<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUV5</accession>
    <name>A0A133UUV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000125">
        <property type="protein sequence ID" value="KXA97994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA97994">
        <property type="protein sequence ID" value="KXA97994"/>
        <property type="gene ID" value="AKJ40_04995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA97994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="122" mass="13153" checksum="0F4C5D0B3346C6EF" modified="2016-07-06" version="1">MGLLLAPLGVFGITESITTLEGFPVSANFYISSMVIAAIISGIIYGAIYSLFYESIPGEPLRKGVYWGLIVWVIKDISAGMFMVSFGASFLALTFIITGLPMWIVFGVILGAIYERISSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUZ1</accession>
    <name>A0A133UUZ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_4-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000124">
        <property type="protein sequence ID" value="KXA98021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98021">
        <property type="protein sequence ID" value="KXA98021"/>
        <property type="gene ID" value="AKJ40_04975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="403" mass="46736" checksum="836D175A3D19785F" modified="2016-07-06" version="1">MKVCLISPVNKKTGISKYTIRLAHALEKKGVDVTILTDYTSNQYEDIIYDHAPKVVFLRSLSSLSKFVRKFDVLHFQVGNSKYHLFQVDLISKVENKGIPVVSTFHDSTLRGLFYYILSENLWRKYSDIFSGLIRKYGIQFLKFVEKIFLEPSDLTIVHSKANKRFLSSKYPEYDFRVIRHIGYFDDFGEEVEEENGCNSDYFLLCSSRYKHSNLDSIFKTFIKKFHDQNISLLISGVSLKKIISDYGFVKNRLGEDIFVLQRVSEQRYISLFKNAKAVIFPSELSSHNTPWERKYKPIKPLLSFLGLSKPPIRTSGALIHALSAGSLVIGPNEVTYKEYIPSDGCYLIEDESYTNLVRVMKNAFYKRVRTDYSDSDILKEIHPDTVGKKHLSEYKKIIYNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UV67</accession>
    <name>A0A133UV67_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000121">
        <property type="protein sequence ID" value="KXA98101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98101">
        <property type="protein sequence ID" value="KXA98101"/>
        <property type="gene ID" value="AKJ40_04940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="163"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="297" mass="31994" checksum="0A76BEA4C44DCE12" modified="2016-07-06" version="1">MLQKELLGGLLAIFSALLHAVRFPMIRKATVTGSSLDAVTVTVAVDTSVFLSLAVLLNYPTFGITRISFFAFFICGFLGPFLGLLCLYKGISRVGGSITAPLARGSLLISVLIAILVLKESVNILHLIGILLLLIGVVFISYEMGNETPILSFESDSDFFYPIGAMISLGLFYPLAKIGYSEGTPVTVGLGIIFTVGFCSLLLFSFYSGQNLLHSFRASEKKFYLAIGGVHSAAVGLYHLSISVSLVTIVTPLRSTSPVFVLPLSYFFLRELEKINKWIFLGTVLTVTGGILIGISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UV74</accession>
    <name>A0A133UV74_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000121">
        <property type="protein sequence ID" value="KXA98102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98102">
        <property type="protein sequence ID" value="KXA98102"/>
        <property type="gene ID" value="AKJ40_04945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="207" mass="24018" checksum="3C20A38379041143" modified="2016-07-06" version="1">MTQEPVSDKESSFAPDGTGIPTSMKKNWESEGNGGDHEGYDYMIGMAGTTYGIYSAVEFPKNPNAHESPFFEPLLQRTAVHYSSIDLITGDSAFLARDNCDLVIEAGGIPRFYPKRGITLKRKGSWSWTNMLMNLIENPQGWLRDYHQRSNIETTYSTLKRDFQIPLRKRIKKRRETEKYARVCDYNLKRLCYIRRLEKIPIHWKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVK5</accession>
    <name>A0A133UVK5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000118">
        <property type="protein sequence ID" value="KXA98214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98214">
        <property type="protein sequence ID" value="KXA98214"/>
        <property type="gene ID" value="AKJ40_04895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="33" mass="3858" checksum="1BED1D3F57914D0F" modified="2016-07-06" version="1" fragment="single">RSEVVETILAAFFKSSVDHTKKARELIIKKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UW79</accession>
    <name>A0A133UW79_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000113">
        <property type="protein sequence ID" value="KXA98429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98429">
        <property type="protein sequence ID" value="KXA98429"/>
        <property type="gene ID" value="AKJ40_04805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="189" mass="21947" checksum="1E0F83895A16757D" modified="2016-07-06" version="1">MNKQSGSLNGTVVKDFEIDESKVVFRYPNMEDIDDLLEYINSLIEENTFICRKEKVERDDEVDWLKNTLKEIEEKRKVHLVVEFDDKVMGSADVKKKSGKQSHVGELGIGLRREIREKGIGVRLMKSLIDEAKSVLNLEILTLEVFEKNKIAKNLYEKVGFKKAGVIQDKFFQNDEYQDSIVMELDLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWA6</accession>
    <name>A0A133UWA6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_04765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000110">
        <property type="protein sequence ID" value="KXA98456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98456">
        <property type="protein sequence ID" value="KXA98456"/>
        <property type="gene ID" value="AKJ40_04765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="81"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="175"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA98456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="561" mass="60424" checksum="0D6541DD7A3E6482" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWJ0</accession>
    <name>A0A133UWJ0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000104">
        <property type="protein sequence ID" value="KXA98559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98559">
        <property type="protein sequence ID" value="KXA98559"/>
        <property type="gene ID" value="AKJ40_04670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="59"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="463" mass="52555" checksum="C45771AC999A7F0A" modified="2016-07-06" version="1">MKEFFKGKAQHIRDASYTKRWRRQTSATTIASLRSAPPKITIIKIKKQGEVRIFMTVFAGLDVHKKYFHATVLEESGNVLVQKNFPNSSDGYDSLLAVTGKDVEVALEATYAWEYVFEELEDRVEEIKLAHPKRTEAITKERIKTDVKASEALAKLLRMGWLPEAWAPPKETRRVREKLRRRAYLVWKRTGFKNKIKADLAKLGIRKKVSYSDEGREWLRDLEVDSINDYLDMIEALNDPIERITKEVRREARATEDAKLLMTIPGVGFVWSLALTIELGDLERFSNPNEVPAQAGIVPSTEESGSKSIHGSITKDGNKYLRWAAVECAYLHERYADDTHLKRFFHKLAAKKNDQTAAVATGRKNPHSRLLDAHKERRVPSSWLTPQNQSLQVDGTGTPRFMDWGLDPAALIGGPSANYQCVALTTNRCMPKQVPAGVRDCSSHRLVSVVRVVEGNSFMRRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWL3</accession>
    <name>A0A133UWL3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000103">
        <property type="protein sequence ID" value="KXA98572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98572">
        <property type="protein sequence ID" value="KXA98572"/>
        <property type="gene ID" value="AKJ40_04645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.118"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="372" mass="42357" checksum="407793A08872A585" modified="2016-07-06" version="1">MSKTNESIHITETKKFKNGWGYSKNSRGIIYVHLRNDGKPYTVRFPWDVVLEEGEASDDAQRMRKRRKLEKSFRSEGERTELSKDIIVWEGIVKYPRGRRNKDEGVTVAEAMDEDEGSNEQEDSQEKEVSEESQDDSDGSEETSEKDGDEKERMCITSGTATPERIFKGSLEEAKKHPPVKRAFSILKEAFGGHYITSNTAESLFNVKPPLKAHRTMKNGNGFAQMLLFLRTKLRKKNRAEIKSFFRNKVVTYERLLKVSVNRLGPPPPGNQPEEVVLDAYRNNEPVTIIYKDGEGTKTSRMIEPLKIETDPYSGVRRIESYCYLRHAERTFLLERIVDAIPADTELSEGTTNDERTAAGPPPPSLESFPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWN8</accession>
    <name>A0A133UWN8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tfb</name>
        <name evidence="9" type="ORF">AKJ40_04630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000102">
        <property type="protein sequence ID" value="KXA98593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98593">
        <property type="protein sequence ID" value="KXA98593"/>
        <property type="gene ID" value="AKJ40_04630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.112"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXA98593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="231" mass="26359" checksum="EEA95F704A640246" modified="2016-07-06" version="1" fragment="single">MIKNYSSKRKKNKNSEINCPSCRNSVTVRDYQQNKIICESCGLVLRAAIKDNGPEWTAFTQEGYEEKSRAGPPATETIHDKGLSTQIDWSNRDGHGNSLSPKRRSQMYRLRKWQSRLRVVDATDRNLAFALSEINRMASQLGLSRSVQEIAAKIYREVVKKGLVRGRSIESVASAVLYASCREAQVPRTLEEIAEISRVNKSDIGKNYRFLSRELEIYLPPIDPTRYVARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWQ3</accession>
    <name>A0A133UWQ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000101">
        <property type="protein sequence ID" value="KXA98613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98613">
        <property type="protein sequence ID" value="KXA98613"/>
        <property type="gene ID" value="AKJ40_04610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="626" mass="71544" checksum="19BA2BEE027FC155" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWW2</accession>
    <name>A0A133UWW2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000098">
        <property type="protein sequence ID" value="KXA98686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98686">
        <property type="protein sequence ID" value="KXA98686"/>
        <property type="gene ID" value="AKJ40_04550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="121" mass="14138" checksum="41D298E0DC8BD5E7" modified="2016-07-06" version="1" fragment="single">MSYLYAPRIFTKKLFIVKAYMLVRIMSWHITLEENSWEEARENFEWNIPKDYNVIHDLLRKHDDPKSSIALFQALPGTKNKKYTFHELDNLSNRLANGLSELNVGVGDRIAIMLSQRASNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX12</accession>
    <name>A0A133UX12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_04515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000096">
        <property type="protein sequence ID" value="KXA98733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98733">
        <property type="protein sequence ID" value="KXA98733"/>
        <property type="gene ID" value="AKJ40_04515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA98733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="204" mass="22902" checksum="3392E4A10E0A07B4" modified="2016-07-06" version="1">MIVAKLRSIYFAILTLAFGEIVVGIIYYFKNLTGGSLGLYVTLPKILQTSPNYYYFVLLVSLIAIFIYYRIANSPFGLIIQTIRDNDRRIESLGINVYRYKIINFTISGVLAGLGGLLYVYNVGMAFPTLANWQTSGHPIIASLLGGTGTYFGPFLGMIIYETVRTSALIITQRWMIIVGLLLVLVILFMPEGILGFLERKFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXG0</accession>
    <name>A0A133UXG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000091">
        <property type="protein sequence ID" value="KXA98883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98883">
        <property type="protein sequence ID" value="KXA98883"/>
        <property type="gene ID" value="AKJ40_04375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="93" mass="10620" checksum="ECEB9638E0829620" modified="2016-07-06" version="1">MSENEEQKKEESESSEDRLEKMREKMKEKREEGAGPERMPSGSGLASMMQRMGGGPGGPQQNRGMMETIKGLRKETKEIKNYLKEILDTLQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXK4</accession>
    <name>A0A133UXK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000090">
        <property type="protein sequence ID" value="KXA98919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98919">
        <property type="protein sequence ID" value="KXA98919"/>
        <property type="gene ID" value="AKJ40_04310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="379" mass="44320" checksum="9DEF0C4172CD0DEC" modified="2016-07-06" version="1">MAVSYSEFSPSELFQRWDQQEKEAREKDDGLGFYEPVQKLSNARDVFLDNRFDLNDSLPGLIKIYRRWVGEKTYLCNQYLDHETNETKYKFQLAPKRGNEKYVSDVKSRIYEKVPSTEQLEKQHLLADENGSNVLHITLTVDPKRYLGDLQSAWANLPYYLNKFLSAFRKRYGRCWVLRSFEAQENGFPHVHLFIISEQTFSCEWYKGKKYWRWLIPELTDDHKAIGADETVDGFENLWSLGFVYARGVGKRPYMRKQIDVKNYVVKDVVSEVSVVDVDSDVEVKNPELTLALNWLFRRQAFSISGSDVLESVFNLIPVCLTQTEVLKNAFLRRLFEFSRYEFISFCGIVRCSEPPPDGFIKLSNDQEHELEAQAIGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXQ5</accession>
    <name>A0A133UXQ5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000088">
        <property type="protein sequence ID" value="KXA98969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98969">
        <property type="protein sequence ID" value="KXA98969"/>
        <property type="gene ID" value="AKJ40_04260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="5"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="383" mass="44809" checksum="1B41917D2CDCCFE6" modified="2016-07-06" version="1">MKLKSINLKNIRTFKDEKIDLGTGTISATGDNGSGKTTIIESIGHALFGYDPEYRRGESIKLPNGQEYSPNVRNMFLRKGTKTGEIHINFEDDMGGDFLVVNKITSTAQEWEIYRNGMIKDQDPGKQGILNEVRNVLNIKDSYRGTLENYFSHIVTVLQGEIVDPFLKSQQKRKDYFDEILGISYYRDAERDFVHVKNYFSEILQSLREDIKELTGAVESLPEKRKNLQKRKKEIKNLQNKVDSLEDILEDLTKRKKKLDGLEKEINDLEKEKEKIITKINALQKQLEKAKERRNECEEARNLANKLKKDAKNYEKLEKELENIQTLLDKKNKLENKLGESKTQLREWECRADELKKKIRKRGLQRLQHFSNGRYLRYGKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXR2</accession>
    <name>A0A133UXR2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000088">
        <property type="protein sequence ID" value="KXA98970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98970">
        <property type="protein sequence ID" value="KXA98970"/>
        <property type="gene ID" value="AKJ40_04265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="389" mass="45558" checksum="42A00327D0A81ACA" modified="2016-07-06" version="1">MAEIEFVHLADTHLGYRQYGLEERFKDWGKATKQSVDYAVEKDVDMVIHSGDLFNSNKIDQDALVQAFEIFEPLKKKDIPLLVIEGNHDRRRGRQKNTTMDVLDRLGYCTFLDPGGRDISNAIYEIKEYNVIGLGYPGMYLKNWIDDYAEQLPENRKNNIILLHAGVEGYIESMASHVTPSKLKELKQKSIYLALGHFHDSFQLDNWAFNPGSVERERFDRKEKSKIFYHVKIQDGVVEAEKVQLNTRNMFQFDLKANDNWKQVKTKLREKVEAHDLEESMVRVRIFGKLESEFKRWELEELFGDEPLVLKIFDETYSEEKKSEWKGMESHEIEKDILVNYFENDFEDPEALADFVRSILDNILEKSLSSSDEAKPLAKDIANWRRDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXS4</accession>
    <name>A0A133UXS4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000086">
        <property type="protein sequence ID" value="KXA98994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98994">
        <property type="protein sequence ID" value="KXA98994"/>
        <property type="gene ID" value="AKJ40_04210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="106" mass="12377" checksum="E6A03C7C9964BB67" modified="2016-07-06" version="1">MMESGIDNGQEKDPIAWIEMKPYGDVDEVKQDLRELSDRAGFEITDFETVDPPNSRNGNKIVKAYTDTFREVPKDKLTAVREWLLREVYWAQHVCNAKVNIDKRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY01</accession>
    <name>A0A133UY01_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000078">
        <property type="protein sequence ID" value="KXA99068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99068">
        <property type="protein sequence ID" value="KXA99068"/>
        <property type="gene ID" value="AKJ40_04050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="188" mass="21949" checksum="A18000BB8D7C9906" modified="2016-07-06" version="1" fragment="single">MKAELVEKVNDGELTPAVELGLAISFAEDLKGDILQRFHRNETDKMDKRFTEFVLIEAVRMLLGIPPVTFYDYLRHNEELRNVMDLKCLKNLGNYMDFKRKRKKLDVRFKDVSIRNFDGKSDEVYALDNFKIEVDLNKYRSGKKIKQEKFDAEFQHSTTKGTIVGFQASLLINLSNFSLQKLEIYPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY10</accession>
    <name>A0A133UY10_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000077">
        <property type="protein sequence ID" value="KXA99078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99078">
        <property type="protein sequence ID" value="KXA99078"/>
        <property type="gene ID" value="AKJ40_04010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="149" mass="17151" checksum="582176D98D00AF0D" modified="2016-07-06" version="1">MLPSDRYGQMKIFFDQKSIPSQNFCSEQTWKLQSGNDGIWSVKTNLVLEIMTKMNKCPLELPVPSKSAMKDGTLCLSDLHTADQNLFGALFIYERKRPETKEEEVQIYEDLDYSADKFFVKFSDNVQIEKLSEKISHLLEIAKGGECRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY32</accession>
    <name>A0A133UY32_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000075">
        <property type="protein sequence ID" value="KXA99098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99098">
        <property type="protein sequence ID" value="KXA99098"/>
        <property type="gene ID" value="AKJ40_03945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="182"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="347" mass="40222" checksum="0ABD4F39D7B289DF" modified="2016-07-06" version="1" fragment="single">MPKRKKQKRLEKFIDKLKNDEIDYEPIDEEDSGVNWSSYDKAQVNELKDMILFVRNSVDEAVERLGFDNDSETGRGRPSYPPEDLAKGVLLQQYFEVSNRVAAGFVDLFKEKLGIEEAYSYKTLERAYDNPHVAMILREVFEMSQESVEDEEDTFSPDGTGIPNSIKNNWEKEKDSEDGEPSNSFTKMIAMIGATYQLISSVKFPDNPKAHESPYFEPLLEETADRYVQITLVSADSGFLSRDNCDLVEKHGGEPRIYPKEGITLKRKGSWAWTDMLLDFIENPQEWLREYYTRSNVESGFSTFKRHFLSPLRKCIQRRRKTEAFARACDYNLKRASYVRRQEGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY43</accession>
    <name>A0A133UY43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycine/betaine ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_03970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000075">
        <property type="protein sequence ID" value="KXA99103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99103">
        <property type="protein sequence ID" value="KXA99103"/>
        <property type="gene ID" value="AKJ40_03970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="92" mass="9627" checksum="0A946E0BF2F4F48C" modified="2016-07-06" version="1" fragment="single">KSFGASKLQTLKDVQLPLASPTIFASFVESAMIIFMMVVYASLIGAPGLGVEILRSLGRLRIGVGIEAGIAIALIALLLDSLLGGFHETIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY57</accession>
    <name>A0A133UY57_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH asnC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_03890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000073">
        <property type="protein sequence ID" value="KXA99125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99125">
        <property type="protein sequence ID" value="KXA99125"/>
        <property type="gene ID" value="AKJ40_03890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="143" mass="16432" checksum="9D1ECD5D414E0367" modified="2016-07-06" version="1">MFIWEVLNMDEINRKILNILRKNSRTPYVDIAERLEISEGTVRNRVKKMQSEGIIDRFTIELGEAETARAFVMVNLSTDTDISELVKKFPEDSDTFEVAGDYDLIAEIRRKNTSKINEAVDAIRSLNGLTSTKTYMVLNKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY61</accession>
    <name>A0A133UY61_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000072">
        <property type="protein sequence ID" value="KXA99142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99142">
        <property type="protein sequence ID" value="KXA99142"/>
        <property type="gene ID" value="AKJ40_03880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="402" mass="46295" checksum="9FE72A35579AEAE7" modified="2016-07-06" version="1">MTSEQEYEVRLIQADNERLDEYREHFARTRKQSLNTFGWVWLVDDLRAEAPSGAARSRLKNIQSSVSKNAPWFNPEDVLKEFLHEEWGNLEKRREEVRALVEKCELFSLTDKKGNTLEMSERVKAALLTEVFGLVEVHREDKGTCPAYKLTGYTFESWVMKSVGLVGEHLVDEERMRDHVDLMTDILEEGGMDMIPDLSYPCSQVIFVTSRKVKTVVLWEKLVELGRKKIRLRETIEMEKGETIQLPEETTKRLMKQGAVARFVYRCESCNSAIPRNEPSKEPPQCPECGSSNIQSVHPETPEEVADVLRKYYRQGLQTESSPEDLMATFATGLSRESYPRISAEQTWELGSRVVPRKGAGFLDKVVDRFMWARKTDKRISEGKSSRHEGNGPIERIAREDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY72</accession>
    <name>A0A133UY72_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000072">
        <property type="protein sequence ID" value="KXA99138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99138">
        <property type="protein sequence ID" value="KXA99138"/>
        <property type="gene ID" value="AKJ40_03860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="251" mass="29014" checksum="A55DE0F59290643E" modified="2016-07-06" version="1">MIEMERDELRDELLTLSENLTGEDLDYAIDYLEVERKRMKGKSHNNSVVSFVGDYCEFGPGRVYLLMAIARSKNNPLSSSEELCFREVVRSRGDVRRKYAKLKAIMVSPLENGRTYDFYLYLSANARNVLKAHFNFRGKMDRWIRNRLNGADNHEKFKKLGKYWLSELSKPSSRDETNLLIDVDDDSDSRLCEVKNALADRTEVLAERKTPNGWHLVTNPFNHERLSIGLDIKTDGLLFLEHVNGGGRYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY93</accession>
    <name>A0A133UY93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000070">
        <property type="protein sequence ID" value="KXA99166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99166">
        <property type="protein sequence ID" value="KXA99166"/>
        <property type="gene ID" value="AKJ40_03820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="66" mass="8198" checksum="31463178ADF2B28D" modified="2016-07-06" version="1">MKEFIEIEVEVDLESIVEDSQEKDDALQMLNYRLKKKRRQAEEEFEKKYDDLKVEFEKELDKIWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYF5</accession>
    <name>A0A133UYF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_03705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000066">
        <property type="protein sequence ID" value="KXA99209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99209">
        <property type="protein sequence ID" value="KXA99209"/>
        <property type="gene ID" value="AKJ40_03705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="233"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="311"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="440"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="486"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="555"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="606"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="683" mass="80190" checksum="CB794249D4ADEE63" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYF6</accession>
    <name>A0A133UYF6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE_Tnp_IS66 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_03725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000067">
        <property type="protein sequence ID" value="KXA99197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99197">
        <property type="protein sequence ID" value="KXA99197"/>
        <property type="gene ID" value="AKJ40_03725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="3">
        <location>
            <begin position="210"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="498" mass="58370" checksum="7303443B3C00CA76" modified="2016-07-06" version="1">MISQDSSYPDCESTCSKVAELKERIEELEEVVEELRREKQELRGEKQELEKKLNYQKEKYARLWKEHRKFVGGPHKPSSKKTRAEKEEEKRRKRERKKKESGEGDTGREDEEDKEDKEDEGKGKPGRKPGHKPAWRKKPDPKEEIDVTQDKCEDCGNPLGDPTDSHTRMIEDVPDPEPPTATQFNIFEYYCDPCDKKVTATHPNCPDEGDFGPNTLVQATLFKFEERLPNRKAADLLETLYGLEISHGTVFKLTERVSKCLRPHYESIRRELRGAEALHVDETRFSVGGENWWLWSFSDNEHVLYRLVNSRGSNVLEEVLGEDFDGWITSDGLSAYPAFTDKLQRCWSHLFNESEYAADRFEEAVPIDEKLHEIYNHLNEFLEEDPPPSKREEKREWAMNAMKDLTEKEYEEEKVEDLITYIENGMEYWFTYVVEPDVDPTNNQAERDLREPIVIRKIIGTLRNEKGTRIFKTVMTMLATWKRQGLNPREEMLKAVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYF8</accession>
    <name>A0A133UYF8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000063">
        <property type="protein sequence ID" value="KXA99240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99240">
        <property type="protein sequence ID" value="KXA99240"/>
        <property type="gene ID" value="AKJ40_03635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="59" mass="7463" checksum="3944EDB1D6006591" modified="2016-07-06" version="1">MALRENFWKTRIRKDKIIRSVFKRYFISSLEELNSFFYNWSERFPQSEFIINEKYEKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYH6</accession>
    <name>A0A133UYH6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_03680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000065">
        <property type="protein sequence ID" value="KXA99217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99217">
        <property type="protein sequence ID" value="KXA99217"/>
        <property type="gene ID" value="AKJ40_03680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="315" mass="35126" checksum="F98281751640F058" modified="2016-07-06" version="1">MMGEPVIQTENLTKKYGYKTAVDNLNLEIDKGEIFGLIGPNGSGKTTTVLMLLGFTEPTHGKCRVLGLDPLTNPREVKRRTGYIPERVGFYEELTSGENLYYVAKLNDIPKDEVEDQIVDVLENVGLEGEERTKVEEFSQGMRQRLAIASVLIKEPEIVFLDEPTTGLDPEGAEEILKIIEEMKAEKEMTVLCSSHLLHHLRRISDRVGMMIDGSMVAEQKISELEDEVSSLIVAEVSEITEDLLDEIGSIEEVESVDTKDGEITVKGKGDLRGKIAETIVNTGSTLLGLERKKVELSDFYERYSKEREKRGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYI1</accession>
    <name>A0A133UYI1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000062">
        <property type="protein sequence ID" value="KXA99248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99248">
        <property type="protein sequence ID" value="KXA99248"/>
        <property type="gene ID" value="AKJ40_03595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="218" mass="24727" checksum="4A1B1EC6C83BA6DD" modified="2016-07-06" version="1">MAVLFDLDGTILGSYRDKNEVRNECVRKYGVQEIDKEKYFDVLNEVLHNSKVEDREPIFRRFIGDEELSGIVAEEYEERSLENAFVYPDAEEVLSKIKSKKGIVTNGPRLTQWGKIRKFELEKYFDSIVVSGEVGKSKPGKEIFQIALRSLKATTGESLYVGNVPHLDVKGAENVGLVSVLIDRDGNFEDSEKVNPKPDYIIGDLRELYGIVDTEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYI4</accession>
    <name>A0A133UYI4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000064">
        <property type="protein sequence ID" value="KXA99231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99231">
        <property type="protein sequence ID" value="KXA99231"/>
        <property type="gene ID" value="AKJ40_03660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="10"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="271" mass="30955" checksum="BF111D8617CF17B9" modified="2016-07-06" version="1">MKMKEINIPRYGPIRDINWTLEGGIQPIYGPNESGKTLLVEALMRIFGGKDISLPEGAERVEEKPEGYVVVEMDGEEKKINFDNPLCEYLNVDPDELTNTLVVRNSDLCIESEDQFYERVSDKLSGLWTDGIRRVEGELKKLGRLTGTLKLSNKKDFNKAKDQLNAAQDLREDVEKYLTEAEEEGISKLEAQKLSAESRINRLKKRKEKLKLGKLLEAHDKASSALNQLFDIPSEDLTSDLRVKVDKSKDLLEKKPEFEKNLDLFNNPTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYK5</accession>
    <name>A0A133UYK5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000060">
        <property type="protein sequence ID" value="KXA99276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99276">
        <property type="protein sequence ID" value="KXA99276"/>
        <property type="gene ID" value="AKJ40_03540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="87" mass="10409" checksum="7569B554A0BA4B6E" modified="2016-07-06" version="1">MKVLFCWDIDTENGEGKRRQFYRKLYGYTQKKEEKTYKYQGVLEEVDGERINQSVILVTEEGAGEIRKLLEDFSEIFGTWRSFKVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYL3</accession>
    <name>A0A133UYL3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_03560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000061">
        <property type="protein sequence ID" value="KXA99261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99261">
        <property type="protein sequence ID" value="KXA99261"/>
        <property type="gene ID" value="AKJ40_03560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="241" mass="26710" checksum="ADB42EFD9C2B7384" modified="2016-07-06" version="1">MLLKVSGLTKRFGDLIAVDNVEFDIGEGEIVGLIGPNGAGKTTLFNCLMGLHKPDEGEAIFDEKFDLMKMKPHQICKAGIARTFQEVRTFLNLSVLDNLKASSTFGRETENRRRDDEPHQLLESVGLGEKKDALAKNLNIGNRRLLELAMALSTHPRIILVDEIASGLSLSEISSLTDTIEEIRNSHGISIFWIEHVMSAIMESTDRVIVLDNGSIIAEGKPEEIKKSKKVTEVYLGTEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYM4</accession>
    <name>A0A133UYM4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000059">
        <property type="protein sequence ID" value="KXA99283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99283">
        <property type="protein sequence ID" value="KXA99283"/>
        <property type="gene ID" value="AKJ40_03490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="76" mass="8532" checksum="DEF36FD9B54361B0" modified="2016-07-06" version="1">MENVALDQSVRKVVEIIREKAEADGLKLSRVISPGSGRINWRIKNQELICKNLKPEVIGVSLTSNYALKPLNRFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYN8</accession>
    <name>A0A133UYN8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000057">
        <property type="protein sequence ID" value="KXA99320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99320">
        <property type="protein sequence ID" value="KXA99320"/>
        <property type="gene ID" value="AKJ40_03405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="64" mass="7353" checksum="C60F6331E5988360" modified="2016-07-06" version="1">MRKGNSTKPIKTSETSFLNSSPLLPSINTDTRAAALKIHNKKYQRFQKKETYKSTLEVLQVFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYQ7</accession>
    <name>A0A133UYQ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000056">
        <property type="protein sequence ID" value="KXA99340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99340">
        <property type="protein sequence ID" value="KXA99340"/>
        <property type="gene ID" value="AKJ40_03385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="142" mass="16507" checksum="17353C5EF541BBC6" modified="2016-07-06" version="1" fragment="single">MYDILDLYQEPYDSKRPVVGVDERPKQLIGEKKKPIPMKPGSPERVDYEYVRNGSVNVFVAVDPKKGKRDAKVTNRRTKKDFATYIKRLVDGVFLDAEVIRLVVDNLNTHNESSFYETFDKAEAERILSKIEFHYTPIHGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYR3</accession>
    <name>A0A133UYR3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000058">
        <property type="protein sequence ID" value="KXA99307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99307">
        <property type="protein sequence ID" value="KXA99307"/>
        <property type="gene ID" value="AKJ40_03475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.890"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="114" mass="12518" checksum="764BBECE34BDB7F4" modified="2016-07-06" version="1">MKVRRGDIVLVDLDPVKGSEQGRTRPAVVIQNDVGNKHSPTTIVAPLTSSYRKVYPVNIEVESGENGLERDSIILLNQIVTVDIKSRVLKKLGKLSPEKMKKVDSAIEISLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYV6</accession>
    <name>A0A133UYV6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_03340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000055">
        <property type="protein sequence ID" value="KXA99354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99354">
        <property type="protein sequence ID" value="KXA99354"/>
        <property type="gene ID" value="AKJ40_03340"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.852"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="165" mass="18597" checksum="AFC99A5E9123D846" modified="2016-07-06" version="1">MGKDRGLYITEIDFLLTYRCLKECDHCFVWGGPSATGTFNLEDLYTLIGEGEELGTVKTIYFEGGEPFLYYPVLLAGLKRAKECGFEVGVVSDAYWATSREDAEEWLRPIASIGVSDLSLSCDRYHGKELEVEEVSLVLNPSTFSTLLRPEERSVHYDCYPEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYY9</accession>
    <name>A0A133UYY9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000052">
        <property type="protein sequence ID" value="KXA99405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99405">
        <property type="protein sequence ID" value="KXA99405"/>
        <property type="gene ID" value="AKJ40_03230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.822"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="454" mass="53694" checksum="ABB10C8C3DA70EE9" modified="2016-07-06" version="1">MKRKKWDRSDIEDYPGWKRSPNFEHTLPYRFTPGEWERTPLTETDLDRPEGMHGESTITKQFKKLVRRVKRLDLTPQRFLALAISARDSWREQRFIDYSGSAPEPEPRRSAYDLRRYLDAHQKLLGSSWSDRDRFDKALEEVIYLLQRMGFLHEFPVEGREHPLNWVTEKGLEKVVTVDFKEWDQTKTPHRMEQIEACILGAELGCLVWLVQHGGHEKKEVEPDVIWVPPLNAERWDWNRALWVEVDPAPKQHGEKIERQTEADLREGWRVIWITGSDEKLAKIGNHLRSAPLVQEIELGWDSLGEDTDVVLQPTLLRQRSGREMRRSREKADKVRDRVVKALKANWKIYPKEPHRIHIGTEITARQKLGRGEYKTHKLGTVQDYETVQLLRGELAPDELEEREKEAREEREIRNALERARDPSVRIDSGWIWLDGEKKWRATERNKRIVREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ36</accession>
    <name>A0A133UZ36_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000048">
        <property type="protein sequence ID" value="KXA99466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99466">
        <property type="protein sequence ID" value="KXA99466"/>
        <property type="gene ID" value="AKJ40_03090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008304">
        <property type="entry name" value="UCP017998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06557">
        <property type="entry name" value="DUF1122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="110" mass="12681" checksum="94FA28C63CBCB6FA" modified="2016-07-06" version="1">MNNGFLSKIDGQKIGGFSLVVEDRREGRFSEETNFELYLEDNEGEKSRKPVVWGKYFSGRGKYYSPWIELNFAEKIKFKSNSASFFGGNIGEELFETFFRNLPSGGRLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ46</accession>
    <name>A0A133UZ46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_03105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000049">
        <property type="protein sequence ID" value="KXA99451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99451">
        <property type="protein sequence ID" value="KXA99451"/>
        <property type="gene ID" value="AKJ40_03105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="63" mass="7140" checksum="98AA34C570E6A409" modified="2016-07-06" version="1">MKGTVKFFDDRKNYGFIEPEGRGEDHFVHRSDIESGPLNEGDKVEFDSEQGDRGPKAVNVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ67</accession>
    <name>A0A133UZ67_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000047">
        <property type="protein sequence ID" value="KXA99483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99483">
        <property type="protein sequence ID" value="KXA99483"/>
        <property type="gene ID" value="AKJ40_03060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="89" mass="10001" checksum="2D45A45E5BD2EA3F" modified="2016-07-06" version="1" fragment="single">LPLSLGLSIKDHDPEKMAEALSDIKEKKVEEAMTENVKILPPDAGLGKIARKMKKHEINRVPIVDEENKLLGLVARADVVKGFWEKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ95</accession>
    <name>A0A133UZ95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000045">
        <property type="protein sequence ID" value="KXA99516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99516">
        <property type="protein sequence ID" value="KXA99516"/>
        <property type="gene ID" value="AKJ40_02935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="312" mass="34581" checksum="06D5F98E4BE0D5FA" modified="2016-07-06" version="1">MNRSGTNKTLLFLIITVTCFMVAASLPVVMGDTIDGEASVSNTSCEFIDKTVDTNTVDPESYFWIKTQVRDSDTLSDIENVVVKIFDNQTAVGAQDTKRSHYTFWFDANDNSWNSNLNNTLGNPFIDAAASEYPNDATVTEDNYNFKILLNGTANPNQDWNVYVEVNDEASSENNGTHTNALAVNTYVNYDVKADLIEWTNLQPDTNDNPSDSNPVIIENIETNVNYDVQTKLSGDWLNTNGDTITVTETSFDSTDSSGYHGQVSSSIFKDVYTYESYGEDLTEGINYFLDIPDGTSSGTFTNTFEIEVVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ99</accession>
    <name>A0A133UZ99_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000046">
        <property type="protein sequence ID" value="KXA99497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99497">
        <property type="protein sequence ID" value="KXA99497"/>
        <property type="gene ID" value="AKJ40_02995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="193" mass="22597" checksum="2CDD9845A08943C4" modified="2016-07-06" version="1">MLDYAEDLLNPRLVLLDRGFYSVEAIRELKSRKMGFIMPAKKTSPVEKICKEFKKGEASAGTDYTVSGRKGEEEVRLLLSEKETENGKEIHPFITNLDIDPDEASENYSWRWRIETNIRELEKFKPFTTSQSMELRRLYFLISMTLYNLWILTRDGKEHPRGHEFKDWLEIELISFKVLKKSRAKPPPLPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZB5</accession>
    <name>A0A133UZB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000044">
        <property type="protein sequence ID" value="KXA99536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99536">
        <property type="protein sequence ID" value="KXA99536"/>
        <property type="gene ID" value="AKJ40_02905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="86" mass="9905" checksum="88F6C4B8B5F7DFA8" modified="2016-07-06" version="1">MKRDPFEEIEKKMKEMMEEGMPESKRSISIKQTGDGTTVDVSGDVSDEEIDRLKERYPDADIRVEGKSLEEEEGPIIEVIDEENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZC0</accession>
    <name>A0A133UZC0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000044">
        <property type="protein sequence ID" value="KXA99535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99535">
        <property type="protein sequence ID" value="KXA99535"/>
        <property type="gene ID" value="AKJ40_02900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="53"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="134" mass="14768" checksum="BFB1672EBDB8ABB7" modified="2016-07-06" version="1">MAVMELYVLVGLISAAFIGGGRVLEKRGVEDLPHFSEKQWFKDGKIQFSRIRKVMKKLLNSYFLSGVFLDVAGWLLTLKALAIGFISIIQPLKAFGNLVAVLLGVIWLNENLDTSEYLGIGLIIVGTVLINMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZE7</accession>
    <name>A0A133UZE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000043">
        <property type="protein sequence ID" value="KXA99552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99552">
        <property type="protein sequence ID" value="KXA99552"/>
        <property type="gene ID" value="AKJ40_02865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="204" mass="23179" checksum="4475A4C54E13DDDB" modified="2016-07-06" version="1">MKVLIEKNFEHEGETYEPGQTVDFPEEIAEEAIEKGYAKNAEEIEDEIDIKSGGEVDTSSGDEGFPEEVSMPSEEERAEEGEEEVWEELDSELDEQSRAPAWRPEEVGDQLLGEVTRTGRGPNGRLLEVKTPEGEKYVLWEKVALQDLFDRVKAGDKIGVRFLGEEESSSGRSYHNYRTTLKKDKKLTHLEILSTTPHENYKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZI0</accession>
    <name>A0A133UZI0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000042">
        <property type="protein sequence ID" value="KXA99569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99569">
        <property type="protein sequence ID" value="KXA99569"/>
        <property type="gene ID" value="AKJ40_02835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="107" mass="12493" checksum="F348366F2958775E" modified="2016-07-06" version="1">MKEKKEKVMVRNVSLSFPPVIRKDKPEFRFIPLPSIFGILSTDGHMKKTRDMRVVGAERLESFLWGGFLMNVQISWWAIEFYKANGFETVDSSEERLAIEFMSSFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZV4</accession>
    <name>A0A133UZV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000035">
        <property type="protein sequence ID" value="KXA99702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99702">
        <property type="protein sequence ID" value="KXA99702"/>
        <property type="gene ID" value="AKJ40_02575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="62" mass="6834" checksum="14CB48A8391A4E03" modified="2016-07-06" version="1">MKFGELKNTIMAIILIQSIVGILFFKWIGKVPGVNTYSLILSIILLIVFSSAIATIVYFLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V002</accession>
    <name>A0A133V002_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000032">
        <property type="protein sequence ID" value="KXA99760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99760">
        <property type="protein sequence ID" value="KXA99760"/>
        <property type="gene ID" value="AKJ40_02450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="191" mass="22240" checksum="770230068000450E" modified="2016-07-06" version="1">MNDLKEVLKDRFPRNNWNFKKLSKILLEAAERGKYRLDDEEDILFFEGERLLLPKNFYQSRSWDDRLLTSGSDFLMPETIRYLVKRAEEEGEWNPEYAVERYLDEIGEENKTLFLEFFKKMKKGIESCSEYKKNTISGDLIVTIAEELGMGKEKADVIRGEFKKGGIISPCSSRVKGGCLSFEINPSLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V017</accession>
    <name>A0A133V017_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000031">
        <property type="protein sequence ID" value="KXA99778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99778">
        <property type="protein sequence ID" value="KXA99778"/>
        <property type="gene ID" value="AKJ40_02425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.550"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5_nucleotid_C" evidence="1">
        <location>
            <begin position="305"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="480" mass="54384" checksum="60BFC4E007512525" modified="2016-07-06" version="1">MSDRLSILQINDSHGYLDLHDEYFWKNGKQTYREVGGYARITSYFNEVRDENSDAVIVLDNGDTIHGTYPVVKSEGEVLIPILNRMGFDAWTAHWDFAYGPDHLVKFAEKLNYPLLAINCYYEDSEELVFDPYKIVKRDGVKMGLIGIANTIVDKTMPDRFSEGIYLTLGNEELPKYIEELRVENNVDLIVVLSHLGYPQEVKLAKQVDGIDVLVSGHTHNRLYEPSEVNDTIIIQSGCHGSFIGRLDLDVDQGKIRGYNHELVEIDESVTPDREVQKMVNEVLEPHEDMLGEVVGETKLGLARDKVMETRMDNLLLKALIDASGAEMAFSNGWRYGSPVPPGKITVRDLWNIIPTNPPVSVCEITGRELWNMMEENLGNTFARDPYNQMGGYVKRCYGVNVYFKIENADGLRIQEFFVGDERLDKDKTYKASFVTTQGIPARYGKNRKDLNINAIKALKGYISKNSPVKPEIEGTIIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V046</accession>
    <name>A0A133V046_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000030">
        <property type="protein sequence ID" value="KXA99806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99806">
        <property type="protein sequence ID" value="KXA99806"/>
        <property type="gene ID" value="AKJ40_02375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.493"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="77"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="178" mass="19890" checksum="50F39836CF392C75" modified="2016-07-06" version="1">MDYEKGLAFLGNLDDVAKKGGKWMADRKPIRNIRDWAINFSLWPVHLTTACCGCEFAPTAAPRYDSERLGVLPWIGARQTNVLIVEGTLTRKMAKAAKIVHSQMPEPKYVMAMGACASDGGIFWNSYNIVRPKEILPIEVYIPGCPPRPEAVIRGFMKLKEKTRKELEFQETSGGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V059</accession>
    <name>A0A133V059_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000030">
        <property type="protein sequence ID" value="KXA99810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99810">
        <property type="protein sequence ID" value="KXA99810"/>
        <property type="gene ID" value="AKJ40_02400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="61" mass="7012" checksum="1F58E5C5F8E7D737" modified="2016-07-06" version="1">MDGEFEPISARTDVSITDREVFEYANGKLAYYLLEKKEVYSQIPKKTREIIALFPQALPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V079</accession>
    <name>A0A133V079_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="16">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 20" type="primary">carB</name>
        <name evidence="20" type="ORF">AKJ40_02350</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="16">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 16">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="16"/>
    <dbReference type="EMBL" id="LHXU01000029">
        <property type="protein sequence ID" value="KXA99834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99834">
        <property type="protein sequence ID" value="KXA99834"/>
        <property type="gene ID" value="AKJ40_02350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.485"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 16" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="677"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="19">
        <location>
            <begin position="935"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="16">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="16">
        <location>
            <begin position="937"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="827"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="839"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="841"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KXA99834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="1077" mass="117828" checksum="8E6CF0E697B59942" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0H8</accession>
    <name>A0A133V0H8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="LHXU01000025">
        <property type="protein sequence ID" value="KXA99934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99934">
        <property type="protein sequence ID" value="KXA99934"/>
        <property type="gene ID" value="AKJ40_02170"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="63"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="157" mass="18237" checksum="34888592CDDF92BA" modified="2016-07-06" version="1">MDLDEKDREILKEIQEGIPIEKNPYLRVAESIGIETEELLNRLRNMEEKGAIRRFGASVNHRKFGYEANGVVVCEVDRNRLNIVGRKISEFDEVTHCYQRPSRPGRWDYNLYFVVHASSRSECEKITEKIIAEAGVDPEKYEIVYSTKAFKREGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0K0</accession>
