000199447.4 5176411 535 ENSP00000165524.1 5268781 535 ENSP00000340969.5 5138612 535 ENSP00000379372.2 5254078 535 ENSP00000370546.1 5260804 535 ENSP00000217652.3 5197958 535 ENSP00000308815.2 5227063 535 ENSP00000231751.4 5200912 535 ENSP00000290299.2 5151177 535 ENSP00000348936.4 5148079 535 ENSP00000498446.1 5197304 535 ENSP00000312735.5 5149092 535 ENSP00000429430.1 5127433 535 ENSP00000258229.8 5255847 535 ENSP00000264595.2 5159789 535 ENSP00000375148.1 5177831 535 ENSP00000381036.3 5161222 535 ENSP00000377250.4 5247278 535 ENSP00000434821.2 5222801 535 ENSP00000043402.7 5203316 535 ENSP00000498626.1 5204643 535 ENSP00000315212.8 5158357 535 ENSP00000492240.1 5128471 535 ENSP00000374274.4 5139118 535 ENSP00000343691.3 5221963 535 ENSP00000362330.3 5134834 535 ENSP00000369592.4 5240841 535 ENSP00000384909.1 5255843 535 ENSP00000301908.3 5189593 535 ENSP00000508967.1 5135286 535 ENSP00000365963.3 5230437 535 ENSP00000355893.4 5265003 535 ENSP00000305193.3 5160757 535 ENSP00000480960.2 5156962 535 ENSP00000357437.2 5197306 535 ENSP00000282869.5 5270766 535 ENSP00000378851.3 5170175 535 ENSP00000356094.4 5249744 535 ENSP00000303758.4 5234787 535 ENSP00000509633.1 5162750 535 ENSP00000252951.2 5135252 535 ENSP00000305702.5 5252798 535 ENSP00000341562.4 5253667 535 ENSP00000332340.6 5232603 535 ENSP00000343126.5 5247739 535 ENSP00000330945.6 5197045 535 ENSP00000302855.3 5261889 535 ENSP00000490174.1 5128673 535 ENSP00000361900.3 5215391 535 ENSP00000264126.3 5175452 535 ENSP00000485244.1 5256401 535 ENSP00000493007.1 5264803 535 ENSP00000419539.1 5194813 535 ENSP00000387047.1 5237592 535 ENSP00000286371.3 5136856 535 ENSP00000399970.2 5141730 535 ENSP00000327604.1 5203435 535 ENSP00000206423.3 5252371 535 ENSP00000389682.2 5143421 535 ENSP00000365569.3 5256727 535 ENSP00000011691.4 5262032 535 ENSP00000496900.1 5205272 535 ENSP00000359689.1 5201589 535 ENSP00000274217.3 5145323 535 ENSP00000424870.1 5192990 535 ENSP00000309899.10 5269202 535 ENSP00000358814.5 5136234 535 ENSP00000465614.2 5255026 535 ENSP00000489255.1 5170995 535 ENSP00000443216.1 5173011 535 ENSP00000386759.3 5240253 535 ENSP00000497294.2 5230889 535 ENSP00000429344.1 5263686 535 ENSP00000307275.3 5268674 535 ENSP00000414022.3 5221742 535 ENSP00000320431.2 5208526 535 ENSP00000259030.2 5170672 535 ENSP00000462265.1 5259919 535 ENSP00000217740.3 5179663 535 ENSP00000265403.7 5135874 535 ENSP00000377103.1 5265413 535 ENSP00000343873.4 5265744 535 ENSP00000474678.1 5197152 535 ENSP00000362208.5 5145000 535 ENSP00000490576.1 5265908 535 ENSP00000305221.6 5218185 535 ENSP00000220514.3 5131131 535 ENSP00000372005.2 5235695 535 ENSP00000368710.3 5230502 535 ENSP00000253270.7 5244448 535 ENSP00000450114.1 5174761 535 ENSP00000384008.3 5225476 535 ENSP00000445480.2 5127850 535 ENSP00000485141.1 5247715 535 ENSP00000363318.3 5196794 535 ENSP00000299320.4 5170930 535 ENSP00000329880.8 5204213 535 ENSP00000355518.4 5247204 535 ENSP00000405786.2 5259239 535 ENSP00000398789.2 5205528 535 ENSP00000368678.2 5264813 535 ENSP00000262241.5 5185526 535 ENSP00000318406.3 5199283 535 ENSP00000389168.2 5245950 535 ENSP00000360500.3 5149306 535 ENSP00000229266.3 5134053 535 ENSP00000503163.1 5193438 535 ENSP00000446955.2 5201689 535 ENSP00000358732.3 5142715 535 ENSP00000313384.2 5165109 535 ENSP00000271732.3 5182139 535 ENSP00000286744.5 5178156 535 ENSP00000387365.3 5243279 535 ENSP00000318066.3 5194188 535 ENSP00000330488.5 5145291 535 ENSP00000259845.4 5196209 535 ENSP00000294353.6 5207061 535 ENSP00000359643.3 5245135 535 ENSP00000231134.5 5259913 535 ENSP00000360730.3 5224360 535 ENSP00000443168.1 5183524 535 ENSP00000344741.4 5240450 535 ENSP00000321038.3 5176473 535 ENSP00000410608.1 5157611 535 ENSP00000238647.3 5230852 535 ENSP00000508142.1 5192926 535 ENSP00000304802.2 5226629 535 ENSP00000274773.7 5176302 535 ENSP00000297325.4 5190667 535 ENSP00000410910.2 5130240 535 ENSP00000361467.2 5195435 535 ENSP00000502065.1 5185448 535 ENSP00000381003.2 5230749 535 ENSP00000297873.4 5152774 535 ENSP00000360165.3 5159470 535 ENSP00000338769.3 5208580 535 ENSP00000354872.2 5197114 535 ENSP00000353600.8 5223123 535 ENSP00000261845.5 5191990 535 ENSP00000408295.2 5212768 535 ENSP00000483469.2 5171060 535 ENSP00000392617.2 5259122 535 ENSP00000364089.1 5247216 535 ENSP00000421172.1 5188488 535 ENSP00000355354.2 5224358 535 ENSP00000282282.3 5174523 535 ENSP00000378289.2 5150155 535 ENSP00000394842.2 5133950 535 ENSP00000375622.2 5231190 535 ENSP00000349961.3 5183138 535 ENSP00000351181.5 5197329 535 ENSP00000401947.1 5149736 535 ENSP00000302895.4 5244050 535 ENSP00000330746.2 5180857 535 ENSP00000332634.9 5150231 535 ENSP00000279804.2 5239823 535 ENSP00000371126.1 5243977 535 ENSP00000243056.3 5188294 535 ENSP00000448059.1 5141104 535 ENSP00000368874.3 5146464 535 ENSP00000371940.2 5228590 535 ENSP00000278865.3 5143714 535 ENSP00000255030.5 5259905 535 ENSP00000267163.4 5199816 535 ENSP00000296137.2 5207680 535 ENSP00000221138.4 5129364 535 ENSP00000374152.4 5160494 535 ENSP00000499172.1 5236029 535 ENSP00000333181.7 5257779 535 ENSP00000375855.2 5229540 535 ENSP00000349654.5 5245190 535 ENSP00000369218.4 5231028 535 ENSP00000256953.2 5218905 535 ENSP00000367446.3 5187332 535 ENSP00000354586.5 5258459 535 ENSP00000360166.3 5140875 535 ENSP00000255764.3 5265876 550 ENSP00000407821.2 5147951 535 ENSP00000299752.4 5208397 535 ENSP00000358794.4 5150291 535 ENSP00000311502.3 5139202 535 ENSP00000301057.7 5176192 535 ENSP00000255681.6 5157683 535 ENSP00000302961.2 5181690 535 ENSP00000264039.2 5154073 535 ENSP00000362900.4 5205505 535 ENSP00000415698.2 5243553 535 ENSP00000493435.1 5221272 535 ENSP00000296387.1 5249290 535 ENSP00000271532.1 5206238 535 ENSP00000325868.5 5184480 535 ENSP00000226460.4 5192047 535 ENSP00000274458.4 5173320 535 ENSP00000304435.8 5178048 535 ENSP00000386134.3 5270978 535 ENSP00000343521.1 5219139 535 ENSP00000296438.5 5256526 535 ENSP00000341957.7 5171133 535 ENSP00000328928.5 5246302 535 ENSP00000295588.4 5178158 535 ENSP00000363019.3 5263458 535 ENSP00000265997.4 5186279 535 ENSP00000364289.3 5174864 535 ENSP00000264235.9 5244230 535 ENSP00000374399.4 5155715 535 ENSP00000257215.5 5260127 535 ENSP00000486001.1 5190598 535 ENSP00000386439.3 5144029 535 ENSP00000410369.1 5156671 535 ENSP00000284957.4 5242917 535 ENSP00000378442.4 5208285 535 ENSP00000350836.2 5151531 535 ENSP00000294312.3 5165029 535 ENSP00000493548.1 5151873 535 ENSP00000217073.3 5209845 535 ENSP00000374273.3 5223512 535 ENSP00000244565.3 5221865 535 ENSP00000275233.7 5144486 535 ENSP00000369238.4 5165239 535 ENSP00000361650.3 5212915 535 ENSP00000395260.1 5163431 535 ENSP00000478104.1 5264689 535 ENSP00000357175.4 5236150 535 ENSP00000269945.2 5133105 535 ENSP00000496686.2 5172706 535 ENSP00000187910.3 5245974 535 ENSP00000354061.2 5136490 535 ENSP00000333896.4 5207835 535 ENSP00000283629.3 5271370 535 ENSP00000382783.1 5141613 535 ENSP00000376436.3 5198768 535 ENSP00000370697.4 5205138 535 ENSP00000341483.5 5155498 535 ENSP00000417617.2 5205820 535 ENSP00000484638.1 5239929 535 ENSP00000427900.1 5143817 535 ENSP00000271526.4 5163305 535 ENSP00000255324.5 5224823 535 ENSP00000295759.7 5197984 535 ENSP00000467843.1 5252531 535 ENSP00000424424.1 5176695 535 ENSP00000358238.1 5206669 535 ENSP00000312244.4 5227155 535 ENSP00000340998.4 5153587 535 ENSP00000419005.1 5181935 535 ENSP00000506280.1 5198631 535 ENSP00000300184.3 5254424 535 ENSP00000375150.1 5265489 535 ENSP00000490297.1 5232656 535 ENSP00000414887.2 5213185 535 ENSP00000256443.3 5175485 535 ENSP00000299886.4 5189044 535 ENSP00000362987.4 5237517 535 ENSP00000377631.2 5157910 535 ENSP00000419038.1 5246307 535 ENSP00000361710.5 5268165 535 ENSP00000296220.5 5232300 535 ENSP00000377319.3 5215347 535 ENSP00000483523.1 5202146 535 ENSP00000399078.4 5219897 535 ENSP00000372218.1 5193477 535 ENSP00000359804.2 5223228 535 ENSP00000500986.2 5185625 535 ENSP00000433295.1 5146458 535 ENSP00000265022.3 5206827 535 ENSP00000369636.5 5203630 535 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ENSP00000437629.1 5157805 535 ENSP00000402017.1 5171772 535 ENSP00000347927.2 5199465 535 ENSP00000326830.4 5206156 535 ENSP00000468612.1 5127165 535 ENSP00000378394.3 5201157 535 ENSP00000364336.4 5194602 535 ENSP00000309629.5 5143765 535 ENSP00000268389.4 5226262 535 ENSP00000429608.1 5152637 535 ENSP00000276420.4 5220781 535 ENSP00000455469.1 5181017 535 ENSP00000316628.3 5230087 535 ENSP00000366248.4 5140555 535 ENSP00000250617.6 5254785 535 ENSP00000467341.1 5177832 535 ENSP00000497532.1 5237018 535 ENSP00000302456.3 5209543 535 ENSP00000483185.1 5172864 535 ENSP00000267889.3 5253497 535 ENSP00000371364.3 5223360 535 ENSP00000338607.3 5245080 535 ENSP00000356989.3 5186557 535 ENSP00000452792.1 5159548 535 ENSP00000307540.2 5204164 535 ENSP00000451882.1 5205015 535 ENSP00000251170.6 5240624 535 ENSP00000417806.1 5231174 535 ENSP00000269439.6 5171454 535 ENSP00000456927.1 5129433 535 ENSP00000269385.4 5153051 535 ENSP00000381489.1 5205444 535 ENSP00000473474.2 5239238 535 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ENSP00000362588.5 5259718 535 ENSP00000299164.2 5190067 535 ENSP00000352248.3 5249627 535 ENSP00000219596.1 5146032 535 ENSP00000256178.3 5223193 535 ENSP00000307126.5 5133908 535 ENSP00000375872.4 5141190 535 ENSP00000408527.2 5168392 535 ENSP00000481581.1 5221881 535 ENSP00000344242.4 5157659 535 ENSP00000420927.1 5198711 535 ENSP00000380750.4 5184702 535 ENSP00000246069.6 5142268 535 ENSP00000315604.5 5186853 535 ENSP00000307078.4 5190970 535 ENSP00000518851.1 5152179 535 ENSP00000209728.4 5219939 535 ENSP00000269878.3 5238228 535 ENSP00000472024.2 5137208 535 ENSP00000293845.3 5227667 535 ENSP00000258654.8 5150512 535 ENSP00000452398.1 5214836 535 ENSP00000306356.4 5191021 535 ENSP00000440509.1 5187514 535 ENSP00000322524.4 5219119 535 ENSP00000315602.5 5251023 535 ENSP00000484710.1 5211414 535 ENSP00000304185.5 5188313 535 ENSP00000281441.3 5192324 535 ENSP00000336850.3 5259005 535 ENSP00000493053.1 5159033 535 ENSP00000304236.6 5161420 535 ENSP00000320672.3 5264441 535 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ENSP00000401751.3 5127216 535 ENSP00000299421.4 5256253 535 ENSP00000311196.2 5251594 535 ENSP00000376822.2 5207740 535 ENSP00000354859.3 5131501 535 ENSP00000362403.4 5250611 535 ENSP00000512260.1 5245641 535 ENSP00000238558.3 5170729 535 ENSP00000248901.6 5209579 535 ENSP00000506999.1 5132263 535 ENSP00000400514.2 5216112 535 ENSP00000382021.3 5267475 535 ENSP00000355163.5 5159880 535 ENSP00000396445.2 5230102 535 ENSP00000348657.3 5166430 535 ENSP00000252998.1 5150631 535 ENSP00000344430.4 5166778 535 ENSP00000222726.3 5181143 535 ENSP00000356370.3 5231756 535 ENSP00000340329.4 5238847 535 ENSP00000262316.5 5227646 535 ENSP00000379042.3 5227461 535 ENSP00000436785.1 5136232 535 ENSP00000338039.6 5190968 535 ENSP00000357086.3 5244026 535 ENSP00000376139.4 5270556 535 ENSP00000405562.2 5181050 535 ENSP00000318086.9 5136874 535 ENSP00000303325.2 5159486 535 ENSP00000264552.8 5266906 535 ENSP00000386730.3 5270192 535 ENSP00000362621.3 5262492 535 ENSP00000356599.3 5146300 535 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ENSP00000495254.2 5237997 535 ENSP00000255695.1 5201082 535 ENSP00000370737.4 5142446 535 ENSP00000357917.3 5136345 535 ENSP00000316518.3 5187076 535 ENSP00000463151.1 5192592 535 ENSP00000421863.1 5237043 535 ENSP00000266397.2 5269199 535 ENSP00000497775.2 5146493 535 ENSP00000343745.3 5231368 535 ENSP00000291744.6 5254419 535 ENSP00000403130.1 5158934 535 ENSP00000342711.4 5188668 535 ENSP00000409009.2 5171335 535 ENSP00000356792.3 5210538 535 ENSP00000410852.2 5138782 535 ENSP00000461862.1 5234392 535 ENSP00000313034.3 5235122 535 ENSP00000300105.6 5165095 535 ENSP00000356671.3 5268245 535 ENSP00000279907.7 5171163 535 ENSP00000259633.4 5259262 535 ENSP00000339913.6 5230042 535 ENSP00000263791.5 5255814 535 ENSP00000359333.4 5229469 535 ENSP00000305343.1 5177758 535 ENSP00000349392.3 5266820 535 ENSP00000359987.2 5159022 535 ENSP00000417078.1 5236819 535 ENSP00000364919.3 5230760 535 ENSP00000242152.2 5161279 535 ENSP00000428815.1 5235896 535 ENSP00000328061.3 5138170 535 ENSP00000476384.1 5229504 535 ENSP00000319897.5 5147127 535 ENSP00000302968.4 5185983 535 ENSP00000480221.1 5239044 535 ENSP00000336868.4 5193372 535 ENSP00000482704.1 5195544 535 ENSP00000437532.1 5151887 535 ENSP00000387124.1 5135573 535 ENSP00000371548.4 5265062 535 ENSP00000298299.3 5191902 535 ENSP00000262854.6 5160571 535 ENSP00000509124.1 5226004 535 ENSP00000445926.2 5227339 535 ENSP00000306099.4 5152998 535 ENSP00000309186.6 5143646 535 ENSP00000263733.4 5142503 535 ENSP00000295901.4 5138079 535 ENSP00000299642.5 5231824 535 ENSP00000471512.1 5141110 535 ENSP00000373474.3 5208050 535 ENSP00000394902.2 5195327 535 ENSP00000430767.1 5261622 535 ENSP00000305260.4 5262076 535 ENSP00000302194.5 5207576 535 ENSP00000492981.1 5225295 535 ENSP00000332404.4 5156287 535 ENSP00000278772.4 5258638 535 ENSP00000506930.1 5223408 535 ENSP00000325663.5 5260528 535 ENSP00000378576.2 5135956 535 ENSP00000263346.8 5255041 535 ENSP00000340656.5 5235898 535 ENSP00000377428.2 5183885 535 ENSP00000371553.1 5165308 535 ENSP00000257765.5 5250554 535 ENSP00000261304.2 5248749 535 ENSP00000520374.1 5220382 535 ENSP00000206380.3 5260146 535 ENSP00000409016.3 5208981 535 ENSP00000337289.2 5256361 535 ENSP00000259870.3 5256298 535 ENSP00000380794.1 5211717 535 ENSP00000334750.3 5173503 535 ENSP00000370262.3 5270356 535 ENSP00000283921.4 5223221 535 ENSP00000246186.6 5188423 535 ENSP00000410051.2 5158063 535 ENSP00000369146.3 5232861 535 ENSP00000354891.4 5178445 535 ENSP00000508889.1 5180180 535 ENSP00000363398.3 5262434 535 ENSP00000497641.1 5141900 535 ENSP00000276282.6 5217676 535 ENSP00000366402.3 5261287 535 ENSP00000398632.2 5167930 535 ENSP00000368265.3 5231495 535 ENSP00000190165.2 5220958 535 ENSP00000259727.4 5241882 535 ENSP00000326804.3 5207977 535 ENSP00000507575.1 5262219 535 ENSP00000432456.1 5217700 535 ENSP00000502390.1 5178510 535 ENSP00000317564.4 5168971 535 ENSP00000261296.5 5254001 535 ENSP00000274024.3 5215295 535 ENSP00000471754.1 5133431 535 ENSP00000356110.4 5210666 535 ENSP00000365227.3 5219646 535 ENSP00000341679.5 5208870 535 ENSP00000239461.6 5135761 535 ENSP00000362648.4 5142227 535 ENSP00000498019.1 5238152 535 ENSP00000494686.1 5183048 535 ENSP00000488305.1 5213521 535 ENSP00000254663.7 5190693 535 ENSP00000369461.3 5158629 535 ENSP00000256897.4 5128536 535 ENSP00000245919.3 5151653 535 ENSP00000339495.6 5270765 535 ENSP00000230381.5 5269667 535 ENSP00000413079.1 5127921 535 ENSP00000282728.5 5175202 535 ENSP00000304826.5 5127209 535 ENSP00000312070.3 5199661 535 ENSP00000296498.3 5139745 535 ENSP00000345580.5 5243902 535 ENSP00000389111.1 5154357 535 ENSP00000261438.5 5195006 535 ENSP00000316454.4 5131388 535 ENSP00000376609.2 5250723 535 ENSP00000258080.3 5187146 535 ENSP00000501180.2 5231446 535 ENSP00000433808.1 5242014 535 ENSP00000359160.2 5250930 535 ENSP00000401883.3 5242525 535 ENSP00000221455.3 5227134 535 ENSP00000432816.1 5158406 535 ENSP00000351530.4 5188023 535 ENSP00000380999.1 5129344 535 ENSP00000496089.1 5151743 535 ENSP00000324064.6 5219930 535 ENSP00000357706.2 5245220 535 ENSP00000225916.5 5241080 535 ENSP00000301258.4 5142353 535 ENSP00000374447.3 5255539 535 ENSP00000262077.3 5163051 535 ENSP00000478933.3 5171444 535 ENSP00000355922.3 5165202 535 ENSP00000343023.4 5261777 535 ENSP00000304127.1 5183608 535 ENSP00000265097.5 5188948 535 ENSP00000296564.7 5182795 535 ENSP00000334153.4 5270851 535 ENSP00000373752.4 5246240 535 ENSP00000286628.8 5145199 535 ENSP00000377522.2 5140019 535 ENSP00000357861.5 5147932 535 ENSP00000510611.1 5220719 535 ENSP00000299705.5 5265492 535 ENSP00000341094.2 5194943 535 ENSP00000355315.3 5201231 535 ENSP00000371877.1 5158576 535 ENSP00000233840.3 5142217 535 