    <name>A0A133V0K0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99966">
        <property type="protein sequence ID" value="KXA99966"/>
        <property type="gene ID" value="AKJ40_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="131" mass="14976" checksum="211736E3B57F8867" modified="2016-07-06" version="1">MSSKTRHSEPDERVAKAEKLLEEGKTKYEALEDLEKELGTIKRASEGCENVFHSLVEVSEAILSKHGQTARNHIERMDKLSKIGRGDLADLYAIAKDHLHTSGYYGQQFNTIQKHTLERVEKKVKEEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0K3</accession>
    <name>A0A133V0K3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_02105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99969">
        <property type="protein sequence ID" value="KXA99969"/>
        <property type="gene ID" value="AKJ40_02105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="68" mass="7409" checksum="55644F8C0F49E01F" modified="2016-07-06" version="1">MAELPLAAVDRIIRRAGGQRVSEGAAVELAEVLEEKALEIAKEATTLSEHAGRKTVRDTDIRLAIRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0K9</accession>
    <name>A0A133V0K9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99964">
        <property type="protein sequence ID" value="KXA99964"/>
        <property type="gene ID" value="AKJ40_02070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="132" mass="15781" checksum="C70980540D746A8C" modified="2016-07-06" version="1">MLFTTHEDWSVERVIKAYTGKWRVEHSFRLLKGPISVRPVYHGEDNRIREHYFLLFLLLVIHRWLMERIRGPVLREFGIGEEAVLHFLKELRMVTDKPSNSNKPDFKLEEQNEIQEAIVNNLNLKRFVPGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0P4</accession>
    <name>A0A133V0P4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_02050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000023">
        <property type="protein sequence ID" value="KXB00004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00004">
        <property type="protein sequence ID" value="KXB00004"/>
        <property type="gene ID" value="AKJ40_02050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="237" mass="26087" checksum="6DCEABD20F47340E" modified="2016-07-06" version="1">MVDTVLELENVTKSFGAITAVDNVSFEVEKGEIKGLIGPNGAGKTTLFNLVTGVFPPDNGDIYLRGEKINDLDTEDRIRKGIGRSYQITRNFADLTVRENLRVIPYDETEKDQEKRIDELIELTGLGPVETEFPTSLSFGQKKLLEMARVLMVGADVVLLDEPIAGVNPTLTNKLLEVINELNERGVTFMVIEHNFGVISEICDNIIALRSGSVKARGTPQEISENNELIEAYFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0X0</accession>
    <name>A0A133V0X0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000020">
        <property type="protein sequence ID" value="KXB00094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00094">
        <property type="protein sequence ID" value="KXB00094"/>
        <property type="gene ID" value="AKJ40_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="168" mass="18844" checksum="95F3DB7595DB3D70" modified="2016-07-06" version="1">MSDTESEKARLNPLFDYVRAKVDDPRLEDSELRVIGLSQRARVQSGDKLAGRVTVDYLEGTKIVVLNATRTREMRDPGVAGLIAHEFAHFLLKESGDFVSEEGSTPYRALEKSEEEADKLATEWGFGDEVEVARAEVEGFEHSELTLTEYRSLVRSWCLPEDFGGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0Z7</accession>
    <name>A0A133V0Z7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="1">HPPK</shortName>
            <ecNumber evidence="1">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="1">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="1">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mptE</name>
        <name evidence="3" type="ORF">AKJ40_01830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="1"/>
    <dbReference type="EMBL" id="LHXU01000019">
        <property type="protein sequence ID" value="KXB00124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00124">
        <property type="protein sequence ID" value="KXB00124"/>
        <property type="gene ID" value="AKJ40_01830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.331"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAF_flag10" evidence="2">
        <location>
            <begin position="38"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="245" mass="27704" checksum="C36EC60A5C562DA7" modified="2016-07-06" version="1">MRYVMDWETWRPKYENIVERLNLDRKMDRRSAELLHDILGKTDFSELKRRVTGNKCVVFGAGPSLEEDLERMDRADWFDKVLVSADGATSAVMKYEVPALVVTDLDGKVVDQLEAWRRGAWMVVHAHGDNLEEIKKVVPRLEGRVLGTTQVDQPEQLPNFGGFTDGDRAAFMLHEFGASRIYLAGMDLGEEIGRYSGRTQRDRKPIKLEICGELLSWLAGELGADLVNVTAEGEEIPGVPRREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V131</accession>
    <name>A0A133V131_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_01800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000018">
        <property type="protein sequence ID" value="KXB00157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00157">
        <property type="protein sequence ID" value="KXB00157"/>
        <property type="gene ID" value="AKJ40_01800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.323"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="136"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="221" mass="23405" checksum="7FF2101C98F0870B" modified="2016-07-06" version="1">MKIVIVGGGRTGRGLAERLIKLDHEVTIIEQEEETAQELASDLDALVMEGSGSSMDVLKDAEAKNADVLAAVTGSDEVNFMACKLAKKVGVDRVITRVNESEHAEIYEDVGADVTISPVGATIGLFERAVTGPGIYGMLSLGGSEADVIEVTVSEDSEAVGKSIDELDLPRLCTIAVVNRGGKLISPRGKTEFLEDDRVIIAGPPDDVITAGKLFHKKNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V170</accession>
    <name>A0A133V170_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00189">
        <property type="protein sequence ID" value="KXB00189"/>
        <property type="gene ID" value="AKJ40_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="321" mass="37292" checksum="090E3E6CAE82E116" modified="2016-07-06" version="1">MKVETINKINKGELDGEATLDFALSHAEKVKKDILQSWFKKGASRNDKALNEFLLIEIIRSILGAEPRSFFVLLNVSRRLRALLDLKYVDDLERYKYFKRKIKNLKGRLREISKRSLGSEGDESFAFDSSIVTADLNGYRNGKKVKKGDYDARFTYSTTKGTVIGFQTLLLFADGGFFAYENYIQSANHRVEAIINPRCDCRENLKEKLENMSPRLELFEIHDPEKKEKVMSEMKDLVSSIIEKSLNYDEYKERRSTIEKIFKIAKQVYGVKDLHVYHEEGAYWKIFIGFYFSCLLYQDLKDEKINVDKAVGLFGDNADVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1D4</accession>
    <name>A0A133V1D4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MtrH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000015">
        <property type="protein sequence ID" value="KXB00257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00257">
        <property type="protein sequence ID" value="KXB00257"/>
        <property type="gene ID" value="AKJ40_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023467">
        <property type="entry name" value="MeTrfase_MtrH/MtxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028342">
        <property type="entry name" value="MtrH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02007">
        <property type="entry name" value="MtrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004960">
        <property type="entry name" value="MtrH_MtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01114">
        <property type="entry name" value="mtrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="303" mass="33416" checksum="365B45B88ACFF347" modified="2016-07-06" version="1">MFLFSKDQEVYDIAGVKIGGQPGEYPTVLVGSVFYDGHNVVEDDDRGIFDEEKAGKQIKKMEELSESTGNPAMLDVVGGSSESLINYIDFIADVTELPFLIDGTTADIRIEATEHVKNMELSDRVIYNAITVDCSEEEIEVIKKADIKSAVLLCYNAKKPTIEGRMESFEKVSNYASDAGIEKPLVDPSIIDLPDPGPASRTIFKIKEGYGLPCGCGAHNSVDQWRERVEMSPEMYKLRTAVTNSFPITMGADFSLFGPIEDAEEAYAACSLVDAFVGYSMRMEEGLGPESKDHPLYKIFRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1L2</accession>
    <name>A0A133V1L2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000013">
        <property type="protein sequence ID" value="KXB00334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00334">
        <property type="protein sequence ID" value="KXB00334"/>
        <property type="gene ID" value="AKJ40_01485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="71" mass="8285" checksum="761E1B2E833879DF" modified="2016-07-06" version="1">MLDRLGFPPGVTESKNFSLSTEKPSKSIISKDLSQSIISEMRLKIPVFHSKHWKRRFLRIGYRPRNDKKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1N1</accession>
    <name>A0A133V1N1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anthranilate synthase</fullName>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ40_01520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000014">
        <property type="protein sequence ID" value="KXB00296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00296">
        <property type="protein sequence ID" value="KXB00296"/>
        <property type="gene ID" value="AKJ40_01520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.256"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="8">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB00296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="121" mass="12800" checksum="90C44A61476B51E2" modified="2016-07-06" version="1">MSTVSGKLKEDTDAFDALRTVFPAGTVTGAPKVRAMEIIEELEPTQRGIYSGAVGSISYTGAADFAIAIRTLTSDGERAQVQVGAGIVADSIPEEEYYETQNKARSLLRAAGVENESSGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1R3</accession>
    <name>A0A133V1R3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0146 protein AKJ40_01370</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0146 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00379">
        <property type="protein sequence ID" value="KXB00379"/>
        <property type="gene ID" value="AKJ40_01370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.153"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00341">
        <property type="entry name" value="UPF0146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005353">
        <property type="entry name" value="UPF0146"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03686">
        <property type="entry name" value="UPF0146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016725">
        <property type="entry name" value="UCP016725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="128" mass="14399" checksum="57A74F7F47BC5CE4" modified="2016-07-06" version="1">MAQWISENYSTADKIIEIGIGNTPQVISKLKEELENCELIATDIRKVDTPEGVKSVKDDITKPELSFYENADLIFSIRPPPDLHPQLNKIARRVKGDLLIKPADSEESPSWGELVNYRGAAFYILKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1V1</accession>
    <name>A0A133V1V1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00424">
        <property type="protein sequence ID" value="KXB00424"/>
        <property type="gene ID" value="AKJ40_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="240" mass="28455" checksum="91E361EBB78FBCB4" modified="2016-07-06" version="1" fragment="single">MKPGKKKKEERRKKKEMLYAYEVFEKMYKESGYAKEKIPEKILSNNLYGIDIDNRSVQLSALSLYIKGKTKNSNAKIKDVNLVSADAVLMDGEKKERLLRKCKKPIEKEIIKEIWDNFQHLDERGSLVKVKESVREKIEQYRDNLSEEEKKQQYLDQFSNEKINKKKISVQQKLAEKISTEDYWNMIEDRMMQRIFELGEEAIQSRDMSVQLFAAETEKTLHLLDYLMSKYDCVTTNPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1W7</accession>
    <name>A0A133V1W7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00422">
        <property type="protein sequence ID" value="KXB00422"/>
        <property type="gene ID" value="AKJ40_01355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.98"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="1175" mass="136240" checksum="C2325B91C92D6750" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1Z4</accession>
    <name>A0A133V1Z4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DsbD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00470">
        <property type="protein sequence ID" value="KXB00470"/>
        <property type="gene ID" value="AKJ40_01265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1180"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="221" mass="24381" checksum="063E76551EE5DAE8" modified="2016-07-06" version="1">MTNFEIISLAFSAGAASFLNPCSFALLPAYLSFFLGKDEKRPNPENWTQSILKGLKYGLSATLGFAVVFLTIGFLVSLASVQIKPFLTPFTWLIGILLIILGFFWILNKPFLYLSSISGKIELQRTSFFLFGAAYALSSLACVFPVFLMLIFSTIQTGAFISGVSVFIAFTLGMGFLMITVSIAMALSKEYLINQFRKVRKYITRISGGILILAGIYLLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1Z7</accession>
    <name>A0A133V1Z7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00477">
        <property type="protein sequence ID" value="KXB00477"/>
        <property type="gene ID" value="AKJ40_01305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="98" mass="11404" checksum="8F8B6071C643DBC8" modified="2016-07-06" version="1">MVNLPPLENKDKLVNWLAGYEILPLTSKCISSDGYERIKKNIEENLKKRRILNASDQEINSKFLDEFNDFNELIQEGCTVESAVTLTRKSKETFFFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V211</accession>
    <name>A0A133V211_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00472">
        <property type="protein sequence ID" value="KXB00472"/>
        <property type="gene ID" value="AKJ40_01275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="166" mass="19193" checksum="E3BD880FCD03F7E5" modified="2016-07-06" version="1">MDKEIPEIVRDAYKSLPHFKDGRIDYSDAEKAPVVVVFLKYGDEILILKRSDRVGTHQGRWGTVAGYLDELKPVVEKAFEEIEEETGIGREKIAKVLKNGVYKFRSESEDICYTTHLVLAILKERTDVKLSWEHTDYKWVKISNSDRYLSHNASEELKKVLYSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2D5</accession>
    <name>A0A133V2D5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_01125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00585">
        <property type="protein sequence ID" value="KXB00585"/>
        <property type="gene ID" value="AKJ40_01125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1013"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="347" mass="39350" checksum="4274428813B3A7EE" modified="2016-07-06" version="1">MQKPAKFWEKSSGEDVKCVLCPRECNISPENVGYCRARKNIEGELYTLVYGESTSANPDPIEKKPLYHFYPGSRVFSMSTAGCNFECKHCQNWNLSQASVEEIDTEFIEPEEAIERTKKTNCQGIAYTYGEPVIWFEYALDVAKLASEEGLYNVFVTNGYMNLDGWKELKPYLDAMNVDVKAFSDKFYKTICGGASVKPVLETCEWAVDNGIHLEITNLIIPEENDSPEEIRKLCQWIAQDLHPRVPIHFSRFRPMYKMVDKSSTPVSALERALEIAKDEGLEHIYVGNVPGHEADNTYCPECGELLITRHGFSVAKYNLKDHQCPSCGAEINVIGEYKPSSSRFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2H4</accession>
    <name>A0A133V2H4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CARDB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00648">
        <property type="protein sequence ID" value="KXB00648"/>
        <property type="gene ID" value="AKJ40_00970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARDB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="409" mass="45714" checksum="9FCDB19F14AF4804" modified="2016-07-06" version="1">MKKLTKLMAIIVVALVGITGYLVLSREAKATEPAKFEYSDLIVSPSEVAPGQLVTISVTVKNIGGTKGSENVKLVITDNSGNLDMSIETPLTLKAGESKTYSLLEMSKQEEGTYTVEVADLSNSFKVVGHEEKSKELAEEFILENSSTYKYDGYDLEYKETLYPDIAGHPYLWTFVYEFKSKHSGYGDRTGENLLQVITPHEAHITVDNGKVVTAILDLKWDMIEQKMLEEKPTIHVYKTPEGPNIDNAELVWEKVKDLEEARYVTMEKDSSALIYVHPYSVGAFDPSTAETIIVLSSTSGEKVRTAIFRLDSETNQLKKAYNSSYDAIENFKLEQGIELMEEKISELSYGERDIPAEEVKNLHPYYVYSYPAGDFGGTLITHKQAGKVVFYATTVWDGSGELLIPQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2H9</accession>
    <name>A0A133V2H9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_01000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00654">
        <property type="protein sequence ID" value="KXB00654"/>
        <property type="gene ID" value="AKJ40_01000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="308" mass="33927" checksum="509D0894EF85257A" modified="2016-07-06" version="1">MDSIPIDGFTVEPTEEKKTLRLEITRLFDDSPVSLPTGLISNGEDTKVCIISGQHGNEWNGIYSSQKFFKNVPHEAVKGTLIVIPIVNPLAFNEKSRVSSVDSIDLNRTYLNHSYRKPAEQIGTKLFAELFGETDYIIDIHGGGPGEYSPHVAVTDENLIEKASDLLLPDVYLGSSSSGSLASACAKENIPLFTVEAGKRRHIDRAYTDKIIKGLENFLKGVDMLDGKPQEGKPVVHSNKDKVTSPASGFFTPQVDLGDRIEKGDKIGELEKLFGEEKIIRTSVSGKILYLRSEKVVSKGENLIHVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2K4</accession>
    <name>A0A133V2K4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00663">
        <property type="protein sequence ID" value="KXB00663"/>
        <property type="gene ID" value="AKJ40_01050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="93" mass="10504" checksum="30027FE882F0B926" modified="2016-07-06" version="1">MDGSIAPPPETKNRGPTLSTMHEIERILREAEEPLSLNEIKRRMSAKAVRHSTVRKVIDEFKRLGFVAEGSKGAIWSLNLSPDFWSKGRAEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2K5</accession>
    <name>A0A133V2K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00655">
        <property type="protein sequence ID" value="KXB00655"/>
        <property type="gene ID" value="AKJ40_01010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="408" mass="46562" checksum="D9D82246DD498AFA" modified="2016-07-06" version="1">MNGPIPSDGQDLLDFAEERIFSLGPRDLGSALSYRNMRFGIGKMIYASGSEDVHCILAPDASITRNRERWFSGFGYGGVIRWDDENLAFPQIKPNACGMILVQLNDLPEEKELIERASAVNETELSLNGIEIDPDFGSGNHFFEFYEPLEISESFEYFSHDSYYAILHCSAPELKDEVYSYIGKGRQVQTPLGEITVLEGKEAERYRDKWEKMKTFARKRRRLLAEEVLGSYNYRIISNYLHQGLFSETEARLGCYDTQAEYGENIYPVTLRWDCPVYIFEGKKNLSENLMKRLEFQDRAKKLGLEESLLNANILPHGGGYKVKLSYQNVETTDTDFGKVFTLSNPEPFYEEREGGNESDFSDFGKMCVTSPGELPYTYRGKGVSRKIMEFDLSDLVAKLKPVTTLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2L0</accession>
    <name>A0A133V2L0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00682">
        <property type="protein sequence ID" value="KXB00682"/>
        <property type="gene ID" value="AKJ40_00855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="62" mass="7029" checksum="53C685BB5C520A76" modified="2016-07-06" version="1">MSSRWEIKGPEAEKPCQELGYCPYGSEYFPVAEPGEERGCKAFGHVRPVYFVGEDASEKNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2L2</accession>
    <name>A0A133V2L2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00684">
        <property type="protein sequence ID" value="KXB00684"/>
        <property type="gene ID" value="AKJ40_00865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="115" mass="13073" checksum="3A1A764A2D7157EF" modified="2016-07-06" version="1">MTEEKGKVPLLKVLGVSPELRVLNALLDNPVFDLTAGEISDISGLKVAEVEEVLNKLRSWNIVEIKCEGEKKCYSLNTSGVSTLSWLGKGRKRDDILRTGYHRLKRTRKRCFREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2N1</accession>
    <name>A0A133V2N1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00717">
        <property type="protein sequence ID" value="KXB00717"/>
        <property type="gene ID" value="AKJ40_00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="137" mass="15345" checksum="17B7163918728258" modified="2016-07-06" version="1">MGGEREERETATGVSRKLTGELRKGDKIVATKECGGMPSYVPIPDPQYDFGEYICPRESDLVLRHPESGNGVFFLYGDSQVVVDPGNEITLVFTATERTLDVYHVTLGDLLEFAEILEERFGYNVRIIPRRTNSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2N5</accession>
    <name>A0A133V2N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00691">
        <property type="protein sequence ID" value="KXB00691"/>
        <property type="gene ID" value="AKJ40_00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="176"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="249"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="344" mass="37426" checksum="BCB4C92738E3971E" modified="2016-07-06" version="1">MKKAVITGVVLACLLAFGSLPSASSLKGPIGGQPDGGKIIPVPKPPNPAPPEEKPPRADAGGPYTVRAGRRTKLDGSGSRDPGGMIVNYEWRIVHDPTGGARIIDIGVFSSPYAVFEAPKNISGDVVVVVELTVTDEEGLKGSDTAKVLVEGMRGRGNRKPVPRYRYRPRDPEPRERILFDATWSTDPDGRIVSYSWRFGDNETGKGRVVEHRYSKAGTYSATLTVTDDDGATSSVSKRISVGASNKPPVARFYYWPRNPSVNRCVFFSASTSFDPDGHIAGYSWMFGDGTTERGKFVTHSYTDPGLYPVRLTVADDDGARGSSTRTIRVGKYLPWFPPIYLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2N6</accession>
    <name>A0A133V2N6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00699">
        <property type="protein sequence ID" value="KXB00699"/>
        <property type="gene ID" value="AKJ40_00955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="96" mass="11490" checksum="CCFE467A7CBE8993" modified="2016-07-06" version="1" fragment="single">AIVIYQIRNLSQAKKVKFGREFRGYTDKSNKGQYEYYREGLLDEIPHRKFIRGVLLIKRKDRKKMLDFMNEYKVEIHTRNVELTPEDIEILSSHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Q0</accession>
    <name>A0A133V2Q0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLDc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00722">
        <property type="protein sequence ID" value="KXB00722"/>
        <property type="gene ID" value="AKJ40_00750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="196" mass="21491" checksum="042AB7FD4B2BF4B3" modified="2016-07-06" version="1">MKLTRNAGENVLPLLDRAEGKVTVYSPFISPKYAKLLLEKSENGVDVSLFTANADTNYHQKSLRILRNGPELPKTLRNAGLLLVSLGTVSALIVYFLELLALPFSLLLLVGGSLGGGYLLKKHFERASEWSESHGDINIKIVQGLHAKLYSRDSGEEIIFGSANFTNNGMRRNLEVVGGCRNKSPLQEGELNGMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2V2</accession>
    <name>A0A133V2V2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00755">
        <property type="protein sequence ID" value="KXB00755"/>
        <property type="gene ID" value="AKJ40_00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="138" mass="16203" checksum="C71F4D1B1E1CD78F" modified="2016-07-06" version="1">MGEPTSEYYINNPEDPSKYEKLVDTLMEEEHPARLILDRFDTLPRWIGEEEAFRLLKRLMGYIESCGGVGLYIVTEGLLSSRMEMLVRDRADLTLHTVREKDEKHVEITNFRSRLSPYRKWKIGTEGEKINLSELHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2W0</accession>
    <name>A0A133V2W0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00765">
        <property type="protein sequence ID" value="KXB00765"/>
        <property type="gene ID" value="AKJ40_00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="77" mass="8237" checksum="1607DED46288E51E" modified="2016-07-06" version="1">MTCPCQSPLFAHPLRGFLEPEIAAIQCGAVGHGTYAAPAAPTTYHLGRGSFSGLGQAPWSPTHQGPDPQLFSKRWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2W3</accession>
    <name>A0A133V2W3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00773">
        <property type="protein sequence ID" value="KXB00773"/>
        <property type="gene ID" value="AKJ40_00575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="93" mass="11100" checksum="AD7DF34E969124D9" modified="2016-07-06" version="1">MYRTLKETGELFKVLSDPTRIKILLSLAEEEKCVHEIARETSSKLSNISHHLRRMKDKNLVDYRREGRHKYYRVKDEHIINILKQGVAHAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2W5</accession>
    <name>A0A133V2W5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00771">
        <property type="protein sequence ID" value="KXB00771"/>
        <property type="gene ID" value="AKJ40_00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="95" mass="10499" checksum="CE6B17D7B0285638" modified="2016-07-06" version="1">MKSENAVVACLVCINILMTAGLFVKNIAFLEGWNDFNLVYSILMATLGVFGGTMIKVQDCRSVSKSRLIGIAKLFLIISFDSFERIAKNNGRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2W9</accession>
    <name>A0A133V2W9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_00630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00775">
        <property type="protein sequence ID" value="KXB00775"/>
        <property type="gene ID" value="AKJ40_00630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="91"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="186" mass="21910" checksum="9D5241EB87D7E461" modified="2016-07-06" version="1">MRREMRRGFPTFGEEEEEEYWSPFEEMMNQFEEEVPEEFEEFVKEEKTPHGKVRRYGPFVYGFSYSKKPGEEPEIQEFGNIKPTGRGKIKPSPEGEREPLVEVVDLNGKYEVTIEMPGVEKEEIDLSATEEKLRVKTTGERKYQKSITFEEKIDPETIDANFRNGVLTLEIEKKEEEEEGKQIEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2X4</accession>
    <name>A0A133V2X4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00756">
        <property type="protein sequence ID" value="KXB00756"/>
        <property type="gene ID" value="AKJ40_00590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="99" mass="11723" checksum="5D37B948BDF7E270" modified="2016-07-06" version="1">MDGSVVIYQIRGLSQAEKAKFRRELYGYTDKSNRGQYEYYRPGLLDEVPYRKLIRGVLLIRKRDKEKISGFMEKYEAEVHMRNVELTPEDTEILSSNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Y7</accession>
    <name>A0A133V2Y7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="6">DHOD</shortName>
            <shortName evidence="6">DHODase</shortName>
            <shortName evidence="6">DHOdehase</shortName>
            <ecNumber evidence="6">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrD</name>
        <name evidence="8" type="ORF">AKJ40_00545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="6"/>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00817">
        <property type="protein sequence ID" value="KXB00817"/>
        <property type="gene ID" value="AKJ40_00545"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.379"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="7">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="71"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="301" mass="31902" checksum="16759121F92BD56E" modified="2016-07-06" version="1">MTKEKLKVTIGTIEIKNPTILAAGILGQTGANLKRVLRSGAGAVVTKSIGPKPREGYSGPNIVQTPCGLLNAMGLPNPGMENMVEEIETVKEKGGTVIGSIFGEGLEEFKKLSRKMEEAGVDAVELNLSCPHAKKLSTIGNDPEMAERITKGVSKESDAPIWTKLPGNTNISNLLEVAQSVQKAGADAITIANTFPGMAIDARAERPVLGHETGGLSGPAIKPIALRLIYEVYKKVDIPIIGSGGVMNGEDMIEYLLAGASAVEIGTGIMWRDIDIFEKVCEEALPYLEDRSVTKLIGSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Y9</accession>
    <name>A0A133V2Y9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00801">
        <property type="protein sequence ID" value="KXB00801"/>
        <property type="gene ID" value="AKJ40_00490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="170" mass="19329" checksum="C5A3CF743AA531CD" modified="2016-07-06" version="1">MRNMLSISIRDRISVHPLLYEIISLLLLVGIIVFAVKGGLILGLQSSSPIMGVSSGSMTHSDDSWKNYYYRENYDPSEFPFQRGIREGDLVFVKGVHSYEDINVGDVVIWWDGDRELKIIHRIVEINKDRNYIRTKGDAVPQPDDKIPFKNIIGKAVFSIPYLGYPSQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V317</accession>
    <name>A0A133V317_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00838">
        <property type="protein sequence ID" value="KXB00838"/>
        <property type="gene ID" value="AKJ40_00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="105" mass="12120" checksum="119169C37BA8450E" modified="2016-07-06" version="1">MAEGKPPSMDIPRLFNVFDIPEIKSVRAVSSLRQDIALEEVWNKVNKARKVRTSGKDVVKFEEGKGEYLLLFPSGYVQIYAPSEEKIRQVLRSFRDELYEMGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V338</accession>
    <name>A0A133V338_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AKJ40_00325</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00854">
        <property type="protein sequence ID" value="KXB00854"/>
        <property type="gene ID" value="AKJ40_00325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.74"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="73"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB00854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="533" mass="61268" checksum="DEB2AC32E8D1FAF5" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V355</accession>
    <name>A0A133V355_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00863">
        <property type="protein sequence ID" value="KXB00863"/>
        <property type="gene ID" value="AKJ40_00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019300">
        <property type="entry name" value="CooT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10133">
        <property type="entry name" value="CooT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="59" mass="6676" checksum="DF3F75BCFCDB76D2" modified="2016-07-06" version="1">MCEFDVFLDGEKVFEEAVYLKRENGNVLARDILGNEKELGDVVVEEINVSSEKLLLTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V360</accession>
    <name>A0A133V360_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00869">
        <property type="protein sequence ID" value="KXB00869"/>
        <property type="gene ID" value="AKJ40_00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="109" mass="12643" checksum="FEB7A8F2D5AA5008" modified="2016-07-06" version="1">MSSKKKTGLVSLERIFEEILEIEETVQNHSDNPESKIFEQVFSSLEEIRNEIKPLARERDCRELNNVLEEIELAIANSKGDLKIPNILEALESARINLIKYNLRSRKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V362</accession>
    <name>A0A133V362_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MoCF_biosynth domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_00065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00870">
        <property type="protein sequence ID" value="KXB00870"/>
        <property type="gene ID" value="AKJ40_00065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.14"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="169" mass="18421" checksum="7B9674F2698FA8B4" modified="2016-07-06" version="1">MDRNDNEESSKYLHVEVITISDSKKAAMGEGRDEDKSGKIIQKKLEDAEISSNRVIISDDKAEISKELDKKIYNSEANAVITTGGTGIASRDKTVDVVSEFLDKRISGFGELLRWRSSEEVGGAAVLTRATAGIANQKLVFCLPGSPNSVKTGMDLIAYDLPEILKDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V364</accession>
    <name>A0A133V364_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00887">
        <property type="protein sequence ID" value="KXB00887"/>
        <property type="gene ID" value="AKJ40_00175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="103" mass="11341" checksum="FB3D0896553ACD37" modified="2016-07-06" version="1">MKRLLNGLNHLKDIDEFPFKRKLDSNPAGFLFQIGVRNGQTVLDFGCGSGTFTVPAASLVGEEGTVYGLDKDIRSLERLRESAEREGLRNVETIVTGGALRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V375</accession>
    <name>A0A133V375_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00894">
        <property type="protein sequence ID" value="KXB00894"/>
        <property type="gene ID" value="AKJ40_00215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="355" mass="39570" checksum="DB9622191E6AF7E0" modified="2016-07-06" version="1">MRSIKILGSGPSGLSAAINLAKAGREVEVFERGKGIGSRFYGDLEGLENWSDRKDARRMLDSMNIEINFNFSPFHELTVSNGSRTVSFSLEKPAFYLVKRGSVSGSLDRGLEKQALDLGVDIHFGETIPEGEASIVATGPTPEKAIAIVKGSRFSTEMEDTAVAVLGDRIAYKGYSYLLVRDGYGCMCSVVFDELEKVAACFRRTKKIFSDLADLDIRNPQRVGGIGNFSAGGTFERDGRLYVGEAAGIQDFLWGFGIKNAIISGFLAAKCLIENENYEKIAREYFEDKLKASLTNRFLWETFCFKDYSFILDVLGCTDDITKLFFSFHNFNFLQRALYPFASNWLGGRYRNPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V382</accession>
    <name>A0A133V382_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00866">
        <property type="protein sequence ID" value="KXB00866"/>
        <property type="gene ID" value="AKJ40_00030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="148" mass="16404" checksum="873122EA2AD6ADA2" modified="2016-07-06" version="1">MERNTQITLLLFLILGLGLVYVGQQVNVLQKRVNELDYLIIETGVTIDNGADTTTKTVNLTRGATPIEALQRVAAIETETYHGLGTRVTTINGVSDNKKTGTYWLIAKKSENENSWIGVTKPGRDELKDGDNLLFWYGKPSDAPFEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUV6</accession>
    <name>A0A133UUV6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase_S24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_04985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000125">
        <property type="protein sequence ID" value="KXA97992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA97992">
        <property type="protein sequence ID" value="KXA97992"/>
        <property type="gene ID" value="AKJ40_04985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="5">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA97992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="178" mass="19502" checksum="5437BB52698D9306" modified="2016-07-06" version="1">MDIKHKIAYGITIFVVISAAVIYFSPARFLQGYGHSMEPVIKSGDGIIVVPVKKEEISIGDTIAFKSGGVIIAHKVVGFEDGKIITHGVNLPKDDVEKIDPSQVIGKRVLTIPKAGIIIRYVGTRIGFILLILIPASLIIVNEVRKIKKELEKENYTDSKTEIIHTGLRNSDQSKDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVM9</accession>
    <name>A0A133UVM9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_04870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000117">
        <property type="protein sequence ID" value="KXA98255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98255">
        <property type="protein sequence ID" value="KXA98255"/>
        <property type="gene ID" value="AKJ40_04870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA98255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="69" mass="7643" checksum="CBC90472F5395A8F" modified="2016-07-06" version="1">MAELPIAAVDRIIRKAGGQRVSESAAEELADVLEEKGLELAREAVELTEHAGRKTVRDEDIRLAMRKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UW83</accession>
    <name>A0A133UW83_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000110">
        <property type="protein sequence ID" value="KXA98454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98454">
        <property type="protein sequence ID" value="KXA98454"/>
        <property type="gene ID" value="AKJ40_04755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="142" mass="16444" checksum="56559B801D1F9C44" modified="2016-07-06" version="1" fragment="single">MYDVLDLYQEPYDPKRPVVGVDERPKQLIGEKKKPIPMKPGSPEKVDYEYVRNGSVNVFVAVDHKGGKRDAKVTDRRTKKDFATYIKRLIDKVFLDAEVVRLVVDNLNTHNGSSFYETFDKAEAERILSKIEFHYTPIHGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UW97</accession>
    <name>A0A133UW97_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000109">
        <property type="protein sequence ID" value="KXA98467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98467">
        <property type="protein sequence ID" value="KXA98467"/>
        <property type="gene ID" value="AKJ40_04730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="114" mass="13632" checksum="E02C2BBFDEF8C9F3" modified="2016-07-06" version="1" fragment="single">MELYPDRRPSGTYWKIRESYYEDGKVKKRNVLYIGKAEKVFERFSKPIPKDAELVTVSFGPAAALRWAFEDLELDILFTELFDSEEGHDFPAWKKIYLLVWRRFFQNLSMREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWA0</accession>
    <name>A0A133UWA0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_04745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000109">
        <property type="protein sequence ID" value="KXA98469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98469">
        <property type="protein sequence ID" value="KXA98469"/>
        <property type="gene ID" value="AKJ40_04745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="PTHR14025:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="47"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA98469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="157" mass="17934" checksum="92FA15F18A000136" modified="2016-07-06" version="1">MQEFHEKNSTAERKGEDTKASSLILKRNETKRLKKETERNSGSPNPKLEKVHGILQKHFRKRPKGRAMVFAEYRDTVESLTEKLNEYPNLRAEKFIGQAGSEGMTQKEQKEILERFDQGEFDILVSTSIVSHFGLSVVILPVGYLFIEAPLSRVIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWC6</accession>
    <name>A0A133UWC6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000109">
        <property type="protein sequence ID" value="KXA98470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98470">
        <property type="protein sequence ID" value="KXA98470"/>
        <property type="gene ID" value="AKJ40_04750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="65" mass="7493" checksum="0A838F6203AD5FD6" modified="2016-07-06" version="1" fragment="single">MLSPLKKGLEERAWRRSLKEVAKEVKNVKEEPDGADLEKARERTKSILRKILIADDVVGMKFREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWQ5</accession>
    <name>A0A133UWQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000101">
        <property type="protein sequence ID" value="KXA98615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98615">
        <property type="protein sequence ID" value="KXA98615"/>
        <property type="gene ID" value="AKJ40_04625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="114" mass="12884" checksum="48DE08730D1F756C" modified="2016-07-06" version="1" fragment="single">MSEKEDLDELLSKEDIELDKEDPNDIKRKVQVVEEELGNLWNLQWSYAKHLLKFGFAAWIFGISAFVSSLLIYKGPSLITETPAISISLLISAGAAPALITAFLVERHQRKINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWS3</accession>
    <name>A0A133UWS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000100">
        <property type="protein sequence ID" value="KXA98640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98640">
        <property type="protein sequence ID" value="KXA98640"/>
        <property type="gene ID" value="AKJ40_04590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="153" mass="17448" checksum="1F8D9AFBCE8BA804" modified="2016-07-06" version="1">MEIGVDTGDNAVSMVKSAMKNFPPEKIEYYGFDTFSGKNNNQLERVKRRLSKTGCRFELYKGDSTETLPRNIGDLTKMDLIFIDGGHAYQVTKSDWENSKVLMHSNTAVFFHNYDFSGPKKVVDDIPRKKFNVEILDPPSDCRTGLVKTRNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX35</accession>
    <name>A0A133UX35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000095">
        <property type="protein sequence ID" value="KXA98756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98756">
        <property type="protein sequence ID" value="KXA98756"/>
        <property type="gene ID" value="AKJ40_04475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="223" mass="25676" checksum="EF76E4629BE325A2" modified="2016-07-06" version="1">MPVIFDQPFQILLNLARDKKIDPWDVDIDKVANLYVDKIREMERLDLRVSGRALFSASTLLRMKADNPPYNGNGKEEDEIIEELNFDMPDLGPITILRQNPQQITLSDLASSLQEALEKKEDGKKKKKRVSTVKDVVWELDDYHLNIEEHIQDFHEKISLLASPGEKINFIQLLPVENKTEVCRNLLLALFLSSNGKVRLHQEEHFGDIFIELLEPFEGNNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX50</accession>
    <name>A0A133UX50_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tfb</name>
        <name evidence="10" type="ORF">AKJ40_04495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000095">
        <property type="protein sequence ID" value="KXA98759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98759">
        <property type="protein sequence ID" value="KXA98759"/>
        <property type="gene ID" value="AKJ40_04495"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1232"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="134"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="228"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXA98759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="322" mass="36587" checksum="B0537F846B4C4ED5" modified="2016-07-06" version="1">MLFNGVKIAKAKESSDINKECPTCDNSPVVRDYQRNITICGKCGRILKEGIKDRGPEWRAFDQEQREERSRGGAPMTYTIHDKGLSTKIDWKNRDGRGQSLSPQKRSRMYRLRKWQRRIRVSDATERNLAFALSEMDRMSSQLGLPRNIREIAAMIYRDAVKNQLIRGRSIEGVSSAALYAGCRETQMPRTLEEIAEVSRVDKKEIGRSYRFITRELDIHLPPTDPANYVSRFGSQLEVSGEVRTEAMGIIKKAQEEKLTSGRGPTGIAAAALYVATLKKGERRTQREIAEVAQVTEVTVRNRYKELAEELDLEINKSTTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX99</accession>
    <name>A0A133UX99_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000093">
        <property type="protein sequence ID" value="KXA98813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98813">
        <property type="protein sequence ID" value="KXA98813"/>
        <property type="gene ID" value="AKJ40_04420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="59" mass="6690" checksum="FB61303557A3C9A5" modified="2016-07-06" version="1">MCFGDNFDEKAVFIEFENLQPLDKPIKSEKGRGIQGTLYTTFTKIRESSSVLDLFGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXD1</accession>
    <name>A0A133UXD1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000092">
        <property type="protein sequence ID" value="KXA98846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98846">
        <property type="protein sequence ID" value="KXA98846"/>
        <property type="gene ID" value="AKJ40_04395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="237" mass="26609" checksum="6908348DA23AF3C0" modified="2016-07-06" version="1">MKSKILEQSIEKGIRSLTEYEAKQVLREYDIPCPNEFMIENGDMIEKLSDFEAKDAGINYPLYMKISSRDILHKTDAKVIAKASSDSEIVDKGRTILENAEKYNKDAEIEGILLSEDVSGEEKRELIVGSVLDEQFGHVISLGIGGVSVEVYEDVEFRAVPLERRDVFSMVENLKGRKMLQEFRGNPPVDMDSLVETVLKVSEILEENEEIEEIDINPLFVGPEGTVAADALITLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXL5</accession>
    <name>A0A133UXL5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000090">
        <property type="protein sequence ID" value="KXA98917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98917">
        <property type="protein sequence ID" value="KXA98917"/>
        <property type="gene ID" value="AKJ40_04300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="79" mass="9270" checksum="64CA8065CF1AE2EC" modified="2016-07-06" version="1">MSIEDRIAKIFEEEDNGYGLKSSYIAERLGLRVQRITPFLENSPRFKRASTNYFVVIEEGSSRRSNTHTDIKERYNHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXM0</accession>
    <name>A0A133UXM0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000090">
        <property type="protein sequence ID" value="KXA98921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98921">
        <property type="protein sequence ID" value="KXA98921"/>
        <property type="gene ID" value="AKJ40_04320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="89" mass="9851" checksum="368283324823E1C6" modified="2016-07-06" version="1">MSRSIPVSGDDGWDVEKIVGECMRVAPKRLTQEFKIKICELFAQHRYDEIVKVCWNELARAPMSAWDQDDAVLLIDTINSLNAGGGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXS6</accession>
    <name>A0A133UXS6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HisKA_7TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000086">
        <property type="protein sequence ID" value="KXA98992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98992">
        <property type="protein sequence ID" value="KXA98992"/>
        <property type="gene ID" value="AKJ40_04200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_7TM" evidence="2">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="156" mass="17922" checksum="490CDFB07F9C65F1" modified="2016-07-06" version="1">MYRPEGVLVVVLFLCSGVSILTLSISVYRNKRSPLSRIFFFLGMSGAFWVFAHLFELVSPGSFGTLLWGKLKYLGIATLPVFWLVFALQYTGRGRYVTWKSIALLLVVPIIVLFSLWTNSYHHLFYRELVIKDLGGVTYFYLTPPIFKFLRFGNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXS7</accession>
    <name>A0A133UXS7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000087">
        <property type="protein sequence ID" value="KXA98977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98977">
        <property type="protein sequence ID" value="KXA98977"/>
        <property type="gene ID" value="AKJ40_04230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="186" mass="20835" checksum="9FEA6C607595BAD8" modified="2016-07-06" version="1">MITARTTITEAEIMIGGGTKPSELAEERKKYLEKKREKEFRRMERGAAERALERVLGSGLEGMMVEDLEKGLKDEGYSEGVVRAAVERLQGEDQVRVEEDTIRSKGAARAGGEAYPDDDIHDFFVEKVRKGAAVVKVDGKWRAVLAPENYEGPRNLIKKGKSFEAIADLYKEDGKFRAWVKDVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXU5</accession>
    <name>A0A133UXU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000084">
        <property type="protein sequence ID" value="KXA99009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99009">
        <property type="protein sequence ID" value="KXA99009"/>
        <property type="gene ID" value="AKJ40_04165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="106" mass="12200" checksum="9576B0E8E6F585B2" modified="2016-07-06" version="1">MLRNNYSSGCIYFAKGLKLISLVAKKNRGKLKINNCPNCGRVVVHCPKCGDRHPITLVIKRKGVYELQGEDCHLDIDSHTWEEIETKFKKRSKSLENFPKIVEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXX0</accession>
    <name>A0A133UXX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000082">
        <property type="protein sequence ID" value="KXA99030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99030">
        <property type="protein sequence ID" value="KXA99030"/>
        <property type="gene ID" value="AKJ40_04120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1129"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="216" mass="23975" checksum="8472E249E0C5A3D3" modified="2016-07-06" version="1">MDLLETYGISIPKGEIVEDPERATEVASNIEGKIVMKIVSPDILHKSDIGGVKVNVARDKIREEYEDLIVRARNYQPDATILGVQIQEMTDIDTGVETILGMNRDPQFGPVLMFGLGGIFVEVLEDVSFRIAPISESEVREMINDLKSSPLLRGARGKKPVNIDSLVETMQRFSQLVSDIPAVLELDINPLVVTPEEAKAIDLRLTVDEERLGYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXX7</accession>
    <name>A0A133UXX7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable porphobilinogen deaminase</fullName>
            <ecNumber evidence="3">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ40_04095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="3"/>
    <dbReference type="EMBL" id="LHXU01000081">
        <property type="protein sequence ID" value="KXA99040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99040">