ENSP00000510345.1 5196874 535 ENSP00000390722.2 5233335 535 ENSP00000338290.5 5153702 535 ENSP00000251127.6 5236667 535 ENSP00000366331.3 5157366 535 ENSP00000377721.3 5201649 535 ENSP00000362014.4 5179980 535 ENSP00000331127.4 5221319 535 ENSP00000288912.4 5243878 535 ENSP00000409542.2 5179032 535 ENSP00000269919.3 5231149 535 ENSP00000506273.1 5196471 535 ENSP00000261839.7 5134929 535 ENSP00000383866.4 5207171 535 ENSP00000307958.5 5234728 535 ENSP00000380888.2 5270503 535 ENSP00000389380.1 5178805 535 ENSP00000366876.4 5158173 535 ENSP00000364805.4 5160109 535 ENSP00000491320.1 5262848 535 ENSP00000221543.4 5182569 535 ENSP00000478671.2 5144053 535 ENSP00000265131.4 5160820 535 ENSP00000219069.5 5165768 535 ENSP00000419712.2 5209259 535 ENSP00000319788.5 5220634 535 ENSP00000364687.4 5228674 535 ENSP00000336988.7 5196948 535 ENSP00000368808.3 5134420 535 ENSP00000488951.1 5146025 535 ENSP00000496779.1 5213945 535 ENSP00000513632.1 5223199 535 ENSP00000477437.1 5245301 535 ENSP00000319511.3 5233946 535 ENSP00000451229.2 5183870 535 ENSP00000493250.1 5261628 535 ENSP00000265316.3 5237771 535 ENSP00000501355.1 5197990 535 ENSP00000368759.5 5254286 535 ENSP00000296978.3 5263100 535 ENSP00000260324.7 5260627 535 ENSP00000493527.1 5154947 535 ENSP00000248643.3 5208188 535 ENSP00000229214.4 5196686 535 ENSP00000493871.2 5184466 535 ENSP00000341843.4 5203317 535 ENSP00000447433.1 5197107 535 ENSP00000402653.3 5163073 535 ENSP00000340609.5 5149037 535 ENSP00000372319.3 5255029 535 ENSP00000259455.2 5201430 535 ENSP00000365437.3 5182085 535 ENSP00000227618.4 5181368 535 ENSP00000492936.1 5195621 535 ENSP00000493410.1 5154355 535 ENSP00000403804.2 5199313 535 ENSP00000318351.5 5222104 535 ENSP00000364150.3 5164505 535 ENSP00000386069.2 5210848 535 ENSP00000493578.1 5201972 535 ENSP00000259526.3 5269248 535 ENSP00000315791.4 5195086 535 ENSP00000507475.1 5258957 535 ENSP00000258886.8 5161230 535 ENSP00000369682.3 5244546 535 ENSP00000361867.3 5234564 535 ENSP00000386444.1 5202476 535 ENSP00000261556.6 5230442 535 ENSP00000384700.2 5250437 535 ENSP00000481956.1 5158575 535 ENSP00000374309.3 5262311 535 ENSP00000491574.1 5150698 535 ENSP00000349365.1 5249125 535 ENSP00000384597.3 5188664 535 ENSP00000355319.2 5224496 535 ENSP00000308583.2 5249831 535 ENSP00000483467.1 5141223 535 ENSP00000318878.3 5233616 535 ENSP00000445595.1 5207088 535 ENSP00000339155.4 5223990 535 ENSP00000479850.1 5209800 535 ENSP00000296582.3 5244964 535 ENSP00000251607.6 5145257 535 ENSP00000474071.1 5189607 535 ENSP00000318472.8 5184895 535 ENSP00000359531.5 5190695 535 ENSP00000362507.3 5249135 535 ENSP00000427336.3 5178234 535 ENSP00000272519.4 5256357 535 ENSP00000349929.3 5215681 535 ENSP00000435150.2 5251081 535 ENSP00000325748.4 5170119 535 ENSP00000356385.4 5233763 535 ENSP00000383223.1 5148663 535 ENSP00000261789.4 5265312 535 ENSP00000306627.5 5186178 535 ENSP00000304710.5 5138169 535 ENSP00000262719.4 5242350 535 ENSP00000371535.2 5131128 535 ENSP00000292475.4 5213413 535 ENSP00000322238.4 5189584 535 ENSP00000261658.2 5158795 535 ENSP00000376299.4 5205764 535 ENSP00000258607.5 5227504 535 ENSP00000508349.1 5159587 535 ENSP00000477907.2 5262664 535 ENSP00000403683.2 5219181 535 ENSP00000343140.3 5171766 535 ENSP00000259396.8 5133938 535 ENSP00000362968.5 5153501 535 ENSP00000223215.4 5178946 535 ENSP00000490638.1 5191622 535 ENSP00000492284.1 5205225 535 ENSP00000368538.3 5270958 535 ENSP00000512407.1 5151468 535 ENSP00000382646.2 5185406 535 ENSP00000403783.1 5150167 535 ENSP00000360117.5 5129411 535 ENSP00000221930.4 5131702 535 ENSP00000473553.1 5250403 535 ENSP00000384330.2 5143657 535 ENSP00000309285.4 5238154 535 ENSP00000258399.3 5268686 535 ENSP00000282587.5 5222459 535 ENSP00000507100.1 5171903 535 ENSP00000394080.2 5191511 535 ENSP00000307321.4 5126789 535 ENSP00000304987.2 5142920 535 ENSP00000347872.2 5233418 535 ENSP00000318113.5 5135289 535 ENSP00000329967.5 5161864 535 ENSP00000507827.1 5207034 535 ENSP00000345229.4 5135664 535 ENSP00000380872.2 5117767 58 This CCDS representation lacks full-length human transcript support. Its exon combination is therefore inferred, but it is supported by the full-length orthologous transcript in mouse (AF222444.1). 5115286 58 This CCDS, which is supported by the mRNA AF430806.1, represents a VEGFA isoform derived from an AUG start codon. Alternative translation initiation from multiple upstream non-AUG(CUG) codons is also possible for this gene, as indicated in PMIDs:11352659, 11563986 and 11731620. The longest isoform encoded by this variant, which is derived from the 5'-most CUG start codon, is represented by CCDS 47432.1. 5115287 58 This CCDS, which is supported by the mRNA BC065522.1, represents a VEGFA isoform derived from an AUG start codon. Alternative translation initiation from multiple upstream non-AUG(CUG) codons is also possible for this gene, as indicated in PMIDs:11352659, 11563986 and 11731620. The longest isoform encoded by this variant, which is derived from the 5'-most CUG start codon, is represented by CCDS 47434.1. 5115288 58 This CCDS, which is supported by the mRNA DQ229900.1, represents a VEGFA isoform derived from an AUG start codon. Alternative translation initiation from multiple upstream non-AUG(CUG) codons is also possible for this gene, as indicated in PMIDs:11352659, 11563986 and 11731620. The longest isoform encoded by this variant, which is derived from the 5'-most CUG start codon, is represented by CCDS 55007.1. 5115383 58 The coding region has been updated to start at a downstream in-frame start codon that is more supported by conservation data 5117782 58 This CCDS ID represents the protein described in PMIDs: 12364586 and 14966479. This transcript is supported by AY170469.2. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 18544534. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5117770 58 This CCDS representation lacks full-length human transcript support. Its exon combination is therefore inferred, but it is supported by the full-length orthologous mouse transcript U96411.1, by partial human transcript alignments, and by data in PMID:23122587. 5114893 58 The coding region has been updated to shorten the N-terminus, using a downstream start codon that is better supported by available conservation data and peptide data. 5114907 12 49 49 U 5114921 12 92 92 U 5114950 144 1 1 M 5114988 58 The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data. 5115022 144 1 1 M 5115048 144 1 1 M 5115049 144 1 1 M 5115050 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. 5115099 58 The coding region was updated to make it identical to the current human reference genome sequence. 5115280 58 This CCDS representation starts at an upstream non-AUG (CUG) translation start codon that is supported by conservation data and experimental evidence, including that in PMIDs:11352659, 11563986 and 11731620. Most of the publicly available long mRNAs at this locus do not extend far enough 5' to include the CUG start codon, including DQ229900.1 which supports this variant. However, BC058855.1, several unspliced partial transcripts and the aforementioned publications all support transcription initiation further upstream. Hence, this CCDS representation includes the extended 5' CDS. Alternative translation initiation from a downstream AUG codon (Met-181), which results in a shorter isoform with a predicted signal peptide, has also been shown for this gene. The shorter isoform encoded by this variant is represented by CCDS 55015.1. 5115280 144 1 1 M 5115281 58 This CCDS, which is supported by the mRNA AJ010438.1, represents a VEGFA isoform derived from an AUG start codon. Alternative translation initiation from multiple upstream non-AUG(CUG) codons is also possible for this gene, as indicated in PMIDs:11352659, 11563986 and 11731620. The longest isoform encoded by this variant, which is derived from the 5'-most CUG start codon, is represented by CCDS 47433.1. 5092117 58 The coding region has been updated to extend the N-terminus to one that is more supported by available transcript and conservation data. 5092124 58 The coding region has been updated to represent an alternative splicing pattern, resulting in an extended N-terminus that is more supported by the available transcript data. 5092157 58 The coding region has been updated to extend the C-terminus based on the functional allele represented in the GRCh38 reference genome assembly, supported by publications (e.g., PMIDs 9804831, 11042094) and orthologous data. 5092184 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript data. The update also extends the protein N-terminus. 5092254 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5092255 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and conservation data. 5092265 58 This CCDS ID represents the protein described in PMID: 19203586 and is supported by BC014390.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in PMID: 19203586. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. 5092267 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5092276 58 The coding region has been updated to represent an alternative 5' splicing pattern, resulting in an alternative N-terminus that is more supported by the available transcript data, and by conservation in other primates. 5092295 58 The coding region has been updated to represent an alternative 3' splice pattern, resulting in a distinct C-terminus that is better supported by available transcript and homology data. 5092306 58 The coding region has been scaled back at the 5' end to begin from a start codon that is better supported by conservation data. 5092307 58 This CCDS representation uses the 5'-most in-frame start codon found in the transcript. It should be noted that this start codon has a weak Kozak signal, and its conservation is restricted to primate species, squirrel, rock hyrax and armadillo. Two better conserved potential start codons with stronger Kozak signals are located two and five codons downstream, respectively. It is possible that leaky scanning by ribosomes would allow one of the downstream start codons to be used some of the time. There is no experimental evidence indicating which start codon is preferentially used in vivo. 5092338 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5092385 58 This CCDS ID represents the short isoform encoded by this gene. It is also known as 53BP2S, and is described in PMIDs 8668206 and 14766226. This isoform is shorter at the N-terminus compared to the full-length isoform, also known as 53BP2L and represented by CCDS44319.1. The presence of an upstream in-frame start codon, use of which would extend the short isoform N-terminus by 62 aa, should be noted. This has a weak Kozak signal compared to a strong Kozak signal for the represented downstream start codon; the use of the downstream start codon is also supported by in vitro translation experiments in PMID:8668206. 5092455 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates. An alternative downstream start codon, which is more widely conserved, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 1 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5092456 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in higher primates. An alternative downstream start codon, which is more widely conserved, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 1 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5092464 58 The coding region has been updated to represent an alternate splice pattern that is more supported by the available transcript and protein data. 5092471 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available human transcript data and by sequence conservation. 5092473 58 This CCDS representation uses the 5'-most in-frame start codon, which is conserved in primates, rat, kangaroo rat, dolphin, cow, cat, elephant, tenrec and armadillo. An alternative downstream start codon, which is more widely conserved and has a stronger Kozak signal, also exists. It is possible that leaky scanning by ribosomes would allow the downstream start codon to be used, at least some of the time. The use of the downstream start codon would result in a protein that is 2 aa shorter at the N-terminus. There is no experimental evidence showing which start codon is preferentially used in vivo. 5117753 58 This CCDS represents an inferred full-length model of the OBSCN gene. The exons included in this inferred variant are supported by a combination of available cDNA data and sequence analysis of repetitive exons. 5117749 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by the full-length paralogous transcript AB084917.1. 5117572 58 The coding region has been updated to represent an alternative protein C-terminus as encoded by the GRCh38 reference genome assembly, and supported by the available transcript and conservation data. 5117560 58 The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript and primate conservation data. 5115356 58 The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data. 5115439 58 The exon combination of this CCDS representation is inferred based on partial transcript alignments, RNA-seq data and orthologous transcript support from mouse and rat. 5115496 58 The coding region was updated to include a 6-nt insertion found in the GRCh38 reference genome assembly and in aligning transcripts, resulting in two extra amino acids in the protein C-terminus. 5117786 58 The exon combination of this CCDS representation is inferred based on highly similar paralogous transcript alignments, e.g., AY465170.1 or BC101005.1. 5117787 58 The exon combination of this CCDS representation is inferred based on highly similar paralogous transcript alignments, e.g., AY465170.1 or BC101005.1. 5117789 58 This gene represents one of several golgin A8 family genes. This family member lacks full-length transcript support, and thus the exon combination of this CCDS representation is inferred. It is supported by a combination of tiled partial transcript alignments that are specifically derived from this gene, e.g., DB068178.1 and BQ477899.1, and by transcript alignments from other family members. 5117796 58 This gene is one of several nuclear pore complex interacting protein (NPIP) gene copies that are present on chromosome 16. There are no full-length transcripts derived from this gene copy in support of this CCDS representation, and thus its exon combination is inferred based on paralogous transcript alignments, e.g., the mRNA AF132984.1. 5117388 58 The 5'-most in-frame start codon is annotated for this transcript variant, which is supported by mRNA AK126875.1. It is present in a novel exon not found in other transcript variants for this gene. The annotated start codon is restricted to select higher primate species, including human, chimp, gorilla, orangutan and gibbon. It has a weak Kozak sequence and may sometimes be bypassed due to leaky scanning by ribosomes, which could result in use of a better conserved downstream start codon. There is no experimental evidence to indicate which start codon is preferentially used by this variant in vivo. 5115285 58 This CCDS, which is supported by the mRNA BC058855.1, represents a VEGFA isoform derived from an AUG start codon. Alternative translation initiation from multiple upstream non-AUG(CUG) codons is also possible for this gene, as indicated in PMIDs:11352659, 11563986 and 11731620. The longest isoform encoded by this variant, which is derived from the 5'-most CUG start codon, is represented by CCDS 34458.1. 