        <property type="protein sequence ID" value="KXA99040"/>
        <property type="gene ID" value="AKJ40_04095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="3"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXA99040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="285" mass="31485" checksum="8241F91777145BC5" modified="2016-07-06" version="1">MKIKVGTRGSDLALIQTRSVVKDLESCHPSAEVEIEIIKTSGDLKSKPFGDGVFVKEIDMVVLDRKIDMGVHSLKDEPTDLPEGLSLACVPERLNPCDILITRGGNGLRELAEGSLVGTGSPRRRREIQHLRSNLNFKNIRGNIPTRIKKVEKGKYDALVTSYAAVDRMDLEEKVSQEFDPKEVVPAAGQGALGVVCRSGEEKKLKLDRLNDERGYRQTSCERSFLRELGLGCRSGVGAIAETEGEYVRLFGVLNEGKERLIVQMEGEDPIELGKRAGEVIKNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY27</accession>
    <name>A0A133UY27_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_S49 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000077">
        <property type="protein sequence ID" value="KXA99077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99077">
        <property type="protein sequence ID" value="KXA99077"/>
        <property type="gene ID" value="AKJ40_04005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="2">
        <location>
            <begin position="113"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="280" mass="30327" checksum="995F3652EBDB648C" modified="2016-07-06" version="1">MVLVFKRLSGGGIRRKDSNSKKHFKVIGVLIVLALVAAGFYYLGSLDFGGVKVGKKPKVAVVNVTGVIENFQTAHRVSRTAEDKTVKAAVIKVNSPGGYVSPCFQLESAISKLAEEKPTVGAVGQLGASGAYLAVSAVDNLYVHHSSLVGALGVIAIWISYKEYYENKGIEHYVFKTGPHKDMYAPWRGPTENEKEMIRKEIDRIEDRMLGEIIQNRPSLENNLPLSLVGGEIVRGFESVEMNLAEGIIGTYGEAIEKAAEAAGLSEGEYQVVRAENLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY37</accession>
    <name>A0A133UY37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000076">
        <property type="protein sequence ID" value="KXA99089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99089">
        <property type="protein sequence ID" value="KXA99089"/>
        <property type="gene ID" value="AKJ40_03990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="81" mass="8984" checksum="0F1025DDDE4CC0C4" modified="2016-07-06" version="1">MHILYPRGAPPLELYCRREVKKVRPPRPRGGPPPWGDGAGKLGEVPFRAARRFEGRTAGCPELEPEISEIQTNGAKARPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY77</accession>
    <name>A0A133UY77_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000072">
        <property type="protein sequence ID" value="KXA99140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99140">
        <property type="protein sequence ID" value="KXA99140"/>
        <property type="gene ID" value="AKJ40_03870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="63" mass="6838" checksum="0FE328560C99D246" modified="2016-07-06" version="1">MRVPKHKGETMGLVAPYLDLSGFQALLGSQPWLEVVASASLCVILLVVLDRSALTKKLRGEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY81</accession>
    <name>A0A133UY81_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000070">
        <property type="protein sequence ID" value="KXA99162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99162">
        <property type="protein sequence ID" value="KXA99162"/>
        <property type="gene ID" value="AKJ40_03795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="90" mass="10269" checksum="45FB018CA3F9D58F" modified="2016-07-06" version="1">MEFGASFTCPSCGEEVAVSIKQEDEQWDINIEKPESKGGLKKEKESEETEKETTEKETEEAEIMSRMDQIEEEVGEQNEEQISEGESRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYA2</accession>
    <name>A0A133UYA2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000069">
        <property type="protein sequence ID" value="KXA99176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99176">
        <property type="protein sequence ID" value="KXA99176"/>
        <property type="gene ID" value="AKJ40_03780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="90" mass="10780" checksum="3950E1C571055027" modified="2016-07-06" version="1">MKAKLVTYRTEKLNKSEKSKLSKKLYGYTDKSHHGKYVYEREGLLDKTKHIKIYKNTFIVPIENWAPIKKELKKRKANIKTWDIILLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYF9</accession>
    <name>A0A133UYF9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rio2_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000065">
        <property type="protein sequence ID" value="KXA99215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99215">
        <property type="protein sequence ID" value="KXA99215"/>
        <property type="gene ID" value="AKJ40_03665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rio2_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="183" mass="21268" checksum="795EDEA2B0C1D1E0" modified="2016-07-06" version="1" fragment="single">MTLKAIEIFHDVEEKDIELLSDLEEAASRFEWIPEDRLSKIIDLPEQDIEYRLDRLNKFELVERGIAKYRGYRILPPGFDLLALNSLVQRDVLEAFGIALGIGKEADIYDAITPEEKRVAVKFNRLGLTFTRLKEKRSYRPKHGWIDASKKAARREFEVLEKIYPDVEVPEPIAFDRHVLVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYG3</accession>
    <name>A0A133UYG3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MmgE_PrpD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000067">
        <property type="protein sequence ID" value="KXA99194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99194">
        <property type="protein sequence ID" value="KXA99194"/>
        <property type="gene ID" value="AKJ40_03710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="1">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="92" mass="9911" checksum="CCEC1EBF6D4DDE54" modified="2016-07-06" version="1" fragment="single">MTVYSEKLASYVLGLTFDRFDESVIDRSKELILDFLGSAVAGSTVSSSQMIIETISRWGGIEESTIVNNNKKVPSLNAALANGTMGHALEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYG6</accession>
    <name>A0A133UYG6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000066">
        <property type="protein sequence ID" value="KXA99207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99207">
        <property type="protein sequence ID" value="KXA99207"/>
        <property type="gene ID" value="AKJ40_03695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021219">
        <property type="entry name" value="DUF2703"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10865">
        <property type="entry name" value="DUF2703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="143" mass="15768" checksum="0CDC5F6054BF4070" modified="2016-07-06" version="1">MTLNIRWQRLVSGGDTCERCRLTEEEVDEAVGKLIRALEPLGIDVELEKDSLSREEFEENPTISNMIHIDGRPLEKWIDADIGQSECCEVCGDEECRTVILGGEEYEVVPADLIVNAGLRAVSRVPSDGECCSSSGEYPCCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYI0</accession>
    <name>A0A133UYI0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000061">
        <property type="protein sequence ID" value="KXA99260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99260">
        <property type="protein sequence ID" value="KXA99260"/>
        <property type="gene ID" value="AKJ40_03555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="80" mass="9340" checksum="699393108C7C7020" modified="2016-07-06" version="1">MKLRKLYFFISISLYSQGSSTRTGCEHPRIHEFKDWLEIELIAFKVLEEHGTSLHYSQLSPKKIEGDSSVKNIQNQNLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYI7</accession>
    <name>A0A133UYI7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000062">
        <property type="protein sequence ID" value="KXA99249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99249">
        <property type="protein sequence ID" value="KXA99249"/>
        <property type="gene ID" value="AKJ40_03600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="176" mass="20270" checksum="C4AC6929A164F3CE" modified="2016-07-06" version="1">MNKLRSGFFEIFKISLDKNYRLESNQKLNKESFTGKEKQGDNMSRDPFDEFRKIEEMFRKMLNSNDLSMGGTSRGISVQKIGNNVKVDVHGDISERELERLKRKYPDAEISVNGEQIEGSAPVEVLDEEDPKETKGVSGGEKLRQPEIEEVDEEEVDPGELALRRFKEKKKEEPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYM9</accession>
    <name>A0A133UYM9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000057">
        <property type="protein sequence ID" value="KXA99322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99322">
        <property type="protein sequence ID" value="KXA99322"/>
        <property type="gene ID" value="AKJ40_03415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="136" mass="14597" checksum="535471053E9C36EE" modified="2016-07-06" version="1">MNGENTDEKNRYKESTRVAILLAVTAGVLFGFRAVFIESITQTIGVFDLLSPEDWVVFLKSLSFVAIMLSQTGGIIALVGALRTGRVAIVGPVTMGFVLFVPVLLGLTYFGESLDLFKAIGILMIGVGSIGLAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYN1</accession>
    <name>A0A133UYN1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000058">
        <property type="protein sequence ID" value="KXA99306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99306">
        <property type="protein sequence ID" value="KXA99306"/>
        <property type="gene ID" value="AKJ40_03470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="103" mass="11646" checksum="F8BD91F72709AC98" modified="2016-07-06" version="1">MSLIKEIEEQLPLPVYPRPGLCQVLQKQGVDVDTATELRATKVFDSGEAGGIVCSIIDKGGRIDEEKQPIVVSLTHLRVKQDHPLSQKISNYQRRRRKNLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYP3</accession>
    <name>A0A133UYP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000059">
        <property type="protein sequence ID" value="KXA99284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99284">
        <property type="protein sequence ID" value="KXA99284"/>
        <property type="gene ID" value="AKJ40_03495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="107" mass="12473" checksum="6A33609B49CDA4A5" modified="2016-07-06" version="1">MEILKDIEINLNRDLVFDSPPLSKWIKSEKTRGKLEKLLDKWSKKIERRLSVKAIYNILKREETDIEEYSPPDPILEAEYLAMGIVTIGKQIEKDSEKSNSTRKGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYP8</accession>
    <name>A0A133UYP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000058">
        <property type="protein sequence ID" value="KXA99303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99303">
        <property type="protein sequence ID" value="KXA99303"/>
        <property type="gene ID" value="AKJ40_03450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="74" mass="8089" checksum="EFC0118164B3C1F1" modified="2016-07-06" version="1">MDFLEEKDIEISLDKLTCDFDEGLACPGAKPSEIEGKGIEEGSVVDAPSRLKQWPVQLRLVPTKLLSSTLPNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYR9</accession>
    <name>A0A133UYR9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000057">
        <property type="protein sequence ID" value="KXA99323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99323">
        <property type="protein sequence ID" value="KXA99323"/>
        <property type="gene ID" value="AKJ40_03420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="123" mass="13264" checksum="9ADAFB2EBABB37AF" modified="2016-07-06" version="1">MFELYLLIAIIAAALLGLSQVFLKKGLDRVPSLKLEWEAIKRAVNDLMNNYFITAVVLGLGGGLSHLVALSMGKITIVQPLMSFASFVAVALGVLWLDETLSKTEYCEIGLILGGIILLSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYS7</accession>
    <name>A0A133UYS7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000057">
        <property type="protein sequence ID" value="KXA99324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99324">
        <property type="protein sequence ID" value="KXA99324"/>
        <property type="gene ID" value="AKJ40_03425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="103" mass="12325" checksum="6A639F2494CF829F" modified="2016-07-06" version="1" fragment="single">MVRRLVSVFVVIKVEKTIKCKITDLTERKREALEREYKNLQKYLHENEDVELYSANKQQADRYYEEIKAGKEYPISVRKDLIDLKIMDNVVSKYWLKVRVGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYT1</accession>
    <name>A0A133UYT1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000056">
        <property type="protein sequence ID" value="KXA99338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99338">
        <property type="protein sequence ID" value="KXA99338"/>
        <property type="gene ID" value="AKJ40_03375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="232" mass="26222" checksum="9F6828EA88F33D36" modified="2016-07-06" version="1">MKDGTEVEGWEINFRGLKGFKVVKGPKIVSSNPLVKDTDNDGLMDFEEKNLGTNPSSQDADGDSCTLWTFKVNMNDYREVHVYGTDPTRYDSDNDGKSDGDEIHRGTSPTGENKEPKPTYKEVKEFLEEDTTNENEYVPPPENFHYESRPYTCGSFSATLSRNASERNMRSGIVTLFYAGKSGLVGGHSIVAFDTVDRGLIFVEPQTDKIYPDLEVGNEYRKRTIRSLNIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYX0</accession>
    <name>A0A133UYX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000054">
        <property type="protein sequence ID" value="KXA99371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99371">
        <property type="protein sequence ID" value="KXA99371"/>
        <property type="gene ID" value="AKJ40_03305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="120" mass="13891" checksum="7225177E617A8E28" modified="2016-07-06" version="1">MKPSVETFLALSTPVVFLIQGFGRCQNFLEGASRGGKERKEKREPRTGPVVHTFLGTEAELRVPGRMQIRRNDSFHRPYRGERTINLRGGFRRAAEDSSEEYLEEVKEILKSSFPRRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ01</accession>
    <name>A0A133UZ01_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000052">
        <property type="protein sequence ID" value="KXA99404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99404">
        <property type="protein sequence ID" value="KXA99404"/>
        <property type="gene ID" value="AKJ40_03225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="107" mass="12088" checksum="18C84C2865990AF4" modified="2016-07-06" version="1">MPPVPLRPSCPFPPFVPFFTAVSGGVAEKEIRRVAKLVKSAKKEGKTARHFRRLETRRAGRRKQRMGPRAEEMEAEEKQEPPEARSSPFPVPSHPLTSHSFAQDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ16</accession>
    <name>A0A133UZ16_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrothymine dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_03195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000051">
        <property type="protein sequence ID" value="KXA99421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99421">
        <property type="protein sequence ID" value="KXA99421"/>
        <property type="gene ID" value="AKJ40_03195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044512">
        <property type="entry name" value="DPYD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="PTHR43073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="407" mass="45093" checksum="CBC1E835FC7F86D8" modified="2016-07-06" version="1">MKNPDISVEVCGLRFKNPIVLASATPTKSPEKMLKGMKKGAGGVIAKTVTDEPLLQKYVRPRFTVLHKSGWPQVYSNYSCEYLYPGTPEEWLDELEKTKEYAEKYDSVLIGSVSGRTVEKWAEMARKTEEAGADIIEMNFGCPHPKSGKKMEHKEGTEIGQDPEMAAEITKAVKNETSVPVFAKLTPENTRVEDVTKKVEKAGADGVTAINRFQALDIDIEAEGRPLLHGDYAGVGGPWMRPLTLKYLTRVAKEVDLPISATNGVSTWKDVVKMIMCGATTVQTATAIIYGGKGYDPVEQFNNNLEEFMAEHGYSSIEDMCGVTLDKIIPFEDVEREPDVWSEVVQEECTQCGLCENWCFYNAIQSSEDRVGIEKEKCDGCGLCVSLCPQSAIEMKGETPVYFGDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ35</accession>
    <name>A0A133UZ35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000050">
        <property type="protein sequence ID" value="KXA99440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99440">
        <property type="protein sequence ID" value="KXA99440"/>
        <property type="gene ID" value="AKJ40_03160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="84" mass="9583" checksum="CE75A31674FC1BEE" modified="2016-07-06" version="1">MKTSTTGGSHVEIWDPSMRMKRKGWKLENTRDSLHEPGGKTVGGALTLKTKDPDPTEVQTQLHFSRPREIGLYIRPSLPKRHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ44</accession>
    <name>A0A133UZ44_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000050">
        <property type="protein sequence ID" value="KXA99437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99437">
        <property type="protein sequence ID" value="KXA99437"/>
        <property type="gene ID" value="AKJ40_03145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="116" mass="13147" checksum="29E3CB3DD90AA96F" modified="2016-07-06" version="1">MKRTSSSRTCRTSVSENSPGRKPKSSWRTSPSHPSTRGKKNSGRISKKSEEGIREEALNRKPVPFEPPDEPNQLAAMGPYSTGSPLGYVSEKQEELKKDLSRELEKMQKREYPGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ59</accession>
    <name>A0A133UZ59_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0145 protein AKJ40_03030</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000047">
        <property type="protein sequence ID" value="KXA99478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99478">
        <property type="protein sequence ID" value="KXA99478"/>
        <property type="gene ID" value="AKJ40_03030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="104" mass="11197" checksum="9955F0B623BB8ACE" modified="2016-07-06" version="1">MIIANTDFIAGKKVKENLGLVRGNTIRAKGLGKDIKAAFRNIAGGKIDEYVDMLSESREEALNEMVEKAEEMGADAVINVRFMTSSVMGSAAEILAYGTAVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ75</accession>
    <name>A0A133UZ75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-dehydroquinate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_03045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000047">
        <property type="protein sequence ID" value="KXA99481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99481">
        <property type="protein sequence ID" value="KXA99481"/>
        <property type="gene ID" value="AKJ40_03045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.737"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="251" mass="28106" checksum="301138A78EFB1ECF" modified="2016-07-06" version="1">MITIQDLWKDYNGKTALRNVDLEIKEGEIFGLLGPNGSGKSTLMKTIIGMIRPTKGNVRVNGVDPSENDIEVKKMVGFVPESPQLYESLSPKEFFEFIGSVRGIHANSLERVEKLIDAFEIWDDVNSDIGSLSFGMRQKVSIIATLIHNPKVLILDECMNGLDPKSVRVLKEFLNSFSKKGGTVVYSTHVLEVAEKMCDRVAILRKGNVEAVGSVEELRDILKSQSLEDIFFKVTEEEDFEPIIRALEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZB6</accession>
    <name>A0A133UZB6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000045">
        <property type="protein sequence ID" value="KXA99517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99517">
        <property type="protein sequence ID" value="KXA99517"/>
        <property type="gene ID" value="AKJ40_02940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="273" mass="30767" checksum="8287373B3230E3C7" modified="2016-07-06" version="1">MNLKKFSMSFAIVLAISLAVFIYPETVSADQLEGRINVTEPSVGNEPPIASIGGPYSVMEGGKIELDGAESRDPDGEPVDYSWKITSNLSRKAILEDSQTSTPFLHAPLVDSDRKIIVSLTVKDEHEAVDREKTVVTIKNNPAPADFSLTDLSIDPENPKPGEIVTISTKVRNHGEQTDDYEIELLIENRRENTETVELDPNTAKIVQFTTSRENEKTYRVKVNDLTGSFTVEKPLIIHPLLITISLFLAVIILIILFWWFFKDRRDEKRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZB8</accession>
    <name>A0A133UZB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000045">
        <property type="protein sequence ID" value="KXA99520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99520">
        <property type="protein sequence ID" value="KXA99520"/>
        <property type="gene ID" value="AKJ40_02955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="111" mass="12875" checksum="D9CBF8038B25C040" modified="2016-07-06" version="1">MSLEESLTEFLEDGDDWERKKTSVDGVFTLKLPEYKGNPPRLAVELNPTDSSGKPTKKRGLMIFNMGELEDFREMINEERLDGLMENIMEVNPEKGKKKRPEEEKEDIIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZD9</accession>
    <name>A0A133UZD9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000042">
        <property type="protein sequence ID" value="KXA99568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99568">
        <property type="protein sequence ID" value="KXA99568"/>
        <property type="gene ID" value="AKJ40_02830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="86"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="284" mass="30002" checksum="90F9708E8087C1C9" modified="2016-07-06" version="1">MLISIFLPETVRERKDLHLDFFGVLTFGVIIASFMLIFKNLSSNALLSSAVFPFLLALSAAAVFFILNEKRLDHPAVDLSFFSRPEFSAAILVGILGGVGMFLFQTMIPSFAQVSLGYSVSTASYSINAMAVTMIIFSAVSGRGCDRLGPEKLMLFSVVVTAVACYLTANFVGGEISYYLTIALAGVGLGSLITPINYIAMRGAGKGSEGVGSGMASLSRTAGGVVGPTVAGFIISQASLSGLSAMENLLNAYSKVFMFGFWVCIAAAFITVALITIRRLRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZE4</accession>
    <name>A0A133UZE4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000044">
        <property type="protein sequence ID" value="KXA99539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99539">
        <property type="protein sequence ID" value="KXA99539"/>
        <property type="gene ID" value="AKJ40_02920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.711"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="337" mass="40011" checksum="28EEF8DE010561A2" modified="2016-07-06" version="1">MDILIRFGFLIKHGMKITRKRAKKLYKVLEEEKEKIRKENEEGEDEYPYEKWERERKEIVERLRELPDLVEEAASRIEFDRPNRGRKQKLDPEQKTMLFLFARLTQKSNRDMEAILSLLGPAFGVDVSYKTIERLYSDEEVKMVLHNLFLLLIDKEDISGDCSGDGTGYSLQAGKHYRSESEKNGKKYRYVFRLVDLQTGMYIGYGYSNKSEKRAFKKAVKFVKKYNIPFHKVRLDKYYSNKKDIQELGEDVEACVLPKKDLSNFGYEWHEILNKIKEDPYGFLKDYFKRELSETFFGADKKRFGRKISQRREDRRETASFATAILHNLFTIRLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZI3</accession>
    <name>A0A133UZI3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000041">
        <property type="protein sequence ID" value="KXA99580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99580">
        <property type="protein sequence ID" value="KXA99580"/>
        <property type="gene ID" value="AKJ40_02785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.677"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009185">
        <property type="entry name" value="Nucleotidl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005928">
        <property type="entry name" value="Nucleotidltrnsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="232" mass="26851" checksum="8E39A571FBE210E5" modified="2016-07-06" version="1">MVRPRKTVTRRNVDYSEEDWKRLDSFRSMAVEILEALKKFDIFGLVHGSVARGDVNESSDIDIIIPDSIPSFKVELALKENGFRNLDRRIVMATPWQLPKAHIYVEGNRMVTIPLEKPKRLEEDFYKFGGAASLEQIENEERVPGVDKRLVLIEPIKNGHRESQVIGREKEVAKILDVGIEIVEERIHVLLKRDEIGRTGVFLERELTPEESFESAWNQITKNNPQITKRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZJ7</accession>
    <name>A0A133UZJ7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerB_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000039">
        <property type="protein sequence ID" value="KXA99626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99626">
        <property type="protein sequence ID" value="KXA99626"/>
        <property type="gene ID" value="AKJ40_02715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025266">
        <property type="entry name" value="TerB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13208">
        <property type="entry name" value="TerB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="256" mass="30402" checksum="D91CBCBB7973630A" modified="2016-07-06" version="1">MNSEPRKSEKYSNVPEFETHFPSISDMSKEQESFYKHWLRRWKENDPIDVEGNISYLFVYVYDVLSWIRENRFEDVISELEKIRKVYKHEEKIYRSLGGWIADTYIIKGEYKKALEVQKSASLKLTNDKYLSLKRNLGLSLDGEDALSICRKKDLTDYGRAHREKVEKALTKVLREYENKNQTKLIEDFTNRHRNENLPGEFPLYNATPGIIPFENQYIDDLNYYKLDLKKARNVLTQENREGLSLIRKAENIARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZN3</accession>
    <name>A0A133UZN3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000039">
        <property type="protein sequence ID" value="KXA99629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99629">
        <property type="protein sequence ID" value="KXA99629"/>
        <property type="gene ID" value="AKJ40_02730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.627"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="436" mass="50347" checksum="E14F82E2A4898263" modified="2016-07-06" version="1">MADVFRHMGFEEVRITRRTSDKGRDILMKEHLEGDEPCYVIVECKHTKRVSRPVIQKIHSAVTTYHYDGKKRGIVVTSGKFTNPAREYVEEVNQGTGTKVIQLIDGRDLRNIGDDIGLNLYNGKIEVLCDETLPHPPDLRTVSSKIRQEFMSINAFKQKHYTEPDCSIDFLPTLNISARIDSTFETSVGVIHQINEKDNIVILGKRGSTDLLNQKVARMAQKNLKKSINLEKEKLEEKFHNINVLRFGKTETDYKEEAIDILRKKHETKVTYTGDNNVTYHKECTPKKSDITILNITPVYVPLVKTKTEIKKYSYPFQYLSAHPETVKYGDKIHICVQCGKSNGTTFTYCKNCGSINCPDHTKTERLEQTPICTGCAIREYFFYKEKYFYNEENLKKFRKIYEKMPFYRKALENKTLTAIIIALITIMTIIILSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZQ6</accession>
    <name>A0A133UZQ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000037">
        <property type="protein sequence ID" value="KXA99668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99668">
        <property type="protein sequence ID" value="KXA99668"/>
        <property type="gene ID" value="AKJ40_02660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="67" mass="7873" checksum="B2DEA6FA6977AA90" modified="2016-07-06" version="1">MEPDAVFRASFRYALLNTEPEMMLNRELRSYESVACFRPKFSAEIHQGENVFRSRSGEMVQSLVERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZQ8</accession>
    <name>A0A133UZQ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_02650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000037">
        <property type="protein sequence ID" value="KXA99667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99667">
        <property type="protein sequence ID" value="KXA99667"/>
        <property type="gene ID" value="AKJ40_02650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.608"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXA99667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="485" mass="53191" checksum="1D3A3AA0F560060E" modified="2016-07-06" version="1">MRPIYVYISVAIWAIFGILIAYFARKRMGEGIPEFFIGGRNIGGFVSGMTYAATTYSAFMMVGLVGLTYASGVVALGFELTYLIFTVFLLLVFAPRFWAAGRRYGYTTPPDLLADRYENKYVGVAASGLAMVMLVPYASVQLMGSGYLFSGITGGQVPFMVGVLIMAVFSGITAYWAGFRSVSWTDAFQAITMIVTSILLLFFVFYHFFGSPTGFFETIEAEAPQLLRINWDFQKFLGLTLPWAFFALSNPQVSQRMFVSENIASLKRMIIYFSIFGFIYTVITALFGFSINVIEPGLETADNAMPVLLNRVPIILALLAFVGIFAAATSTLGSIVLTLSSLGTENIVKPIKPGISEKKRVFIGRLMILGLLVVCIGFASLKIDLIAVLSSMASGGLMVAIPAFFGAFFWKEGTAQGALWSIVIGGLLTGSLYISGYYPFGWWPPVWGIIATTIIYVTVSLLTEPPDKADRFLDYIDGEIEKHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZR2</accession>
    <name>A0A133UZR2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trpD</name>
        <name evidence="6" type="ORF">AKJ40_02630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="LHXU01000036">
        <property type="protein sequence ID" value="KXA99683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99683">
        <property type="protein sequence ID" value="KXA99683"/>
        <property type="gene ID" value="AKJ40_02630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.601"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="77"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="111"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="351" mass="37799" checksum="8E8597058F049837" modified="2016-07-06" version="1">MNSLPSAIEKLVKKRDFGPREAKESMRQIMSGRATPAQIGAFLTALRIKGETPTEIASFARTMRSFAHTIQPKVDDTLVDTCGTGGDEINTFNISTSAMFVAAGAGVPIAKHGNRSVTSKSGSADILEALGVNIDSPPEKVEKTIEEIGVGFMFAPNFHKAMKHAVGPRKEIEMRTVFNVLGPLTNPAGAEAQVMGVYDPDLTEKMAKVLKKLDCRKAMVVHGLDGLDEISILGKTKISQLSNDKIQTYTVEPEKFDIPRTQPEEIAGGNPRENAKTLLKLLKGEEGPKADIISLNAAAAIFVGGKAASLEEGIKIAKNVLDSGRGYEKLVQLVKVSEGDENRLRELEDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZR5</accession>
    <name>A0A133UZR5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-dehydroquinate synthase</fullName>
            <shortName evidence="3">DHQ synthase</shortName>
            <ecNumber evidence="3">1.4.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate synthase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroB'</name>
        <name evidence="4" type="ORF">AKJ40_02600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:25956"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="EC" id="1.4.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal-type DHQ synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.24" evidence="3"/>
    <dbReference type="EMBL" id="LHXU01000036">
        <property type="protein sequence ID" value="KXA99678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99678">
        <property type="protein sequence ID" value="KXA99678"/>
        <property type="gene ID" value="AKJ40_02600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.595"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102042">
        <property type="term" value="F:dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01244">
        <property type="entry name" value="Arch_DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002812">
        <property type="entry name" value="DHQ_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33563">
        <property type="entry name" value="PTHR33563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01959">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006655">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="366" mass="40425" checksum="45F72F7FC77B0DD0" modified="2016-07-06" version="1">MSKEVWVKADWSEPWEERKKFITSALEAGAEAVIVPNEDVEKTRKLGNIETISKSEESDFFLREASNVEEVEDAISKSQKSDKKSVLLVEVSGKEMEKAVARAGNQVDYLIMIAQDWKVIPLENLIAELQTTHAQLFTGVKNAREAKTAVETLEVGADGVLLDPKIGGIEEIRKTREVLEELGQEKFELVCGKITKIETAGMGDRVCVDTASLMKVGEGMLVGSQSNGLFLVHSETLESEYVEARPFRVNAGAVHAYIRAPGGKTRYLSELESGDKILIVNSEGEASAATVGRVKIEKRPMLLIEAEYEKRKIKTLLQNAETINLVNKNGDPISISDLEVGDEILINLQEGGRHFGVQVEETLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V040</accession>
    <name>A0A133V040_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000030">
        <property type="protein sequence ID" value="KXA99804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99804">
        <property type="protein sequence ID" value="KXA99804"/>
        <property type="gene ID" value="AKJ40_02365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="96" mass="10939" checksum="FE4C79C5D905C700" modified="2016-07-06" version="1">MIGMKEFSNSKAQVVSGRLLYQTTEASNFHHPNASLRSAPQNYHHQTKNYQEDKEITVDRWGGFTNGLRRRLKISKAPLHSLDIRRAFPSRSIASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V051</accession>
    <name>A0A133V051_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000030">
        <property type="protein sequence ID" value="KXA99805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99805">
        <property type="protein sequence ID" value="KXA99805"/>
        <property type="gene ID" value="AKJ40_02370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="141" mass="16001" checksum="D355E6C6C24DAD60" modified="2016-07-06" version="1">MLHILELLFTGAEVSLLSISSLLPVFLALTLPVAALLVGFFLSRLFTPRDYSKEKYDRFEAGNPPTGRARGYLAMQYYPYLVVFLTVEPVLIFIFLSIMSLHEYTLLVGSLFAILTIILALPLAFALDSARRLKLWIMRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V091</accession>
    <name>A0A133V091_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000029">
        <property type="protein sequence ID" value="KXA99835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99835">
        <property type="protein sequence ID" value="KXA99835"/>
        <property type="gene ID" value="AKJ40_02355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014424">
        <property type="entry name" value="UCP004897_ACT"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004897">
        <property type="entry name" value="UCP004897_ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="167" mass="18459" checksum="CA3AC2117732AEFB" modified="2016-07-06" version="1">MRAKVRRFFKGNPAQLKVARVLYKYGFRVSENGDILCGDIRIPAVQIAEEASVDRRAVDATSETILNNEELREIFSNLRPVPFLKGIARPLGLGLIEIIPTDATQAGIISEVTNVISDHGLSVRQSIADDPYFTAQPKLTIITTELIPGEVVEELRELPSVKSVVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0M7</accession>
    <name>A0A133V0M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99965">
        <property type="protein sequence ID" value="KXA99965"/>
        <property type="gene ID" value="AKJ40_02075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="75" mass="8941" checksum="B8FD6D50835D2655" modified="2016-07-06" version="1">MKTENPLFQSLDTERVAEEIYEIHKKLDERNFGTKARQLSKEIPHLRKNAIGYVCRNSDRFRLVSESSRRYIRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0P5</accession>
    <name>A0A133V0P5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000023">
        <property type="protein sequence ID" value="KXB00005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00005">
        <property type="protein sequence ID" value="KXB00005"/>
        <property type="gene ID" value="AKJ40_02055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="315" mass="34174" checksum="BFB63C8AED74DCBF" modified="2016-07-06" version="1">MIGKLLKNPILWASVLLICMGAFVPSLAGGYTVNVFIMVFIYIVVALGWNISSGFLGYVNLGYAAFIALGAYTTAYMLNLGYHWTFAILTAGIVGGALIGLLVGLVLGRLRGVYYAITMIAFWQATRVLASSNQLAWFTGGGRGTYAPNALGQTAVMRILTVVVVFAFLFTAFLARSKLGLKMLSIRSDESAASMTGIKTWRIKNISWAISNFIGAIGGGILAIHVGYIDPVAIFNPLYILIPVVMVVFGGRGSVIGPIVGGLFLGFLKNWLWARFLALDFAILGITLIVVLYFMPQGLIPWLKENNILPRTRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0R1</accession>
    <name>A0A133V0R1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000022">
        <property type="protein sequence ID" value="KXB00032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00032">
        <property type="protein sequence ID" value="KXB00032"/>
        <property type="gene ID" value="AKJ40_01975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="139" mass="16286" checksum="BA830D23804FE1C9" modified="2016-07-06" version="1">MKNGKAFAQVLLYLRTKLRKRDRSDIKSFFRNEVVTYDRLRKVSVKQLGLHYPDTSPEEDVLNAYRNNEPVTIIYRDRNGTKTSRMIEPLKVETDPYSGVRRIKSYCHLRHAERTFLLERIVDAIPANTELSVISKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0S1</accession>
    <name>A0A133V0S1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000022">
        <property type="protein sequence ID" value="KXB00034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00034">
        <property type="protein sequence ID" value="KXB00034"/>
        <property type="gene ID" value="AKJ40_01985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="159" mass="17160" checksum="5E84615B53389044" modified="2016-07-06" version="1">MARKIRMTVNGEKRQLEVEDNELLAEVLRDNLGLTGVKMGCESGNCGVCTIVMEGEAVLSCSILAPQADGSEIITVEGLSKMHEGEGLHPIQEAFIDNHGVQCGYCTPGFLMSTYALLKENSNPSEDEIRKAVAGNLCRCTGYDKIIKSIKSASEMMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0S5</accession>
    <name>A0A133V0S5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000022">
        <property type="protein sequence ID" value="KXB00040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00040">
        <property type="protein sequence ID" value="KXB00040"/>
        <property type="gene ID" value="AKJ40_02015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.402"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="292" mass="31286" checksum="31F682FBB74DF3E5" modified="2016-07-06" version="1">MVAIPVGLILNAIFKGGLYGMVAMGLAISFGMLDIVNIAHPTLMVFSSYLLMMFAAVTDLPLEVGLLVFVPAFFVLGLLIYRFIGSTIGGADQPIRMLVFFFGVALVVQMISLFGWGSQWQSLEVFWAGRPLNLGWGVILRLGYVVTMIMAVILYGAFEYVLRNTYFGLSIKSVAQNEELARVSAISPARTKMVGFGISLAIVAIAGYFWGGIHLFSPFSGLHELGLVFSIVVLGGMGSVIGSLVGGVLISVGMSLMGYYGSAPLVPAVPFIVILFVFFVRPAGLLGKGFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0T7</accession>
    <name>A0A133V0T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000021">
        <property type="protein sequence ID" value="KXB00060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00060">
        <property type="protein sequence ID" value="KXB00060"/>
        <property type="gene ID" value="AKJ40_01940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="80" mass="9398" checksum="681C5D58ED5ED814" modified="2016-07-06" version="1">MVDLLLAARISYVLGIVNLVSMSLVVLSCRCMMGVGFVNRMQEYAWYRRFYRAHCYYWWIFFLSVLFHAVLAVTAFGNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0W4</accession>
    <name>A0A133V0W4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="10" type="ORF">AKJ40_01890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="LHXU01000020">
        <property type="protein sequence ID" value="KXB00093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00093">
        <property type="protein sequence ID" value="KXB00093"/>
        <property type="gene ID" value="AKJ40_01890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.343"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="2"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB00093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="446" mass="49742" checksum="608A4D30F79ECFB7" modified="2016-07-06" version="1">MKDVKDRAAEAKQASLELANVTEEVRNEALEEAAAAIEENRPRILEANEEDVTEANKLLERGEYSQALVDRLKLSEEKIDSISRMIRSVSERDDPLNKTISARKLDEDLKLYKVSVPIGVVGSIFESRPDVLPQISSLCLKSGNAVILKGGSEAEKSNRVLYQIFKEATEGVGIPEEWIQLIEARREVRELLELHEKVDLLVPRGSKSFIKYIQDNSRIPVLGHAEGLCHTYVDKEADLEKALKISYDGKVQYPAVCNATETLLVHQEIAEDLLPELAEKYRKAGVELRGCERTRDILDQIDEATEEDWRTEYLDLIISIKVVDGIKEAIGHINKYGSKHTDAIVSQKGSRLLEFMTGVDSSSVMANASTRFSDGYRYGLGAEVGISTGKIHARGPVGLEGLTTSKYYLVGDGQIVGDYVESEGKTFEHGELSDTWKEESDSLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0Z6</accession>
    <name>A0A133V0Z6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000019">
        <property type="protein sequence ID" value="KXB00123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00123">
        <property type="protein sequence ID" value="KXB00123"/>
        <property type="gene ID" value="AKJ40_01825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="508"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="621" mass="69599" checksum="D012C8DB14F37B2C" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V122</accession>
    <name>A0A133V122_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000020">
        <property type="protein sequence ID" value="KXB00096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00096">
        <property type="protein sequence ID" value="KXB00096"/>
        <property type="gene ID" value="AKJ40_01905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="153"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="352" mass="40230" checksum="2257D951F032577A" modified="2016-07-06" version="1">MHGKFRTAAKARSEAMRTFAGFFDPAPNSVYGSFDLAQSIMKMGMEGTSAESRSRPSPDVVLRRLYEVDEKSARRELENFNEWIFGELFSSRELTIAVDFTVIPYYGEENLMLVSDSRLPGTNLGIKFAVLSVVEESKTLTLKTKQVNPIESEVSVLGEMLDYAEEVLNPSLVLLDRGFYSVEAIGELKSRSMGFTMPAKKTNPVKKTCKKFKKGEAPPEIGYTVSGAKGEEDVRLLLTEKETENGTEIHPFITNLEITPEEASENYSWRWRIETNIRELEKFKPQTTSQSMELRRLYFLFSVTLYNLWIITRNGSEHPRAREFKEWLEFELLAFKVLEEYMAEPPPPHTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V169</accession>
    <name>A0A133V169_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_01695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00188">
        <property type="protein sequence ID" value="KXB00188"/>
        <property type="gene ID" value="AKJ40_01695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.295"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="248" mass="27593" checksum="2C8B406B5931F329" modified="2016-07-06" version="1">MAKNKVLTVKNLNSGYGKAQVLDHVSIEAYRGEITLLIGTNESGKTTLLKTICGLVEPWSGEMMYHSDGEEISLVGRVASEIAEMGIVYIPDERSVFPELTVKENLMIGSFREKSRDILDENLEIVYDMFPKLKERSQQNAGTLSGGEKQMVAVGKALMADPDFLLMDEPSLGLAPILVKNLFEIIDRLKEEYGLSIFLTEQNFEQSIKIGDRGYIIVDGEITFEGDKSELKDSEMVSKHYLGGAQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1A3</accession>
    <name>A0A133V1A3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000016">
        <property type="protein sequence ID" value="KXB00224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00224">
        <property type="protein sequence ID" value="KXB00224"/>
        <property type="gene ID" value="AKJ40_01625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="274" mass="30410" checksum="F71E4E3600C73A0B" modified="2016-07-06" version="1" fragment="single">GRIMTIAERDVITIPPSLPIKEASEKMVRNGVRRLPVTSPGTEKLHGMLVTRDIVDFLGGGEKNQIIEKKHNHNFLSAINDPSKIIMDRDAPYADNKSSISDVAKILIEKNVGGTPIVDKERKVVGIVSERDFARYIPSPAQTRVEAHMTQNVVTAEPDLFLIDIMKRMINEGFRRLPVVDNNKLVGVITSVDVLEYFGTSEMFEHMSSGDAKDAMAIEIRELMTKNPITVDPKADLGETARRMEKHGYGGLPVVENGKLVGLITERDIVELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1D6</accession>
    <name>A0A133V1D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000016">
        <property type="protein sequence ID" value="KXB00231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00231">
        <property type="protein sequence ID" value="KXB00231"/>
        <property type="gene ID" value="AKJ40_01630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.281"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="153"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="329" mass="35403" checksum="0CEFA0D4307F5042" modified="2016-07-06" version="1">MPLPSGKVNPYELAEIVFPYLELEDERVLVGPDVGLDASVIDCGEKVLVFSSDPITGAIKDPGWLSVHVNANDVATIGAAPRWFLINLFLPEGVDRSQIRNIMKRANDACRDLDVSIVGGHTEVTPGLDRVLISGAMAGEAPADGWVSAAQAKPGDRLLFTKSAAVEGTFILALDRGEELEREYGPDLVDRAESFREKLSVVPDALTAIETGGVHAMHDPTEGGLAGGLHELADASQVGFSIDSEKIPVAEETRKICNYFEIDPIRTIGSGSLLICVNPEKCEEVIDSLEGAGIGVSNIGSVLKNKEKRVIDGKTLEFPEQDELWKIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1H0</accession>
    <name>A0A133V1H0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrom_C_asm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_01555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000014">
        <property type="protein sequence ID" value="KXB00300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00300">
        <property type="protein sequence ID" value="KXB00300"/>
        <property type="gene ID" value="AKJ40_01555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.265"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003567">
        <property type="entry name" value="Cyt_c_biogenesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43653">
        <property type="entry name" value="PTHR43653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01410">
        <property type="entry name" value="CCBIOGENESIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="607"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="813"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="4">
        <location>
            <begin position="88"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="854" mass="94296" checksum="A69DAC036BE28795" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1K0</accession>
    <name>A0A133V1K0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000013">
        <property type="protein sequence ID" value="KXB00330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00330">
        <property type="protein sequence ID" value="KXB00330"/>
        <property type="gene ID" value="AKJ40_01465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="165" mass="18272" checksum="C90BB2B43B827108" modified="2016-07-06" version="1">MRARIEMELEDTPGQLVKVLKPVSRYGANIQNVVHKREEMTPLGRVPVTVIFEVKQEGRLQKILDEVKEAGAKITRVGEEEAAVRAVVLLVGDIIGTDVRDSLDRINSIKGAKVSDLNLAIGESDEEHSARVIIWATDKEKLQSAVLKLKEIAEEKNLLVIDPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1K6</accession>
    <name>A0A133V1K6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000013">
        <property type="protein sequence ID" value="KXB00338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00338">
        <property type="protein sequence ID" value="KXB00338"/>
        <property type="gene ID" value="AKJ40_01505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="60" mass="6633" checksum="8112620DF53F8438" modified="2016-07-06" version="1">MIVLVETSEVVGKFLDKGMHVTPDALDRISNSSETVISRILSELEGREDRPSIVTDMEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1M5</accession>
    <name>A0A133V1M5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ40_01470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LHXU01000013">
        <property type="protein sequence ID" value="KXB00331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00331">
        <property type="protein sequence ID" value="KXB00331"/>
        <property type="gene ID" value="AKJ40_01470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.215"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="10">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="9">
        <location>
            <begin position="157"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB00331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="338" mass="35585" checksum="B36BCAEAA36090B9" modified="2016-07-06" version="1">MKVTLIGFGNLGQGLARVLLEKEEYLEKEAGVFLEIVAAVDSGGAVTDEGGIDIEELLEAGESEDTVAEYLDGGEKGTSALEVIRNVDSDLVVELTPTSIKDGEPGLTHIKESMNLGKHVVTSNKGPLVVAFQELEKLREDTGVEFRYSATVGGAMPIFGLAKGQMSGDSVSEIRGVLNGTTNYILTRMSEEGAPFDVVLSEAQELGFAEEDPTLDIEGIDTAAKVTILANAFLERNVKLDDVDVEGISRIGPKVTQLARDTGYEVKLVGVANSDTLEVGPKLIPSGDPLAVKGSLNSVTLKTDLAKEITITGFGAGPRETSSALLGDIVNIYKSVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1Z9</accession>
    <name>A0A133V1Z9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00416">
        <property type="protein sequence ID" value="KXB00416"/>
        <property type="gene ID" value="AKJ40_01325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="84" mass="9934" checksum="49E2AD4C6B7A52E4" modified="2016-07-06" version="1">MKALLDKNDFEDRINEFDRQREELPSYNDFGDCLLSSGIISYGNLEDVEKSEYKKFRRQGIPAIRESTEDKEENDRTIARSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V201</accession>
    <name>A0A133V201_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00474">
        <property type="protein sequence ID" value="KXB00474"/>
        <property type="gene ID" value="AKJ40_01290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="70" mass="8094" checksum="146DE7D29B134483" modified="2016-07-06" version="1">MSCYFRWMEDKLAKAGIDVKKENREEIDRAIHSVTGVDYKNCSAVLKKGKEMIAENEENFVVKLEKALNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V239</accession>
    <name>A0A133V239_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proton_antipo_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00517">
        <property type="protein sequence ID" value="KXB00517"/>
        <property type="gene ID" value="AKJ40_01185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1105"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="144"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="510" mass="55234" checksum="7BF2F08B367C6D32" modified="2016-07-06" version="1">MIQFTFPILLISTLIPLVLCLPLSLLGDRLRGRTIAVISFILLAIPLATYLVIILKFGLGVGTIDPAYFAHPFVGSFSMLFDSLSAPFALGIAIITPFVALYSHPYMRHRIEEMREEGLSVPSLGTFYALYTMFAAAMLGTVLSTNLLEFYIFLELTLIPSFLLIAIYGYGERVKIAYMYLLWTHIGALVFLFGILYLGISVGTFDILNMQSLTINQALGAGLPMFILVAIVVGLLFKMATFGVHIWLPYAHAEAPTPISALLSPNLIGISGYALVRIGGFLFPIQFKAISIYLMGLAFLTAIYGGLMALAQDDFKRMLAYSSISQMGWLLLGISTLTADGITGSMLLYLTHAFGKSVLFMTAGVIIVRFNGLRSISKMGGLISKVPKVAGLSLIGFMFLVGIPPTLGLWSKILIIIGIFNIPGAMNPIGFLVLVIVLILAAGVTAVYSFVTLKRVFLGDLADGIGEPSKEGWSIMTGIMAIIAGIGVAFFFYPNIIINPLKELLSTILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V251</accession>
    <name>A0A133V251_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_01200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00520">
        <property type="protein sequence ID" value="KXB00520"/>
        <property type="gene ID" value="AKJ40_01200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB00520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="105" mass="11432" checksum="B5A00F8126267C82" modified="2016-07-06" version="1">MNMLNYFLFLALAATIFGIGIYGLLSRRNILRMLLSAEVMFSSAILTLITLAATSDPSGGRVIALIAIGTATAEVGVLISITILFFRTTGETDVFELSERRKEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V293</accession>
    <name>A0A133V293_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_01180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00516">
        <property type="protein sequence ID" value="KXB00516"/>
        <property type="gene ID" value="AKJ40_01180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1104"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="7">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="134"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="501" mass="53225" checksum="8D57637A3693DA69" modified="2016-07-06" version="1">MISAAPILSIVVLLAGAFIIPIISLIQKKTDRTGACGYFALGFMILTLLLVLSMAPKVWNGEIIIYKLAGRSPPLGINLTIDGLAIQMALMIGILGSAVIAYSIPFMKDKDELGKFYTLILTSIAGMMGIVLTGDIFNFYVFLEIMSISSYGLIAIHRDSDGLVAGLKYLFIGTAESSFILLGITLLYGTIGSLNIADIGAKIKAIQSAAQAMPDILLLALALFVTGILIKTAMVPFHGWLVDAIASAPTPVSALLAGPEAVVGIYLIVRIPYLPFRTSIGSILIGFGAVSMVVGVLMALLSSKFKKMLAYHVISQKGYMVMAIGIGTALGLKGGLFHLLNHSTYKSLLLMSAGVVVMRLNTQNFDDYGGLLKKMPYVALTFLVGALAISGVPPLNGFLSKFTIYLAGIDADLPILTFLALLASALTLASFFKAFKKTFLGQESESHKDVKGVPLGMLIPMLILAAICIIVGLLPSLGFNIVEPAQRSVVHAEKYINAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V299</accession>
    <name>A0A133V299_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_01075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00578">
        <property type="protein sequence ID" value="KXB00578"/>
        <property type="gene ID" value="AKJ40_01075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="246" mass="27334" checksum="606B678FD23BF959" modified="2016-07-06" version="1">MNIINLENVDTIYEGADLPTIRNINLDIERGEFVCVMGPNGAGKTTLLETINGLLEHTQGRVSVFGKTIKQDGTEARKRIGYLLQNFSFDPGEPFLVKDVVMMGRVGRIGLLNTPDEKDWEIVRKALDSVGVREFENRPIGKLSGGEQQKVLLARVLAQEPDILLLDEPLTNLDLKAKEELQELIEKIYEEKHLTVVMVTHDVSSIPKVSSRLVLMNGGEIVLDGKPKQVIESGVWRSSYGLSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2A7</accession>
    <name>A0A133V2A7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Riboflavin synthase</fullName>
            <ecNumber evidence="4 8">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ40_01110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin</text>
            <dbReference type="Rhea" id="RHEA:20772"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="EC" id="2.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4 8"/>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00584">
        <property type="protein sequence ID" value="KXB00584"/>
        <property type="gene ID" value="AKJ40_01110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1010"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09210">
        <property type="entry name" value="Riboflavin_synthase_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006399">
        <property type="entry name" value="Ribfl_synth_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015750">
        <property type="entry name" value="Ribfl_synth_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01506">
        <property type="entry name" value="ribC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB00584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="153" mass="16851" checksum="965E8DD2A8C004B1" modified="2016-07-06" version="1">MACVGLVDTTFARYDMASEAKDKLENLCSVGIKHKTVPGIKDLPVAALNLLRKDCDIVMAFGMPGPEPIDKQCAHQASTGLIKAQLMTGKHIIEVFVYEDEAADENELAELAKNRAREHAENIYRLLFKQDELRKMAGTGQREGGPDAGPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2C3</accession>
    <name>A0A133V2C3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">AKJ40_01105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00583">
        <property type="protein sequence ID" value="KXB00583"/>
        <property type="gene ID" value="AKJ40_01105"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="134" mass="14734" checksum="EA12DA741BF00CA4" modified="2016-07-06" version="1">MVKLGICAAEFHWDIVGEMVEFAKRHADFLGAEIVEEKIVPGTFELPLAAKRLVERDDIDAVVALGAVIEGDTGHHETVMQQASRKIMDISLETGKPVSLGVSGPGETRMEAEERIDEYARRAVEAAVKSFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2H1</accession>
    <name>A0A133V2H1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00647">
        <property type="protein sequence ID" value="KXB00647"/>
        <property type="gene ID" value="AKJ40_00965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="177" mass="19646" checksum="C24ED38BDCF09244" modified="2016-07-06" version="1">MKLTHIQIGFLISLTLLVCTTGFSYLIFNQTLEKNLFSDEDEKIEPSASRSGSVSVINFDPLPFSLGIGSIVSLIAMASWIGSSRIKVDAVSLMLDNGLGDMTLNDLEIVKHMMSSEKFTVPELTGKTNFSRQTVWRQVNKMIEEELVKETGEKKLPKSGRGKPSKVFRFIGPTTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2J4</accession>
    <name>A0A133V2J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00653">
        <property type="protein sequence ID" value="KXB00653"/>
        <property type="gene ID" value="AKJ40_00995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="78" mass="9294" checksum="1D3B2B75F277DD3F" modified="2016-07-06" version="1">MVEVDVDAVESLVKYSHYFGKDFVSLKKIREGQDPELVKEIRAEALEKLIEIDYYPYYRPILLFHFPNIIPTFSMFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2N4</accession>
    <name>A0A133V2N4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00700">
        <property type="protein sequence ID" value="KXB00700"/>
        <property type="gene ID" value="AKJ40_00870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="404" mass="44960" checksum="CCA40207C32C9583" modified="2016-07-06" version="1">MRASFEDAVNRAIDEGADFVLLAGDLFHSRDVDAETLDVAESQLSRLKDEGIEVIAVEGNHDAGLYRKELSWMEYLHRRGLLTLLAADFHGKRVFSPPALDRGEVSGYVDRDGIRIFGVQYLGRRFTERIPQILEGIERANDGDEPEATILLAHFGISGQIPGAPGVSKEEARKLSRAVDYAALGHFHRRFEIGPIHNPGSLEAHSRRQAKWERGLYFLDITPRGKILLRYEGSKSRPYHPVSLDVSRSDTPSELRSDFETVLEKESVPSRSPVVPLTLKGKLGFSREELNLDWFEGVTEDELGALHVIVNDATESTAVSPLLDELESEGGEVSLEEGRLDREKLEGAVFSHIAAEDSRYSDEKEEVAEAMSLAKRMLLAGEEPASVAGELKAKRRDLFKEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Q5</accession>
    <name>A0A133V2Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00720">
        <property type="protein sequence ID" value="KXB00720"/>
        <property type="gene ID" value="AKJ40_00740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="86" mass="10004" checksum="9A643787B50A78CE" modified="2016-07-06" version="1">MSENHKEPSLKEKAKEIQSARNEKWGSAWGDWHPVSFVDHAIAKVKRAHNVLGDEDEVEECLIDTHNYLNRLKEKILKEEIERDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2R9</accession>
    <name>A0A133V2R9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00721">
        <property type="protein sequence ID" value="KXB00721"/>
        <property type="gene ID" value="AKJ40_00745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="152" mass="17973" checksum="8007DD361344D0DC" modified="2016-07-06" version="1">MPEKTYQDLKDEFDKKVEKLREECDHLEVSDWRKECWAIGHTTGFEVKVCEICRETVAKRTSCANCGKLIEEEDFEEGNGTRRPSSEIFCPECQEEWEKFIQEHPYRPESEESVKVVKHLSGGGTEETERELKEGDHYMRLHRKFLEREADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2T1</accession>
    <name>A0A133V2T1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00716">
        <property type="protein sequence ID" value="KXB00716"/>
        <property type="gene ID" value="AKJ40_00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="143" mass="15703" checksum="01120961C752A762" modified="2016-07-06" version="1">MRVPSLEYRIANALDDIPVPYAKNVGSFPKNYEKIAEFVVLNAEFEPQATICGLDLSGDTSKCLGALLLWINRWVEEKKEMDIVLVVKDKAKQGVLEEKSSLLEAEIFDGVLHKRNLSSSKLAECLGVDQSNSSTGSKGGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2T7</accession>
    <name>A0A133V2T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ40_00555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00750">
        <property type="protein sequence ID" value="KXB00750"/>
        <property type="gene ID" value="AKJ40_00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB00750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="169" mass="18244" checksum="AF50011E9583757E" modified="2016-07-06" version="1">MSIIDLIFGRTWGQRAVIMFAVALYLYLYIRSPTVALKSFTDTRHMFVSLLTLIFAAMLIANAIGNMIEPEAISGVLGEAAGLRGVFMGGFIGGVLPGGPYATYPIISELYREGASLAAIISMVIGWSILGISRIPYGITFLNSEIVALRYIFGVPALLVVCVLSYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2U0</accession>
    <name>A0A133V2U0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_00580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00754">
        <property type="protein sequence ID" value="KXB00754"/>
        <property type="gene ID" value="AKJ40_00580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.510"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Lactamase_B" evidence="3">
        <location>
            <begin position="13"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="435" mass="48442" checksum="B7DB44BF1B397E9A" modified="2016-07-06" version="1">MEIHTIGGYEKVGGNMTAVEVNDEILILDMGADIEQIVELGENIEEMKTVEAIESNVVPDDSKVKKKRDNVVGIVIGHGHQDHCRGIPKLAGAYDCPIITAPYTADIIERFIENDRENVTNEIIRMEPGEVLQISNEFELELVPITHSIPHSALTVLRTNEGNVIYSLDYKLDDNPTLGEPVNYDKLKELGEEGVKVYIVDCTRADEPGKTKSESQTRDQLREILSEAYSKGRGIIVTTFSSHIARLNNIIDANDGERKIVMLGRSLKEYTEDARKNGLIDLNGIEVGSYREEVENILKDVSRNKSDYLLVTTGNQGEPNAMLSRIASNEYPYSVGVEDLIIFSSVTIPTTINELNREYLKRKLKQEGAKLELDVHSHGHAMKEDHRQMLQMLQPEIVIPAHGGREKLSACAQLAREEGISSVRISQNGGVISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2V3</accession>
    <name>A0A133V2V3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00736">
        <property type="protein sequence ID" value="KXB00736"/>
        <property type="gene ID" value="AKJ40_00825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="70" mass="7984" checksum="BDF94894A56BDD65" modified="2016-07-06" version="1">MKVTIPEERELKTVYVCYDCFDKQWKGLETGWIGPIVAVFHRLKGHDVRRAEVIPDEGIIVSSARTSHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2X5</accession>
    <name>A0A133V2X5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA primase</fullName>
            <ecNumber evidence="8">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ40_00460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="8"/>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00798">
        <property type="protein sequence ID" value="KXB00798"/>
        <property type="gene ID" value="AKJ40_00460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.362"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="PTHR10536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB00798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="315" mass="36800" checksum="7E10B76A98D682DD" modified="2016-07-06" version="1">MLEMREATPEERERYYKNEWSSKDLPDYILHTLSLREFGFDHKGTGPSDRYNQFMTPDELSDYLRNKYPYAVYSSVALYEKPSERKKWLKSELAFDIDAKDLPFRRCECSEGEVCEVCLEDAKRVTAEFGETLKNNLDLENVSYIYSGRGFHIRVSDDSVMEMGQTGRSQVVEYITGNVVPTDLTLSLGYSKVFRKRTLRTFENLRERDFIDEGLQRNFAEKIMKEKNRVMDLIKKGRLEKIQDFEGIGTTYFKKLLEFLTRLNTEHTDGKVTIDKKRILRVPSSLHSTVSRTCTEIQNIDKFSPDEAAPNFLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2X7</accession>
    <name>A0A133V2X7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 6">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_00525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 6"/>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00807">
        <property type="protein sequence ID" value="KXB00807"/>
        <property type="gene ID" value="AKJ40_00525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.375"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="333" mass="36781" checksum="7E64C1FAAE76A442" modified="2016-07-06" version="1">MYDFEPESVKKFIEENEANKVAVQLPSGLRPYYSEIKKDYDEAGVKALFLTGSCFGACDIADREAETMECDALVHYGHADMGVPTSIPVLYVEAHMEAEPFDVLEKALPELRGSVWGLTTTVQHIDHLYEVKEVLSGEKIKSVIGDPGPRAKYPGQILGCDWGSARSVSGEVDGFIYIGTGEFHPVGIILATGKPVISINPLADDYERTNPELEKFMRKRWAVIAEAKSCQSFGVLVSVKGGQNRMSLAESLSEKLDKQGYDSCILVADDVNTEALRDFQIEAFVNTACPRLAISDEELFDGPVLTPFEAEVLIGDRDWEDYHLNGIGINFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Y0</accession>
    <name>A0A133V2Y0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein AKJ40_00495</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00802">
        <property type="protein sequence ID" value="KXB00802"/>
        <property type="gene ID" value="AKJ40_00495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="DUF99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="PTHR39518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="DUF99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="204" mass="22981" checksum="C9689B8E9D793276" modified="2016-07-06" version="1">MKKKKFREIKPEIRTIGIDDGAFEPDSEGETCLVGVVLRGGKWIDGVLVDEVEIDGRDSTSTIIDMIENSRHKDQLRVVLTSGITFAGFNVLDIDEIFKKTDLPVIVVSREKPDMHSIKKALKNLPDWEERWEILTSTEKIIPVTRKNSDRRKSTVYIQVKGMGEEEAKELVRLTSTRSSVPEPLRLAHLIATAISRGESVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Y6</accession>
    <name>A0A133V2Y6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00799">
        <property type="protein sequence ID" value="KXB00799"/>
        <property type="gene ID" value="AKJ40_00475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="116" mass="13085" checksum="5ED8F202B9ED9EB1" modified="2016-07-06" version="1">MSSFIPQYRPSARPRRISEVKTGDEQVQVVGLTVDKSESSLVLDDGSGRLNVFFEDPALLKGIDVGSKVRVFGTPLNIGNGHEIHAEIIQNLKKLDLDLYKKVMHEVRKFEKELHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V343</accession>
    <name>A0A133V343_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00850">
        <property type="protein sequence ID" value="KXB00850"/>
        <property type="gene ID" value="AKJ40_00380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="222" mass="25925" checksum="E00EB586180DD7C5" modified="2016-07-06" version="1">MSLRGFEKRWKTAAGRAERRWTTRSTRGTGITGCERFPESLSPFFPLPLFHQQLFIKEVFGGLHITTNVVENVFNVKSKLEEHRTMKFDERILVCLLYGHLELNGMSKEELSKFLKDEVITRDFIRNKTLHGSGLQKDKPEEPPPIDTIKKAVKTGQQLAIHYCDRNRNHTSRVITPEKIEKNSYDGTTRIKAHCHLRDAHRTFRLDRIRDLSIFNPDPYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-06-17" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V366</accession>
    <name>A0A133V366_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00881">
        <property type="protein sequence ID" value="KXB00881"/>
        <property type="gene ID" value="AKJ40_00135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.30"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="306" mass="32982" checksum="1CC2D7C912A35D0A" modified="2016-07-06" version="1">MNIAVGVDIGGTNLRVTVSDESGDFLHTEKKKIEVSDEMGISRNIVDMTRRSCEAIDVKVDEVKGIGIASTGPLDVEKGILIRPTNLPFGKVPLVEPVRKELGIPTSLLNDCSAGVLGEKTFGAGKGCENLVYINIGTGIGGGAIVDGNLLLGKDGNAAEIGHFTVDPKGKLICGCGKKGHWEAYCSGRNIPNFVELRSEELISRYGEMSPEKFFKAVEEGDREAVSLMEEISKLNAIGTADVIDAYDPELVTFGGTVVLENEERIVNPIRGRIEDHIRNEKPEIIVTPLKDKVSLYGAIARALEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V380</accession>
    <name>A0A133V380_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug transporter MatE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00891">
        <property type="protein sequence ID" value="KXB00891"/>
        <property type="gene ID" value="AKJ40_00200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.43"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="451" mass="48680" checksum="918CF7F272CE6607" modified="2016-07-06" version="1">MIKGKEKLDLTNGSIGKTLFHLSTPIIIINLLRMAYNIGDTFWLGQLSNEALAAIGFGFPLIFLFISLGMGVAVAGSVLVAQFEGGGNEKMVNFSASQTLTFSFIVSLIFGLIGFVAAEDLLILYGASEKVVSLGVSYLQIIFLGLSFMFGFAVFIALMRGYGDTRTPMFVMLFSIVLNVLLDPFLIFGWSFFPKLGIEGAAIATIFCRSLAFLIGLGMLLRGWKGLKISPSKMIPDLSFLQRLLKIGFPASIGATGRSVSVNVLVAIVGMFSTSVIAGYQVGTRIILVLFFSAMSVSRGVSTMTGQNLGAGNFERAEKVNYIGAKYLFLILTGIGIVLFLFPKPFVSVFTNDGEIVAIGGEFLRYTALSIGFIGIMRVFAGGFRGSGKTLTAATISIITLGIIRVPTAFTTSRFLGPTGIWMAFPISNILGATIAYFWFRRGTWKQRIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V383</accession>
    <name>A0A133V383_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00890">
        <property type="protein sequence ID" value="KXB00890"/>
        <property type="gene ID" value="AKJ40_00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="17"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="407" mass="43934" checksum="CDB9CF97331D8013" modified="2016-07-06" version="1">MSEDSNPFISLLRENRDFATLWFGQIVSRIGDGILIVALPWLIYKIGTETDLGLIMALYSLAAVLFGYIAGMTADRFSRKRLMIMSSIGAGVFVTLMPVLYDSGLLVIPLLGILAFLASLCSQFFEPALDASIPNLVEDDMLETANSMSMTTRRVGMIAGPAVAGVLITVTSSSTTLLIDSISFFFLAGIIAFISVPQKIPDRRNSIWSDFVDDTGDLFSYVKSQPLIRLILLLTLVVNAVLGPFFIITVVFTKNVLASGSGSFGLLVSILSLGTVAGMLTVGQFKEIHAKKFILLGFSLSGLSLIILSQTRWLGLAVGLYLLVGIGFGVINVPAKTALQRFSPDKLRGKIMGITFTMASAAQPISQASSGFVLSFIDTPIMFLFMGMGVLLLLLPLILSEELERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V387</accession>
    <name>A0A133V387_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00895">
        <property type="protein sequence ID" value="KXB00895"/>
        <property type="gene ID" value="AKJ40_00230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="99" mass="10655" checksum="CCECC3C5E934A448" modified="2016-07-06" version="1">MEKELPEFLEILKEKDPQYAGNILENYEKNFSNGALTAKTKTLIALALDAGNGDVEGVKALTKQAKELGVTEEELLEVVEVVEGTSGFQGLAAAMKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V392</accession>
    <name>A0A133V392_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dUTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_00105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00876">
        <property type="protein sequence ID" value="KXB00876"/>
        <property type="gene ID" value="AKJ40_00105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.23"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="144" mass="15787" checksum="6C169EF2BD014DA4" modified="2016-07-06" version="1">MSEEKVIFEKIDENAKLPERQHPNDAGYDLYSSENLVLKVGEIKSVGTGLRAKLPENIEGQIRPRSGLSLSGITVMNSPGTIDPGYRGEIKVIMGNLLGEDKKIKKGDRIAQIVFAPIRHPEITWGRLDETDRGDGGFGSTGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUS2</accession>
    <name>A0A133UUS2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_05010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000126">
        <property type="protein sequence ID" value="KXA97963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA97963">
        <property type="protein sequence ID" value="KXA97963"/>
        <property type="gene ID" value="AKJ40_05010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA97963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="88" mass="10001" checksum="DA830D066D14FEC2" modified="2016-07-06" version="1">MSEVSSTIREDLGVVTERLIPFAPRGETREKLWELHEEYKEKVSNMDDLRHNKRMCCPIHGHNEEVTITGAGKTMGRSSCARSGTTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUS6</accession>
    <name>A0A133UUS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_05005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000126">
        <property type="protein sequence ID" value="KXA97962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA97962">
        <property type="protein sequence ID" value="KXA97962"/>
        <property type="gene ID" value="AKJ40_05005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA97962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="99" mass="11727" checksum="2524ABB65B9E24CF" modified="2016-07-06" version="1">MKSRYEELKEKLYRLGDLSLGSIQKRMLSCGDPDCKCARGEKHGPYYYFTYTDPETGEPAQISLQESEVRELRKRIENYRDFKEDLKELLDLEVELRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUZ2</accession>
    <name>A0A133UUZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000124">
        <property type="protein sequence ID" value="KXA98022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98022">
        <property type="protein sequence ID" value="KXA98022"/>
        <property type="gene ID" value="AKJ40_04980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="96" mass="11035" checksum="D4E132C9C98B8C24" modified="2016-07-06" version="1">MFKLLEEKGVDPPPGVKLRKDANTGLSPRGKAAKQFHDLGYEEWKEEHDYGKRWSVEGLFSAVKRCFGETVRATSPEGMFREVKRKFALYNWVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVP2</accession>
    <name>A0A133UVP2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000117">
        <property type="protein sequence ID" value="KXA98254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98254">
        <property type="protein sequence ID" value="KXA98254"/>
        <property type="gene ID" value="AKJ40_04865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="2">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="81" mass="9512" checksum="82D2F0716B0ADC43" modified="2016-07-06" version="1">MIMEKMAEKVLVDINVPREVSERLEDAGFDMIYLTEKFPQDTDDEEIFEWMETKKIPILTRDKRFPENGGNLKSHSRANPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UW56</accession>
    <name>A0A133UW56_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine hydroxymethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_04800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000112">
        <property type="protein sequence ID" value="KXA98432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98432">
        <property type="protein sequence ID" value="KXA98432"/>
        <property type="gene ID" value="AKJ40_04800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA98432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="144" mass="16800" checksum="6EF074CF1781D8D3" modified="2016-07-06" version="1" fragment="single">KALAGALYERGFDVLAEHKGFTESHTILIDITKLKDKVGLGKDVEQRLEKANIILNRNLLPWDIREDRHFENPGGIRMGTSEVTRLGMEESEMKAIADFFERLLIDEEKPEKVKEEVVEFRSDYQDMHYCFESDKKAHEYIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UW67</accession>
    <name>A0A133UW67_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000111">
        <property type="protein sequence ID" value="KXA98442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98442">
        <property type="protein sequence ID" value="KXA98442"/>
        <property type="gene ID" value="AKJ40_04770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032580">
        <property type="entry name" value="SatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16264">
        <property type="entry name" value="SatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="219" mass="24902" checksum="AF6AA4BF111620C9" modified="2016-07-06" version="1">MSESRKIAVLIADVVKSREIDDREGLQENLKEELERVSKESENLVSTPSIMRGDEIEVAHENALGCFLQFERLEDILFPHRLKGGIGIGTFDTGIRENVSEMDGPAFHLARDALKESKKTGGRSIVYIRSGNTEWDELINTVLSLLSAVKEDWTRREREISLFYLRNQSKTHEEISEYFDVSRPMVSKTLNSAHIKSVKAARNFLFKNLSSIEGVGERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWA7</accession>
    <name>A0A133UWA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000113">
        <property type="protein sequence ID" value="KXA98430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98430">
        <property type="protein sequence ID" value="KXA98430"/>
        <property type="gene ID" value="AKJ40_04810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="210" mass="24496" checksum="4E963CAD0F1F9DF4" modified="2016-07-06" version="1">MEPKIVSFDLDGTLVKLDLIDRFWFEEVPKLYSKYHDMKLDDAVEFVRKSYGEVGPEEIGWYLPQYWFDEFGFEEDPEEVLEGVSHEVEVFQDARDVLEELQGVYELIVVSNASREFLKAQLEEIKGYFSKTYSCVSDLERVKKDVGVYREVCEEIGIDPKDMVHVGDDQEFDYNVPRHIGIRSFLIDRDGDCSNDGGVLRDLRELLDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWC9</accession>
    <name>A0A133UWC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic ribonucleoside-triphosphate reductase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_04715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000108">
        <property type="protein sequence ID" value="KXA98484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98484">
        <property type="protein sequence ID" value="KXA98484"/>
        <property type="gene ID" value="AKJ40_04715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA98484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="86" mass="9731" checksum="E18B63968A097B01" modified="2016-07-06" version="1" fragment="single">MQFKGLEKNSLIEWPGKAVTLTYTGGCNFRCPYCQNKDLVLDPEKIPSIDGEEIIEHLNSKKKWLDGLMVSGGEPTIHRPLLNFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWG7</accession>
    <name>A0A133UWG7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000106">
        <property type="protein sequence ID" value="KXA98522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98522">
        <property type="protein sequence ID" value="KXA98522"/>
        <property type="gene ID" value="AKJ40_04705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="237" mass="27611" checksum="D7F4D0B39F494747" modified="2016-07-06" version="1">MCIRKCHGVIMDEDGEVLRDEKFENSLAGVREFFKGFKHADVVMESSYSWRPTYERFEEIGFEAKLAHPKGTRAIAESEIKTDSIDARTLTHLLRAGLVHESYVPSEEVRQLRDKVRLRTKLVRERTKFKNKIWAELEKNRVNMEKNPFTKKGKEKLRELNISSVDHYLAVLETIDERIKMVSKELEGIAEDREDARLLMTIPGISHFSALLILSEIGEIDRFPDPEKTMFLRWVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWI4</accession>
    <name>A0A133UWI4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000104">
        <property type="protein sequence ID" value="KXA98558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98558">
        <property type="protein sequence ID" value="KXA98558"/>
        <property type="gene ID" value="AKJ40_04665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="53"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="170" mass="19540" checksum="DB735DFE78F49DCA" modified="2016-07-06" version="1" fragment="single">ENIVTHCPHSFNTFKKDYLEGEGDYKIYHHTQFILNLIKQDKIKLENKVNKTVTYHDPCFLTKHNDITEAPRKIIESIPGLEFIELPRNKKNSFCCGGGGGRMWMEQPKEEERPNVERAREVADTNADILLTACPFCLVQLEDGMKMIDKNEEIQVIDIGEFVIESIGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXE9</accession>
    <name>A0A133UXE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_04400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000092">
        <property type="protein sequence ID" value="KXA98847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98847">
        <property type="protein sequence ID" value="KXA98847"/>
        <property type="gene ID" value="AKJ40_04400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="136"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA98847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="218" mass="23579" checksum="C10861BE2550619B" modified="2016-07-06" version="1">MYIIIVGGGRAGKNLAKRFIDTDHEVAIVESEEERAYELTQELDALVIHGSGTDIEILRDAGGERADALVALAPSDEVNLMACKLANDLEIPRIITRVNKSEHAKMFEEVGADVAVSYITATAGLYEKAVTGPEIFGLLSMGGKEANVLEVSIDEESKVVGKAIEELDLPELCTIAIITREGELIPPRGETTLEAEDRVILAGRAEDVQSVSRMFRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXT8</accession>
    <name>A0A133UXT8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000085">
        <property type="protein sequence ID" value="KXA99000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99000">
        <property type="protein sequence ID" value="KXA99000"/>
        <property type="gene ID" value="AKJ40_04180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="209" mass="23918" checksum="2B6B5D7B46211749" modified="2016-07-06" version="1">MVQPGNCALVIGETGSGKTVFSLQFLCEGLFECGSIGTLVSFHNDKRDLIKYAREFGWHLKRFDRNETIKILAKRPSKPSSDNGMDAVKEVIKMVEDIEADRIALDGLQTLSRFFRNERGFEEGLKFLKRELRKQKCLSIMTSNPKFGFQEIMDSVLILHQINSRFGRIREIEIKKAWGTDKGGTISFEITNEGVRFEDKGQYSPEREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXU3</accession>
    <name>A0A133UXU3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tfb</name>
        <name evidence="10" type="ORF">AKJ40_04215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000086">
        <property type="protein sequence ID" value="KXA98995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98995">
        <property type="protein sequence ID" value="KXA98995"/>
        <property type="gene ID" value="AKJ40_04215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1154"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="134"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="228"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXA98995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="318" mass="35857" checksum="1E5154E072F73A00" modified="2016-07-06" version="1">MLLTETHPSDEEENEKVEVECPSCGDSITVRDYQQNIVVCENCGLILKENIKDRGPEWTAFSQEGYEEKSRAGPPSTETIHDKGLSTQIDYGDRDAKGKKLSPERRKQAYRLRKWHKRIRMSDSTDRNLAFALSEINRMSSQLGLSRSVQEIAAKIYREAVEEDLIRGRSIEGVASAVLYIACREAQVPRTLEEVAEASRVDVKEIGKTHRFLIRELGIDLPLTDPSKYVARFGSELGISGETRVEAMNIIRRAQEKKLTSGKSPSGIAAAAIYIASQKSGEQRTQREVARVADVTEVTVRNRYKELVEELDEEIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXZ9</accession>
    <name>A0A133UXZ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000079">
        <property type="protein sequence ID" value="KXA99055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99055">
        <property type="protein sequence ID" value="KXA99055"/>
        <property type="gene ID" value="AKJ40_04070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012017">
        <property type="entry name" value="UCP004977"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09846">
        <property type="entry name" value="DUF2073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="127" mass="14533" checksum="3D71B434A9BBA7E6" modified="2016-07-06" version="1">MYVLGEDERKGVRIEFLSKRTLAESDFEEKLDLIIDNVKKENILVLEESLRSGEKKELIKRTMEEVGEDFPGIEFSGFDSDASFLERVVNTLLGKEEREGLLVVGPSPIMEKIREERDSISLLAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY23</accession>
    <name>A0A133UY23_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000077">
        <property type="protein sequence ID" value="KXA99079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99079">
        <property type="protein sequence ID" value="KXA99079"/>
        <property type="gene ID" value="AKJ40_04015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="593" mass="67594" checksum="1AF69A710EA49EFF" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY25</accession>
    <name>A0A133UY25_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000077">
        <property type="protein sequence ID" value="KXA99080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99080">
        <property type="protein sequence ID" value="KXA99080"/>
        <property type="gene ID" value="AKJ40_04020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="99" mass="11771" checksum="3E22663C1E9A20DB" modified="2016-07-06" version="1">MKSRYEELKEKLYRLGDLSLGSIQKRMLTCGDPDCKCARGEKHGPYYYFTYTDPETSEPAQISLQESEVRELRKRIENYRDFKEDLKELLDLEVELRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY46</accession>
    <name>A0A133UY46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000073">
        <property type="protein sequence ID" value="KXA99126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99126">
        <property type="protein sequence ID" value="KXA99126"/>
        <property type="gene ID" value="AKJ40_03895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="101" mass="11833" checksum="BB58873E016C0FE6" modified="2016-07-06" version="1">MPNMITGVRLAVNLRKIKTDTYCLDKSRMVSLETCKNCGFYTKFSEKENFILCRHSGTSNAKRKVYRRVWCSGENLHKNLDTCEDCDRFKRIHNHHVVCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY48</accession>
    <name>A0A133UY48_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000076">
        <property type="protein sequence ID" value="KXA99091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99091">
        <property type="protein sequence ID" value="KXA99091"/>
        <property type="gene ID" value="AKJ40_04000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="82" mass="9409" checksum="8C62083D433EC8F1" modified="2016-07-06" version="1">MKLPEYKGNPPRLAIELNPTDSRGNPTKKRGLMMFNAGELEEYREMIGEEGLDGLMETIMEVNPKKGKKKRSEEEKEDVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY89</accession>
    <name>A0A133UY89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000072">
        <property type="protein sequence ID" value="KXA99139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99139">
        <property type="protein sequence ID" value="KXA99139"/>
        <property type="gene ID" value="AKJ40_03865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1044"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="247" mass="28648" checksum="53761D0F6D9B3027" modified="2016-07-06" version="1">MLKKTTRHHQQIALFAKRTQREKEEARLARELLREKLEEHIKKQGAERIVGPLTSSDSLRIYYCPKEDRILEIRYPKSKGHGKGSLERYKLLHISTDTRFERTSMLEEDLLSLQHAISLNHMQFDSEIEEKVERMAKHFNSDTSFSLEGTSKSELKSLYNEIQKKVGSSSINAAHLYRVYSETPDVFWEEVPLSHWLEGSGRWKFEEKHSSRTLPGPELFQKVREEKPTELTAVRLGGSPGDRNGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY94</accession>
    <name>A0A133UY94_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000071">
        <property type="protein sequence ID" value="KXA99155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99155">
        <property type="protein sequence ID" value="KXA99155"/>
        <property type="gene ID" value="AKJ40_03850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="65" mass="7566" checksum="09AFCF87C1DB6FB3" modified="2016-07-06" version="1">MCETKSNMNLTKTVVLKLEETDDSIQETMERYTEGMNFASKVVYENGEPLSANRLQRLIYEEFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYA7</accession>
    <name>A0A133UYA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_03825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000071">
        <property type="protein sequence ID" value="KXA99151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99151">
        <property type="protein sequence ID" value="KXA99151"/>
        <property type="gene ID" value="AKJ40_03825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="259"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="333"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="420" mass="48175" checksum="CD42C2A6DF8B238E" modified="2016-07-06" version="1" fragment="single">MKALLVDDEVDILEQAKIFLQKEVEELNVETVASAEKGLERLKEDEFDAIVSDYQMPAMDGLEFLETVRKEKKSNIPFIIFTGKGREEVAMEALNLGADRYLQKGGNPRSQYGVLAQAIVQEVKHSKIEFEKAKVEAELSSLVKGSNDPIYIVDENCRIVFANQAELEKTGMSFEEIIGSKFRESHPEKDARAFEKKVRKTFDTGNSQRQEVKHEETGRYYDRTLSPIKNPRTGKVDRIAVISKDVTERKQREKELRESEARFRRFFENEPEYCYMVSPKGKIIDVNESALDTLGYRKEEIKGKPLLSTVYAPSSQEKARKLFEEWKKGKEIKGEELQIITKEREKRTVLLSAASVKDGEGNVRYSVSIQRDITERKEREKELRKSEEKYRELFESTNVGIVVHGSEGEIISVNPAAEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYB2</accession>
    <name>A0A133UYB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000070">
        <property type="protein sequence ID" value="KXA99165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99165">
        <property type="protein sequence ID" value="KXA99165"/>
        <property type="gene ID" value="AKJ40_03810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="146" mass="16393" checksum="FFE0D674081E98FA" modified="2016-07-06" version="1">MMKCENCGGEITEVKCPECGAIQTDLLEEASEMFESLPEEVQEFLKKSVEESATDEEFISKVMVGNCPNCGSDLTVDCENVRGIEDPTVGLCEECQHVWCLECMTPLDRDGLDCPHWEICDDCQEDFKRCHARGYLPECPKIKSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYB8</accession>
    <name>A0A133UYB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000070">
        <property type="protein sequence ID" value="KXA99161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99161">
        <property type="protein sequence ID" value="KXA99161"/>
        <property type="gene ID" value="AKJ40_03790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="71" mass="8070" checksum="761E10C12AE3D6A5" modified="2016-07-06" version="1" fragment="single">VKNISALKEINLIKTQAPITPLHQTIQNLNFNTSKPMMFAPAVKIWVRDSSLPRSRAGSTTYPYFLKYAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYD5</accession>
    <name>A0A133UYD5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NPCBM_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000065">
        <property type="protein sequence ID" value="KXA99216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99216">
        <property type="protein sequence ID" value="KXA99216"/>
        <property type="gene ID" value="AKJ40_03675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM_assoc" evidence="2">
        <location>
            <begin position="277"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="402" mass="43750" checksum="8CFC9ED4B6B5DF8E" modified="2016-07-06" version="1">MNSKSAKMKKITILLTIGLVVALSLATPSVNASSSEGLSMTTPFPHVVIGSGETIERNITIHNTTSSSKLINFSTSTDSDNWSADLRESGVEVKSAYLQAGGESDLTLRISPPTDIDEGTYPVEVQALDREGTVLDALEILVEIKPTAVTGIEVQTKYPEMEGPPGTDMEFSIDIINHGSKKTIDYEVNVQGQEDWKTNISPRFEDKSIRSQSFEAGEEKTINLTVTPPETVTPQDYRVDFEASSGAIKDNLSLIVSIPGTYKLDLTTKSERLNTKVERGSTGTIQLVVRNRGSAALKNIQLSTGYNKPSGWTTEFNPEIIPVIEPQSQKLVELTVGTASDTVPGDYSFKVRANAREPYQRSASFDLRVTVSPGTSWGLVGVGIIGIILAGLFLLFWRFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYH0</accession>
    <name>A0A133UYH0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000062">
        <property type="protein sequence ID" value="KXA99250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99250">
        <property type="protein sequence ID" value="KXA99250"/>
        <property type="gene ID" value="AKJ40_03610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="181" mass="20444" checksum="EE37FEC16D359C85" modified="2016-07-06" version="1">MKVFEAIKNRRSVRDFEDRNVEEEKIERVLEAARWAPSWANTQCWRFVVVKNQETKSDLAEALSENNPAADAIIEAPVVIVACAKKKVSGYKGGEPATEKGDWYMFDTGLAMQNLMLEATNLGLGTVQIGYFNSERVEEILDLPEDVTPVTMTPLGYPKRVPDPTSRKDLDEIVFAEKFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYJ8</accession>
    <name>A0A133UYJ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000061">
        <property type="protein sequence ID" value="KXA99259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99259">
        <property type="protein sequence ID" value="KXA99259"/>
        <property type="gene ID" value="AKJ40_03550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="97" mass="11334" checksum="0DBD7741D45A07BF" modified="2016-07-06" version="1" fragment="single">DELKNMLNLRPVYHSTDVGVKGHVFVCILALLLRRLMERETDESFESVFEELKELKVNVIDLEGEKIFQRNRLTSTQEDLLESLKVKRPPKILVNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYT8</accession>
    <name>A0A133UYT8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000055">
        <property type="protein sequence ID" value="KXA99356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99356">
        <property type="protein sequence ID" value="KXA99356"/>
        <property type="gene ID" value="AKJ40_03330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="204"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="303" mass="32425" checksum="36089E9C0630A879" modified="2016-07-06" version="1">MKSVVKIEVSKTTEGLFGPQESTALGSGFVYNASGYIISNEHVVGGADEINVTFYNGDTVEADPVATDPYSDIGVVKISPEEVENLRPLPLGSSSDLQVGERVIAIGSPFGLSRTVTTGVVSQKDRLLQTQTSYSIPSVIQIDAAINPGSSGGPLLDFQGRALGITTAIETRTGTFTGVGFAVPTDLIRKVVTGLIERGEYRHPWIGVGGQNVTFETAKERGLDKARGFLISYIESDSPAEDAGLQEEDIILGIEDRKIFGLEDILSYIELNTRPGDTITLQIYRDGETTDIDLTLGTRPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYU0</accession>
    <name>A0A133UYU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000054">
        <property type="protein sequence ID" value="KXA99372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99372">
        <property type="protein sequence ID" value="KXA99372"/>
        <property type="gene ID" value="AKJ40_03310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="68" mass="7852" checksum="110D6C86318B1D89" modified="2016-07-06" version="1">MKEPKTSFGIRTDEDLAKNLDKIVEESDDLNVSRSEAVESILMAYFKSDTDHVKKVRELVIRKRKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYV5</accession>
    <name>A0A133UYV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000054">
        <property type="protein sequence ID" value="KXA99376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99376">
        <property type="protein sequence ID" value="KXA99376"/>
        <property type="gene ID" value="AKJ40_03315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046074">
        <property type="entry name" value="DUF6092"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19585">
        <property type="entry name" value="DUF6092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="74" mass="8864" checksum="16BFF00A4FC99C99" modified="2016-07-06" version="1">MVKEDDPFYDLICYIATSARGCVEEPKIYGSFRLIETMERVINILEEEGYADDFYLNLRDKINDERNRKTRCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYW2</accession>
    <name>A0A133UYW2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000054">
        <property type="protein sequence ID" value="KXA99375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99375">
        <property type="protein sequence ID" value="KXA99375"/>
        <property type="gene ID" value="AKJ40_03280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="62" mass="7123" checksum="503208F7317C0462" modified="2016-07-06" version="1">MRDLFEEIKSLTMVREARMLAGFYDIMVIAESDKLSEIMDTLIEKIRSIDGVGETATHIFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYW8</accession>
    <name>A0A133UYW8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_03240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000053">
        <property type="protein sequence ID" value="KXA99385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99385">
        <property type="protein sequence ID" value="KXA99385"/>