5126702 535 ENSP00000243563.2 5178598 535 ENSP00000364721.5 5244049 535 ENSP00000355609.2 5256109 535 ENSP00000265395.2 5167788 535 ENSP00000483375.1 5203147 535 ENSP00000390500.2 5237853 535 ENSP00000235090.5 5167728 535 ENSP00000361052.3 5143814 535 ENSP00000403104.2 5228947 535 ENSP00000328511.6 5266605 535 ENSP00000284856.3 5202923 535 ENSP00000379271.2 5170337 535 ENSP00000455274.1 5268231 535 ENSP00000387266.3 5259038 535 ENSP00000489814.2 5200877 535 ENSP00000296877.2 5266225 535 ENSP00000338788.6 5169091 535 ENSP00000358095.3 5266508 535 ENSP00000419126.1 5207043 535 ENSP00000270221.5 5163555 535 ENSP00000283752.5 5259916 535 ENSP00000245304.3 5171534 535 ENSP00000260605.8 5188724 535 ENSP00000316589.3 5221594 535 ENSP00000307023.1 5195526 535 ENSP00000299192.7 5237092 535 ENSP00000462996.1 5160312 535 ENSP00000200453.4 5242248 535 ENSP00000413251.3 5231086 535 ENSP00000394888.3 5269879 535 ENSP00000260743.5 5191132 535 ENSP00000418668.1 5228356 535 ENSP00000380234.3 5177644 535 ENSP00000215631.3 5230037 535 ENSP00000370419.3 5178128 535 ENSP00000454014.2 5194396 535 ENSP00000493218.2 5151701 535 ENSP00000233057.4 5196172 535 ENSP00000362792.3 5245871 535 ENSP00000413625.1 5221091 535 ENSP00000372720.3 5244020 535 ENSP00000343900.4 5141678 535 ENSP00000239243.5 5161679 535 ENSP00000347933.3 5174946 535 ENSP00000052754.5 5151127 535 ENSP00000333956.4 5248424 535 ENSP00000265361.3 5194766 535 ENSP00000013070.6 5216319 535 ENSP00000462099.1 5126753 535 ENSP00000484196.2 5204356 535 ENSP00000382880.3 5176018 535 ENSP00000374071.3 5219067 535 ENSP00000493106.1 5248494 535 ENSP00000365395.1 5218173 535 ENSP00000223368.2 5244881 535 ENSP00000354774.3 5264108 535 ENSP00000510041.1 5232254 535 ENSP00000240851.4 5217732 535 ENSP00000391358.1 5165348 535 ENSP00000494550.1 5265852 535 ENSP00000507762.1 5170994 535 ENSP00000477871.1 5259767 535 ENSP00000303533.7 5167950 535 ENSP00000417002.3 5213030 535 ENSP00000216487.7 5150381 535 ENSP00000363452.4 5147626 535 ENSP00000270014.1 5239319 535 ENSP00000080059.7 5162304 535 ENSP00000478941.1 5244608 535 ENSP00000302867.2 5239305 535 ENSP00000238256.3 5187092 535 ENSP00000277540.2 5267381 535 ENSP00000520460.1 5243649 535 ENSP00000297156.2 5142530 535 ENSP00000386385.3 5142543 535 ENSP00000295213.4 5260742 535 ENSP00000490760.1 5180337 535 ENSP00000341412.2 5267875 535 ENSP00000264161.4 5164175 535 ENSP00000476510.1 5242119 535 ENSP00000252542.3 5234344 535 ENSP00000304290.2 5205729 535 ENSP00000357980.3 5135154 535 ENSP00000357733.3 5190179 535 ENSP00000263174.4 5206472 535 ENSP00000377686.2 5216669 535 ENSP00000359305.3 5230927 535 ENSP00000304102.3 5157528 535 ENSP00000344831.5 5168548 535 ENSP00000357008.3 5154312 535 ENSP00000346634.5 5232706 535 ENSP00000263266.2 5204338 535 ENSP00000284061.3 5176752 535 ENSP00000368173.4 5244732 535 ENSP00000335357.6 5148633 535 ENSP00000332194.3 5157549 535 ENSP00000278460.8 5223941 535 ENSP00000480129.1 5220444 535 ENSP00000365606.5 5171977 535 ENSP00000328181.4 5271001 535 ENSP00000257567.2 5252240 535 ENSP00000495424.1 5240895 535 ENSP00000380271.3 5138133 535 ENSP00000468934.1 5154510 535 ENSP00000511932.1 5159892 535 ENSP00000290291.6 5255357 535 ENSP00000304604.9 5221116 535 ENSP00000345339.6 5145294 535 ENSP00000385790.4 5200657 535 ENSP00000375904.2 5208789 535 ENSP00000485259.2 5207965 535 ENSP00000274140.4 5188298 535 ENSP00000222644.4 5200902 535 ENSP00000316674.3 5138294 535 ENSP00000381823.2 5174033 535 ENSP00000027335.3 5201435 535 ENSP00000270747.3 5266174 535 ENSP00000370936.3 5139862 535 ENSP00000248076.2 5248912 535 ENSP00000361761.3 5133340 535 ENSP00000366988.3 5141059 535 ENSP00000336756.6 5195522 535 ENSP00000296870.2 5264322 535 ENSP00000356990.4 5154855 535 ENSP00000332549.3 5254850 535 ENSP00000340281.6 5210230 535 ENSP00000370770.3 5203156 535 ENSP00000262352.3 5218788 535 ENSP00000304941.5 5266231 535 ENSP00000285381.2 5231945 535 ENSP00000363746.4 5128362 535 ENSP00000312143.9 5202788 535 ENSP00000322159.4 5253554 535 ENSP00000491894.1 5182979 535 ENSP00000329584.2 5194408 535 ENSP00000388825.2 5182146 535 ENSP00000328236.6 5187409 535 ENSP00000473853.1 5191883 535 ENSP00000446152.3 5128186 535 ENSP00000260682.6 5270561 535 ENSP00000255266.5 5241865 535 ENSP00000502585.1 5163537 535 ENSP00000284951.5 5201799 535 ENSP00000350386.2 5206090 535 ENSP00000307954.2 5192260 535 ENSP00000365693.3 5227185 535 ENSP00000239906.5 5155154 535 ENSP00000342448.1 5199762 535 ENSP00000257572.4 5243750 535 ENSP00000383219.1 5265901 535 ENSP00000359534.2 5136779 535 ENSP00000295824.9 5243198 535 ENSP00000399465.1 5175634 535 ENSP00000355385.4 5239190 535 ENSP00000334052.4 5208280 535 ENSP00000417402.1 5214285 535 ENSP00000357792.3 5193893 535 ENSP00000215574.2 5224038 535 ENSP00000363228.3 5241364 535 ENSP00000333938.7 5134918 535 ENSP00000506377.1 5202928 535 ENSP00000260953.5 5196379 535 ENSP00000199389.6 5220176 535 ENSP00000262209.4 5165045 535 ENSP00000326060.6 5226120 535 ENSP00000231887.3 5166035 535 ENSP00000384651.3 5137945 535 ENSP00000299163.4 5227190 535 ENSP00000246792.2 5193257 535 ENSP00000484181.1 5172197 535 ENSP00000328977.7 5197961 535 ENSP00000263212.5 5183928 535 ENSP00000264051.3 5159496 535 ENSP00000262043.4 5211472 535 ENSP00000361993.3 5136873 535 ENSP00000255381.2 5236457 535 ENSP00000312059.7 5177910 535 ENSP00000269216.3 5205921 535 ENSP00000495760.1 5154549 535 ENSP00000306275.3 5250424 535 ENSP00000235349.5 5262384 535 ENSP00000315351.4 5131980 535 ENSP00000406197.2 5184113 535 ENSP00000480386.1 5167182 535 ENSP00000289788.4 5152264 535 ENSP00000264554.4 5253409 535 ENSP00000418719.1 5250093 535 ENSP00000229595.5 5217686 535 ENSP00000298171.2 5223318 535 ENSP00000338004.3 5251174 535 ENSP00000265148.3 5226437 535 ENSP00000353013.2 5191969 535 ENSP00000236979.2 5173206 535 ENSP00000210187.6 5204532 535 ENSP00000457076.1 5208599 535 ENSP00000343690.5 5165515 535 ENSP00000376708.3 5172397 535 ENSP00000348449.3 5183810 535 ENSP00000216797.6 5215818 535 ENSP00000217423.3 5266716 535 ENSP00000358880.4 5259733 535 ENSP00000273064.6 5263075 535 ENSP00000348496.3 5224136 535 ENSP00000288078.6 5184945 535 ENSP00000318196.6 5131932 535 ENSP00000369176.3 5129114 535 ENSP00000380679.4 5173481 535 ENSP00000242059.5 5210600 535 ENSP00000325690.4 5265044 535 ENSP00000467661.1 5181652 535 ENSP00000296003.5 5162383 535 ENSP00000366586.2 5259563 535 ENSP00000457731.2 5200961 535 ENSP00000386375.1 5249041 535 ENSP00000264553.1 5243978 535 ENSP00000396520.2 5248380 535 ENSP00000263119.5 5140451 535 ENSP00000379658.3 5259079 535 ENSP00000348108.5 5260200 535 ENSP00000362401.3 5258524 535 ENSP00000389787.2 5212267 535 ENSP00000384432.3 5235708 535 ENSP00000479130.1 5239959 535 ENSP00000362081.1 5231769 535 ENSP00000233552.6 5203745 535 ENSP00000363836.4 5242416 535 ENSP00000436812.1 5135311 535 ENSP00000489869.1 5221792 535 ENSP00000403885.2 5159162 535 ENSP00000423972.1 5244280 535 ENSP00000370849.3 5197468 535 ENSP00000306449.2 5178161 535 ENSP00000320563.5 5186716 535 ENSP00000375237.2 5167155 535 ENSP00000382474.5 5212871 535 ENSP00000290130.3 5189549 535 ENSP00000498999.1 5269211 535 ENSP00000400247.2 5227030 535 ENSP00000504292.1 5175546 535 ENSP00000267484.5 5133941 535 ENSP00000302199.2 5269848 535 ENSP00000373575.3 5138505 535 ENSP00000361668.4 5131132 535 ENSP00000514265.1 5171900 535 ENSP00000344504.2 5169131 535 ENSP00000363516.3 5217249 535 ENSP00000493109.1 5179259 535 ENSP00000261674.4 5189648 535 ENSP00000468688.2 5264469 550 ENSP00000366546.4 5215682 535 ENSP00000342082.2 5169019 535 ENSP00000298556.7 5223861 535 ENSP00000354294.4 5135889 535 ENSP00000406970.2 5241005 535 ENSP00000365103.3 5139754 535 ENSP00000217939.5 5220093 535 ENSP00000272371.2 5147418 535 ENSP00000168712.1 5178637 535 ENSP00000473153.1 5239158 535 ENSP00000364976.3 5186659 535 ENSP00000392996.2 5259263 535 ENSP00000518850.1 5201561 535 ENSP00000268910.8 5160115 535 ENSP00000472469.1 5181740 535 ENSP00000264344.5 5186808 535 ENSP00000394071.2 5165098 535 ENSP00000411070.2 5236205 535 ENSP00000451261.1 5133433 535 ENSP00000430073.1 5193584 535 ENSP00000350881.4 5156075 535 ENSP00000356885.6 5208372 535 ENSP00000384371.2 5262125 535 ENSP00000485387.2 5244540 535 ENSP00000363298.4 5139859 535 ENSP00000384725.3 5249058 535 ENSP00000496954.1 5187861 535 ENSP00000279101.5 5178814 535 ENSP00000310117.3 5266226 535 ENSP00000349658.4 5154144 535 ENSP00000284767.8 5157441 535 ENSP00000380840.3 5251560 535 ENSP00000332407.4 5139899 535 ENSP00000285879.4 5174354 535 ENSP00000303248.5 5135440 535 ENSP00000369293.3 5231508 535 ENSP00000292432.5 5157682 535 ENSP00000216115.2 5219452 535 ENSP00000268766.6 5184590 535 ENSP00000253925.7 5208916 535 ENSP00000302657.3 5141757 535 ENSP00000440365.2 5224582 535 ENSP00000468977.1 5199731 535 ENSP00000222271.2 5185619 535 ENSP00000355621.4 5163355 535 ENSP00000370420.1 5171575 535 ENSP00000511643.1 5151197 535 ENSP00000376623.2 5183765 535 ENSP00000430276.1 5222255 535 ENSP00000330737.2 5271217 535 ENSP00000294954.6 5148514 535 ENSP00000385597.2 5186399 535 ENSP00000274787.2 5221016 535 ENSP00000220809.4 5206596 535 ENSP00000406598.1 5154603 535 ENSP00000476746.1 5268051 535 ENSP00000419628.1 5257089 535 ENSP00000308759.5 5154172 535 ENSP00000356853.4 5128247 535 ENSP00000502837.1 5236543 535 ENSP00000299155.6 5185741 535 ENSP00000381968.2 5193435 535 ENSP00000300146.9 5143649 535 ENSP00000399324.2 5245646 535 ENSP00000225538.3 5187748 535 ENSP00000508500.1 5193976 535 ENSP00000253109.3 5157601 535 ENSP00000263408.4 5267546 535 ENSP00000255304.4 5193324 535 ENSP00000220616.4 5202047 535 ENSP00000502818.1 5192316 535 ENSP00000359507.5 5133740 535 ENSP00000305675.4 5187330 535 ENSP00000175238.5 5221787 535 ENSP00000341564.4 5257987 535 ENSP00000262613.5 5192892 535 ENSP00000370817.4 5168286 535 ENSP00000359474.3 5224173 535 ENSP00000347847.5 5230984 535 ENSP00000407287.2 5198777 535 ENSP00000368523.2 5250308 535 ENSP00000463471.1 5195485 535 ENSP00000374387.4 5246595 535 ENSP00000277309.2 5183968 535 ENSP00000311134.7 5257467 535 ENSP00000246868.2 5191800 535 ENSP00000278671.5 5209817 535 ENSP00000344468.6 5262493 535 ENSP00000312770.5 5248355 535 ENSP00000496832.1 5148971 535 ENSP00000392335.2 5231078 535 ENSP00000266646.2 5249318 535 ENSP00000508772.1 5165310 535 ENSP00000302579.5 5220524 535 ENSP00000379696.2 5169314 535 ENSP00000381468.4 5142437 535 ENSP00000281282.5 5223189 535 ENSP00000400088.1 5190191 535 ENSP00000269967.2 5259644 535 ENSP00000276590.4 5263258 535 ENSP00000357863.4 5237722 535 ENSP00000319308.5 5205282 535 ENSP00000363779.5 5152849 535 ENSP00000344648.2 5177378 535 ENSP00000351329.4 5192554 535 ENSP00000295709.3 5130343 535 ENSP00000394472.1 5157603 535 ENSP00000266682.5 5193755 535 ENSP00000357596.3 5178415 535 ENSP00000257894.2 5232512 535 ENSP00000252677.3 5205465 535 ENSP00000371393.4 5239754 535 ENSP00000430000.2 5268567 535 ENSP00000287020.4 5165465 535 ENSP00000518235.1 5252402 535 ENSP00000230671.2 5201175 535 ENSP00000308354.5 5172576 535 ENSP00000300773.2 5230297 535 ENSP00000433138.1 5137699 535 ENSP00000456974.3 5128854 535 ENSP00000040738.5 5164635 535 ENSP00000364737.3 5157374 535 ENSP00000357594.1 5262495 535 ENSP00000482241.1 5177620 535 ENSP00000493143.1 5146149 535 ENSP00000413728.2 5228129 535 ENSP00000299162.5 5227728 535 ENSP00000378152.6 5177665 535 ENSP00000417659.1 5160423 535 ENSP00000419542.2 5151956 535 ENSP00000370800.2 5205759 535 ENSP00000303088.4 5266772 535 ENSP00000387641.2 5211738 535 ENSP00000410216.2 5162360 535 ENSP00000291560.2 5170205 535 ENSP00000354911.2 5170189 535 ENSP00000508487.1 5143539 535 ENSP00000483300.1 5178189 535 ENSP00000280346.7 5204972 535 ENSP00000360058.2 5177438 535 ENSP00000263269.2 5144600 535 ENSP00000397818.2 5267617 535 ENSP00000378071.2 5269640 535 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ENSP00000478473.1 5177517 535 ENSP00000472421.2 5186209 535 ENSP00000341787.6 5173598 535 ENSP00000364163.3 5175299 535 ENSP00000371475.5 5266946 535 ENSP00000331636.3 5132372 535 ENSP00000362803.5 5151937 535 ENSP00000385433.4 5203505 535 ENSP00000368766.4 5139477 535 ENSP00000371169.4 5229156 535 ENSP00000287461.3 5219512 535 ENSP00000353804.2 5213696 535 ENSP00000264867.2 5231652 535 ENSP00000029410.5 5208983 535 ENSP00000328992.4 5265188 535 ENSP00000346103.7 5246742 535 ENSP00000265016.4 5219844 550 ENSP00000495368.1 5130087 535 ENSP00000499063.2 5271270 535 ENSP00000265983.3 5170605 535 ENSP00000350686.5 5187682 535 ENSP00000206020.3 5173053 535 ENSP00000251547.5 5224691 535 ENSP00000507236.1 5249303 535 ENSP00000387095.2 5186672 535 ENSP00000367440.4 5227476 535 ENSP00000352003.2 5244360 535 ENSP00000281471.6 5165470 535 ENSP00000280665.6 5126565 535 ENSP00000483631.1 5210615 535 ENSP00000311313.2 5197754 535 ENSP00000289119.2 5195077 535 ENSP00000362525.3 5182215 535 ENSP00000313752.5 5160872 535 ENSP00000239231.6 5136944 535 ENSP00000401435.2 5242544 535 ENSP00000381097.3 5192540 535 ENSP00000342235.4 5212599 535 ENSP00000445021.2 5172169 535 ENSP00000328307.5 5224506 535 ENSP00000264499.4 5230398 535 ENSP00000325018.5 5177703 535 ENSP00000262225.3 5128453 535 ENSP00000359403.3 5264530 535 ENSP00000265678.4 5147725 535 ENSP00000415836.2 5149374 535 ENSP00000382870.1 5202309 535 ENSP00000364860.3 5149517 535 ENSP00000348234.4 5235551 535 ENSP00000369442.3 5187831 535 ENSP00000360281.4 5252012 535 ENSP00000253115.1 5179759 535 ENSP00000355747.3 5135452 535 ENSP00000381703.1 5227721 535 ENSP00000472020.1 5196456 535 ENSP00000415662.2 5237398 535 ENSP00000311184.4 5143478 535 ENSP00000356975.4 5154541 535 ENSP00000337998.6 5230652 535 ENSP00000354842.1 5205732 535 ENSP00000507139.1 5141254 535 ENSP00000340297.3 5181919 535 ENSP00000387535.1 5137305 535 ENSP00000474988.1 5147043 535 ENSP00000377748.2 5177975 535 ENSP00000435506.1 5208236 535 ENSP00000497822.1 5141435 535 ENSP00000326349.1 5233225 535 ENSP00000374328.4 5158394 535 ENSP00000480364.1 5184111 535 ENSP00000330221.6 5218212 535 ENSP00000484277.1 5152117 535 ENSP00000249071.6 5154730 535 ENSP00000508020.1 5247724 535 ENSP00000303507.8 5208000 535 ENSP00000371512.1 5174919 535 ENSP00000385695.1 5239232 535 ENSP00000385319.2 5172582 535 ENSP00000365462.1 5187843 535 ENSP00000429065.1 5132050 535 ENSP00000220849.5 5262770 535 ENSP00000402394.1 5256814 535 ENSP00000252108.4 5223235 535 ENSP00000382091.4 5204811 535 ENSP00000282077.3 5249363 535 ENSP00000364119.2 5216905 535 ENSP00000361625.4 5229130 535 ENSP00000258530.3 5127606 535 ENSP00000393017.2 5236668 535 ENSP00000351211.2 5208819 535 ENSP00000229395.3 5227562 535 ENSP00000369162.2 5141955 535 ENSP00000260402.3 5201705 535 ENSP00000247883.4 5211856 535 ENSP00000246006.4 5193230 535 ENSP00000229281.5 5145959 535 ENSP00000252530.4 5269973 535 ENSP00000324882.6 5245182 535 ENSP00000507109.1 5230205 535 ENSP00000478653.1 5240634 535 ENSP00000354394.4 5195943 535 ENSP00000353846.3 5189449 535 ENSP00000442778.1 5217727 535 ENSP00000353796.3 5130761 535 ENSP00000376506.2 5217999 535 ENSP00000328079.5 5219676 535 ENSP00000320096.2 5201642 535 ENSP00000354920.3 5162280 535 ENSP00000229030.4 5248993 535 ENSP00000259365.3 5183962 535 ENSP00000299166.4 5173606 535 ENSP00000226004.2 5214329 535 ENSP00000316416.8 5192254 535 ENSP00000323872.4 5229123 535 ENSP00000216465.5 5171852 535 ENSP00000242462.4 5192288 535 ENSP00000423152.1 5205566 535 ENSP00000456566.1 5140109 535 ENSP00000261292.4 5164608 535 ENSP00000337501.4 5193785 535 ENSP00000322218.4 5166927 535 ENSP00000397563.1 5229318 535 ENSP00000327675.3 5144125 535 ENSP00000364749.2 5187038 535 ENSP00000485287.1 5188141 535 ENSP00000259089.4 5189796 535 ENSP00000290868.2 5158167 535 ENSP00000318868.3 5157684 535 ENSP00000355866.3 5186371 535 ENSP00000390111.1 5183144 535 ENSP00000271452.3 5249780 535 ENSP00000375429.1 5126706 535 ENSP00000459028.1 5236340 535 ENSP00000376110.2 5222555 535 ENSP00000394178.2 5237604 535 ENSP00000377224.1 5202901 535 ENSP00000258385.3 5238691 535 ENSP00000390625.3 5141413 535 ENSP00000257347.4 5140062 535 ENSP00000406638.2 5152033 535 ENSP00000365107.5 5127923 535 ENSP00000376446.1 5205730 535 ENSP00000493384.1 5187069 