        <property type="gene ID" value="AKJ40_03240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="72" mass="8092" checksum="49BE444EB4E906A2" modified="2016-07-06" version="1" fragment="single">GRKFDLEKIARNHRNTEYEPEVFPGLVFRMEEPKAVILLFVSGKGVGAGFEKQESVEKAAGKIVKNTEKETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYX5</accession>
    <name>A0A133UYX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000053">
        <property type="protein sequence ID" value="KXA99388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99388">
        <property type="protein sequence ID" value="KXA99388"/>
        <property type="gene ID" value="AKJ40_03255"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.831"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="164" mass="19329" checksum="9F5856011FD12663" modified="2016-07-06" version="1">MGRPRSKIDITCQNPDCEYYLKEEGKDIVKRGKNRAGNQQYYCYHCDSWFVETKNTPLYHKHLSEEEIIEICKHLVEKNGIRSIERITGHHRDTISRLMEDMAEHAEKMNDYLIEEVGLTPIECDELWSFIKKKKRKLSKTARIKLEKVMHTSTQASKETHTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYX7</accession>
    <name>A0A133UYX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000052">
        <property type="protein sequence ID" value="KXA99406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99406">
        <property type="protein sequence ID" value="KXA99406"/>
        <property type="gene ID" value="AKJ40_03235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="77" mass="8744" checksum="664D8D1A921F1FD9" modified="2016-07-06" version="1">MPEMRSGADIWHCPVYACPFTAGETEQVVRHLENHYKGDEVIHRELERFRKAVENGGRACGKALDDPEHPKNKDNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYZ3</accession>
    <name>A0A133UYZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000053">
        <property type="protein sequence ID" value="KXA99387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99387">
        <property type="protein sequence ID" value="KXA99387"/>
        <property type="gene ID" value="AKJ40_03250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="151" mass="18076" checksum="D993955B384CBA08" modified="2016-07-06" version="1">MIEKLSERVKTPCPEDKIEFFSDGNSDYTSVLPKYFAESRMNYGQLIKIRERGRVVDKERRVIYGKPSPEDIETTDVENFNGILRERVGRLVRKTKCFSKLRPRLECSIELFQFYWNFMNEFKKGKAPAMMEELTDHVWTWHEFLTWHPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ15</accession>
    <name>A0A133UZ15_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000050">
        <property type="protein sequence ID" value="KXA99435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99435">
        <property type="protein sequence ID" value="KXA99435"/>
        <property type="gene ID" value="AKJ40_03135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="105" mass="12547" checksum="55631194AE634586" modified="2016-07-06" version="1">MSDWFDKEMKKVMKKFDEMFQRMMTPSEKQSLEPDKNFKTFERKGPGFHMKVGMFSLPMGPEDSDRAVTSEFGEDKKVEVVEEDEEEPRKLALRRFKERKEEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ51</accession>
    <name>A0A133UZ51_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_03085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000048">
        <property type="protein sequence ID" value="KXA99465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99465">
        <property type="protein sequence ID" value="KXA99465"/>
        <property type="gene ID" value="AKJ40_03085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="440" mass="50033" checksum="CFEB701507273447" modified="2016-07-06" version="1">MQTTIRGKIFPSKDQAEKLDELMRIQSSCMRYSYSRLCEGKSKSEIEDDLKGKFSEINSRYRRGGYFRAKANYESALELVESGELESPEKVVFGGRKNLKKRERGEISNEEWKRLRNNQLYSRGDKSKRGNLNLRFVEQDGDLHLRVNVGNREWIHVPAYLPREKRRFLAGEKPYGVRIIRKDEEYEVRVSFEEEQEPETSFEGGAVGVDFNHQTIDMAVTNEQGQLKDGKTIQCPEITTSRKNKRENLIGNYAKKVVNYANHWRRGLVLEKLKDVARGQRNQHEFTHKKFLEAVKRRAEREGAKVREVNPAYTSVIGRHKHASYYHITIHQAAALVVARRGQGFSEHLRGLKTPLFEALEAGEEGENVPDRRVHSWSLTRGLPSRKGASRKHPSQSPETIGVESSGTIGSTERSPGEGDSSEGKTVSPGSGPPVREAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ76</accession>
    <name>A0A133UZ76_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000048">
        <property type="protein sequence ID" value="KXA99467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99467">
        <property type="protein sequence ID" value="KXA99467"/>
        <property type="gene ID" value="AKJ40_03070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.743"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="30"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="365" mass="40695" checksum="5193D158A96F4F63" modified="2016-07-06" version="1">MLITLRKGEEKKPADNENLEIEFEVIAQNLEVPWDLDFAPDGRIFFTERPGRIRTIVNGKLDPDPWASLSVFSRGEAGLMGIAISPNFENNGHIYVYHTYRGPEDHIWNRIVRFIDKNNRGEFDKIILDEIPGGQIHDGGRVKFGPDGKLYVTTGDSGNSSLAQNLDSLAGKILRINADGSTPQDNPFQGSPIWSYGHRNPEGLTWHPETGTLYATEHGPSGHDELNVIEKGGNYGWPKVRGKSDGEDYIDPILESGSGTWAPSGTSFYSSNRIPTWKGNLFFVTLGFTPGGGRRSLHRVIFKQNNLRTVENHTILLESRNDRLRAVEEGPDGYLYITTSNRDGRGDPDSGDDRIMRIKVSSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ79</accession>
    <name>A0A133UZ79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000046">
        <property type="protein sequence ID" value="KXA99498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99498">
        <property type="protein sequence ID" value="KXA99498"/>
        <property type="gene ID" value="AKJ40_03000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="166"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="352" mass="38617" checksum="FCC0AFFB40BAE90D" modified="2016-07-06" version="1">MTDLPRDLNRRFLGDIHSALEGASKERVKSVGLPLLSQSSVLPPNPAHLRELLRDGGFDIIHAHHAFTPTPLFSILLANELETPTVLTNHSVSFAYDYSPFWQPLAKFLYPYKELINSVDRVIAVSEAAAIFIGHFVSGEKISVIPNPVHEDYFETGETDSRNRTSRGKTVLYVGRLSREKGVHKLPSILKTVSEEFSDVQLIIAGSGYLSKFIDLTAKLKGIRNKVRMLGKVSREGSLPSLYERADAVVVPSLREAFSITLLEAMASGCPVVASRVGGMKEIIKDGHSGVLVGGKASDFADALLRVLSDPSLSKELGWNARKVASKCRPRKIAEQVEEVYRDVAASRNTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZB2</accession>
    <name>A0A133UZB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000044">
        <property type="protein sequence ID" value="KXA99538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99538">
        <property type="protein sequence ID" value="KXA99538"/>
        <property type="gene ID" value="AKJ40_02915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019205">
        <property type="entry name" value="DUF2080_transposon-encoded"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09853">
        <property type="entry name" value="DUF2080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="56" mass="6375" checksum="EAAC2C2629D02434" modified="2016-07-06" version="1">MGEIRLTDEKVILTEDVETFYEKEVTPFGNSAKIGCPKEYIGRKALVIVLKEDETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZC1</accession>
    <name>A0A133UZC1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000045">
        <property type="protein sequence ID" value="KXA99522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99522">
        <property type="protein sequence ID" value="KXA99522"/>
        <property type="gene ID" value="AKJ40_02965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="70" mass="7568" checksum="B55E17DBF16EF97B" modified="2016-07-06" version="1">MWFEVDISEKKTSILVGIAVLVIVVFAGVFFLGGTSKGQVTNLTFSEDIGSSDHSPIEETIEFGKDVMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZE0</accession>
    <name>A0A133UZE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb</name>
        <name evidence="6" type="ORF">AKJ40_02925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000044">
        <property type="protein sequence ID" value="KXA99540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99540">
        <property type="protein sequence ID" value="KXA99540"/>
        <property type="gene ID" value="AKJ40_02925"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.712"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="5">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="114" mass="12789" checksum="AA27DD2DFBAC9AD7" modified="2016-07-06" version="1" fragment="single">SDIGKNYRFLSRELEIYLPPIDPTRYVARFGSELKISGEAKVEAMKIIRKAQKKRLTSGKSPSGTAAAAIYIATLKCGERRTQSEVSKVADITDVTIRNRYKELVEKLGENVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZF4</accession>
    <name>A0A133UZF4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000043">
        <property type="protein sequence ID" value="KXA99549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99549">
        <property type="protein sequence ID" value="KXA99549"/>
        <property type="gene ID" value="AKJ40_02850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="82" mass="9461" checksum="2B6F8FF6306D5A8B" modified="2016-07-06" version="1" fragment="single">LKLPEYKGNPPRLAIELNPTDSRGNPTKKRGLMMRDVGELETFRDLIGEEGLDDLMEIIVEVNPEKGKKKRREEEKEDVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZG3</accession>
    <name>A0A133UZG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000040">
        <property type="protein sequence ID" value="KXA99598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99598">
        <property type="protein sequence ID" value="KXA99598"/>
        <property type="gene ID" value="AKJ40_02740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="60" mass="6872" checksum="062412063F0A3B00" modified="2016-07-06" version="1" fragment="single">VRSFFQGFLYADAVMEASYSWRPTYERLEEIGIEPKLAYPHEVEAITSSETKTDSIDAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZK0</accession>
    <name>A0A133UZK0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000040">
        <property type="protein sequence ID" value="KXA99602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99602">
        <property type="protein sequence ID" value="KXA99602"/>
        <property type="gene ID" value="AKJ40_02770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="66" mass="7640" checksum="5EEF33F534E56825" modified="2016-07-06" version="1">MPKIKFGVTIDEELRKELIKIVGRSEDLDLSRSEVVETILKAFFKSSVDHTKKASEMIIKKEKVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZP1</accession>
    <name>A0A133UZP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000038">
        <property type="protein sequence ID" value="KXA99651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99651">
        <property type="protein sequence ID" value="KXA99651"/>
        <property type="gene ID" value="AKJ40_02680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="376" mass="43909" checksum="F7421D629D155646" modified="2016-07-06" version="1">MKLAEFFVEELGISEEYWTDNKQELEEISGDAVHRYVNYLPGLRKYDRDSFEITMGITDRLERKDECLAFLSKEILKSELPDKAEILERLTALAFKSPEAYNYPVMDVLDYMSRGGGTVEMEHPEWLVWKDTFSEPKSYVKTLERILESLLSDSRKTAAFIGIAISLRDRKREDLSRKLTTRFFESGEIPYAIREELAWSIITGEFFEKVHARYYKDTVLMPFKGSSSNPPIIDFPKDLELEFDMDVILEAAEYLEEMMYQTQMKLTVEMEEITEWVLGSLEREEAKSFIRDWLGKKYDYRDFPVVRGIIGTLKDWGGTEAGFVKEAIDDLKNANRYQVRMMAFETGYDVLGDEEYLEEAEKDPSMEVREWAGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZR0</accession>
    <name>A0A133UZR0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase</fullName>
            <shortName evidence="2">ADH synthase</shortName>
            <shortName evidence="2">ADHS</shortName>
            <shortName evidence="2">ADTH synthase</shortName>
            <ecNumber evidence="2">2.2.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroA'</name>
        <name evidence="3" type="ORF">AKJ40_02605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate</text>
            <dbReference type="Rhea" id="RHEA:25952"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="ChEBI" id="CHEBI:58860"/>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.2.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.10" evidence="2"/>
    <dbReference type="EMBL" id="LHXU01000036">
        <property type="protein sequence ID" value="KXA99685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99685">
        <property type="protein sequence ID" value="KXA99685"/>
        <property type="gene ID" value="AKJ40_02605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.596"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00960">
        <property type="entry name" value="ADH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010210">
        <property type="entry name" value="ADH_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01949">
        <property type="entry name" value="AroFGH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="251" mass="26491" checksum="0AF6483E9734A190" modified="2016-07-06" version="1">MNRDTQRTVIVPMDHGISSGPIEGLRDMKGAVNKVAEGGANAVLLHKGLVRTGHRGYGRDIGLIIHLSASTALGPDPNNKVTVTSVEEAISMSADAVSVHVNVGAENEEEQLRELGRIAEVCGSGGMPLIAMMYPRGEKIEDEFGAEVVAHAARVGAELGADIVKTNFTEKISSFRKVTKGCPVPVVIAGGPKADSDREILEMVSNSIRAGGAGVSIGRNVFQHKNPTGMVRAISKIVHQEASPEEAEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZS4</accession>
    <name>A0A133UZS4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_02580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000035">
        <property type="protein sequence ID" value="KXA99703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99703">
        <property type="protein sequence ID" value="KXA99703"/>
        <property type="gene ID" value="AKJ40_02580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.591"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="181"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="447" mass="50804" checksum="D7A7783C95980612" modified="2016-07-06" version="1">MRWLLVEPPVQSDIQASLGAVGIPSSAYLAPILERNNEEVRIEDAPALDHNLEDVADVIRDYDPDYVGISALTTDIEEAYRVAEAAKKSDQSRKVILGGAHPTLRPKETLEECSSVDIVARGEGEEIIDEISRFEDLSRIKGISYRENGNIIENQDREPIMDLDSLPFPAYHLLPMERYEFDGIRYATMITSRGCPFNCVFCASSRICGKKWRGKSPERVLEQMKALRYDYDVKEIEILDDTFVLDKNRATEICDLMVEEGLDITWSCSSRVDTMDSSLAEKLREAGCHTVYMGIESGVQEVLDRLKKGITIEQARDAVEAVKEADMNVVGSFILGVPGETKKQMEKTIDFAKELDITLAQFTLFTPYPGTESYVNAEENDLFLTKDWSDFSTLDPIIKNDEMSAEELKNFMRQAYIRFYLRPSYIWRAVKTGELWSLLKKGISWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZS5</accession>
    <name>A0A133UZS5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="6">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trpA</name>
        <name evidence="8" type="ORF">AKJ40_02610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="6"/>
    <dbReference type="EMBL" id="LHXU01000036">
        <property type="protein sequence ID" value="KXA99679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99679">
        <property type="protein sequence ID" value="KXA99679"/>
        <property type="gene ID" value="AKJ40_02610"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXA99679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="275" mass="30636" checksum="10BDD7B137AEA2C2" modified="2016-07-06" version="1">MIKIEEKFKELSSRGEGAYMPHIYYGDPFPRFSRREVEILAENGADFIEFGVPFSDPIADGSTFQEACQRALENDITPEDCIRGIEKLREDGLSIPIIVTSYYNILYAYGMDDFLERLNEAGAQGIIVPDIPIEEVNSLAKAGRKKDIHVILQATPNTSKNRLRKIINTTSGFLYIVNFEGVTGTKRSIPNSTIDMINKVKNLSHMPLMAGFGVSTKNHAKSLVSAGVDGVITGSALRKIYGKDLNNPKEKMSDIAEFARQMKKGCEEGYEKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZT5</accession>
    <name>A0A133UZT5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="10">IGPS</shortName>
            <ecNumber evidence="4 10">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpC</name>
        <name evidence="12" type="ORF">AKJ40_02625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="4 10"/>
    <dbReference type="EMBL" id="LHXU01000036">
        <property type="protein sequence ID" value="KXA99682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99682">
        <property type="protein sequence ID" value="KXA99682"/>
        <property type="gene ID" value="AKJ40_02625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.600"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="11">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXA99682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="258" mass="28467" checksum="A0FE28CD1E34EC4F" modified="2016-07-06" version="1">MSILSEIVETVRRQVRKQKEETPVEEMKIEPIERKSLTENIETNPNTSIIGELKRTSPSSGVIREDFQPSELARSIAEGGAVGISVLTEPVYFDGKIEYLREVSNSVEVPVLRKDFIVEKYQLYQTAASHADSVLLIAEILGEELPEFVALTKELGMEPLVEVRDEGQVELAEDAEAKLVGINNRDLKSMEIDLSRFERIINSIPEGLVTVSESGIEKRQDVERVTKAGADAVLVGTAMMESTDVKGKVLSLIGDPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZW0</accession>
    <name>A0A133UZW0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_02560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000034">
        <property type="protein sequence ID" value="KXA99726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99726">
        <property type="protein sequence ID" value="KXA99726"/>
        <property type="gene ID" value="AKJ40_02560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="267" mass="29574" checksum="BB0227FDD6BA8A1A" modified="2016-07-06" version="1">MGFITSVAGVSLAGMFNLALILKIGLLFWFLHSIAHPINDHIDRESDKIGRPNAPIPAKLVTLRQVKVIILLDYIIAVLLILILPLNVLTRILATIFLVITFIFSAPPIHTNARGILASITIAIAFIIAFLGGWTEVVGKGFEVLLIPLSFLIGSTHIMAKIVVDIVDIDSDKRSGRNTLPMQIGIKRSFYIATVFGLLIVFMYLLTYFIGNLNIIYLFLGGIGSVITLIGLFRFREDYGRELGREYYKIVTLPTYIFPIAIILGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZX7</accession>
    <name>A0A133UZX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000033">
        <property type="protein sequence ID" value="KXA99736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99736">
        <property type="protein sequence ID" value="KXA99736"/>
        <property type="gene ID" value="AKJ40_02485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.565"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="113" mass="13424" checksum="8CF5603187C957F9" modified="2016-07-06" version="1" fragment="single">EYDNYFLNIAIGYSGRQELVNAVRKICKSVKDDELDIEDINKDVIEENLYTADLPDPDLIIRTSGEERLSGFLLWQSAYSELYFCEAYWPEFDKINFFQAVSNFQERERRYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZY1</accession>
    <name>A0A133UZY1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nac</name>
        <name evidence="6" type="ORF">AKJ40_02500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000033">
        <property type="protein sequence ID" value="KXA99739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99739">
        <property type="protein sequence ID" value="KXA99739"/>
        <property type="gene ID" value="AKJ40_02500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.568"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="HYPK_UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00264">
        <property type="entry name" value="TIGR00264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="115" mass="12827" checksum="E2A35872A246D155" modified="2016-07-06" version="1">MFGGRGGFDSKQLRKMMKQMGIEMEELSGVEEVTIKMSDKELVFTDPEVQLTEAQGQKTYQIIGKPTERELGPEISDEDVKMVVEQTDVDEETARKALEETEGDIAQAIVNLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V011</accession>
    <name>A0A133V011_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000032">
        <property type="protein sequence ID" value="KXA99766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99766">
        <property type="protein sequence ID" value="KXA99766"/>
        <property type="gene ID" value="AKJ40_02455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="113" mass="12248" checksum="F61D5B06E3EE299F" modified="2016-07-06" version="1">MDVCEVSEGTSKLRLPMLEEFQNRAGTMQGGLIAAFADCAGGIALRSLLKESETSATTNLDIKYIAPVKNEIFAYAEIVHKGKSTAVGEIDIKNKEGKLLAKITETFAILRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V014</accession>
    <name>A0A133V014_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000031">
        <property type="protein sequence ID" value="KXA99777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99777">
        <property type="protein sequence ID" value="KXA99777"/>
        <property type="gene ID" value="AKJ40_02420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="84" mass="9982" checksum="0D80D13812C69116" modified="2016-07-06" version="1">MLESWLFLAVNAVAPTDIAEKIARKIEKEIEGRSTIKEIRSRVLEKLGDIEEDWVERWKEYEKKKKSEQLEKLMFPTSLQLFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V016</accession>
    <name>A0A133V016_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_02415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000031">
        <property type="protein sequence ID" value="KXA99776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99776">
        <property type="protein sequence ID" value="KXA99776"/>
        <property type="gene ID" value="AKJ40_02415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="126"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="333" mass="39055" checksum="C693C145DF0CBB0C" modified="2016-07-06" version="1">MSAGEIVFWDWDMVEDKLNFDERWEEMIGYDIDELGEDRSIWKDLIHPEDIKMVEKELERYLKGETRIYETISRMKTKDGKWRYFLDAGKVVEWDENDNPKRFIGILRDVTDQMKAEERKNFLHTLLKQDLGSKSQTIRGYLQLLEEELDLPEKHREYLKKAKKASGEADEILGLAKKLEEVEKTEWVGEKNIVKVLEQVLDDISNFVERKGVEIEKPHPEKIGKVKGDYSLNMFLSQILLSRIQLSQCDTIRIDVRERKEDILLKIEDNGKKLPEDIKNLFIGESYTGETTGVGGVRYYMLREIARHNNANIEVKDSDIGGVRFDVHLKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V026</accession>
    <name>A0A133V026_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000031">
        <property type="protein sequence ID" value="KXA99781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99781">
        <property type="protein sequence ID" value="KXA99781"/>
        <property type="gene ID" value="AKJ40_02440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="91" mass="9494" checksum="1F9C81A018905777" modified="2016-07-06" version="1">MGVLLVLIAPFLIGLLVGAIVKKAFSLIILGAVLVIVLIATGAIGLTYGELFNEALDFLPKLWSGAQGWLGILPYSSIGFLIGLALGLWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V077</accession>
    <name>A0A133V077_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="1">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">carA</name>
        <name evidence="3" type="ORF">AKJ40_02345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="1"/>
    <dbReference type="EMBL" id="LHXU01000029">
        <property type="protein sequence ID" value="KXA99833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99833">
        <property type="protein sequence ID" value="KXA99833"/>
        <property type="gene ID" value="AKJ40_02345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.484"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="361" mass="39991" checksum="712E60511357E891" modified="2016-07-06" version="1">MKAYLALEDGTVVEGKGFGSPGKAKGELVFQTGMTGYVEALTDPSYNGQILMLTYPLIGNYGVVPQDYESEGIKAEALVIRDLCQYPSNWRSEMTLDQFLKKHDIPGIEKIDTRKLTRKARIHGTMKAILEVGEENVDEKGLVRKAREQKSIEERENLVPQVSIKGKERFEGEGNSELVMIDCGYKNSILTTLHRENINVTIVPYDTSAENILDLEPDGALVSNGPGNPALLEETIDTIEKLLEETVLYGICLGNQLISLATGAETYKLKFGHRGINHPVKHLETGRVSITTQNHGFAVTEKSLQNTGLEATQINLNDKTIEAIEHENLPVKAVQYHPEAGPGPHDALPFFKQLKNRLQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0E2</accession>
    <name>A0A133V0E2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000026">
        <property type="protein sequence ID" value="KXA99911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99911">
        <property type="protein sequence ID" value="KXA99911"/>
        <property type="gene ID" value="AKJ40_02240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="132" mass="14402" checksum="AEB00220C61DA4C7" modified="2016-07-06" version="1">MLGQYPVVGASALVRKNGGEVLLVKRLNEPGKMKWALPGGKVDLGETVEQTAVREVKEETSIDIELNELLGPYNIIGEDYHYVTICYSGDPKNTEIVSGSDVERAEWVSPKNLNGLTLTSTTKKALKDADIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0E6</accession>
    <name>A0A133V0E6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000026">
        <property type="protein sequence ID" value="KXA99909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99909">
        <property type="protein sequence ID" value="KXA99909"/>
        <property type="gene ID" value="AKJ40_02225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="82" mass="9479" checksum="FEDD9E42EA17BE9E" modified="2016-07-06" version="1">MEIRLCLKDKCIETVAEEKYEELAKELLKGENEEKEKKLEFLKDFLENADFNELRSSGYDGGQEMEVVISNKGSGFSVRKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0G6</accession>
    <name>A0A133V0G6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000025">
        <property type="protein sequence ID" value="KXA99938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99938">
        <property type="protein sequence ID" value="KXA99938"/>
        <property type="gene ID" value="AKJ40_02205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.451"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="330" mass="36437" checksum="6F7D7671F9BBC1A1" modified="2016-07-06" version="1" fragment="single">FGIPCEAENELAEKIVNNVSSADMVRFVNSGTEATMNSIRLARAYTGREKVLMFDGCYHGSHDHLLFDKEGPKTPGIPECLKDSTIVAPFNDIEAVKEIDSQEKLAAIIVEPVMGNCGCIPPEKGFLEHLREVCNQNGSLLIFDEVITGFRLSLGGAQEYYGVDPDLTTLGKIIGGGLPIGAFSGRKEIMQNVEPEGDVYHAGTFSGHPLAMVSGVATLDRLEKNNVIEETTGHAKEIAETFRWASGLTVNQVGPMLQIFFTSKNVSNAEEFPTTNEERFREFWEELLKRGVFIAPAGTESWFFSYAHTAEDLERTKTAIRETFEEIDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0K5</accession>
    <name>A0A133V0K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99967">
        <property type="protein sequence ID" value="KXA99967"/>
        <property type="gene ID" value="AKJ40_02085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="65" mass="7887" checksum="239F79CEAFD60A43" modified="2016-07-06" version="1">MKYEEKLKRAEEFGEIVREEELLTRLKRADDHQYFHPLRLPQLRKGQRETGLRENPVRNLRGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0M8</accession>
    <name>A0A133V0M8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000023">
        <property type="protein sequence ID" value="KXB00002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00002">
        <property type="protein sequence ID" value="KXB00002"/>
        <property type="gene ID" value="AKJ40_02040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="327" mass="37182" checksum="7DD97B6E511F927A" modified="2016-07-06" version="1">MKFGLFLNPQAPLGQEPESIFEGLVEQTREARDGGFDLIMTGQHYLTDYIQLQLFPLLSRLSAESGSMTVATGIVLLPLHHPIEIAEMATTLDVIAEDVVVGVGVGYRDIEFESFGVKKSERGDRLKEGVQLMKELWANEEVTFDGEYYSVNNVSINPRPEKNLPVWVAANSRSAIERAARISEGWLVNSHSTVSEILGLKQSYDDIREQEGETMEVPVIREAFVAPSREEAVEIGRKYLGPKYKRYIEWGQDEAMEDEEDLHRSFDDLTEDRFLLGTPEEVSDQIERCEKKLDANYMIFRIQWPGLPHEKALRCIQLIGDEIIPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0T8</accession>
    <name>A0A133V0T8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000021">
        <property type="protein sequence ID" value="KXB00063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00063">
        <property type="protein sequence ID" value="KXB00063"/>
        <property type="gene ID" value="AKJ40_01955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="131" mass="14754" checksum="27FC0EE7DB541645" modified="2016-07-06" version="1">MWKDLERELDSGSSVNLPPAATPVKVSEVSSRAGRVQVVGKVVELGEDRLLLDDGTGSVRVLFEDLSRVENLETGVTVRVFGSPLSLEEGFELHAEIVQRLDELDLDLYREVREETKKFEDIVKSDRRENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0Y7</accession>
    <name>A0A133V0Y7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000020">
        <property type="protein sequence ID" value="KXB00092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00092">
        <property type="protein sequence ID" value="KXB00092"/>
        <property type="gene ID" value="AKJ40_01885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="239" mass="26967" checksum="184273E8CEE68669" modified="2016-07-06" version="1">MESDLTLKTAGEESRSFSFTLRENLPAHRNPENVYLAHYLTIPENLPPDQYTLEVNVSDKLGGENASISGSFTLVEGEKKISLDPWDGLLRSEDIPSGFVEDTQNEWEMQDNTWFGVPFEKAAARYWMHSTEDKSIGVMGFVCPTESDGQTMFSRLSEYWRNYMENQGYGASTTSWPTYGEETESIQLTKGGERERSVFDPPKINKRSGMIYRSRSESLSSFQVSESSPCSNVLPSDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V106</accession>
    <name>A0A133V106_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000019">
        <property type="protein sequence ID" value="KXB00128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00128">
        <property type="protein sequence ID" value="KXB00128"/>
        <property type="gene ID" value="AKJ40_01865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="78" mass="9257" checksum="1DC8109559BF2444" modified="2016-07-06" version="1">MKIVTHDKVDDHQRTELTLACFDYPYSREYIKETTEVDQRVPDWGGDLYAKEDEKVLGMLKVIFPRTRTKNGMEPFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V143</accession>
    <name>A0A133V143_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000019">
        <property type="protein sequence ID" value="KXB00126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00126">
        <property type="protein sequence ID" value="KXB00126"/>
        <property type="gene ID" value="AKJ40_01850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="159"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="352" mass="40363" checksum="65236F734B1CEDC4" modified="2016-07-06" version="1">MQGKSRTGAKARSGAMRVFAGFFDPAPNSVYGSFDLAQSIMEMGMDGVSAESRSKPSPDVILRRLYEVDEESARRELEEFNEWILDELYSSKDLMIAIDFTVIPYYGEENPALVSDSRLPGTNLGIKFAVLSVVEEGKTFTLKTRQVYPIESEVSVLGEMLDYAESLLDPTKVLLDRGFYSVKMIKELKSRSMGFIMPAKKTNLVKKACKKFKKGEAPSELDYTVSGSKGEENVRLLLTEKETKNGTEIHPFITNLDITPKEASENYSWRWRIETNIREFEKFKPQTTSQSMELRRLYFLFSVTLYNLWILTRNGSEHPRAREFKKWLEFELLALKVLEEYRDKVPPPPTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1A6</accession>
    <name>A0A133V1A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000016">
        <property type="protein sequence ID" value="KXB00229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00229">
        <property type="protein sequence ID" value="KXB00229"/>
        <property type="gene ID" value="AKJ40_01665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="283" mass="32687" checksum="9EA72A6322583EA0" modified="2016-07-06" version="1">MVRGQTIDSPFDGGIPARIYFAAYLQPRTGYQLAKEVFGTREGSEQPKTPSKIYKYIKQFPDFFYKEYPDDSERKYKIHASLEPLLDQLPDSVLEIGSGETVQFVKRYLKREVRETLNEGYRADYWRGIHREEDPELSEEPDVEILSVFLEYLKYASAAKIAVSEIGLDQNSEVGEKEAARWALKEFLSPYLADETEKVLEWIDPLLELIGATEILNTPSLSGRPLGEAYPQGEKILDLTEFTYLVRQKMRSGVDRKARKQIKRKEEELKSVFRKGVERAIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1H1</accession>
    <name>A0A133V1H1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000014">
        <property type="protein sequence ID" value="KXB00297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00297">
        <property type="protein sequence ID" value="KXB00297"/>
        <property type="gene ID" value="AKJ40_01540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="152" mass="17728" checksum="E27047BA1BE2BB8E" modified="2016-07-06" version="1">MSEDRIKKILNESFFAYFCTTDGQKQPYIAPMFFIFDEESYKLYFVTRPKTRKVENIKSNPFASVTVDLRDPANPRNNEGVMVRGKINFFFPQDRWGGEGEKVKEIHGLYHKKYPTTVLEGIDVIASPEIIIELIPAQIIHWKGSKFTKKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1L4</accession>
    <name>A0A133V1L4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="7">BPG-independent PGAM</shortName>
            <shortName evidence="7">Phosphoglyceromutase</shortName>
            <shortName evidence="7">aPGAM</shortName>
            <ecNumber evidence="7">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">apgM</name>
        <name evidence="9" type="ORF">AKJ40_01460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="7"/>
    <dbReference type="EMBL" id="LHXU01000013">
        <property type="protein sequence ID" value="KXB00329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00329">
        <property type="protein sequence ID" value="KXB00329"/>
        <property type="gene ID" value="AKJ40_01460"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.213"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01402_A">
        <property type="entry name" value="ApgM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023665">
        <property type="entry name" value="ApgAM_prokaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02535">
        <property type="entry name" value="hyp_Hser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="8">
        <location>
            <begin position="2"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB00329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="398" mass="43828" checksum="45CFDD29E3C3ED5D" modified="2016-07-06" version="1">MKNVIVIGDGMAGYPIEELGGKTPLQVAEKPNLDWIASNGRNGLLKNVPEKMPADSDVAIMSILGYDPREYYTGRGPLEAAGMDIELEEGDVAFRCNLITMDDGFIKDYSGGHLSTEEAEELMEVVKKNFGNLGDFYVGVDYRHLFVLRNAKDVAGSLSCRAPHKIVGEKVDGNLIEPGSVDIAESLNRMMLESKEILSDHPINEKRVEEGKNPANAIWVWGQGVKPSLVPIFEKYGVRGAVISAVTLVKGLGVLAGMDKVDVPGVTGYYDTDYENKADYGLRSLVDHDLVLIHVEAPDEAGHSGDIEEKIRAIENLDNYIVGRFLDNLDEDFTVSVMADHPTPIVVRNHVSDPVPFSIYSTRGDKDNISRFDEFEARNGSFGTLEGYKFMDVLFSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1U0</accession>
    <name>A0A133V1U0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00414">
        <property type="protein sequence ID" value="KXB00414"/>
        <property type="gene ID" value="AKJ40_01315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="570" mass="66627" checksum="9B4C8C21B07D2277" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V209</accession>
    <name>A0A133V209_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00469">
        <property type="protein sequence ID" value="KXB00469"/>
        <property type="gene ID" value="AKJ40_01260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="49"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="187" mass="21202" checksum="2A84F23420EA8E0D" modified="2016-07-06" version="1">MSEFIEQKDGTLNKMYLVIFVYIIVGLVVLGFVLTQSNQNENSVNEIGTKIGKKAPDFTVQTIRGDYIELANLQGEIVILDFMATWCPPCRREILHLKEVYSNKSYENLRIISIDIDASESIDELTTFKEAYKINWILARGPSLGEKYKISSIPTIYILNEHGNIYYKNVGVTSASEILEKLKGIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V246</accession>
    <name>A0A133V246_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00524">
        <property type="protein sequence ID" value="KXB00524"/>
        <property type="gene ID" value="AKJ40_01220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="158" mass="17751" checksum="349F7DBA9AAD8EC1" modified="2016-07-06" version="1">MNRIKAMLRKKGIELDLDLRTNKDRRKLLELEISSINDHLEVIETLDNRIERVEEEVEDIEKDIEDVEILRKIPGIDYNSALTIIAEITTVERFPTAGHLCSYAGLVPSVKESGSKEVYGLFKVEDPCFVGCSTNAPLAVFCGFGIGVADMYSEAWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V254</accession>
    <name>A0A133V254_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00523">
        <property type="protein sequence ID" value="KXB00523"/>
        <property type="gene ID" value="AKJ40_01215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007516">
        <property type="entry name" value="Co_F420_Hydgase/DH_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045220">
        <property type="entry name" value="FRHB/FDHB/HCAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007525">
        <property type="entry name" value="FrhB_FdhB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31332">
        <property type="entry name" value="PTHR31332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04432">
        <property type="entry name" value="FrhB_FdhB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04422">
        <property type="entry name" value="FrhB_FdhB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="376" mass="41497" checksum="9EC13864EDA1D394" modified="2016-07-06" version="1">MIVNKTHLVMGKSKSERLFGHLMGVVHQDLCLNCGACAASCPWGSIKLINGRATLSGNCTACGLCYAQCPQTVTDETLTKKIFGSSFSTPLGTYKEAYSGCARNPEIRNEGQDGGIVTGLLEFLLKEELIEGAIVMDRDSEWKTQPQVAVTRREIIDSSGAKYTPGPILTATRDAVDHYLLEKMAFVGLPCQVRAIRVMESEEPVLRRITNRVELVLGLFCQHCFSYEGLFEEKLKKEMNVNPSDVVGINLAKNGSLTVKTDDSEHELSPNSIDNCIFEPCRICRDFSARFADISIGAAGTPQKYSTILIRTDKGKEIFRRAVDRGIVEAEPLEDTDPSIKDVKNQSLKKKKSAEKEIQSRREEGKSLPPKISGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V272</accession>
    <name>A0A133V272_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00515">
        <property type="protein sequence ID" value="KXB00515"/>
        <property type="gene ID" value="AKJ40_01175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="291" mass="33736" checksum="FF092673D538081D" modified="2016-07-06" version="1">MHLKNIKLAEKGYNRNKHYIDQIGVILAFSTGTTLPAGVDVFRGSLKDISTFKEFLDLLEPKDIGFIVDRGMFSEPLIKDFRKEGISYVMPLRKNSKYIDLRWLRWKDPFTYRKRTVRWARRHTDIGTLYLFDDPKLRGDQEAALLQKLGKGALTREKYEKKRERAGIIGIISDLDRPGPQIYDLYKSRHDVELALDAMKNHLDADKTYLQSEEAVRGYFFVAFLALRVYFSVLKRLREADKTSEISVDEVFYELSKVERVIGPGDKEFYAQIPEGAREIIDLFPEALPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2B2</accession>
    <name>A0A133V2B2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthine synthase</fullName>
            <ecNumber evidence="6">2.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dphB</name>
        <name evidence="9" type="ORF">AKJ40_01090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36415"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="2.1.1.98"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="6"/>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00580">
        <property type="protein sequence ID" value="KXB00580"/>
        <property type="gene ID" value="AKJ40_01090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1006"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="191"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6 7">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB00580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="263" mass="29241" checksum="D3732F0C8E09C0A9" modified="2016-07-06" version="1">MLLFVGLGMNSKGISIQGLEEARSADVVYAEFYTSIIPGFEIEKMEESISKPIRVLDREAVEVSPDEILKKSETKKVVFLVPGDPMVATTHVDLRLRAGKRGIETRIIHGASIETAGPGLAGLQSYKFGKTATLPLPEKRSITPYDVLEDNKKQGLHTLFLLDIEKEEERYLTADRAIEYLLDLEEELERKVYTGDTLSVVVARAGSEDPLVKADRCGNLIGRGFGRPPHILIVPGKLHFLEAEALEYFADAPKEVVEEYVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2B7</accession>
    <name>A0A133V2B7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00579">
        <property type="protein sequence ID" value="KXB00579"/>
        <property type="gene ID" value="AKJ40_01080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="339" mass="37383" checksum="412A5E4CC485FFC3" modified="2016-07-06" version="1">MTKTLQKKYAKNSGKIINSIIILAALIFLISSLTPAASANVNNDNEKPIVVATTTNLGYFANEVGGNNIEVLNLVPAGACPGHYDTRPTDVEAIVDADLILWNGFEPWLMELVESAGNREVLMNKGPGGEWGPPPRGKLYVENITDALMQAFPQYEESFERRKQDLLSTIDSCAENLRTEAERENIKQVKVICQSFQKPFVQWLGFSVVKTFPSPEQISASQTSEIINTAENEDVALIISNNASGTSFGEQIATETGIEHVVLGNYPGWMKGIDTYVKMVESNAERLFMGLESYRDELGTLSNLKEELKGVKFQRNAAFVAAIIVAIVAALEFMIIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2I0</accession>
    <name>A0A133V2I0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00658">
        <property type="protein sequence ID" value="KXB00658"/>
        <property type="gene ID" value="AKJ40_01025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="76" mass="9094" checksum="A538EF244A895D2D" modified="2016-07-06" version="1">MSSSFSLPYILYSVLQKRILITVHRQNHFLCRQQNKNARRKGKRNINHISKNNYPQKKCENKEVKRKGILKKPSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2L8</accession>
    <name>A0A133V2L8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00646">
        <property type="protein sequence ID" value="KXB00646"/>
        <property type="gene ID" value="AKJ40_00960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="146" mass="17058" checksum="629A14D58B9FE864" modified="2016-07-06" version="1" fragment="single">MLNNKKLVLFEPLLEETADRYVQITLVSADSGFLSRDNCDLVEKHGGKPRIHPKEGITLKRKGSWAWTDMLLNFIENPQEWLREYHTRSNVESGFSTFKRHFLSPLRKCIGRRRKTEAFARACDYNLKRASYVRRQEGLTAPWMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2L9</accession>
    <name>A0A133V2L9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00665">
        <property type="protein sequence ID" value="KXB00665"/>
        <property type="gene ID" value="AKJ40_01065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="160"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="406" mass="47269" checksum="51F4CB615D92380B" modified="2016-07-06" version="1" fragment="single">MWDLTEKKWGWTENQIGFNSEEVILTSPDPIRGLDEPSRKTIGNQKYRFDGRKEKERYKLCWSARSVIYPELVMKQHHNAEYEPTDLFGVLTHAAFTNDFVNNAAETYPLPEDETPHPNTVFYRTGKLSVVEILDQFNSAMERIIEVARGKGALEGKLDLAIDLTDWRYYGDKNDPMVLRVKPKKGTTKAFVLATLYAIVDGERFTLRAIPVSSLSNKEEIIEELLDYAEKMVDIGTLYVDREFFTVDCIKAIKKRKVKFLMPAIKNSRVKKEIKEGNPRVVDFEYGVKRKHPVNFNLGIVENDEGEVKTFATNHDVEKEELEKLFDMYSLRWGIETSYRVKHQFRAKTRTKYYEPRIFLFLFSVCLYNLWVLVNLQAATKFGENSKIYMTAKTFTDKMVEVLPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2M0</accession>
    <name>A0A133V2M0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00692">
        <property type="protein sequence ID" value="KXB00692"/>
        <property type="gene ID" value="AKJ40_00915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="139" mass="15870" checksum="379B4A00A69A225E" modified="2016-07-06" version="1">MLLAFSAIRAFPPGRRGSTLREIKDRKEKTGAAKKKPLPTKKEYRYQPNQTNFPQCRCTAGTSDDGKPIPKIVRERTKSAYRFLMEEHDPESCDLCSGKAAAPSDFYNGLFHYILENGRLTDEQYGCIEKKVEARSHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2M5</accession>
    <name>A0A133V2M5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00690">
        <property type="protein sequence ID" value="KXB00690"/>
        <property type="gene ID" value="AKJ40_00905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.787"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="205" mass="24147" checksum="B3F8F96FADDD5286" modified="2016-07-06" version="1">MYNILDLYQEPHDPKRPVVGVDERPKQLIGEKKKPIPMKPGSPERVDYEYVRNGSVNIFVAVDHKGGKRDTKVTDRRTKKDFARYIKRLVDEIFLDAEVIRLVVDNLNTHNESAFYETFKKEEAERILSKIEFHYTPIHGSWLNVAEIEISAMDAECTDRRIEDKETLIDELLAWTVRRNKDGKKIDWRFTKEDADRKLAKHYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2R1</accession>
    <name>A0A133V2R1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00738">
        <property type="protein sequence ID" value="KXB00738"/>
        <property type="gene ID" value="AKJ40_00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="87" mass="10245" checksum="D4B2A594E4DB836D" modified="2016-07-06" version="1">MEIIDKKMNCSICGKEIIVTVTSIGVTHQMIEGFVCEDCYRERLKELREKVEDEKFERIKEFMKSDKETLKREVETKEPTPEVQGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2R4</accession>
    <name>A0A133V2R4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00715">
        <property type="protein sequence ID" value="KXB00715"/>
        <property type="gene ID" value="AKJ40_00710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="370" mass="43337" checksum="9765A829DEDBD667" modified="2016-07-06" version="1">MKEDELRTRLRFWVETHYDLQDQRIITDNRIDAIERSKDYNQMDAVISGMRETSRKLEDHEEEAKKHIKNLLKEHPLWNRWLAGVHGMGPALTGGLIAWTYCGSKCREMSSGDGYEKYDQQNKRWKECPYWEDCQGKRDIRRFHTPSAYKKYVGLAPGMGKKQGQDHSYKHEFKPHVIKIAKQFRRQGKEYRKLYEQFSEKYWGRARNKGKDIVPSKDLPEDDGGNKYEPEGVVSEGHLENLTLRKLGQTFLIHTYDVWRRILGLPVKEPWITSKSPDAEKHRYLKPRIDNKSKIKRGVPGLWKSDKEVKAENERLEGILDDHPVDAELKTIRDAFDEGSLEEVFGADLPGSAIEEIRETLEREEPTIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2R8</accession>
    <name>A0A133V2R8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00723">
        <property type="protein sequence ID" value="KXB00723"/>
        <property type="gene ID" value="AKJ40_00755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="168" mass="19009" checksum="E37335F8FEC87398" modified="2016-07-06" version="1">MEKSKMAEEGKTESSPSLGDEKFEKNLKVGLDVDGVLCEREVTRTPEECVGVERSRVPVPSHEHEIYIVSSRTKDMGEETRVWLAENGVEYEKLILLEEDSFEGLSEGEIEEKQASFKASAVSELDLDVYVEDQPNVRDHLREHCPDCIVLSPSEAQKAWRFSGYEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2S8</accession>
    <name>A0A133V2S8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00733">
        <property type="protein sequence ID" value="KXB00733"/>
        <property type="gene ID" value="AKJ40_00810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="143" mass="16544" checksum="78CFA9545D07ACEA" modified="2016-07-06" version="1">MNNTDPSKVARKLRYGWGLPEKIGLWFLTNLEKESAVYTATVRFEGVESVAKTEARKRSFHYDIPPFYGIFIYISYDSSPTVSELIPLFQIGTCGSRRETERALLRGLESMDNKEDVKKIFETAVEMYNESWNFSPPEREAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2S9</accession>
    <name>A0A133V2S9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00757">
        <property type="protein sequence ID" value="KXB00757"/>
        <property type="gene ID" value="AKJ40_00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008303">
        <property type="entry name" value="Methan_mark_14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09887">