535 ENSP00000222803.5 5215909 535 ENSP00000225328.5 5141795 535 ENSP00000315417.3 5256783 535 ENSP00000220507.4 5263880 535 ENSP00000357727.3 5148544 535 ENSP00000334958.5 5234050 535 ENSP00000392043.3 5251024 535 ENSP00000172229.3 5201740 535 ENSP00000478388.1 5201521 535 ENSP00000353538.3 5223412 535 ENSP00000253814.3 5178083 535 ENSP00000267970.4 5231707 535 ENSP00000340975.3 5253016 535 ENSP00000217289.4 5143733 535 ENSP00000363463.4 5207904 535 ENSP00000349124.5 5254178 535 ENSP00000357894.3 5174070 535 ENSP00000364404.3 5196630 535 ENSP00000364699.3 5253522 535 ENSP00000363400.3 5149755 535 ENSP00000251849.4 5259214 535 ENSP00000301785.5 5151858 535 ENSP00000314620.7 5203540 535 ENSP00000356567.3 5238212 535 ENSP00000344503.6 5214710 535 ENSP00000384334.1 5191758 535 ENSP00000493454.1 5139838 535 ENSP00000287777.4 5157370 535 ENSP00000359146.4 5248858 535 ENSP00000238561.5 5250320 535 ENSP00000369899.1 5213554 535 ENSP00000365060.4 5233652 535 ENSP00000407249.2 5135795 535 ENSP00000401730.2 5261697 535 ENSP00000497410.1 5182472 535 ENSP00000481054.1 5140872 535 ENSP00000251412.6 5131056 535 ENSP00000271751.4 5251042 535 ENSP00000355920.3 5152017 535 ENSP00000233838.3 5238597 535 ENSP00000507498.1 5161391 535 ENSP00000451851.1 5268293 535 ENSP00000345512.6 5138171 535 ENSP00000340463.2 5265234 535 ENSP00000504128.1 5162828 535 ENSP00000339260.4 5208810 535 ENSP00000447588.2 5156119 535 ENSP00000497208.1 5157876 535 ENSP00000361871.3 5216938 535 ENSP00000377801.2 5163751 535 ENSP00000222284.4 5266006 535 ENSP00000465650.1 5241103 535 ENSP00000436424.1 5154128 535 ENSP00000434480.1 5164564 535 ENSP00000296585.5 5142485 535 ENSP00000493097.1 5164104 535 ENSP00000295256.5 5188417 535 ENSP00000220058.4 5149038 535 ENSP00000264870.3 5153007 535 ENSP00000493383.1 5243028 535 ENSP00000360846.3 5199357 535 ENSP00000240316.4 5178243 535 ENSP00000285311.3 5227309 535 ENSP00000319734.5 5264825 535 ENSP00000216341.4 5173454 535 ENSP00000295727.1 5211890 535 ENSP00000362674.3 5265235 535 ENSP00000356701.3 5209157 535 ENSP00000408598.2 5126880 535 ENSP00000356745.5 5175458 535 ENSP00000349017.2 5134876 535 ENSP00000219479.2 5178713 535 ENSP00000204549.4 5131449 535 ENSP00000320849.3 5158492 535 ENSP00000365042.3 5268148 535 ENSP00000379310.3 5213330 535 ENSP00000494268.2 5261396 535 ENSP00000301962.5 5164163 535 ENSP00000362444.1 5221658 535 ENSP00000371724.1 5130159 535 ENSP00000382858.2 5237957 535 ENSP00000215754.7 5255016 535 ENSP00000430818.4 5230821 535 ENSP00000342828.7 5229262 535 ENSP00000216034.4 5229313 535 ENSP00000266712.6 5266661 535 ENSP00000225430.4 5190881 535 ENSP00000406861.2 5202110 535 ENSP00000508865.1 5127386 535 ENSP00000498299.1 5266649 535 ENSP00000443411.1 5200300 535 ENSP00000260843.4 5254926 535 ENSP00000225899.3 5141576 535 ENSP00000279024.4 5250649 535 ENSP00000281243.5 5189930 535 ENSP00000373828.4 5210648 535 ENSP00000350673.2 5185931 535 ENSP00000278829.2 5174081 535 ENSP00000273936.4 5139905 535 ENSP00000327608.3 5117797 58 This gene is one of several nuclear pore complex interacting protein (NPIP) gene copies that are present on chromosome 16. There are no full-length transcripts derived from this gene copy in support of this CCDS representation, and thus its exon combination is inferred based on paralogous transcript alignments, e.g., the mRNA AF132984.1. 5117816 58 This gene is one of several keratin-associated protein 9 (KRTAP9) genes located on chromosome 17, as described in PMID:11279113. There is no transcript evidence specific for the location of this gene, and therefore this CCDS representation has an inferred structure based on transcript alignments from other family members. 5117817 58 This gene is one of several keratin-associated protein 9 (KRTAP9) genes located on chromosome 17, as described in PMID:11279113. There is no transcript evidence specific for the location of this gene, and therefore this CCDS representation has an inferred structure based on transcript alignments from other family members. 5117881 58 This gene lacks full-length human transcript support, and therefore the exon combination represented in this CCDS ID is inferred; it is supported by tiled partial transcript alignments (human HY028687.1, DR008137.1, DN831393.1 and others) and by homologous transcript alignments (mouse BC147276.1 and others). 5117920 12 13 13 U 5117943 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred. The full-length exon combination is inferred from the paralogous transcript CA454993.1. 5117948 58 This CCDS representation is supported by 3'-partial AF115505.1. The last four exons are inferred from other aligning transcripts, which do not indicate any alternative splicing in that region. 5117949 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but the full-length exon combination it is supported by partial human transcripts and the full-length paralogous transcript EF523384.1. 5117951 58 This CCDS represents an inferred complete model that includes all possible supported in-frame coding exons of the TTN gene. The exons included in this inferred variant are supported by the original sequence analysis and publication data (PMID:11717165), available cDNA and EST data, and additional sequence analysis of the repetitive exons. 5117965 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117966 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117967 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117968 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117969 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117970 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117971 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117972 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117973 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117974 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117975 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117976 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117977 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117978 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117979 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117980 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117981 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5117982 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by data in PMID:10936051. 5118001 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by several partial human transcripts including CR748811.1, HY022779.1, HY202236.1 and HY206240.1. 5118004 58 The exon combination of this transcript is based on the paralogous transcript alignment AK026441.1. 5118005 58 This CCDS representation lacks full-length human transcript support. Its exon combination is therefore inferred, but it is supported by a full-length orthologous mouse transcript, AK302217.1, and partial human transcripts. 5118008 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but it is supported by the full-length paralogous transcript AY037162.1. 5118021 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred, but the full-length exon combination it is supported by partial human transcripts (AA608988.1 and DB476671.1) paralogous transcript U58096.1. 5118139 58 The exon combination of this CCDS representation is inferred due to a lack of full-length transcript support for this gene. It is supported by the partial gene-specific EST, HY013942.1, and by full-length transcript alignments from the paralogous NUTM2A gene. 5118241 58 The exon combination of this CCDS representation is inferred. It is supported by partial human transcript alignments, RNA-seq data from the Illumina Body Map 2.0 project, and by full-length orthologous transcript alignments, e.g., rat BC097406.1 or mouse BC145796.1. 5118299 58 The exon combination of this CCDS representation is inferred. It is supported by partial transcript alignments and by paralogous golgin A8 family alignments. 