        <property type="entry name" value="DUF2114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="249" mass="27563" checksum="677F900AFD7D04BD" modified="2016-07-06" version="1">MSLEKPKIAANELKSKAILVGGKRIISSSTEIDFYPNIFLDISTYFSGISHKYKNPEKITGLVSGLGAEIIDALARAHGKVDSKKGTILQLPNNKGDVYEEEVTECVSKISKIINIQRVPSGTKRVGHIPIDVDESYKQKIKLISCDAGENGSKLEKITDIGRTAASFGTATLRKVIIKTFSRLLSRTIQTMYNEDLISPKSRICISGRQTFPEFQIEETIKHLKSTGFEKIADNTVFIKNPACFGFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2V0</accession>
    <name>A0A133V2V0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00764">
        <property type="protein sequence ID" value="KXB00764"/>
        <property type="gene ID" value="AKJ40_00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="34"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="286" mass="33316" checksum="D8892416112FDC14" modified="2016-07-06" version="1">MSLELPTNKKYHVCFTVDFDAFSLWLGPNQVTSPTVLSRGEYGARVGIGRILDLLEKYDIRSTFFVPGHTTDTYPDIIEDIHERGHEIGHHGYCHERPNDLQRDEEEEVIDKGIKSIEDVIGEKPVGYRSPGWDPSQNTIELLLKKDFVYDSSMMADDFTPYRCRVRDKISKEKPIEFGKETDLLEIPVHWSLDDFPHFAFSEEPSKGSELSSPSKVFEIWSGDFDYMYDKLEKGVFTLTIHPQIIGRGHRINMVEKLIEHIKNYREVTFMKMKEVANFWKQNKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2V1</accession>
    <name>A0A133V2V1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00769">
        <property type="protein sequence ID" value="KXB00769"/>
        <property type="gene ID" value="AKJ40_00670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="102" mass="11901" checksum="371B20119046A1A1" modified="2016-07-06" version="1">MTVRETSIEAFYNLPDLAERQRQVLRGFKLWGPGTDFEITVALNKHRPEYWYPNRVRPRRKELQDMGLIREIGKRECEVTGRTAIVREVSPLGRRMGVVSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2X6</accession>
    <name>A0A133V2X6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00789">
        <property type="protein sequence ID" value="KXB00789"/>
        <property type="gene ID" value="AKJ40_00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="220" mass="24860" checksum="E828B88748D27D15" modified="2016-07-06" version="1">MCAELAKFIPSEIRLKIAQSVVKEKGIRPLAREIGVNPKSVYKYKEGTANPGDEVMSKILAVAEQEDSIKLEEYLEELKSEFLEALELSFEPKQVLTGDSEEQKDVSEPKSPTAEEKKGVVQESTDRKPTEKSVDEKSTLRMEEVYNRIGVKKPFNRSKVEKIIGSFSESSRPNLNEIVELSGLSEEATEKYLEKLASEKIVNRDSQNTYRLSVEIERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Y2</accession>
    <name>A0A133V2Y2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00793">
        <property type="protein sequence ID" value="KXB00793"/>
        <property type="gene ID" value="AKJ40_00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004426">
        <property type="entry name" value="CHP00062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00162">
        <property type="entry name" value="TIGR00162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="254" mass="27744" checksum="CAB2696515232175" modified="2016-07-06" version="1">MSKFEFKLLKEPDLENPVLVEGLPGIGYVGKLAADHLVEELNAEKFAELSSHYFPHHVTVTPEGVLETVKIDFYQAKTEDCDLVIITGDVQATSSEGHYKTSEKLLDISEELGVIKIYCLGGYATGKHSKSKPKVVGASNKEKILEGYRDRGIDVEEGTGPILGVSGLLLGLGKNRGMEGSALLGETHGMLVDHRSAQAVLEALSNLLNFEVDMSKLKERAEKTEEILSRLQKEKKIREVAGMGEGDEEVSYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Z4</accession>
    <name>A0A133V2Z4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">30S ribosomal protein S27e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps27e</name>
        <name evidence="5" type="ORF">AKJ40_00445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3 4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00795">
        <property type="protein sequence ID" value="KXB00795"/>
        <property type="gene ID" value="AKJ40_00445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_S27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_S27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="61" mass="6560" checksum="9945CC081A7EE139" modified="2016-07-06" version="1">MVKVDSETPCFVRVKCTDCENEQVIFSHASSEVNCEVCGKTLASPQGGKAEINSEILEIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V301</accession>
    <name>A0A133V301_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="8" type="ORF">AKJ40_00470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00814">
        <property type="protein sequence ID" value="KXB00814"/>
        <property type="gene ID" value="AKJ40_00470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="7">
        <location>
            <begin position="121"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="246" mass="27594" checksum="49B3AFB528C8BE11" modified="2016-07-06" version="1">MDSSEVWKNCIGAISNLIEEADFEIEEDGMEMKAMDPSHVALADFKLSSAAFTEYEVDKPTKLGVDLTEMDKIFSRANKNDESTLEYTEEDNRLKLEFIGASTRRFSLPLLELEEEELPEPDLNFTATAKVTAGTIREGLKDAALVGDNVRFELTKGKFLMKIESDTGSAEMELSEEDEGLKDLNVDEPTKAMYNIGYLEDMFKAARSKDIVEINHGEDLPIQIIFKMADGEGILKFLLAPRVETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V331</accession>
    <name>A0A133V331_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00816">
        <property type="protein sequence ID" value="KXB00816"/>
        <property type="gene ID" value="AKJ40_00520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="47"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="203" mass="22895" checksum="1DE21E04D841E4F7" modified="2016-07-06" version="1">MKKKELEIKLQKLEPHPNPSPELEQYMTPGDIAASLLYLAHSHGSIKGKKIYDLGCGTGRLAIGAALLGGKKIIGVDIDGEALKIAKKNSAQADVENIEWIRADVSNLELPETDTVIQNPPFGVQKKGADMVFLNKALQFGKDVYSIHKGVPKNRDYISEQVKELGGRITNRIEKEFHIPSQFKYHTRKVYRFKVDLYRIIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V335</accession>
    <name>A0A133V335_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Glutamyl-tRNA(Gln) amidotransferase subunit D</fullName>
            <shortName evidence="5">Glu-ADT subunit D</shortName>
            <ecNumber evidence="5 8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gatD</name>
        <name evidence="13" type="ORF">AKJ40_00310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the asparaginase 1 family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5 8"/>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00840">
        <property type="protein sequence ID" value="KXB00840"/>
        <property type="gene ID" value="AKJ40_00310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.70"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08962">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00586">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011878">
        <property type="entry name" value="GatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040918">
        <property type="entry name" value="GatD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037222">
        <property type="entry name" value="GatD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18195">
        <property type="entry name" value="GatD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500175">
        <property type="entry name" value="Glu_ADT_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141300">
        <property type="entry name" value="SSF141300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02153">
        <property type="entry name" value="gatD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatD_N" evidence="12">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase" evidence="10">
        <location>
            <begin position="94"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="11">
        <location>
            <begin position="306"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB00840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="445" mass="49013" checksum="EDE424F482972542" modified="2016-07-06" version="1">MKGYRDNAKNLLKSASVDIGDRIKIRKRGQEFEGLLMPRTKGEAADHIVMKLDSGYNIGIKATEDTEIEKIREGKEPEMRRHGEKVEPDADKPNISIIGTGGTVASRVDYRTGAVHPAFSASEIYNSAPEIAEIANIETNNVCNVLSENMTPELWSKVGNAVAEDLNDGADGVIVAHGTDTMSYTASALSFMLKNLSKPVVLVGSQRSSDRPSSDVTLNLTGAVSVAISNLAEVCVVMHGSTEDEFCLIHRGTKVRKCHTSRRDAFQSINDLPLGIVRDKSVRFFQDKRGRRKNGKVEVEDGFEEKVALVKIFPSIQGEIIEKLIEDGYKGIVLEGTGLGHTPESLFSGIEKAIEKNIPVAMTSQCIWGRTNMRVYSTGRDLLDLGVFPVEDMLPETALVKMMWILDKTQEMEEVQARMKENIAGEISSRTRADTFLKPKIPGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V342</accession>
    <name>A0A133V342_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RPOL9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00862">
        <property type="protein sequence ID" value="KXB00862"/>
        <property type="gene ID" value="AKJ40_00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPOL9" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="83" mass="10233" checksum="D0D72EB40E70927A" modified="2016-07-06" version="1">MEFCQKCGTILLPQKKKKVIWLVCPKCGYYKHIKEPEHYKLIQLKERRNLKVPILEYEERRKFEQPDYDIDTDEFADLYEDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V352</accession>
    <name>A0A133V352_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="10" type="ORF">AKJ40_00285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00836">
        <property type="protein sequence ID" value="KXB00836"/>
        <property type="gene ID" value="AKJ40_00285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.64"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00285">
        <property type="entry name" value="TIGR00285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="9">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB00836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="90" mass="9910" checksum="92201661B6C6090A" modified="2016-07-06" version="1">MSNDNVVYVGNKEVMNYVLAVTTQFNEGSEEVILKARGRAISRAVDTAEIVRNRFLQDVEIKDITTGTEEIEGEEGETSNVSTITITLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V353</accession>
    <name>A0A133V353_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00872">
        <property type="protein sequence ID" value="KXB00872"/>
        <property type="gene ID" value="AKJ40_00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="184"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="447" mass="49666" checksum="6788C7BD8CB8F038" modified="2016-07-06" version="1">MVQGAVESYLEELSDLVSFPSISSNPKYKEDVRKCSNFLQEKFADLGAKTEIVETSGHPLVVSDISNYDDALTLAFYGHYDVQPIASPEDWKTDPFTLVEDNGKLYGRGTSDDKGNLLTAVKAAEIALEEDLRLNFQFIIEGEEESGSPNFESGLKKSRDMLDPDVVIVADGGWVSKDIPSIEYGLRGLLYMHWNLRTAGKNAHSGAVGGPARNPLLELFDVVCKCLDSDTGEIKIPEIYDDVKEASSEELEHWIGTKFSVEEFKESYQLEKLRFEDKAKVLKSLWARPTFEVHGCVGGYMERDSKMTLLPSDGQLHVSMRLVPDQDPKMVFEKIRNFVGDKNPDIEVKSVSHVEPYLTDFNSPMVKAAAESLEETFEKPAARIRSGGSIGAVPIMNRVFGGGDIIIMSFGLPEHGAHGPNEYFTKEMAKGGMEAYLNFFESLEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V354</accession>
    <name>A0A133V354_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="6" type="ORF">AKJ40_00120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00878">
        <property type="protein sequence ID" value="KXB00878"/>
        <property type="gene ID" value="AKJ40_00120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.26"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="39"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="296"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB00878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="435" mass="48662" checksum="7A9BA6EAD208D6CF" modified="2016-07-06" version="1">MLKSHLGVNEDNELTIGGVSTVELADRFGTPVYVTDENKIRENYHRFYEAFDKKWDDFAIWYAYKANSNLAVCKVLQDEGCGAEVGSLCELKIALKVGTPGEQIIFNGNNKSEKELELCIKNKVLINVDNLQELEIINRIAEEIGENARVGFRVNPDVEAPTHPHISTGLRKSKFGLDVPSGKAIKAYKKASKMDNITVEGIHSHIGSQILDPEPFMEQARKTLELRKKIRKEIGIELKIVDLGGGLGIPYRPGEKELPPEEFASKIVSTVEESLKDQELSKPKLVFEPGRFIIADTTLLLGRVGYVKERKNIPHWVSIDAGMNALIRPALYDSYHHIEVANKMNEEKTESTNVAGPLCESGDYLGKDRKLPPVERGDLLAIYDVGAYGLSMASQYVGNTRPCMVMVKSGKADTVRERETCEDLTRLDKFPDWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V358</accession>
    <name>A0A133V358_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="11">ASA dehydrogenase</shortName>
            <shortName evidence="11">ASADH</shortName>
            <ecNumber evidence="7 11">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">asd</name>
        <name evidence="13" type="ORF">AKJ40_00095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 11"/>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00874">
        <property type="protein sequence ID" value="KXB00874"/>
        <property type="gene ID" value="AKJ40_00095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.21"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="12">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="39"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB00874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="354" mass="38823" checksum="0FF6EAC4E5E1730B" modified="2016-07-06" version="1">MSKIPVGLLGATGMVGQRFIQSLSDHPWFELEALTASEKSAGKRYEEAAKWYLYPPMPEEVKDIEVRPTEVEAVEDTEIVFSALPSSIAEEVEPKMAKAGKIVASNASSYRMDPDVPLMIPEINPDHLNLIEQQKENRGWDGAIVTNPNCTTIILLLALKPLIDEVGINRVFVSTMQALSGAGYGGVKSMEIEDNLIPYIPKEEWKTENEPLKILGKYEKGKIEKAEIDISASCNRVAVLDGHTESVFLELENEASPKSVERIMSEFKAEPQELNLPTAPIKPIIIEKEPDKPQPRSARHAGSVPGMAVAVGRVREDPVFENGIRFLISGNNAIRGAAGASVLNAELMKAKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3A2</accession>
    <name>A0A133V3A2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00886">
        <property type="protein sequence ID" value="KXB00886"/>
        <property type="gene ID" value="AKJ40_00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="93" mass="10485" checksum="47D0DEDD7E235F64" modified="2016-07-06" version="1">MDKSAFLAIKDALEENNLPVTKETVKAFMVGEMELIRSNVEAHLTGRCSSEEILEMNFNRFKEQGGEPIGDNKTYYELETEGLEGFISNYSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUS5</accession>
    <name>A0A133UUS5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_05020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000126">
        <property type="protein sequence ID" value="KXA97965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA97965">
        <property type="protein sequence ID" value="KXA97965"/>
        <property type="gene ID" value="AKJ40_05020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.251"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA97965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="158" mass="18682" checksum="91DF14CE3E6A4BEE" modified="2016-07-06" version="1">MTAYKFRVKADWKPRDLWRDVVIGEDRTLRDLHEAINPAFGLDFDHLYFFARGQSYWDSEVRYVHRAEIENNPYDAIPEVDIDLRDADETSIHDLGLKVKDRLCYLFDYGDEWRFYMILKEKLEDEPSDKKPEIVKEKGEKIKNQYGPGLPGIGGYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUW2</accession>
    <name>A0A133UUW2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_05000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000125">
        <property type="protein sequence ID" value="KXA97995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA97995">
        <property type="protein sequence ID" value="KXA97995"/>
        <property type="gene ID" value="AKJ40_05000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA97995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="118" mass="12769" checksum="0FB847A4A9883876" modified="2016-07-06" version="1">MKNFHKRLVSAILIGAVLGIFCILGVGIRLGFSGNEWYLFGMWYNRVLMGILIGLAGSWKIVTGKENRTKNAVVRGLILGVIVTSAVLFSTSFKDLPSWGAGIVYGVIIDIGATHLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVA0</accession>
    <name>A0A133UVA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000120">
        <property type="protein sequence ID" value="KXA98132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98132">
        <property type="protein sequence ID" value="KXA98132"/>
        <property type="gene ID" value="AKJ40_04910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="73" mass="8234" checksum="A750C1F28B2B5277" modified="2016-07-06" version="1" fragment="single">MFAWLRNFFSRLFGGKDQIALGIYGPPNTGKTTLANVISEEFTGEKLGNVSEIPHETREVKRKEKVTLETDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVS7</accession>
    <name>A0A133UVS7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">tfb</name>
        <name evidence="11" type="ORF">AKJ40_04845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000116">
        <property type="protein sequence ID" value="KXA98289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98289">
        <property type="protein sequence ID" value="KXA98289"/>
        <property type="gene ID" value="AKJ40_04845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.191"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="132"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="226"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXA98289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="315" mass="35900" checksum="56265485FA30C753" modified="2016-07-06" version="1">MREKTTKKDSGRKKLAKDCPSCEKNSVVRDYKRNIEICDNCGRIVKEDIKDRGPEWRAFDQKQRDEKSRGGPPSTETIHDKGLSTQIDYKNRDAKGNKLSPERRRKVYRLRKWHKRGRVTDSKDRNLAFSLSEINRMSSQLGLSKNVQEIASKIYRKAVERGLIRGRSMEGCASAALYAACREADVPRTLEEVTKASRVDKSEIRKTYRFLSRELDIHLSPTDPVRYVARFGSELGISGETRVKAIEIIRKAQEKKLTSGKSPTGTAAAAIYIAALEVGERKTQRETAEAADVTEVTIRNRYKEMVEELNFQIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWA3</accession>
    <name>A0A133UWA3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000109">
        <property type="protein sequence ID" value="KXA98468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98468">
        <property type="protein sequence ID" value="KXA98468"/>
        <property type="gene ID" value="AKJ40_04740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004376">
        <property type="entry name" value="CHP00024_Pesterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337:SF5">
        <property type="entry name" value="PTHR30337:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00024">
        <property type="entry name" value="SbcD_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="250" mass="28433" checksum="902AA8AC74B56822" modified="2016-07-06" version="1">MNIFDFEIVNSYPALWNEESGSVVVSDLHLGLEGLLAEEGTYFPKFQLEGVKEDLGNIFAHEEASRLIIVGDLKHEFSKASYFERKEIEEFLNFLEDLVGNIIILKGNHDNYLMYSVEGRENVALEDIYIDNRICYFHGHQDDLGLERTDAEIFVMGHEHPAIVLRDEVGVEEKFRVFLHGELEGGRKIIVMPAFSKLASGNRVNGVPKTELLSPFLKRHADLGRMKPVAVHEDSEPLGFPKLSDLEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWG0</accession>
    <name>A0A133UWG0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AKJ40_04700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="10"/>
    <dbReference type="EMBL" id="LHXU01000106">
        <property type="protein sequence ID" value="KXA98521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98521">
        <property type="protein sequence ID" value="KXA98521"/>
        <property type="gene ID" value="AKJ40_04700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.140"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXA98521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="329" mass="36949" checksum="0F8333360420E5FD" modified="2016-07-06" version="1">MRFPKIRMRRLRKKKNIRKLVRSINVSKTDLLYPVFVKEGLKKKSEIKGLPNQYQYPLERLDELINKCEEAGLPAVLVFGIPESKDKIGSEAFNEEGIVQKALRYLNNNSDLGIFTDVCLCQYTSHGHCGVLDDTGLNNDKTLEILGKVAVSHANAGADFVSPSGMIDGQVKSIREKLDDAGYSGVGIMSYSAKYESNFYGPFRRAAESFPMQTGKEPTISGRSTYQMDYRARNQALREVALDVQEGADIVMVKPALPYLDVIRRVRETFDIPISAYQVSGEYSMIKKFEGESEEDILMETLFSIKRSGCDFIITYAALEVADLLMETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWG9</accession>
    <name>A0A133UWG9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate-1-semialdehyde aminotransferase</fullName>
            <ecNumber evidence="2">5.4.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="2"/>
    <dbReference type="EMBL" id="LHXU01000106">
        <property type="protein sequence ID" value="KXA98520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98520">
        <property type="protein sequence ID" value="KXA98520"/>
        <property type="gene ID" value="AKJ40_04695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.139"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="111" mass="12268" checksum="4DA28971CFE44141" modified="2016-07-06" version="1" fragment="single">MKSQRQYELAKKLMPGGVSSPVRAVKPYPFFVEAGNEARIQDIEGNEYIDYCLGYGPLILGHRPDPVMKAIKEQLGKGLHFGIPCEAENELAEKIVNNVSSADMVRFVNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWK7</accession>
    <name>A0A133UWK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000103">
        <property type="protein sequence ID" value="KXA98573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98573">
        <property type="protein sequence ID" value="KXA98573"/>
        <property type="gene ID" value="AKJ40_04650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.119"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="78" mass="9167" checksum="9D06E69EC630B610" modified="2016-07-06" version="1">MKLKSRYTRDFGSCMSPFNAFLFLQGLETLHLRMERHSKNAKEVAEFLKDHPKVDWVVYPGLSNHETHQSAEKYLRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWQ0</accession>
    <name>A0A133UWQ0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000101">
        <property type="protein sequence ID" value="KXA98616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98616">
        <property type="protein sequence ID" value="KXA98616"/>
        <property type="gene ID" value="AKJ40_04620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025658">
        <property type="entry name" value="Cyclophilin_TM1367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04126">
        <property type="entry name" value="Cyclophil_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="118" mass="13237" checksum="EFBAF3F80D9D693A" modified="2016-07-06" version="1">MPNKIVISTEDFEVEAVLLEEDRPETCEKIWNALPIEGKASLYKEEIYFEIPVDIGPEDATPSAEKGDVSYWPEGNSFCVFFGESQPVSPVNTFAKIEESSEEFRGVESGEKIEVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWY2</accession>
    <name>A0A133UWY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000097">
        <property type="protein sequence ID" value="KXA98705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98705">
        <property type="protein sequence ID" value="KXA98705"/>
        <property type="gene ID" value="AKJ40_04545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="128" mass="14897" checksum="9ED633532A6D1275" modified="2016-07-06" version="1" fragment="single">MRRKDKKIEDRREIESIIERANVCRIGLCDEGVPYIVPLVFGYKNSCLYFHSATEGKKIEIIRKTDTACFEIDIDKELVKAEDACSFSMKYRSIIGFGEIQIVDDTKEKIEALNTIMSHYTEENFQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWY9</accession>
    <name>A0A133UWY9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3HCDH_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000098">
        <property type="protein sequence ID" value="KXA98688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98688">
        <property type="protein sequence ID" value="KXA98688"/>
        <property type="gene ID" value="AKJ40_04565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="62" mass="6693" checksum="F77689FC85C16374" modified="2016-07-06" version="1" fragment="single">MEDIKRVACIGGGTIGSSWAALFSANVQKVYLYDLKEEILDSALNNLSAQLSFLSSKGLINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX29</accession>
    <name>A0A133UX29_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMC_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000095">
        <property type="protein sequence ID" value="KXA98755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98755">
        <property type="protein sequence ID" value="KXA98755"/>
        <property type="gene ID" value="AKJ40_04470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="77" mass="8326" checksum="7F9A89DF898064D2" modified="2016-07-06" version="1" fragment="single">VLDEIDAHLDPKNRNEVAKLIKSFSKEAQIAIVTLHDSVMSAADKLFGVNMDDDNISHIVSVNLEEVKGGNPNAGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX75</accession>
    <name>A0A133UX75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000094">
        <property type="protein sequence ID" value="KXA98782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98782">
        <property type="protein sequence ID" value="KXA98782"/>
        <property type="gene ID" value="AKJ40_04450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="78" mass="9413" checksum="3C09E134A7C959B3" modified="2016-07-06" version="1">MRNPKPKTRNRIDPEVLDCREYLRIFEGRFTGGRSLSLLFFFIRSVFKAGLRMFKLFMVWGLVFGWHCSSWSGEWAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXA0</accession>
    <name>A0A133UXA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000093">
        <property type="protein sequence ID" value="KXA98814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98814">
        <property type="protein sequence ID" value="KXA98814"/>
        <property type="gene ID" value="AKJ40_04430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012415">
        <property type="entry name" value="Restrct_endonuc_II_Cfr10I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07832">
        <property type="entry name" value="Bse634I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="264" mass="30577" checksum="82536E694E9E4E60" modified="2016-07-06" version="1">MELNQWGNPGIKTEEAFFYLKDKIDFDNPISKILEKIEQEIKEISRELLGEEPTGNSLRRSRGDWFELIVFEAVWEAIPPNNNFVAIKLPRARVGSGGYLGNFRESEVKDNLIKKNLYCSNPDFMVFKESEENGSGWKDMSLRKIWGDKSKEISGTIKMENVFSIIAAKTNPRPDRRYQHLHEATTTKTIHKLADKPKGGIKYHTVMMKMGEKDKEVYTYPFIYNMIVNGSVKPVIDSYLVSESYTDILEFFRKIFNKSEGSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXL0</accession>
    <name>A0A133UXL0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000090">
        <property type="protein sequence ID" value="KXA98920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98920">
        <property type="protein sequence ID" value="KXA98920"/>
        <property type="gene ID" value="AKJ40_04315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="64" mass="7836" checksum="1B8810919EDF4AED" modified="2016-07-06" version="1">MPEFAEVFCPNCGELVALFDLDKERFENKKFFRDHLQDKHRFSKLQAREFVRLLENRWRWFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXW9</accession>
    <name>A0A133UXW9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000083">
        <property type="protein sequence ID" value="KXA99021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99021">
        <property type="protein sequence ID" value="KXA99021"/>
        <property type="gene ID" value="AKJ40_04155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="75" mass="8842" checksum="3D548FC5A51B2C2E" modified="2016-07-06" version="1">MLPPYEYIKNEIKSKRKEANWTKKKLSEESGVPKDIIEMIESGAKGKEQKYHYLKKIDEALEEAEAVKKEEDEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXX5</accession>
    <name>A0A133UXX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000081">
        <property type="protein sequence ID" value="KXA99039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99039">
        <property type="protein sequence ID" value="KXA99039"/>
        <property type="gene ID" value="AKJ40_04090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="67" mass="7682" checksum="C14411085EC745FB" modified="2016-07-06" version="1" fragment="single">NAKNIRNGKIVTELPWMMHKGELVHLFSVDVPETCSECGSKLNDNKNHDRFILTKVGTLKILVTYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY17</accession>
    <name>A0A133UY17_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000076">
        <property type="protein sequence ID" value="KXA99088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99088">
        <property type="protein sequence ID" value="KXA99088"/>
        <property type="gene ID" value="AKJ40_03980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="71" mass="8135" checksum="62A901091BB69FD7" modified="2016-07-06" version="1">MRNLRISDNGKSFQIKRGSEGFPPIDQKEKGKRMVKLEITESGEFSMTHSPTKDENVPITGFFVEFEITEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY79</accession>
    <name>A0A133UY79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000073">
        <property type="protein sequence ID" value="KXA99127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99127">
        <property type="protein sequence ID" value="KXA99127"/>
        <property type="gene ID" value="AKJ40_03900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="140" mass="17123" checksum="86318247551BA495" modified="2016-07-06" version="1">MRRKGVRSRSLKNFFYLHPAWTEFKRKFRRNGEGTLGEYLEEVKEILQGSFPMEDEIVKLPRHSRARKKHREVLEGLDGIPDDEVSREVFVRMRTGEEYREFRRTAKREIRTIEKMEEFEEKKEELPKKRKVIMLVEEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYB3</accession>
    <name>A0A133UYB3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_03760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000069">
        <property type="protein sequence ID" value="KXA99173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99173">
        <property type="protein sequence ID" value="KXA99173"/>
        <property type="gene ID" value="AKJ40_03760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="156" mass="17943" checksum="1FF34F6ACEC0881E" modified="2016-07-06" version="1">MELIFLFGFLISPQPRVYLFSRFLFPLPYVDFSISFFHLMIGISSIIAGAWIAIWAVKEMSEKVGFKVVDTHSAAKKVVTSGPYTIVRHPQHLGAILSYIGGSVLFSAYYALLFLPIYVTCNYLISWKEEKELVKEHGKKYQNYQEETPMIIPDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYG0</accession>
    <name>A0A133UYG0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lig</name>
        <name evidence="16" type="ORF">AKJ40_03670</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="LHXU01000065">
        <property type="protein sequence ID" value="KXA99219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99219">
        <property type="protein sequence ID" value="KXA99219"/>
        <property type="gene ID" value="AKJ40_03670"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.971"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="327"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="13">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXA99219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="567" mass="64075" checksum="823F75649B1E657C" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYG9</accession>
    <name>A0A133UYG9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000063">
        <property type="protein sequence ID" value="KXA99238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99238">
        <property type="protein sequence ID" value="KXA99238"/>
        <property type="gene ID" value="AKJ40_03620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="94" mass="10578" checksum="68ACCC661FF8EAB1" modified="2016-07-06" version="1">MEKIEFKLSQPLKMKYGREKVNVQIPDGGKLRRGLEELGREIGETFVVKGKIDGPWKNHINLVVNGEPVHRSEINNYVLKDGDTVHILIPFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYL0</accession>
    <name>A0A133UYL0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000058">
        <property type="protein sequence ID" value="KXA99302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99302">
        <property type="protein sequence ID" value="KXA99302"/>
        <property type="gene ID" value="AKJ40_03445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="286" mass="32695" checksum="643AA4EA75700ED1" modified="2016-07-06" version="1">MSRKKSKKSKPVGTFPALSLYSQYLYPPAILMDIFPSLEKVFLDLQTEKGFGKGRLKRGERVKGLGGSVTMVVVDGANVIRATAEPSLENLKRVLDFLEGENLGYEVVLDASVRYDFGRIASLPACFKEDIRKGRTERLEEEFEERGIDSGKLQIRKRDYPFKVVGDDTHLISIGGGRVTVFDPDDEERRELETILEREEFELVPPKTDADLRIIERMRMYPHSKILSNDKFDRFKHDFPLLKDESRFIRFRIEAGEIKIGKKSKDEGSKPSFPSGLEEKMRKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYL5</accession>
    <name>A0A133UYL5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000058">
        <property type="protein sequence ID" value="KXA99300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99300">
        <property type="protein sequence ID" value="KXA99300"/>
        <property type="gene ID" value="AKJ40_03435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="79" mass="8639" checksum="0FE654DE72F1F15D" modified="2016-07-06" version="1">MVCLVEALILINTTSGVMDKVHEEVKNIKEVRKATKADGPHDIIAIVEIEAVGEIRDALMDKIRSIKGVKETTTNLIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYL7</accession>
    <name>A0A133UYL7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000060">
        <property type="protein sequence ID" value="KXA99275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99275">
        <property type="protein sequence ID" value="KXA99275"/>
        <property type="gene ID" value="AKJ40_03530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="122" mass="12505" checksum="1AD70AE6D44F0AF4" modified="2016-07-06" version="1">MDREFWLGLIGGIFGILGAIAAIIVGAAGEALTGSSEGLYAQGAVAMIFSIVGIVAPAILDKKKWVGVLMIISGIIVLIAISLFGVLTVILFVIGGAVALKNRGTEDRRQSSTTSRSSSDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYN0</accession>
    <name>A0A133UYN0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MtrH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000059">
        <property type="protein sequence ID" value="KXA99285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99285">
        <property type="protein sequence ID" value="KXA99285"/>
        <property type="gene ID" value="AKJ40_03500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023467">
        <property type="entry name" value="MeTrfase_MtrH/MtxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028342">
        <property type="entry name" value="MtrH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02007">
        <property type="entry name" value="MtrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004960">
        <property type="entry name" value="MtrH_MtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01114">
        <property type="entry name" value="mtrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="303" mass="33360" checksum="07C314172B82244F" modified="2016-07-06" version="1">MFLFSKDQEVYDIAGAKIGGQPGQYPTVLVGSVFYDGHNVVEDDDKGVFDEEKADEQIKKVEELSESTGNPAMLDVVGGSSESLINYIDFIADVTDLPFLIDGTTADIRIEATEYVKDRGLADRAVYNAITVDCREEEIELIKKADIKSAVLLCYNAKKPTIDGRMESFEKVLDYASDAEIEKPLVDPSIIDLPDPGPASRTISKIKEGYGLPCGCGAHNSVDQWRERVEMSPEMYKLRTAVTNSFPITMGADFSLYGPIEDAEEAFAACSLVDAFVGYSMKMEEGLGPESKDHPLYKIFRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYN5</accession>
    <name>A0A133UYN5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_03525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000060">
        <property type="protein sequence ID" value="KXA99274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99274">
        <property type="protein sequence ID" value="KXA99274"/>
        <property type="gene ID" value="AKJ40_03525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="85"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="263" mass="31350" checksum="8FBE6BDAB077C6F0" modified="2016-07-06" version="1">MNIDEGLAERTINQHLNNIKDLSSFLDKPLTKVTKQDLRDYLKKYKKYSRSYFANKIKSLRAFYGRFLDTDLADSFKIPQPQSENNQKVPDRKELERFYNNIDGRAGKKYRAFFLIKATSGLRTNELTNLTMENLDLEERMIEPNHNSKTKRSYISFYNQETEKVLKKFLPHRKEDDERLFQVGESNVHRKFRKISEKANVKIIPKMLRKWFTKQMQNSEIPGKYIDAFCGRLPRSVRAKHYTDYSPERLKEIYENADIKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYR1</accession>
    <name>A0A133UYR1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000058">
        <property type="protein sequence ID" value="KXA99304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99304">
        <property type="protein sequence ID" value="KXA99304"/>
        <property type="gene ID" value="AKJ40_03455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="82" mass="8759" checksum="C56B2564F830D73C" modified="2016-07-06" version="1">MIPGFNSKIPLQSWILAGTVKNLGFALPGGSSLVVEPATSIPRIAKRNGSHLYIINLENTRLDGIAEVVIQEKAGKVLPKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYT0</accession>
    <name>A0A133UYT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000056">
        <property type="protein sequence ID" value="KXA99335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99335">
        <property type="protein sequence ID" value="KXA99335"/>
        <property type="gene ID" value="AKJ40_03360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="61" mass="7248" checksum="44F60AD5F7B67118" modified="2016-07-06" version="1">MKQKDLDGDKRRNKPEEAFDEIVENFDEVIEEIRDGKRIPTERSSRYNDGERISLSFRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYT2</accession>
    <name>A0A133UYT2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000056">
        <property type="protein sequence ID" value="KXA99339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99339">
        <property type="protein sequence ID" value="KXA99339"/>
        <property type="gene ID" value="AKJ40_03380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="144" mass="16961" checksum="A646AECBB82F2503" modified="2016-07-06" version="1">MTIEIELKEEERAFLEEFVKKGTKKARAIRRANILLLADKNYRVKDISEIVGVHERTVWRIKKRYLEEGLESALEEKPRPGQPKKWTEEHEAEIIATACSSPPEGRKRWTIRLLRDELQKKPMFKGINRETIRLVLKKTKLNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYZ1</accession>
    <name>A0A133UYZ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000052">
        <property type="protein sequence ID" value="KXA99399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99399">
        <property type="protein sequence ID" value="KXA99399"/>
        <property type="gene ID" value="AKJ40_03200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="124" mass="13937" checksum="4710CF81C1C8112D" modified="2016-07-06" version="1" fragment="single">NRNPVTFVTDEIQQYKNAFKNQFDHIADLDLARSTGALKRARKVRDPETLLLLIMSHAATGLSLNQTSARAKRLGIASISKVALFKRMRNAETWLHELAVRMFAASPFDHTAGTDVTDRRIRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ09</accession>
    <name>A0A133UZ09_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ald_Xan_dh_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000051">
        <property type="protein sequence ID" value="KXA99419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99419">
        <property type="protein sequence ID" value="KXA99419"/>
        <property type="gene ID" value="AKJ40_03185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.807"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="758" mass="82826" checksum="2729EA88A550BD30" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ22</accession>
    <name>A0A133UZ22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000050">
        <property type="protein sequence ID" value="KXA99434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99434">
        <property type="protein sequence ID" value="KXA99434"/>
        <property type="gene ID" value="AKJ40_03130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="91" mass="10285" checksum="DE4A1A08C351F1CC" modified="2016-07-06" version="1" fragment="single">LTRDGQEHPRGHEFKDWLEIELISFKVLKKSRAKPPPQWEASNTTKSSKSKPNRSRTNDPQRPLNPSAITKNHKKGKLPSRQQGNSACVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ43</accession>
    <name>A0A133UZ43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Citramalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_03120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000049">
        <property type="protein sequence ID" value="KXA99454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99454">
        <property type="protein sequence ID" value="KXA99454"/>
        <property type="gene ID" value="AKJ40_03120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.761"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011830">
        <property type="entry name" value="LEU1_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02090">
        <property type="entry name" value="LEU1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXA99454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="525" mass="56558" checksum="BAD5F66356071FB2" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ52</accession>
    <name>A0A133UZ52_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000049">
        <property type="protein sequence ID" value="KXA99450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99450">
        <property type="protein sequence ID" value="KXA99450"/>
        <property type="gene ID" value="AKJ40_03100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="151" mass="15429" checksum="B99CD0C457917161" modified="2016-07-06" version="1">MVRAFAWCLVLTLVIVFSVYPIASRELTGLAGPVLLVLGLAPLAVLKLNNGSLASVVADIAFGAFDTGFMTIAILLGATFAGILGAVIGAGAGDAITDAWAGLIEGKVAVWLRKRGIDEARRPFTTSMGKMSGCLLGAGVTVSFASLNGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ65</accession>
    <name>A0A133UZ65_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_03055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000047">
        <property type="protein sequence ID" value="KXA99484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99484">
        <property type="protein sequence ID" value="KXA99484"/>
        <property type="gene ID" value="AKJ40_03055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.739"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="315" mass="34115" checksum="5F0AF1BE0F123355" modified="2016-07-06" version="1">MSSAIETSGLVKTYGTVRALDGLDLEVEEGKVHGFLGPNGAGKTTTIRILTGLLKPDQGVARIFGRDVTSGSGVRTNVGYMPELPSFPAHLTGRELLNIYGQLYGLGKSERESQADELLDLVGLENSGDRRIGGYSKGMQQRLGVAQSLLGDPDLVIMDEPTAGLDPEGRAEVREVVKQIGEEGETVFLSSHLLEEVEKVCTHVTIIHRGRGVVSGSVGEISRRVSEREEIVVEVDELGEKIINSVEKIPQVRGVNADGNELTVLTDIGTDIRREVSRTVFQAGGIIIGMREKKKSLEDVFLELTRGKGRKNERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ74</accession>
    <name>A0A133UZ74_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000046">
        <property type="protein sequence ID" value="KXA99493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99493">
        <property type="protein sequence ID" value="KXA99493"/>
        <property type="gene ID" value="AKJ40_02975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="79" mass="8897" checksum="C436E684EA212662" modified="2016-07-06" version="1">MGAKEVKIVDYGKKMEEESRGLLGSALEQLFGDRATSTLFPSPPIYWMLKLKEEFHPKVMILTHHAKEVRAIPRGGSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ82</accession>
    <name>A0A133UZ82_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_02985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000046">
        <property type="protein sequence ID" value="KXA99495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99495">
        <property type="protein sequence ID" value="KXA99495"/>
        <property type="gene ID" value="AKJ40_02985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="159" mass="17126" checksum="E23E4309C071358C" modified="2016-07-06" version="1">MSDENRSENDEGLKELSEVELRRRMLFFAVSVVVLVVVSVIPAPDGLSLRGQRALGILAFVAVLWVTETFPLGLTALFGAMLLPVLGVLPPADSFAGFGSTALFFLIGALSFGIAMQKTNLHKRIALRFIGRVGKSSSRLILSICLLGGILSWTMPEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZA7</accession>
    <name>A0A133UZA7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="LHXU01000046">
        <property type="protein sequence ID" value="KXA99500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99500">
        <property type="protein sequence ID" value="KXA99500"/>
        <property type="gene ID" value="AKJ40_03010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol_B" evidence="2">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="145" mass="16252" checksum="2E285AD7F16797BF" modified="2016-07-06" version="1">MGNTPWGFRSKFLGPNGHPGSVVFIIHETGEHNGVNMRGLLLDADYLRLFIKAGEEVVSVLERELPPGSPEKAARIVREATRRVERGRTDLEELVIHKNLKKPIGDYETEGPHVIAAKRLRKAGREVEPGMEGYPLLPLHRMEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZA9</accession>
    <name>A0A133UZA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000044">
        <property type="protein sequence ID" value="KXA99534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99534">
        <property type="protein sequence ID" value="KXA99534"/>
        <property type="gene ID" value="AKJ40_02895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="130" mass="13791" checksum="2B2D04180CCE73C6" modified="2016-07-06" version="1">MLEKEEKPQKILAVSLAIFSGCLFAIAATFGKIVAGASGTLSIISLGLWISLLTSLTFWGMIIAVIFGSIFWIWALKEGRVSIVGPVQSGIMIAASVIIGITYFNEILTVPKIGAILIISLGGVILSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZC9</accession>
    <name>A0A133UZC9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000044">
        <property type="protein sequence ID" value="KXA99532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99532">