5118300 58 The exon combination of this CCDS representation is inferred. It is supported by partial transcript alignments and by paralogous golgin A8 family alignments. 5118301 58 The exon combination of this CCDS representation is inferred. It is supported by partial transcript alignments and by paralogous golgin A8 family alignments. 5118302 58 The exon combination of this CCDS representation is inferred. It is supported by paralogous golgin A8 family alignments. 5118303 58 The exon combination of this CCDS representation is inferred. It is supported by partial transcript alignments and by paralogous golgin A8 family alignments. 5118304 58 The exon combination of this CCDS representation is inferred. It is supported by partial transcript alignments and by paralogous golgin A8 family alignments. 5118352 58 The exon combination of this CCDS representation is inferred. It is supported by partial transcript alignments and by paralogous NPIPA gene alignments. 5118353 58 The exon combination of this CCDS representation is inferred. It is supported by partial transcript alignments and by paralogous NPIPA gene alignments. 5118376 58 This CCDS represents one of several keratin-associated protein genes located on chromosome 17. This representation is inferred from paralogous and homolgous alignments due to a lack of transcript evidence for this gene. 5118496 58 The coding region has been updated to remove an internal 3-nt sequence that was removed in the update of the GRCh37 reference genome assembly to the GRCh38 assembly. The update results in a protein that is 1 aa shorter. 5118729 58 This CCDS representation lacks full-length human transcript support. Its exon combination is therefore inferred, but it is supported by partial human transcripts, including DY655290.1 and DY655683.1, and by RNA-seq data. 5118753 58 This CCDS representation lacks full-length human transcript support and it is therefore inferred. Th full-length exon combination is inferred from partial human transcripts and RNA-seq data. 5118764 58 This CCDS representation lacks full-length INSDC transcript support, but it is supported by full-length SLR-RNA-seq data, including the accessions SRR1803611.78619.1, SRR1803614.53228.1, SRR1660807.243528.1 and ERR279849.4405.1. It is also supported by orthologous transcript alignments and by human RNA-seq data. 5118928 58 This CCDS representation lacks full-length human transcript support. Its exon combination is therefore inferred, but it is supported by partial human transcripts including AI208887.1, DR007981.1 and DR007982.1. 5119248 58 This exon combination of this CCDS representation lacks support from transcripts deposited in INSDC databases. It represents the Ik-5 variant that is supported by RT-PCR data in PMID:12937159. 5119399 58 The coding region has been updated to represent an alternative splice site that is more supported by the available transcript and protein data. 5120196 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5120299 58 The coding region has been updated to represent an alternative protein C-terminus that is more supported by the available transcript data. 5120400 58 The coding region has been updated to start at a non-AUG translation start codon that is supported by publications and conservation. 5120400 144 1 1 M 5120401 58 The coding region has been updated to start at a non-AUG translation start codon that is supported by publications and conservation. 5120401 144 1 1 M 5120600 58 The coding region has been updated to represent an alternative splicing pattern that is more supported by the available transcript and protein data. 5120716 58 The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. 5120825 144 1 1 M 5120924 58 This CCDS representation is inferred due to a lack of transcript support for this gene. It is supported by paralogous transcript alignments. 5120976 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5121053 58 This PRAME family member lacks best hit transcript support. Thus, the exon combination of this CCDS representation is inferred from paralogous transcript alignments. 5121054 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121071 12 96 96 U 5121072 12 96 96 U 5121074 58 This gene lacks full-length transcript support, and therefore the exon combination of this CCDS representation is inferred based on partial transcript alignments, orthologous alignments and RNA-seq data. 5121083 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121084 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121086 58 This CCDS representation has an inferred exon combination due to a lack of full-length transcript support for this gene; it is supported by paralogous gene alignments and data in PMID:16079250. 5121099 144 1 1 M 5121125 58 This CCDS representation lacks full-length human transcript support. Its exon combination is therefore inferred, but it is supported by partial human transcript alignments and data in PMID:23122587. 5121153 58 This CCDS representation lacks full-length human transcript support. Its exon combination is therefore inferred, but it is supported by paralogous transcripts. 5121198 58 This gene lacks full-length transcript support, and therefore this CCDS representation is inferred based on partial transcript alignments, orthologous alignments and RNA-seq data. 5121203 58 This gene lacks full-length transcript support, and therefore this CCDS representation is inferred based on partial transcript and RNA-seq alignments. 5121224 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121237 58 This gene lacks full-length transcript support, and therefore the exon combination of this CCDS representation is inferred from partial human transcripts, RNA-seq data and full-length orthologous alignments. 5121319 58 This gene lacks full-length transcript support, and thus the exon combination of this CCDS representation is inferred based on paralogous transcript alignments and RNA-seq data. 5121597 12 606 606 U 5121597 144 1 1 M 5121598 12 642 642 U 5121598 144 1 1 M 5121633 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121758 58 This gene lacks best hit full-length transcript support, and therefore the exon combination of this CCDS representation is inferred from paralogous transcript alignments. 5121766 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121785 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121786 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121787 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121788 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121791 58 This CCDS representation lacks full-length human transcript support. Its representation is therefore inferred, but it is supported by paralogous transcripts. 5121794 144 1 1 M 5121845 58 This CCDS representation lacks full-length human transcript support. Its exon combination is therefore inferred, but it is supported by paralogous transcripts. 5121914 144 1 1 M 5122076 58 The coding region has been updated to start at a downstream in-frame start codon that is supported by conservation data. 5122671 58 The coding region has been updated to shorten the N-terminus, annotating a downstream start codon, to one that is more supported by available conservation data. 5123440 12 427 427 U 5123441 12 493 493 U 5123443 12 522 522 U 5123481 12 49 49 U 5123482 12 49 49 U 5123742 144 1 1 M 5123874 144 858 858 X 5123997 144 249 249 X 5124047 144 1 1 M 5124281 144 424 424 X 5124374 144 1 1 M 5124404 144 335 335 X 5124421 144 428 428 X 5124798 144 1 1 M 5124936 144 324 324 X 5124958 12 46 46 U 5125152 144 335 335 X 5125325 144 1 1 M 5125367 144 371 371 X 5125419 144 1 1 M 5125440 144 1 1 M 5125497 144 588 588 X 5125729 144 465 465 X 5125978 144 1 1 M 5126254 144 381 381 X 5126406 144 1 1 M 5180120 535 ENSP00000007735.3 5208139 535 ENSP00000262395.5 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