        <property type="protein sequence ID" value="KXA99532"/>
        <property type="gene ID" value="AKJ40_02885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="245" mass="28204" checksum="ED3C582E464C0BBB" modified="2016-07-06" version="1">MGKTTLSVNLFYELVCRGRNVLLVDLDPSGHATEHLGFREEYKNSNVTLYDFLVEEANSNSEELLFDSYGGYVIPSSRDMISAEMGLYTAEFGRNTRLKRLLQKVGDGFDYCLIDCPPTLGALTINSFVASDRVMVPFEPNDLSMRAMELLFQNLKKVREYHDSEVRVLKIVPNKVLDTKVAQDTLKTLRESLDIVWEKEIRKRTVFEKCFKEEKPLRMLSKENSSVNSDKLPRFEELAEIIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZD6</accession>
    <name>A0A133UZD6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000043">
        <property type="protein sequence ID" value="KXA99553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99553">
        <property type="protein sequence ID" value="KXA99553"/>
        <property type="gene ID" value="AKJ40_02870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="142" mass="16993" checksum="DD0D2BBF669795DD" modified="2016-07-06" version="1">MMKVITNRDKADKLLKMVKINLFHIDSTYIFKHYFKDRDQFEDFRDYYNSLEFRFEVDENELEDAVEKLVDQGFSVNIVEREDIPEYTVVIDKYKKHSHLLKKSVDVIEVGDEKALVLKDKVAKEEALDQGKEPDEKWETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZG6</accession>
    <name>A0A133UZG6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000042">
        <property type="protein sequence ID" value="KXA99572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99572">
        <property type="protein sequence ID" value="KXA99572"/>
        <property type="gene ID" value="AKJ40_02820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="392" mass="42929" checksum="8D010A196F9FC8B2" modified="2016-07-06" version="1">MGIKKGLTHSFWVAWKDLLELWRNKIALVMLVLMHLFMMAMVGFIFPSQNSMQGVHVAVANLDEGGEGGMLINQLEMVNEEKGLMKLKRASSLQEARQMIVDGEISAAIIIPENFTSSLRQGKQGEVLTVTDQSNPQMSSMLSRVLERVIGAMGTQRAVREVSELIGGEGKSPIAIVEPYRIETKGVVEGETSYFDFVAPGIMAMVVMMAVMTGLPRAISYEKDKGTLDGFLVSPISRMSIIAGKVFAQTTRGLIQGAIILLLAMILFGVTIHCSVAMVFLLLFLGVFSFIGLGIVLTTTAEDEQTAMMIMMTLMFPMMFLSGVFFPLEQMPGFMQFIAKFLPLTYAAEALRKAMIFGTGLGGMLTDILILAAFGTIMLTVSIPLFKRAMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZH6</accession>
    <name>A0A133UZH6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000042">
        <property type="protein sequence ID" value="KXA99570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99570">
        <property type="protein sequence ID" value="KXA99570"/>
        <property type="gene ID" value="AKJ40_02840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="PTHR36536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="160" mass="18071" checksum="EF4EB1686CF2CB78" modified="2016-07-06" version="1">MKEKITTELSKGAYLPPSRGHLLRLITTADDIADNARAAAAKLEFLEPGEFDGEISDRLAQLAYLSQECVKPLKRAFTLLFEKENIKESIHETEKVEKMEEKIDYFRANKLIPKIVEWADKSHRPGTTILITQIEENIEEVADQAENTADTIREIALGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZK5</accession>
    <name>A0A133UZK5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000039">
        <property type="protein sequence ID" value="KXA99624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99624">
        <property type="protein sequence ID" value="KXA99624"/>
        <property type="gene ID" value="AKJ40_02705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="151" mass="17397" checksum="0FBEACCD06B81A93" modified="2016-07-06" version="1">MNIDMELAIISDAHLLQTYTQVFNPIDDFIKVLKEIDSRDPEAIVFAGDMFDKRKTTTAPVLHPEGEQIMTDIRNFLTGIGSPIYAIRGNHEDARVLRGLDQTVETFHYICDDWVPVDNVSIYCLETRYEKAYSRKNLEESLDQVFSELVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZM4</accession>
    <name>A0A133UZM4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000038">
        <property type="protein sequence ID" value="KXA99655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99655">
        <property type="protein sequence ID" value="KXA99655"/>
        <property type="gene ID" value="AKJ40_02700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="79" mass="9359" checksum="55FAE4092F8995F8" modified="2016-07-06" version="1">MRRGWEGRRNRRPGEGAGEGALELCPNLEERVGRGRGRPFTWRGIQERMDELQEVEESTNWSFDEERNSVVRRMENRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZM9</accession>
    <name>A0A133UZM9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000038">
        <property type="protein sequence ID" value="KXA99653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99653">
        <property type="protein sequence ID" value="KXA99653"/>
        <property type="gene ID" value="AKJ40_02690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="536" mass="62488" checksum="DC0CA1A4CBDB1E47" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZN1</accession>
    <name>A0A133UZN1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000039">
        <property type="protein sequence ID" value="KXA99627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99627">
        <property type="protein sequence ID" value="KXA99627"/>
        <property type="gene ID" value="AKJ40_02720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="111"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="338" mass="39207" checksum="BAAF823453961C36" modified="2016-07-06" version="1">MKKGNESVAQADELQILLNLYDDELTLSYPIFPHFDVLRANVHEDGYDLELISGMDDYKDKADSFGEYSDEMPSFYDLRDCLLSSGVIKHENLEELEKYVNRRVESGVKRVFFCPDTNILYQNFLSSFGKIKLRNVAIPDTVKDELKNKLNSKYGRTELQLMKQHAKCQGNLLDELNNRRKKASRKASYLAMQEYERFSGKTITAQRESTYDSGENDRIIVESLRSYEKNNPVRVTLLTADDSLRDLCRAEDLDHFYLKVPHNFEADSCSHGEFLTLIRNLSLVFGFVKLNSSIIFGEFGGKNRADALKLRFLDKKVYKEFKKHQKICRELNKLGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZS9</accession>
    <name>A0A133UZS9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="14" type="ORF">AKJ40_02615</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="LHXU01000036">
        <property type="protein sequence ID" value="KXA99680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99680">
        <property type="protein sequence ID" value="KXA99680"/>
        <property type="gene ID" value="AKJ40_02615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.598"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="59"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXA99680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="397" mass="43798" checksum="25761AE90588F276" modified="2016-07-06" version="1">MNKLVQVEVGDRGLYGEFGGQFVNEMLMPALIQLEEKFEKHYPQTPFRKKFENLLKNFGGRPTPLYHAEKFSGLIGCRVYLKREDLLYGGSHKLNNTLGQALLAQEMGKNRLITETAAGMHGVSTAIAGNVLGLKVEVFIGTRDIDRQPSNVKRMDLLGAEITPVDIGQGVLKDAVSDTLRKWASCSRDTHYLMGSTVGPHPFPEMVARFQSVIGKEIKNQIIEKEDGLPDAIVACGSGGSNALGAFRPFIDEDVEFYFVEGGGKNLDADNSAAAFQVGAPGVIHGALTYTLQDEAGQIKPSKTRSAGLNYPARGPQLSHLYERGRMEACYAFDDQVFEAVRVMAKTEGLIPALETAHAVAFMINNREEFERYETVVLNYSGRGDKDMDTILRYFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZU5</accession>
    <name>A0A133UZU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000034">
        <property type="protein sequence ID" value="KXA99723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99723">
        <property type="protein sequence ID" value="KXA99723"/>
        <property type="gene ID" value="AKJ40_02540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="346" mass="40159" checksum="941979321EF03E5F" modified="2016-07-06" version="1">MLELGQRGAATIVAMVALVAVAGGTVGVPVIVDRAADQRPGAALYGLEIAGERIQEAFSRGQEWDLERAMERIHEYEQVAKREVTPQNHANFIEEVQNRVMKAAGRANNVNGLERARETIREQIRVLEKIKENAPEGAKQALERAITRSRWQERVLENLQIQMGQRGLAPGHLKQSLENKMITWENLKETLENRRIPPGILKQILENRDIPMDNLEDFLAGRRIPYGIVMQILENEDFENAIPEQLRERLEKKIGPIENLDEHMEKIRERIRDRVENRLEQVEEKGERIRERMKNQLENMDEQVREKLNKRLEQLEQQREELKERLGDMDREQKKQGKGSQGRGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZW9</accession>
    <name>A0A133UZW9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_02495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000033">
        <property type="protein sequence ID" value="KXA99738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99738">
        <property type="protein sequence ID" value="KXA99738"/>
        <property type="gene ID" value="AKJ40_02495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="157"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="3">
        <location>
            <begin position="348"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="473" mass="52302" checksum="166C5DD4C2877984" modified="2016-07-06" version="1">MYLLFGCGDVGFALAQKLQEGDREVQIIEKDEGKVRQLRDMEFEVVQGDFTDTEDIGKSDIKEAEVILILASDLETVKRALGGINQLKLDLEIDPIVVARATDSILKSEIKELGADEVVVISEVFAEQVHDRFQEFRERIKEKKLRKLLNGLDGKLAIVLQDNPDPDSISSGMGLRIYAEPLGVESDLIYSGRIGHQQNRALVNTLNSEMLRAEDIDFEDYGAYALVDVSTHGNCSLPEDIDPDIIIDHHSATSSRAEADFEDIINVGSTATIVTNYLRYAEREIDEQLATALTFAILTDTMNFTRGATHLDFSTLEFLLPLISKELLQEFQSPPLSADTLEVIRKAIRSSRVKGGYLIANVGEVKDRDAIAQAADYLLRREGTLTTLIYGIESDAVYMSGRTKDVRLHIGKTMEELYGDIGSAGGHPTAGGGKIPIDAFDVSKDNKKALRGAMDRNIGRKFWAAFGALKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZY8</accession>
    <name>A0A133UZY8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_02505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="LHXU01000033">
        <property type="protein sequence ID" value="KXA99740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99740">
        <property type="protein sequence ID" value="KXA99740"/>
        <property type="gene ID" value="AKJ40_02505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.570"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="191" mass="21589" checksum="3564E5F3633C23C0" modified="2016-07-06" version="1">MKLSGKFFRRDTSKVARGLLGKILTRFTSSEIVKGRIVETEAYYGKDDPASRASEKRTKINEIMWKKAGLALVYMVHGHWLFNVTTEDKGTPGAVLIRAVEPLEGLDVMKKRRGKSKLRELTSGPGKLTQAFDICKEQHGVDLTTSKELYISKPCGEMVENYDIGTSHRIGVTEDLERELRFYIEDNECVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V021</accession>
    <name>A0A133V021_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000031">
        <property type="protein sequence ID" value="KXA99779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99779">
        <property type="protein sequence ID" value="KXA99779"/>
        <property type="gene ID" value="AKJ40_02430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="103"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="283" mass="32122" checksum="AF41D6FEEE8C947B" modified="2016-07-06" version="1">MVDELYPVISSLVRVCYPWTEKGEGRPPKVTPAKAAFLIVIKERGKETTYRDLASSAYMERLGISEVHYTTIHKAIKRLPPSFVEAVMRSFGERVSKDGMDCVFDATGVRIRKYEIVIHAGEERRERQGVKLNAAWDADEKVFHASEVLKGKAREYPGAEEMFKRINTSIENVFADTGYAGRGFIQTVADSGAMPVVKPQSNATPKAKGSPAWRKLVKEYQELGYEDWRDETGYGERFPNEGQFGSLVSRFSKEANVRSTHMAKRVVTARLAFHNFFQWLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V050</accession>
    <name>A0A133V050_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">AKJ40_02405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000030">
        <property type="protein sequence ID" value="KXA99811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99811">
        <property type="protein sequence ID" value="KXA99811"/>
        <property type="gene ID" value="AKJ40_02405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.500"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="235" mass="26527" checksum="77A2F299ECA4E651" modified="2016-07-06" version="1">MKQLQNERDYINAIFSSIVHHYDLMNTLLSLNQDKYWRRFAISKTELDRGGIALDVCCGTGGMLPGLARSVGSQGNVVGIDFNKKMLKKAVENLPEKNLTHCIKLVQGEATNLPFGEDLYDCATISFGLRNIPNMRKTISEMKRVVKPGGKVVSLEFSTPMNPLIRQTYYQYLNYWVPLLGKIINREETYQRLSDSIMSFPHQRKIGELFKKAGLDNTLYFELTGGIATVHVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V098</accession>
    <name>A0A133V098_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000028">
        <property type="protein sequence ID" value="KXA99854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99854">
        <property type="protein sequence ID" value="KXA99854"/>
        <property type="gene ID" value="AKJ40_02290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51" evidence="1">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="205" mass="23514" checksum="D75DC95D2B89C198" modified="2016-07-06" version="1">MNGITSIYNLPHILSVKILHSYRKIDEDRQLLWLDGDNSFNPYLVSQIARSFKAEPEKILEKIQISRTFTCHQLSKLILEKLWHTVEKLKPELVVITGLPSIFAESDLCKREISRSFEPVLEELEKFRREERGLLMTSGTNSTGENVILPKLESLSDIILDVRKGGKEIVIEIGKDFSKSFGSSRIKVPEFESKSNMTLEEFTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0C5</accession>
    <name>A0A133V0C5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000027">
        <property type="protein sequence ID" value="KXA99887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99887">
        <property type="protein sequence ID" value="KXA99887"/>
        <property type="gene ID" value="AKJ40_02275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="351" mass="41332" checksum="B7C70CCBE937AB7C" modified="2016-07-06" version="1">MKSKERVIKTLEFDNPDRVPRDLWWLPAIEMFQEEELEALMSKYPMDITAPEIEPGTTAQQRESDLPSYTTYLIKNPFQGKYLDEWGSIWHIGEDGVLGEVKEPVLNDLDKLDDLDPPWEFLETTDLSKVDSQCEKSDKFMLSHDCSRPFERMQFIRGPEKLYKDLVRNREKVIELRDKVHEYNLEQIKMWLETKVDGIFIMDDWGSQNNLLISPDIWREVFKPLYKEYCDLVHKHDKYIFFHSDGYIQDIYGDLIEVGMDAINSQLFVMNIEKLAEMHKGDVTFWGEIDRQRLLPFGEPEEIKKAVYRVRRALEDGSGGVIAQCEWGKNNPAENIETVYEAWSESLEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0E3</accession>
    <name>A0A133V0E3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OrfB_Zn_ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_02210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000026">
        <property type="protein sequence ID" value="KXA99907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99907">
        <property type="protein sequence ID" value="KXA99907"/>
        <property type="gene ID" value="AKJ40_02210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="285"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="401" mass="45986" checksum="A406C2D1DBC8D4F6" modified="2016-07-06" version="1">MFEREGLDFREKNLNKARKTVKELCYPTADRDSKYNCKGVVHFSHSHYYDTAITEATQKWNSFLTWKEKSSSSKKFPEIKNCSPVLDSQMFELDLEKGWITVKTGRGQESVHIPITVPNKSHYDDLDEDKISSIKLKKKEKCFVFLLSQKLDSPETPSPSDLGERPVIGIDLGERNLAPFVTIRPSSQQFEILNVKFFDGAEIKKLKHREENIRKNLQIKGKSSEIPKRKWKTSNKKKNHCEKIANKIRKIAKKNNVKSVFVGDLKAPTPKNSSTLSKRLNNFPFAKLKEAIKRHLEKAKIFVKTIYEGKTEKHDLGTSQKCHKCGSEGERYKGKFSCPSCNLEDYNADLNAAINIAERGVKSFGKTEGLGVVPWIDTVKWLRPKEVPVRAYKTPNHIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0G9</accession>
    <name>A0A133V0G9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000025">
        <property type="protein sequence ID" value="KXA99941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99941">
        <property type="protein sequence ID" value="KXA99941"/>
        <property type="gene ID" value="AKJ40_02190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.448"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="7"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="363" mass="40489" checksum="2C88E705A4FBC31B" modified="2016-07-06" version="1">MSNRDFDNSPFIVFWETTRACSLACGHCRAEAMPTPAPNELTREEARELIEEISQFEPKPILVFTGGDPLMRDDVYDLIEYGGELGIKTAVTPAPTPLMTRENIEKLKKSGAERIALSLDGSTKARHDELRGVSRSFEAILDVATYAREADLPIQINTTITKETVNDLKGIAELTEQLGAVLWSLFFLVPVGRGEKLEMVSPEEAERIMDFLYREEQKRPYQVKTTEATHYRRVVLQKSGRSLSKDHQKHDKIGRNIGVSDGNGITFVSRTGEIFPSGFLPLKAGSVLEEGLIKTYQESKLFKELRDKSLLKGKCGVCEYNSICGGSRARAYSIYGDYLAPDPLCAYYPEGWDGDLWGVGNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0H1</accession>
    <name>A0A133V0H1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000025">
        <property type="protein sequence ID" value="KXA99932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99932">
        <property type="protein sequence ID" value="KXA99932"/>
        <property type="gene ID" value="AKJ40_02155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="103" mass="11773" checksum="EDABB107A18D7266" modified="2016-07-06" version="1" fragment="single">SPAHLCSYAGLVPSVKQSGSKEVHGSIQGGKPLLRWVLYQAAHHHIRNAPNSHITKFYKRLERKKPEKLAKTAAARKLTTVIYWMLELKEEFHPQGYDPRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0S2</accession>
    <name>A0A133V0S2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Adenine deaminase</fullName>
            <shortName evidence="5">Adenase</shortName>
            <shortName evidence="5">Adenine aminase</shortName>
            <ecNumber evidence="3 5">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ade</name>
        <name evidence="8" type="ORF">AKJ40_02000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3 5"/>
    <dbReference type="EMBL" id="LHXU01000022">
        <property type="protein sequence ID" value="KXB00037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00037">
        <property type="protein sequence ID" value="KXB00037"/>
        <property type="gene ID" value="AKJ40_02000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="73"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="7">
        <location>
            <begin position="416"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="591" mass="64661" checksum="577B4282DA6A03A8" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0V7</accession>
    <name>A0A133V0V7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HELICc2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000021">
        <property type="protein sequence ID" value="KXB00062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00062">
        <property type="protein sequence ID" value="KXB00062"/>
        <property type="gene ID" value="AKJ40_01950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HELICc2" evidence="2">
        <location>
            <begin position="542"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="643" mass="73624" checksum="6263312E99A28ABE" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0W2</accession>
    <name>A0A133V0W2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000020">
        <property type="protein sequence ID" value="KXB00090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00090">
        <property type="protein sequence ID" value="KXB00090"/>
        <property type="gene ID" value="AKJ40_01875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="251" mass="28673" checksum="56266E2276FAC64B" modified="2016-07-06" version="1" fragment="single">KGESLPEVPFFPSETKEKIIENFKKRLRGAEIPPYMIEAESENGENLYGEVNSALLEEKGEPVGVIGVVRDVTERKKAEENLQEYKSAVEASDDSIYMVDEDYRYVFANDEHVTRLMDAGRIEEGDKDRIIGLEYKDIHPQEEWEAFRKNAEKVIETEDSLTETFASLALDRWSERTYSLVKDPRTNEVKGVVVVSKDITKQKEALREAKTVRALLDAFPAHVYYKDEEGRYVYSNESSSSAKRISFNGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V127</accession>
    <name>A0A133V127_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_IS66 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000018">
        <property type="protein sequence ID" value="KXB00153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00153">
        <property type="protein sequence ID" value="KXB00153"/>
        <property type="gene ID" value="AKJ40_01775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="3"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="229" mass="26883" checksum="0470CCD3634AE3F0" modified="2016-07-06" version="1">MELRDAEAVHVDETSFSVGGEYWWLWSFSNDEHVLYRLVNSRGSNVLEEVLGEDFDGWIISDGLSAYSAFTEKQQRCWSHLFREAEDVSDKFEEAVPIDEKLHEIYNHIDEFLEGDPPPPEREEKKEWGIEAMKELTKEEYDEEKVADLITYIENGMGHWFPYVVEPDVDPTNNQAERDLREPIVIRKIIGTLRNEKGTKIFERIMTMLATWKRQGLNPKEEMLKIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V167</accession>
    <name>A0A133V167_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00193">
        <property type="protein sequence ID" value="KXB00193"/>
        <property type="gene ID" value="AKJ40_01730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="68" mass="8020" checksum="B4BB677178CCC92C" modified="2016-07-06" version="1">MKERKISFGVRISEDLVKELDKIVDESEYLDVSRSEVVEAILLAYFKSNVDHEKRARELIIRKRKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V168</accession>
    <name>A0A133V168_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00197">
        <property type="protein sequence ID" value="KXB00197"/>
        <property type="gene ID" value="AKJ40_01755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="70" mass="8344" checksum="2E2A78B1C03E2800" modified="2016-07-06" version="1">MQNGRKERDQIVVRVPSRLTDLIDQYLERDAYMDTFELVRNVLRERIRKDAPELYRGIFREGSEDGRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V181</accession>
    <name>A0A133V181_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00192">
        <property type="protein sequence ID" value="KXB00192"/>
        <property type="gene ID" value="AKJ40_01725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="120" mass="13421" checksum="1685964C63641FB2" modified="2016-07-06" version="1">MDLQSMHNVHEALNTKSKRFIFRKEVLRITVDRTLQLLYMMPRVYGPNSLSLQPGLVLGVHLFVVTYEEFPVNKDTLHCFSVSLKISNLGGKGGAMGSHLFGVCPHFGITPRLLSQSHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1B4</accession>
    <name>A0A133V1B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00186">
        <property type="protein sequence ID" value="KXB00186"/>
        <property type="gene ID" value="AKJ40_01680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="68" mass="7842" checksum="571F9445F429433E" modified="2016-07-06" version="1">MQKDPDESTDDPKYGGLKCLHSGKENKLIVRSKHDQPQTEAIRTLPRLIKKRSKTASEKRQLDQILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1L0</accession>
    <name>A0A133V1L0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_01500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000013">
        <property type="protein sequence ID" value="KXB00337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00337">
        <property type="protein sequence ID" value="KXB00337"/>
        <property type="gene ID" value="AKJ40_01500"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.222"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="56"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="321"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB00337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="424" mass="47996" checksum="1EA0CC826F234B1D" modified="2016-07-06" version="1">MQKKSGGIFKELLENKQIFKDREYLRPSHIPENLPHRDEQVNRLARIWVAPLRGETPSNVFIYGKTGTGKTATVKYLMEELEHVAGDLSREVEVSYLNCEVVDTKYRILATLSNKIRETLVEERDDVSDLPEEVPMTGWPTDEVYDNLLTLLDYRKQVIIVTLDEIDRLVSKGTSDVLYLLSRINSDLDKTKMGVVGISNNLNFVSDLDPRIVSSLGEEEVVFPPYDANQLEDILEERSEKGFADGVIEEGVINLCAAHAARKHGDARKALDLLRNAGEIAEEEEAQKVTTEHVTLASRKIEHDRMEEAIQSLPDQSKLVLLSVLLLQERKARKIGTGDIYEVYSSLCRQHGWDVLTRRRVSGLISELDMMGVINARVVSNGRYGRTKEVELNVDPLQVRSAVQKEIYIQDLDSLPLSKQKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1L3</accession>
    <name>A0A133V1L3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">AKJ40_01480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.-" evidence="7"/>
    <dbReference type="EMBL" id="LHXU01000013">
        <property type="protein sequence ID" value="KXB00333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00333">
        <property type="protein sequence ID" value="KXB00333"/>
        <property type="gene ID" value="AKJ40_01480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.217"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="9"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB00333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="434" mass="47501" checksum="D590BA272EC4204F" modified="2016-07-06" version="1">MGPKGSFDRVLKLLKEHHKWSQETVNLIASENVPSPAVREALVSDFGNRYAEGAPGKRLYAGCKYIDEVEFLAIDLAKEVFGAAHANVQPVSGVVANLATYTAFTQPGDTLMSLSITCGGHISMGKKKFGGTAGSVHGLDVEYFPFDEEAMNIDVERAREKIKEVSPDLVLFGASVFPFPHPVKELSDVASDCGARIAYDAAHVAGLIGGGHFQNPLEEGAEVMNCSTHKTLPGPQHGMILTAEEDLKEIIDRSVFPGVVSNHHLHSVAALAISLAENLEFGEEYGSQIIKNAKSLGEALYNRGVDVLASEKGFTSSHVILADVTDHGLGGEFERKLEDANVIVNRNLLPWDVREGRHYDNPGGIRLGVSEVTRLGMEEEDMERIADFIGRVVIEDENPEIVRKDVEKFARDYSKVNYCFESETEAYEYINIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1M9</accession>
    <name>A0A133V1M9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Threonine synthase</fullName>
            <ecNumber evidence="5 9">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AKJ40_01475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5 9"/>
    <dbReference type="EMBL" id="LHXU01000013">
        <property type="protein sequence ID" value="KXB00332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00332">
        <property type="protein sequence ID" value="KXB00332"/>
        <property type="gene ID" value="AKJ40_01475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.216"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="69"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="10">
        <location>
            <begin position="235"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB00332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="406" mass="44108" checksum="5E9C75EC676D7360" modified="2016-07-06" version="1">MFYECIECGSRFDISMSLYTCPDCDSLLEIELDLESVKEKIDRREFERECVTTWKYRPFLPVREDSKIVSLHEGGTPLYSCDVLAEEIGVDELYVKFEGGNPTGSFKDRGMTVGVTKALEYGADVVACASTGNTSSSLAAYSAKAGLDCVVLTPKGKVALGKMAQAALHGAKIIAIEDNFDKALKLVRRLCNERDEIYLLNSVNPFRPQGQKTIGFEISDQLGFDSPDRVVVPMGNCANIWAIYKGFYEFRETGIVDEIPKMTGIQAEGASPVVNAVKDGADRVVPVENPETLATAIRIGDPVNGPKALLAIRRTEGTAESVTDEEIVKAQKMLARLEGIGVEPASAASIAGLKKLVDMGEIDRSERVASVVTGHLLKDPEEAVDVSEPPVEITAKYDEIISELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1N8</accession>
    <name>A0A133V1N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00367">
        <property type="protein sequence ID" value="KXB00367"/>
        <property type="gene ID" value="AKJ40_01375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="178" mass="19285" checksum="5F29F57E385B1F51" modified="2016-07-06" version="1">MILEKSFFGGGKELVKNMRILTIGFSVYLLSKELREKWENYVWQSAAAGISIFLILYIFVDVINLILLAAAGSSAFTVFALPNNRTAKIRNLNGSYIICVIVGLACSVFGNIWTSGGLAVGFAAFLMVITDTEHPPAAGAALYLSAEPTVKGAIFILIASVVFSVLRYLLSPWLKDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1R2</accession>
    <name>A0A133V1R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alanine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00371">
        <property type="protein sequence ID" value="KXB00371"/>
        <property type="gene ID" value="AKJ40_01400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.162"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="396" mass="44628" checksum="F8E1AD3B13A6C3D7" modified="2016-07-06" version="1">MLKASDRAMNVEYAIRDVILPAKKLEDKGIQVLKLNIGDPGKFDFDAPEHMKKSYCDAIMNGFNYYGDSEGESELRESIVKREKDKNGVDIGVDDVQITTGISEAINLTFGALIDGGEEILMPGPSYPPYSELLKFYGGEPLVYETVEDEDWQPDVEDMREKITEETKAIVVINPNNPTGALYDKKTLKKIIDLAGEHEIPVISDEIYDLLTYEGEHVSPASLSEDVPVIVFNGFSKVYFATGWRLGYLYIADSEGGLDEVKEAIEKLSRVRLCPNTPGQKGANAGLTGSMNYLEENLKKLEERRDFAYKRLNEIENIQTQKPQGAFYIFPKILGGPWKNDKEFVLDVLNNAHVLFVHGSGFGEGGERHFRSVFLPPIETLEKAFDKLEKFMRKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1V0</accession>
    <name>A0A133V1V0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00423">
        <property type="protein sequence ID" value="KXB00423"/>
        <property type="gene ID" value="AKJ40_01360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="203" mass="24266" checksum="D4F8507B9F12C8BB" modified="2016-07-06" version="1">MKEEHRKQVRKATLKSKEILEKDIGNQLKKLGIYPDRRTSPEKLNLPVEKIQKRERILEVLDKLKQRELGDKTPQQFYTGEVAYTYFNRIIAIYLMEKRELLSNVLEPDPEFGNKPEQLWHFEKITNIHQRDTLYQTYFNSVFNEINEEIKKVFDTEDENSVLFPSANAIDEILGQLIEKIPDEAWKEEERRKKKEERNALCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1V7</accession>
    <name>A0A133V1V7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_01435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00376">
        <property type="protein sequence ID" value="KXB00376"/>
        <property type="gene ID" value="AKJ40_01435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.167"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB00376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="171" mass="19119" checksum="E09AB6670B687183" modified="2016-07-06" version="1">MKGEERPSKDEYYLGIAEAVCKRSPCIRRQFGAIIVKEDVIVSTGYNGPPRGVINCTEAGCLKDELDMPHYRQYQFCTAVHAEENAVINAARHGATVMGGTLYLYGQEYETGETFEGKPCDRCKRTLINAGIEEVITKNAEGTVIKKDVSDWVSQDTKKYLNKLEEAKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1Z6</accession>
    <name>A0A133V1Z6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00478">
        <property type="protein sequence ID" value="KXB00478"/>
        <property type="gene ID" value="AKJ40_01310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="157" mass="18124" checksum="E5A59D59A683F82F" modified="2016-07-06" version="1" fragment="single">MKIETISKINKGELDGESTLDFALSHAEKVKEGVLQSWFKKEASRNDKALNEFLLIEIIRSILGAEPRCFFVLLSVSRRLRALLDLKYVDDLERYKYFKRKIKNLKGRLREISKRSLGTEGDESFAFDSSIVTADLNGYRNGKKVKKGEYDARFTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V248</accession>
    <name>A0A133V248_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00528">
        <property type="protein sequence ID" value="KXB00528"/>
        <property type="gene ID" value="AKJ40_01240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="72" mass="8161" checksum="82DC9BBBD1652D27" modified="2016-07-06" version="1">MKLRRLKFPRRLSRIGKKTVDIVAEVIDVPAGLIMKTKPPQIEVFRSSESEGNPYIWQGGIKEDARGRGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V258</accession>
    <name>A0A133V258_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proton_antipo_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_01210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00522">
        <property type="protein sequence ID" value="KXB00522"/>
        <property type="gene ID" value="AKJ40_01210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="126"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="472" mass="50113" checksum="109BB941263E4471" modified="2016-07-06" version="1">MMERAFSLISLVLIGTGLISPTLDYTIFKKERLVSPYLTLGGLGFSGIILGVLAVWSYGRGSVSIYGGMLQIEPFGIFLSFVATIGAILLTVATLSEVKNWSTSPSLYSLVTLGVLGSYFLVSVGDLTLLIAAWALVSVISYVIVGLRKDRASVEAAGKYALMGVIASIFILYAVAMVYGMTGSTSLRSISDLATGEGALIIMSSVFFISAFGFKIGLVPFHGWLPDVYGKAHPILIVFLTSTATVAVVGLIVRVLFTLAPLITSYWPILIGLISVFTMTFGNVTALIQNNVQKMMAFSSIAQMGYIFAGMAAGPLVAGGLTLQGIALHLGSYSFAKAGVFVFLAYLLKKGLSLQISDLKGLGKSMPITATAFGIILLNLVGIPPLLGFWSKFYLFSAAAKITPWLTLIAIINSGISVGYYVRPIKSMFFEEGSDLPDERIGDFEQATVIAASFLLVSGGLVLPSLISILIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V263</accession>
    <name>A0A133V263_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00529">
        <property type="protein sequence ID" value="KXB00529"/>
        <property type="gene ID" value="AKJ40_01245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="117" mass="13552" checksum="96B51298DB1B9088" modified="2016-07-06" version="1">MGAFHKSARESWDHGILKLKGDLIDLKSEVRSLQRMKPIMENKDEIKDMLEQSSGFQEKFQDLQPILENTNKIKNLLQQKPEIGEMKQRFKLTYTLFGVVLAISLALSGLAIYRSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V296</accession>
    <name>A0A133V296_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_01070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00577">
        <property type="protein sequence ID" value="KXB00577"/>
        <property type="gene ID" value="AKJ40_01070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="279" mass="29232" checksum="39E96854F8ED67A3" modified="2016-07-06" version="1">MISLPSGLILRAIIGAVLAGFSCSMMGTFVVQMDLSSIGFSMSHAAFAGAALGLLLAINPLYTAIGFAIAVALLLGPVSQKAKLSPGVVTGVAFSVTIALGFIFLNLQPGAAATGAALSILWGSVFALGFNDLLMLVLLSSVIVLVVIVFRKEFLAMLFDRKMAEASGVNTDPFYFSILFLTGLTVAFSLKFVGGLLVFALIVNTAASANQFTYDIKKIMILSPILGVFCCLSGSLLSLTYNFPVGTTIVIMTALTFTISVLLSKKRKKGKGLFHFSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2I9</accession>
    <name>A0A133V2I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00664">
        <property type="protein sequence ID" value="KXB00664"/>
        <property type="gene ID" value="AKJ40_01060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="78" mass="9246" checksum="A79622000A858217" modified="2016-07-06" version="1">MGERPLRFIHHHNERFLVIISEVFRLVESDRWKNSAETVEVYRSLFLKLSSSSEFLHELISEGELALQRKEDNVMSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2J5</accession>
    <name>A0A133V2J5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00660">
        <property type="protein sequence ID" value="KXB00660"/>
        <property type="gene ID" value="AKJ40_01035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="67" mass="7867" checksum="D6CC07120F46C3DF" modified="2016-07-06" version="1">MRREIVLTVEADIDKIVCESGDRSDAYRRLSDELESERNRVVWEFKRRLREAMLDFRGALDHSLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2K9</accession>
    <name>A0A133V2K9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00687">
        <property type="protein sequence ID" value="KXB00687"/>
        <property type="gene ID" value="AKJ40_00885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="89"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="330" mass="36061" checksum="AB2988DBDE8D9407" modified="2016-07-06" version="1">MSSDKEPSNTPGSPSGQPPLNQGEEGSNAAPKSFDEAFREGLERARNRERLIVDGEKISPCHVPRELVHREEVLERVYGTITSGREGEVGDRILITGPVGAGKTSVAINLSRSIEKEENCPTCSHVDCRIWRTPHQILNKLASDLGQGPPDHDGGQRQALRRLEDRLEAGNSTLIAVLDHLGHHVRKRGLAVIRLIDRAERAAGPSGRIGVVGTAQSARLLARMRAESRERFGRNLVRLEGYGHDQMVDILERRAEKAYKPGAVGGEAIDLISKIAAGDARHAVALLRESGRQAEHRESSEVLPSHVEEAEKGLTPMCDGEVYFASIYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2L1</accession>
    <name>A0A133V2L1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00688">
        <property type="protein sequence ID" value="KXB00688"/>
        <property type="gene ID" value="AKJ40_00890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="2">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="94" mass="10546" checksum="918CEBC4672FC7FF" modified="2016-07-06" version="1">MTSDVMKMFEEEIERETVFEDVSKASPDYVPERLVHRREEEEKLRDVLEPPLNGGPRGVLITGPVGVGKTAMTSKMGRELERKAGEEGPPPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2L3</accession>
    <name>A0A133V2L3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00680">
        <property type="protein sequence ID" value="KXB00680"/>
        <property type="gene ID" value="AKJ40_00845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="301" mass="34007" checksum="16B2CA91E3A8C653" modified="2016-07-06" version="1" fragment="single">GFTVEQSEGESADRWLNWGDSIARFLHNCVEYEEGNKITTTELHDLFARYVDAHDDLEMKSQTALTKQAKKIPYAEYSDQFRFRGKKRSGFKHIAVKLDDSGKTPQRVNKNPLQSFQKDSDTGETGEKVPPGNNGGTFSLPLGEKEETEKEETEKRSQRVLHKSLHSFQNSDDLRVRVIEKFAYNDKTFEGGEELAADEDIPKGVAEDAVEKGYAEEVEEGENAEFPDSPDQRDKIRALREIIREIAEDYEEGAPVSAIIKEAKGEGIASGFVEEFVKRGLREGELIRSEENGEKAVRLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2M6</accession>
    <name>A0A133V2M6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HELICc2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00683">
        <property type="protein sequence ID" value="KXB00683"/>
        <property type="gene ID" value="AKJ40_00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HELICc2" evidence="2">
        <location>
            <begin position="507"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="602" mass="69693" checksum="AAD1CBF430994350" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2P0</accession>
    <name>A0A133V2P0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00712">
        <property type="protein sequence ID" value="KXB00712"/>
        <property type="gene ID" value="AKJ40_00695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="147" mass="16065" checksum="DCFE46C29B383B8C" modified="2016-07-06" version="1">MGLKRGVVRIPITAPNSFTARVHLEDPKRRGARTLFTGLRGMLACTRAAGLIFTSARILNTDLNFLSAHIASVALRRGVTRNRLKARIQIADLKGKVTCRHRTNLITTLARINLLNLTGIVARSLSGGLTGPLARKCFICWFCGSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Q1</accession>
    <name>A0A133V2Q1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00728">
        <property type="protein sequence ID" value="KXB00728"/>
        <property type="gene ID" value="AKJ40_00785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="90" mass="10746" checksum="DA0B3D415E8266F4" modified="2016-07-06" version="1">MSGDEKKYKKYLGWPGSLRLKLSSKEFEGLFSILESHPADSDKGLELVRHFKKRLSEAAERHNAYFGRKLERRKELQEEHPEWFEKPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Q8</accession>
    <name>A0A133V2Q8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00713">
        <property type="protein sequence ID" value="KXB00713"/>
        <property type="gene ID" value="AKJ40_00700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="94" mass="10313" checksum="B15FBFF1CA925C0B" modified="2016-07-06" version="1">MTRTYPVCLSETLVRNRGTGLSRILARNSTADPMKGMTYIRDKGLNDIMARNSAMGPKSSLARTQITALSYSMARILNVVLKCIVARNLPDGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2R3</accession>
    <name>A0A133V2R3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00696">
        <property type="protein sequence ID" value="KXB00696"/>
        <property type="gene ID" value="AKJ40_00940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="101" mass="11607" checksum="8F4AF77A03E675FA" modified="2016-07-06" version="1">MPKAHSRQGEAQNREPKVNRPKFKDQGFSHFLPDWRFTMITSRHRHLPPDPFTGEESPVPFAFTGGGSKPDPGLPPRGRTRFSPCCHGFFQGKHHRSFRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2S7</accession>
    <name>A0A133V2S7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor E</fullName>
            <shortName evidence="2">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tfe</name>
        <name evidence="4" type="ORF">AKJ40_00725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="2">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00740">
        <property type="protein sequence ID" value="KXB00740"/>
        <property type="gene ID" value="AKJ40_00725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006373">
        <property type="entry name" value="TF_E_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE" evidence="3">
        <location>
            <begin position="28"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="190" mass="21749" checksum="DAD10B740EA3EB27" modified="2016-07-06" version="1">MESPNGVSLEWFVQSSALTYILENVEGENGKEVAEVLAEEGETTSEEIANELGMKLGPVRSVLESLYEARATDFRRSRDDETGWISFYWWLNPSGALNYLARKKRSLLQKIKEKLQYERRTVFFACKNRCTKVEFDRAVELEFRCPECGGEMHRADNDGFVCSLEEKSEKLEGNFENRVREREGKAGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2U6</accession>
    <name>A0A133V2U6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZT_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_00570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00753">
        <property type="protein sequence ID" value="KXB00753"/>
        <property type="gene ID" value="AKJ40_00570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="299" mass="32812" checksum="57DD0CB3164C8BB8" modified="2016-07-06" version="1">MQKSDDKTKGHREENGSSKRKLEVVTGINALGFIAELIGGILFGSVALMSDAIHMLFDASAYGTASMANRIAETREGSEFWTFGFHRVEVVTALLNGLLLIPMSIWIVWEAYMRFLSPTHIDIWTTLLIALAGLALNILSVFYLRGEEMNLNEKAAFYHLLGDVGGSLAVIFGVLIVYLTGITAADPIAAVLIAILVLWSSGKVLIEGTSIILQKSPFPPSEIKKEIEKIEGVCSAHNIKCWRVCSDVGVCSLHVQVEVDTLEKAGEIRKKVEDKLRERFGLEQMTVQVESKKGQSCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2X8</accession>
    <name>A0A133V2X8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00790">
        <property type="protein sequence ID" value="KXB00790"/>
        <property type="gene ID" value="AKJ40_00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="98" mass="11616" checksum="7C95238FA60B86D6" modified="2016-07-06" version="1">MLYFRDEEISFADLSSDLGINRSGAWKRWKKGYDKVIESFFTLELAVYGGILDPKATKHFVEDLKDYLKLAHREGDKKAIQKRLERRMTEMEKQDVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V304</accession>
    <name>A0A133V304_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00805">
        <property type="protein sequence ID" value="KXB00805"/>
        <property type="gene ID" value="AKJ40_00510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="77" mass="8788" checksum="4390582463DFF523" modified="2016-07-06" version="1">MIIDRESYKMSETERVLNFSIEDTDQLVEIIKGLTKLNVDVEADSTPSSIKITLQGPEHKVRNSVQKIQKLVEESKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V319</accession>
    <name>A0A133V319_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00831">
        <property type="protein sequence ID" value="KXB00831"/>
        <property type="gene ID" value="AKJ40_00255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029291">
        <property type="entry name" value="Tfx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004645">
        <property type="entry name" value="Tfx_DNA-bd_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018384">
        <property type="entry name" value="Tfx_DNA-bd_euryarc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036657">
        <property type="entry name" value="Tfx_DNA-bd_sf_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14601">
        <property type="entry name" value="TFX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004932">
        <property type="entry name" value="DNA_bind_Tfx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89915">
        <property type="entry name" value="SSF89915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00721">
        <property type="entry name" value="tfx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="136" mass="15158" checksum="9A1D27AED937303F" modified="2016-07-06" version="1">MKSEGTFLTESQEKVLKLRSEGLSQSEIAEKLGTSRSNICSLEKRARQNIKKAEKTVKLAKKIQSPVFLTIEANEDIFDAVKRLFSKANKADIHVSSDTPTLISKIRNEVGEKLEGRKAIGKIKLYLTPKGEVIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V320</accession>
    <name>A0A133V320_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00847">
        <property type="protein sequence ID" value="KXB00847"/>
        <property type="gene ID" value="AKJ40_00365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="196" mass="21997" checksum="7467510D824BAB47" modified="2016-07-06" version="1">MISAIVLAAGKSERMDRCKQLANFGDKCMVDQVISSVEKSKVGEIIVVLGHRAEDIRRKISKRDVKMVINEEYEEGMSTSLKSGLLEVSDRTDAVLVVLADQPLIEPETIDQLIDEYRKSESSIVAPVYKGVRGNPVILDISLRDEIINIRGDIGARNILNDRRDEIREVEVDTPSVVFDVNTREDLERVRKNFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V359</accession>
    <name>A0A133V359_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00846">
        <property type="protein sequence ID" value="KXB00846"/>
        <property type="gene ID" value="AKJ40_00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="165" mass="18337" checksum="C3E959E2CA344E30" modified="2016-07-06" version="1">MEQNQKNTIEIGFTINGEERVIRTKPGKKLLDLIREDLGLTGTKYSCGEGICGTCTVLMDGRPVKSCQLDASIVENKEILTIEGLSGDGDEELHPIQKAFIEAGAVQCGYCTPAMILRTKWFLEKNPDPSREEARKAISPILCRCTGYKKIIDAIMLASEKMRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V370</accession>
    <name>A0A133V370_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">AKJ40_00100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00875">
        <property type="protein sequence ID" value="KXB00875"/>
        <property type="gene ID" value="AKJ40_00100"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.22"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="134"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB00875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="275" mass="29482" checksum="0F4F3500C4791541" modified="2016-07-06" version="1">MIEIAICGACGRMGQRITKTVSNQEDMKIAAAIDKPGTPRAGEDIGKIASVEKLGVEVRGADEIEDVLTEANPDVLVDFTIAKAAVENVKAAANAGLPVVVGTTGFSDEQMKEMEKSIQEAEIPAIIASNMSLGVNVFFKMVEEVAEKLGEYDMELIETHHNQKIDAPSGTALTAAKIAAEASGKDLEKVAKFGREKGELGKRPKDEIGIHSVRAGDITGEHSFMFAGPSERVEVSHVAQSRQAFVTGVMKAIRYIREEGKPGKILDMQDVLFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V373</accession>
    <name>A0A133V373_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_00050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00898">
        <property type="protein sequence ID" value="KXB00898"/>
        <property type="gene ID" value="AKJ40_00050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044065">
        <property type="entry name" value="ACP_MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51901">
        <property type="entry name" value="ACP_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="ACP-type MB" evidence="4">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="186" mass="20685" checksum="C78B9D5035EB9988" modified="2016-07-06" version="1">MNRTVPVKDAMTINVITLGSSASVTEVAELMVEKSIGSVVITENGEPIGIICERDLLEKVISSDLKPSEVTAGNIMVKPVITTNPETDMLDALRTMIEKDIQHLPVVEKGEIVGILTLQDILEITPEILETIPEFEEIEASKKEVEEPVCDICREPRKPLVQYGNKWICEKCREFLVRKGPSRGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V376</accession>
    <name>A0A133V376_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00883">
        <property type="protein sequence ID" value="KXB00883"/>
        <property type="gene ID" value="AKJ40_00150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043868">
        <property type="entry name" value="DUF5828"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19146">
        <property type="entry name" value="DUF5828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="127" mass="14678" checksum="6176971D939BFF6C" modified="2016-07-06" version="1">MEKSTLGKNEKEPEEEIKEAAESAKKIPEVAKREEFDQVKDYLTDAVKKTGRALDSKVRKGVRRIEGQIYENIMLKANSLYFDNSVLSAVLSKRLMPNSDEKYEMTLHSNNSNLRELIAERINWDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V386</accession>
    <name>A0A133V386_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00901">
        <property type="protein sequence ID" value="KXB00901"/>
        <property type="gene ID" value="AKJ40_00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="161" mass="18392" checksum="2B9F599BCBF526D7" modified="2016-07-06" version="1">MKKRRTIYSFKKEPVEEEKIEKILEAGRWAPSWTNTQPWRFVIVKDDDTKKEISEIFLEVFRKGIRDAAVLIIVFVDPDEDQYHFVEDGAVATQNMALAAESLNLGSTWIGVFDTENEEKVKETLNVSKDLRAISALPIGVPEDVPEKGRKDISSLILKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UV14</accession>
    <name>A0A133UV14_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succ_DH_flav_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000123">
        <property type="protein sequence ID" value="KXA98051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98051">
        <property type="protein sequence ID" value="KXA98051"/>
        <property type="gene ID" value="AKJ40_04960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Succ_DH_flav_C" evidence="2">
        <location>
            <begin position="239"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="360" mass="41040" checksum="97050595C101312B" modified="2016-07-06" version="1" fragment="single">GIAMAYRCGAELHSLEFQHWHHSDTLYPNSARRLVHNYPDFSEKKQFLGNDFYEKHGISPGTEISTIVDEDGNPVIKELKENIATDDSFHSPNVQRVIAKRFAKRGELFMRYDKSFIETGELEDIYYNYRVIKNFYDPKEEDIPLGTSAHTSCGGLKVSEKCETTVPGLFGAGGAIGIYPTVNTCLWSGETSAKYASERAEKIGVSEPNTKQINAEKRRVESFLRSKPDDGLIPSQVQKKIRDLMWDKMWIIKNREGIKEAISGLQKIREEDIPKMGLESTTRKGNFAWLHALEVINMLTVSELMARASLKRKESRGSHVVEEYPEKNDDNWRKIIVIKQEKGEPKIEAEKPTCPRKAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UV64</accession>
    <name>A0A133UV64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000124">
        <property type="protein sequence ID" value="KXA98020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98020">
        <property type="protein sequence ID" value="KXA98020"/>
        <property type="gene ID" value="AKJ40_04970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="87" mass="10583" checksum="80E45DBA6BEAA098" modified="2016-07-06" version="1" fragment="single">GGSISLHYVYFMNRNRLFFMIKNLEIHKKIFFLLFFVSYLFWRNALKWINFSSDLSYFKVFIKAVKRGLSFEVSTNKVICQMNEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UV92</accession>
    <name>A0A133UV92_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000120">
        <property type="protein sequence ID" value="KXA98133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98133">
        <property type="protein sequence ID" value="KXA98133"/>
        <property type="gene ID" value="AKJ40_04915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="97" mass="11019" checksum="F6EEFE61710315B6" modified="2016-07-06" version="1">MRLRGTAAVNGYSGYHLRRERGFIREARDSEFPTLIVTLEENIVRVVLFSREDGGPCPSSSDFFQIIQKKEKIKITCGSTADKDKLKNGRRAVKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVF7</accession>
    <name>A0A133UVF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000120">
        <property type="protein sequence ID" value="KXA98136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98136">
        <property type="protein sequence ID" value="KXA98136"/>
        <property type="gene ID" value="AKJ40_04930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="94" mass="11287" checksum="8D65F3DAF4AB8AFC" modified="2016-07-06" version="1">MFERIRNWIFGRGEEKEKRKEIEEVGEEKPKEVAEKEAGEEEIDYRELSKQTISNIKEKDDEVELDYEKLLEAEKANKNRKTLVEWLENKIEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVH9</accession>
    <name>A0A133UVH9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000118">
        <property type="protein sequence ID" value="KXA98213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98213">
        <property type="protein sequence ID" value="KXA98213"/>
        <property type="gene ID" value="AKJ40_04890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="100" mass="11960" checksum="811425D588BA5AA2" modified="2016-07-06" version="1">MEKRYEELKRKSYRVGELSPGAIQTKWLTCGNPNCKCKRGEKHGPYYYLAYRDREAGRTTTVYIPEEKVPELKERIENFGELKEDLWELVEIENEMRKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVI0</accession>
    <name>A0A133UVI0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000118">
        <property type="protein sequence ID" value="KXA98211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98211">
        <property type="protein sequence ID" value="KXA98211"/>
        <property type="gene ID" value="AKJ40_04880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="67" mass="7751" checksum="446C15619D9880D3" modified="2016-07-06" version="1">MSLPEGEDHGREGGARTELGVVELRSTRRGGKVSLHFLVWRRYGLSVIIRRILHTNHLQQLILQFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVI1</accession>
    <name>A0A133UVI1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000118">
        <property type="protein sequence ID" value="KXA98212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98212">
        <property type="protein sequence ID" value="KXA98212"/>
        <property type="gene ID" value="AKJ40_04885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="164" mass="19050" checksum="02B5DAD602664EF7" modified="2016-07-06" version="1">MVTPPKVVFVTEGEVSWVDPIESFLPEAVHVRQFHSENCRGLIYVHLLQVFPFLWKKVRKRRRSEIRSFFRGEVATMERIREVAVGPKGIFLGEPVVISYKDRKGRRTRRMIEPLKIETDPYSGVRRIESFCYLRQEGRTFLLERVTDAIPADTELSVISGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVS1</accession>
    <name>A0A133UVS1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Box A-binding protein</fullName>
            <shortName evidence="5">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">TATA sequence-binding protein</fullName>
            <shortName evidence="5">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tbp</name>
        <name evidence="7" type="ORF">AKJ40_04875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000117">
        <property type="protein sequence ID" value="KXA98256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98256">
        <property type="protein sequence ID" value="KXA98256"/>
        <property type="gene ID" value="AKJ40_04875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="2" evidence="5">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA98256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="176" mass="19460" checksum="227720223F16757A" modified="2016-07-06" version="1">MSDAEYKVNNVVLTVSYRDTELDLEKVASNLEGARYAPEVFAGVIYRMPEPKASFLIFASGKANCVGARSIESAEAAIGNLTEQLREQSFDVGEPEIEIQNMVASVEFHRRFDLEQIARNIPNVEYNPEVFPGLVFRMEGSSVAVLLFVQGKGVAVGAKSEEEIRKALDRIAETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UW33</accession>
    <name>A0A133UW33_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_04790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="LHXU01000112">
        <property type="protein sequence ID" value="KXA98431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98431">
        <property type="protein sequence ID" value="KXA98431"/>
        <property type="gene ID" value="AKJ40_04790"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.176"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA98431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="405" mass="44950" checksum="FDF41913EE4ADC34" modified="2016-07-06" version="1" fragment="single">MTHRYIPISNSERKEMLKEIGVSAINDLYSDVPDKYMLEKELELPGRLSEPEVKKHVKKIFSKNKPASERLSFLGGGVWNHYIPEHVRELVTRSEFLTSYTPYQAEVSQGTLQALFEYQSTIAELVDLPVVNASMYGWGSALGEAALMSSRLTHQDKFLIPEYISPGREAVLRTYTEGPGIKLSRIPQDKETGELDLSQLEAKIGEDTAGIYVEIPSYLGFIETQMKKIGDIAEENETLFVVGVNPISLGLLKPPGEYGADIVIGEGQPFGNPMSLGGPLLGIFACRDDREFVHQLPGRLSGMTKTKKGEKRGFVMALQTREQHIRRERATSNICTNNNLYALVTAVYLSSLGSKGLKKLAKKCAGNARYAIKKLNNIDGIDVPVFDAPHFNEFTISFKDAELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UW61</accession>
    <name>A0A133UW61_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LHXU01000111">
        <property type="protein sequence ID" value="KXA98443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98443">
        <property type="protein sequence ID" value="KXA98443"/>
        <property type="gene ID" value="AKJ40_04780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.174"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="385" mass="43580" checksum="B2FE75B70744DBE2" modified="2016-07-06" version="1">MSIHDSLCEISSSGIRELFDLAQDIEDVVSFGIGEPDFDTPEFIKKAAKRALDEGHTHYTPNIGRDDLREEIVKKLKQENNVETDKENVMITIGANQAFILSLSSFVKDGDEVLIPSPGFVSYGPCVKFSGGTPVEYPLKGENNFRPKIEDLEELTTEDTRAIFLNTPSNPTGYIIRRKELEKIADYLIENDLIALVDEVYENIVYENRHTSLASLNGMSNHVITINSFSKTYAMTGWRLGYVVAPEDKIDPMVKLQMFTCACPPNFTQKAAADIMNTEKAEKAVEKMVEAYRKRRDLLCDRIKEIPEMRLKKPEGAFYAFPNIEKTGMNSKELSRRLIEDAKVVCVPGESFGKYGENHLRLSYATGRETINEGMNRLENFFKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWS8</accession>
    <name>A0A133UWS8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000100">
        <property type="protein sequence ID" value="KXA98642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98642">
        <property type="protein sequence ID" value="KXA98642"/>
        <property type="gene ID" value="AKJ40_04600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="105" mass="11967" checksum="754D71E606A21B3A" modified="2016-07-06" version="1">MAEGESSAVDMPRLFNVFDIPEIKSVRAVSSLRQKVDLEKVWNRINRVQKINTSGKDVAKYEVGKGQYLMLFPSGYLQIFAPDEEGVRKVLENFRDELYGAGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWT4</accession>
    <name>A0A133UWT4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000099">
        <property type="protein sequence ID" value="KXA98662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98662">
        <property type="protein sequence ID" value="KXA98662"/>
        <property type="gene ID" value="AKJ40_04570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="466" mass="53943" checksum="2FDCC1C13F54230A" modified="2016-07-06" version="1">MSSSIKSFLKKNYDKSSSDMYSAFIERVNSFCLDKGISGMITQDTFMFIGSYAKLREKLIRGSFPTLLHLGTHAFQEIGGEKVRSVAFTYRNNIQKTSFYRLIDSKNKKIDYLEGNFKVYKKDLREFRGIEDNVFAYWLPSKYIKLFDEGNPLGQGEKPVAEVKSGMQTGNNSKFLRYWWEVESDKWKPYAKGKGRQKFYVSQKNVVDWENEGKKLKEYEGSVLRNSEYYFHEGITYNSTGGDDFSARYLPEGHIFDNTSQMIFAQKTSNEYLLGLLTSSFANYILSSLNPTLSFQVSDIKKVPFIEPSKDQQKRVESKIEKIISINKDRESFDEISPHFKGFESKKRSFNGFLENIKHNILKKRNKIKSEWKSVDKQVLKIYGLNKSNLPLREYVVSNKISIDKEKLTKRIISYFIQISLGRWEMDGVESDEDGILMVSEGVSEDNPSLIDKIRECISAEWGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWV6</accession>
    <name>A0A133UWV6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000100">
        <property type="protein sequence ID" value="KXA98641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98641">
        <property type="protein sequence ID" value="KXA98641"/>
        <property type="gene ID" value="AKJ40_04595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="72" mass="8171" checksum="326C02819BBBC435" modified="2016-07-06" version="1">MVKKLLQFRSCFLNFLGNGKKVFLKLLAHQIHGKKEDLTAPFGSTKAVKFSQFQDILRIPIELDLILLLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX58</accession>
    <name>A0A133UX58_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000095">
        <property type="protein sequence ID" value="KXA98758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98758">
        <property type="protein sequence ID" value="KXA98758"/>
        <property type="gene ID" value="AKJ40_04490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003831">
        <property type="entry name" value="DUF211"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023129">
        <property type="entry name" value="MTH889-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42240">
        <property type="entry name" value="PTHR42240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02680">
        <property type="entry name" value="DUF211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160363">
        <property type="entry name" value="SSF160363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="94" mass="10467" checksum="4FC14C4BFDB93519" modified="2016-07-06" version="1">MAESDSKEPKVWRIVLDVLKPHDPSLPEFAKQLGMMDGVDGVDVALLEIDKETETLKVTVDGDLNYSEIRSKIEDWGGVVHSVDEVIVGSEMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX59</accession>
    <name>A0A133UX59_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH asnC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_04465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000094">
        <property type="protein sequence ID" value="KXA98785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98785">
        <property type="protein sequence ID" value="KXA98785"/>
        <property type="gene ID" value="AKJ40_04465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA98785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="154" mass="17079" checksum="5B52194D2564F5ED" modified="2016-07-06" version="1">MEGRLIRDLDSIDREILKMLVENGRATLSEMAEEVGLSASGVRRRIKVLEEKEVVQGYTAVVNPEKMGYGVVAFLSIDVRSGEAGRVAGALTRCKGVCEVHKTTGDHCLIAKMRAENRVQISEFVEDRVSTYQGVKDVNITMAIETYKEELLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX66</accession>
    <name>A0A133UX66_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_04480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000095">
        <property type="protein sequence ID" value="KXA98757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98757">
        <property type="protein sequence ID" value="KXA98757"/>
        <property type="gene ID" value="AKJ40_04480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA98757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="168" mass="19412" checksum="C78E4FE1565F3A0B" modified="2016-07-06" version="1">MGIEEDVSTLQAALYASDRPLSLKELKDIVETSSESYIQKLLDHLDEECRKNSPFGLKETSENMYTLQLREEFMPKVENIIPKTKINEAALKTLAVIAYKQPIKQSELAEIRGGRVYQYVKKLKELDFVESKPLGRTKVLRTTKKFAGYFGFEDQMDKIREKLQQMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXA2</accession>
    <name>A0A133UXA2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_04440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000093">
        <property type="protein sequence ID" value="KXA98816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98816">
        <property type="protein sequence ID" value="KXA98816"/>
        <property type="gene ID" value="AKJ40_04440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA98816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="69" mass="7716" checksum="CAEC3CCE60043BF8" modified="2016-07-06" version="1">MVELPIAAVDRIIRRVGGQRVSESAARELAEVLEEKGMEIASEATTLAEHAGRKTVRDEDIRLAMRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXH2</accession>
    <name>A0A133UXH2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="9" type="ORF">AKJ40_04370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000091">
        <property type="protein sequence ID" value="KXA98882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98882">
        <property type="protein sequence ID" value="KXA98882"/>
        <property type="gene ID" value="AKJ40_04370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1201"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00285">
        <property type="entry name" value="TIGR00285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="8">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXA98882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="109" mass="12003" checksum="911B35029204D5B6" modified="2016-07-06" version="1">MADDNVVFVGSKEVMSYVLAVTTQFNEGSNEVVLKARGSAISRAVDTAEIVRNRFLQNVDILDITTKTEELEDEEGTSNVSAISINLGEKQTDLLKIRIKEIDISKTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXL6</accession>
    <name>A0A133UXL6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gatE</name>
        <name evidence="8" type="ORF">AKJ40_04285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="LHXU01000089">
        <property type="protein sequence ID" value="KXA98926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98926">
        <property type="protein sequence ID" value="KXA98926"/>
        <property type="gene ID" value="AKJ40_04285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1172"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="7">
        <location>
            <begin position="483"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXA98926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="628" mass="70469" checksum="048068FB4383EB84" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXM5</accession>
    <name>A0A133UXM5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_04290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000089">
        <property type="protein sequence ID" value="KXA98927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98927">
        <property type="protein sequence ID" value="KXA98927"/>
        <property type="gene ID" value="AKJ40_04290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA98927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="148" mass="16937" checksum="3DF6A8C8CCA5BAA6" modified="2016-07-06" version="1">MTEIDETDVEIVKKLEKNARGSFREIAEELNVSEGTVYNRVKKMQEEGIIKGFSARTDSMKLGKRLVAIIGLRVNGGHLVEVEEELAEEEEIRCAYDVTGEYDAMVIGRFETRAELNEFVKTTLSNKYVERTTTHIVLNVVKEDFRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXQ9</accession>
    <name>A0A133UXQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000088">
        <property type="protein sequence ID" value="KXA98972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98972">
        <property type="protein sequence ID" value="KXA98972"/>
        <property type="gene ID" value="AKJ40_04275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="163" mass="18994" checksum="BA4C30B38CD256C5" modified="2016-07-06" version="1" fragment="single">MLTSLTFFGGLEEVGGNKILLEDGEVKLFLDFGKNFGKEKKYYREPFLKPKNEKHLLNLDLLPEIKGLYHDDNFPPIDGVIVSHPHLDHWGYVCFLDTRIPIYCGECTKKMILNYEFCSYSGTSSEYYLANFRKKSGREVYRDFNTFRTGDILDMENLKIEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXR5</accession>
    <name>A0A133UXR5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000087">
        <property type="protein sequence ID" value="KXA98979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98979">
        <property type="protein sequence ID" value="KXA98979"/>
        <property type="gene ID" value="AKJ40_04240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="140" mass="15779" checksum="570F6A97BEEBB79F" modified="2016-07-06" version="1">MTGLKMRNPKPRKDTEIKILLVDRDQKFLERTKALWESRAEWTTVETTTNPEEALEKIRNANHDAIVAGYVLSGMTGLELLETIRERGGSTPFVVLTGAGSEEIASKALNLEADRYITKDIDPETQFEGIMNAIFDRPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXS2</accession>
    <name>A0A133UXS2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000088">
        <property type="protein sequence ID" value="KXA98971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98971">
        <property type="protein sequence ID" value="KXA98971"/>
        <property type="gene ID" value="AKJ40_04270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046260">
        <property type="entry name" value="DUF6293"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19810">
        <property type="entry name" value="DUF6293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6293" evidence="2">
        <location>
            <begin position="8"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="267" mass="31193" checksum="ED7BC751B0F77DFB" modified="2016-07-06" version="1">MVEKQRGIHVFAGSYEYDRIVEPLFGDFPVEKIIALRSDTSYPIMTKLTDHFIQKLRDNIPREIETVSLDIYNFDEVFRKTLKILREYSKKDIPIFLNISSAPKLTLVAMISAAYFFKNKGNIEIFYVAPETYLVPEILEELDKLDDSNQSKVIENLKELRDIFRKSGIAVSATNYELIPLFPIEGINELDLSILEILDDFGTINSITALIEKLKQKSQREVKRTSVQYRLKKLRENNLIKTKRVERRMEIEIARLGEIYLKSYTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXT2</accession>
    <name>A0A133UXT2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AKJ40_04190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000085">
        <property type="protein sequence ID" value="KXA99003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99003">
        <property type="protein sequence ID" value="KXA99003"/>
        <property type="gene ID" value="AKJ40_04190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1148"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXA99003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="569" mass="60367" checksum="8C49F56FABAB3EF2" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXY7</accession>
    <name>A0A133UXY7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_04080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000080">
        <property type="protein sequence ID" value="KXA99048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99048">
        <property type="protein sequence ID" value="KXA99048"/>
        <property type="gene ID" value="AKJ40_04080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1119"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="6">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="4">
        <location>
            <begin position="103"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="5">
        <location>
            <begin position="550"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="678" mass="76457" checksum="1B2CFBDC92FAD5F4" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXZ8</accession>
    <name>A0A133UXZ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000078">
        <property type="protein sequence ID" value="KXA99064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99064">
        <property type="protein sequence ID" value="KXA99064"/>
        <property type="gene ID" value="AKJ40_04030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="209" mass="23639" checksum="3CB174122C70A6D7" modified="2016-07-06" version="1">MTGRDTTEFRFSTFTSHEAYKVYQDFLTEALTLMTTCEGTLEGIAKYLNISKHMVELSEHTLLDYLDDNGKDVIEVDDDPVVVFADFSGTQISKNTGMIMSKVGDNVPYKVCPTMNYMTAWNFVKGLKERLETDDDTPVVFVTDGGTAWLDPIQSLFPDAVHIRQFHSKNTRGIIYVHLRHAERTFLLERVVDAIPANTELSVISKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY38</accession>
    <name>A0A133UY38_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000076">
        <property type="protein sequence ID" value="KXA99090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99090">
        <property type="protein sequence ID" value="KXA99090"/>
        <property type="gene ID" value="AKJ40_03995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="340" mass="38569" checksum="B68E684EB06FC15D" modified="2016-07-06" version="1">MKERGKPSSGPPYVQNAHACDVSRKGEVQKPEGDGSGRLVREKKGTGRKSRTKTSRGSRETQGRAKLPRAGWSSGGSSPMRTSPKPEGMSPCKEEGRDPYIRPTRRRPPAENDGKGTRLYLCPQPKRGIERWTMAEERGSDRAREVPDEKFIVCKVAGPIEWKENEHSPTSSGFLPVHWETREGKHGRAVEVPVKNMALSGLDYINDTKDNKLGPEDFPKTLDASLVYQTPHVGTLMACYPVKEHCVCLLEYFPEGKTWIPHKVKGAQAQELRRGVRDSDRVLWDVRVKDDDQMVDRKIEFSLMGRDLDLLQRCAERADVEDMDRRVRKIVIGYLKEKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY44</accession>
    <name>A0A133UY44_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000075">
        <property type="protein sequence ID" value="KXA99099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99099">
        <property type="protein sequence ID" value="KXA99099"/>
        <property type="gene ID" value="AKJ40_03950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="97" mass="11529" checksum="838BF184E82909B1" modified="2016-07-06" version="1">MEGNIIVYRQPSSSKSRQLSRALNGYIDKSNHGKYTYERDGLLDKIPHRKLIKGVFIIKNKHLKKFEDLLKKYQAEYHIRKIELKPEDTEILTNQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY54</accession>
    <name>A0A133UY54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000074">
        <property type="protein sequence ID" value="KXA99114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99114">
        <property type="protein sequence ID" value="KXA99114"/>
        <property type="gene ID" value="AKJ40_03925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="441" mass="47340" checksum="77C31B37AA8CAE50" modified="2016-07-06" version="1">MVSEEREEEAFLDEDVFRKVPETETYEWTHFLMIFIGMWASLAAVGRGVTLGLNITPWKGILGLFFGYMICMVYGFLVGRLGVKRRLATYPILQRPFSKFWAILPSLFTFGLAATFIGVQADVIARISMAVVNVPIITLVGPITNRTIISGLLCAGMMFTAYKGIRYIRNLSWASIPFYMSVLVVGIVLATLKFDGSFLELLTVEKHKTSFATATFIGVSLYAGFSAMLPDVSRFVKTMRGFTKAIIIGFISAVFIPASGVLMGAGYGAQYFGVFGAFAFALGIYAAVSMFLAQWTTNDNNAFTSGLALSTASRILDRKFETGRLNRKAATLIPILVGIGLSAAGAGGIGPLIAFVTALGSWLPPMAGVVIGHYYIVEKVAGEKGVAGKGIAGPISWIAVSLLVHLGILPWGAITGVVGGVAVYVALYFGVESPLFGKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY70</accession>
    <name>A0A133UY70_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase</fullName>
            <shortName evidence="2">ADH synthase</shortName>
            <shortName evidence="2">ADHS</shortName>
            <shortName evidence="2">ADTH synthase</shortName>
            <ecNumber evidence="2">2.2.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroA'</name>
        <name evidence="3" type="ORF">AKJ40_03905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate</text>
            <dbReference type="Rhea" id="RHEA:25952"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="ChEBI" id="CHEBI:58860"/>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.2.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.10" evidence="2"/>
    <dbReference type="EMBL" id="LHXU01000073">
        <property type="protein sequence ID" value="KXA99128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99128">
        <property type="protein sequence ID" value="KXA99128"/>
        <property type="gene ID" value="AKJ40_03905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1054"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00960">
        <property type="entry name" value="ADH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010210">
        <property type="entry name" value="ADH_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01949">
        <property type="entry name" value="AroFGH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="269" mass="28545" checksum="B6D31DE974C5AA6E" modified="2016-07-06" version="1">MEVVNLSELGKKVRLERVMNRKTERTVIVPMDYGISMGPVDGLQDMSGAVNKVAEGGANAVLLHKGIVQAGHRGYGQDIGLIVHLSGSTSLGPDPNQKVIVASVEEALRMSADAVSIHVNVVAENEPQQLRELGRIAEVCDDWGMPLIAMMYPRGEKVDDEFDSEVVAHAARVGGELGADIVKTNFTQTVSSFKTVTEGCPVPVVIAGGPKADTDEDILETASKSIRAGGAGVSIGRNVFQHESPSGMVRALSKIVHRGASPEEAEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY95</accession>
    <name>A0A133UY95_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LigD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000071">
        <property type="protein sequence ID" value="KXA99153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99153">
        <property type="protein sequence ID" value="KXA99153"/>
        <property type="gene ID" value="AKJ40_03840"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1039"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigD_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="125" mass="14637" checksum="ABC4C9B9301FF4AD" modified="2016-07-06" version="1">MGELKYSIQKHDASTLHYDLRLEKEGVLKSWAIPKGPSRDPSDKRLAIQTEDHPLDYAFFEGEIEEGQYGAGEVELWDKGSYDLIKWKENEIIIDIYGEKLAGEYVLIRFQPDENPKNWLFFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYA3</accession>
    <name>A0A133UYA3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CbiA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000068">
        <property type="protein sequence ID" value="KXA99186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99186">
        <property type="protein sequence ID" value="KXA99186"/>
        <property type="gene ID" value="AKJ40_03735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014433">
        <property type="entry name" value="CooC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005647">
        <property type="entry name" value="CooC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="262" mass="29329" checksum="1FEE2DBCD90136F6" modified="2016-07-06" version="1">MTKRRKKATEGKTKVIGFGGKGGVGKTTLAALFLRLMGEMDSPAILAVDSDPNTCLPGVLGAEGYQTLGDMVEGYKGGRLPPRKFRQEFNTLLLKNEQEFYDLLPMGRNEGQGCYCSVNDLLRSAFRDFVLKGNYAYDFVVMDCEAGIEHISRKTSSFIDDFVIATDSSRMSLNTIKNIRNTQNEVKIDVNNLYIVANRVEDGEMLDRIEDLSGELGMTFLGRMPEDETLKRLNFKGKSIFELPDDSPAYLRMREMANVILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYF1</accession>
    <name>A0A133UYF1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-CoA decarbonylase/synthase complex subunit delta</fullName>
            <shortName evidence="1">ACDS complex subunit delta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Corrinoid/iron-sulfur component small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cdhD</name>
        <name evidence="3" type="ORF">AKJ40_03745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000068">
        <property type="protein sequence ID" value="KXA99184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99184">
        <property type="protein sequence ID" value="KXA99184"/>
        <property type="gene ID" value="AKJ40_03745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.990"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01135">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016041">
        <property type="entry name" value="Ac-CoA_synth_d_su_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004486">
        <property type="entry name" value="CO_DH/Ac-CoA_synth_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03599">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00381">
        <property type="entry name" value="cdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdhD" evidence="2">
        <location>
            <begin position="104"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="415" mass="46224" checksum="0D90CDD6F4DBB496" modified="2016-07-06" version="1">MEILKEIILKLYDKEKIKEILKEGLEDINDIDLEEGDELVLEGLSIESEDIGFRLSPKAISQLPRLMPSAPAEEVEIEEYEPALKEWENQIQEVPMGATSSDGGTRKKVVKLGGEKCMPFYPDDDNPNMPIVTFDTFDSKIHLPGVISKHYEDVMGSPGEWAKKSVEEYGAKMVTIHLTSTDPKGADTPPKEATKSVEEVLEAVDVPLVIGGSGNPDKDPAVLEAAAEAAEGERCLLASATLDLDWERIADAAMEYNHNVLAWTTIDINLQKELDRKLMNYGVDRDRIVMDPTTAALGYGIEYSYSIMQRIRMAGLEGDEELDFPISNGVTNAWGAREAWMGSEVPKEKYGEDWGPREFRGPLWEVFVGLSMMLSGSDLLMGLNPRAIKVCNKMVNRLSREVEGLSNFQDWVTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYF7</accession>
    <name>A0A133UYF7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000064">
        <property type="protein sequence ID" value="KXA99228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99228">
        <property type="protein sequence ID" value="KXA99228"/>
        <property type="gene ID" value="AKJ40_03645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.964"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="517" mass="58357" checksum="CBE848691DB178E3" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYN7</accession>
    <name>A0A133UYN7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000060">
        <property type="protein sequence ID" value="KXA99277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99277">
        <property type="protein sequence ID" value="KXA99277"/>
        <property type="gene ID" value="AKJ40_03545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="92" mass="10659" checksum="998320EA46E0DA76" modified="2016-07-06" version="1">MLNLRPVYHSTDVGVKGHVFVCILALLLRRLMEKETGEPFESVFEELKELKVNVIDLEGEKIFQRNRLTSTQEDLLESLKVKRPPKILVNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYU6</accession>
    <name>A0A133UYU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000055">
        <property type="protein sequence ID" value="KXA99353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99353">
        <property type="protein sequence ID" value="KXA99353"/>
        <property type="gene ID" value="AKJ40_03335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="284" mass="31174" checksum="5FB685A11BE50177" modified="2016-07-06" version="1">MREINVSAVETSKGGRIVKKILVNGLTESAGKTTAALALYSQLEEAGEVSLFKPLAGNNYWYDYPVVMEGVREGRLYGKDAKLFSERSGIEEEVINPLHRLWAPVGIVGGRGRPGDDVVLLDRICDGEGTRLLIDSRTVVPDALSPLTNGVDRVERYSDEEEHDEYINSLYPPAFRNSLSHFERADVLIVESYSDVSLPYMVEGMDLAVTVEPGAAHVSDGEKFEEANSMVRGVYRNYGFEETRTGKVLRLVDSETLRLNPVDPKDSGGGEGFEELAEAVNGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYV9</accession>
    <name>A0A133UYV9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prim-Pol domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000054">
        <property type="protein sequence ID" value="KXA99369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99369">
        <property type="protein sequence ID" value="KXA99369"/>
        <property type="gene ID" value="AKJ40_03295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="87"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="460" mass="52182" checksum="906F1EB3CCE26C10" modified="2016-07-06" version="1">MEKTSKKHFDKWLDSMPEDLEPYLIPIKEGKNSDEGKAPDYLEIIKRALKEYGLGWEEYRKLKDKHEVVKIKHLAELAGEKDKAEVSLKVSSWRSPYAKLSVGEGRQRIEEGKNLALVMRGVIAVMDVDDAKRAKRILPEELMSTLTVETRTGKSHLYFRNGGVNNCDIRGVVELRAKWRYVLTPGSYVPPGNSEGDGLYKVSQRRELRTLTVDDLPAELKTRMKRIGQDVEKVPGDYSPAKLDEKVKAPCPFFESGEKDLSSLYLDFHNLAKSLIFSRLQVMLKDFLAIDIDGEGSTYQIHLINGKIVLVNEKDSLPLASIEVKTSRNSVKPVKGAYLALKRGIPSILAEINTEDVHVMNEKCADKIIDQAKDQLANLTKLKKENWKIPDRHTCRMCSNKSCPYNRNNRVQQVGQKLVEEKTEQLDKCPSSTVDNIVKAIEQILKDEGYKILELNVNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYW4</accession>
    <name>A0A133UYW4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000054">
        <property type="protein sequence ID" value="KXA99373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99373">
        <property type="protein sequence ID" value="KXA99373"/>
        <property type="gene ID" value="AKJ40_03320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="69" mass="8470" checksum="5D8FC0C35C930F5D" modified="2016-07-06" version="1">MTKEIEKRDVFSEVEIKKMFVIIEVYKRGIEQVRVTDSEEKATEIEKELCDDLSVPFEEEEREKYYWQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYZ6</accession>
    <name>A0A133UYZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000052">
        <property type="protein sequence ID" value="KXA99401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99401">
        <property type="protein sequence ID" value="KXA99401"/>
        <property type="gene ID" value="AKJ40_03210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="80" mass="8537" checksum="2614E009D0342149" modified="2016-07-06" version="1">MGRQGPQTLSPPASEMGHPGARYLGSRGGRHAFCPFLYKRTGVFDLLILSLRGKGITSTFYLGGFAGLAGQFSVAGFWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYZ7</accession>
    <name>A0A133UYZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000052">
        <property type="protein sequence ID" value="KXA99403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99403">
        <property type="protein sequence ID" value="KXA99403"/>
        <property type="gene ID" value="AKJ40_03220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020994">
        <property type="entry name" value="Uncharacterised_Ca-bd_CcbP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11535">
        <property type="entry name" value="Calci_bind_CcbP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="119" mass="13856" checksum="E46BDE8271110706" modified="2016-07-06" version="1">MKEEERIAQIFSVQKKSNIPKVSKETLRTFHSYLSKNLSFPFGAKYRKESFPSDEISDVKITDLLGIDKYEVEVVYGLICEGRVGRRKIQAPLAMITVSQEGKNEQLVKDYRTWFANYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYZ9</accession>
    <name>A0A133UYZ9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000052">
        <property type="protein sequence ID" value="KXA99400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99400">
        <property type="protein sequence ID" value="KXA99400"/>
        <property type="gene ID" value="AKJ40_03205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.814"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="233" mass="27004" checksum="B93C7B18581EAF8E" modified="2016-07-06" version="1">MHYVLQLPSLECDFFDLTDRFGGETYERTPVQNGDIILGDRGYCHREGVAHIMEEGGDVIVRLNWNNFPLVKKSGESINILKRLRTLDGYNLGEWSVWFEAFDQMYNGRLCAVRKSKEAAEKSKERIRKTARKNGGSPRPETLESAEYVYVLATTDQKTLSTEAVLELYRARWQVELAFKRMKSLFEVGQVPKKNERSARSWIYAKLLAVLLIERMIHAANFFSPWGFDERKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ19</accession>
    <name>A0A133UZ19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000051">
        <property type="protein sequence ID" value="KXA99420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99420">
        <property type="protein sequence ID" value="KXA99420"/>
        <property type="gene ID" value="AKJ40_03190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="105" mass="11932" checksum="F574858B498309FC" modified="2016-07-06" version="1">MKVEIDSLIGSRKHYSIIFDKDNITFADVLEKISKEYEELSSKIFDDEGNLSNEVIAILSREEEKSTSFTNTYRSGENIRSRENYLETGVKDGDKITLFPPMSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ20</accession>
    <name>A0A133UZ20_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000051">
        <property type="protein sequence ID" value="KXA99417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99417">
        <property type="protein sequence ID" value="KXA99417"/>
        <property type="gene ID" value="AKJ40_03175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.805"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="287" mass="31584" checksum="CD52637110E09A66" modified="2016-07-06" version="1">MSFEYIKPESLKNASELLKEYGEDAHLIAGGTDLLVQIKDGDVQPQYLIDLKSIKDELDYIDLDRDALRIGSGCTLSEILRSEVVRDKCNVLFQAVREMGSVQIRNIATVGGNICNASPAADTATPLLVLNAEVKIVSEDGERLVPLDEFFEGPSAMVLSEGEILSEVIIPEFSFEGEDNFLKQKRRKAFSLAVVNSAFKIFEKDGLCEEVRIGLGAVAPTPIRASQAEDYLEGREINVENIEKTAESAQELCTPITDVRACGEYRNELIYSLVKKGLSELVGLSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ34</accession>
    <name>A0A133UZ34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000050">
        <property type="protein sequence ID" value="KXA99439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99439">
        <property type="protein sequence ID" value="KXA99439"/>
        <property type="gene ID" value="AKJ40_03155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="72" mass="8133" checksum="9A0EEC2A43D71C57" modified="2016-07-06" version="1">MSKFVAECPIDGCDFQVESYWEYTARGEVILHAYRAGGGGHGEKGSRPRDRDPQILRDELATFTKELALKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ68</accession>
    <name>A0A133UZ68_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000046">
        <property type="protein sequence ID" value="KXA99496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99496">
        <property type="protein sequence ID" value="KXA99496"/>
        <property type="gene ID" value="AKJ40_02990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="158" mass="17859" checksum="9AF3DE78E1E4209D" modified="2016-07-06" version="1">MKKVRKILVPYFGGKLPKKAEEEAFNRLEAGGELYLLHIFDEESTRSFRYMSGQRDESDLLKTAGESIKGLQEKEAEKYVEKVKSRAEKKNFNVSALYTSGDPAEETLKVADERSVQLIVVERLRDSVTSVFLGSEINRLKNDAPCDVITVKPEKGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ69</accession>
    <name>A0A133UZ69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_03050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000047">
        <property type="protein sequence ID" value="KXA99482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99482">
        <property type="protein sequence ID" value="KXA99482"/>
        <property type="gene ID" value="AKJ40_03050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="324" mass="34827" checksum="0C261D68AA0A7216" modified="2016-07-06" version="1">MNEVDKEDYPETWGQISAIFKYEILWNLRKKKVLAMFIIAIGLTSLDLFLPAIWGEGGPDPKFLIGNLGPRSFIMILLAVTVAMSSISGEFEKNTIIPLASKPVSRKIIYFGKLLAMLTVLLIIYIVLDAYLLIGGRILYGPQSGMNITVIALPFLTTLSTAVWIGVTLLIGSATKSSTIAAIGTLGLLFALGIIGGLVPVLTSASGQPLNYLPGSGESGQVSGDFIQGPTPENLSINTGTDSLSRNFLLYSNDPTAKVTIRKQQLSFENIENTPGTTPIVTVGTRTEPLSQVLTRSVLVALAYLVAFNLLSLTLFKRSEVTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ77</accession>
    <name>A0A133UZ77_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000047">
        <property type="protein sequence ID" value="KXA99479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99479">
        <property type="protein sequence ID" value="KXA99479"/>
        <property type="gene ID" value="AKJ40_03035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018646">
        <property type="entry name" value="12TM_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09847">
        <property type="entry name" value="12TM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="411" mass="45577" checksum="E6305841C6D63D17" modified="2016-07-06" version="1">MSWLLSGGAAILIIPIPAAIIYTWATGNYLSILVSFLWGVLTTMFGHSLGLIVTNFFSLKTTDRSTFGKALRILKIGGALLLFLLWFFIFTQEGFLNPLLKPLTRISETLWFLYPFNASRSIVDFSTVYLLSLFLYGFLFSAIYWLAGRRTWKNITTPTFAVSEKVEELEIGISGKFRSLIKKDLTISFRSGQKFLSILIFPLMILFMNLIDVIQGGTISLFRAELIYIAIGILSGFGIIYLYIQEGESASVMSALPITRREFSTQKALSAFILFPLYAIPAILLVSVKMRYGIPAVLMQLVSGFAMALTSCLVVSNSLADRLPDNPTVITQETFGSRYTPLLLLLKSAILSGWPVPASIGLYLIITRSLSALVGSIILLALTTILVALNLVFTLWRYDLLGVSSSNTIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZB3</accession>
    <name>A0A133UZB3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000045">
        <property type="protein sequence ID" value="KXA99521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99521">
        <property type="protein sequence ID" value="KXA99521"/>
        <property type="gene ID" value="AKJ40_02960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="416" mass="46386" checksum="2493F139D025FFD3" modified="2016-07-06" version="1">MERKYLISIIIVLVVVGVGIIALTGGFEFSTASLGNFATAEEVDDDYRPVEVVDEFSPDTEVIYATCEVSNAPSETEIKTEWYYLDDNERFNTLKHTVDGGSGPLSFSYEPEDGLWPVGDYEVRFFLDGQQVGVVEFSVEVEEEASISDVAMAEEIDNKGKPVEVVDEFSPETEIFYATFEISNALPSNEIETELYFVDNDQLVLSEPIPLDGFYTGPAHVSYTKPHDGWPTGNYEVRVFLDGERVGTAAFSIKEDRISLDPESDLITTADLPSEFVEDTEAGWKEEQSEFEGVPFDSAAFRFWEQSSEDRFVSSTGFVCPSVDDAQEMLDESHSYWTDHFGSYDDTTVETVDFSNYGDELTASEAVNVENGTTYAYIVTLRVQNVTVTVVTGNISKSETEDYCSLVESRIVVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZB7</accession>
    <name>A0A133UZB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000044">
        <property type="protein sequence ID" value="KXA99533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99533">
        <property type="protein sequence ID" value="KXA99533"/>
        <property type="gene ID" value="AKJ40_02890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="102" mass="11289" checksum="3C6BA657F3BBEA29" modified="2016-07-06" version="1">MTEVICAVPGCENNLTDEQRENKIPVCSECEAANMHVCESCNKRLSTEQIQNGGSLCSECEGNPSGLEESMEEYGEEYIMGTDTEEEGFMVGESKEDEDFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZH9</accession>
    <name>A0A133UZH9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000041">
        <property type="protein sequence ID" value="KXA99577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99577">
        <property type="protein sequence ID" value="KXA99577"/>
        <property type="gene ID" value="AKJ40_02795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="241" mass="28546" checksum="7494798A2A4BE76A" modified="2016-07-06" version="1">MPVVFAIDALEYEKVEEFDCDNLKQVTYGKTDISEFDQPRTMVLWSSFMTGENKEEEILAKGDKEMWNTKFSLEETFFSNFENPEIIDLPGYSYDREQHERERELLKEFFEEAENEEDKKEIRKEYNQHGLEHHRKIKEKFLQTLKKDHDFVLGYFSAADVIGHLNFGNRTLMEMIYDDLDEIAEKIGEIRDDHLLILSDHGMEGVGMFGDHNGYGYWSFDDECELERPELTDFADFLVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZJ0</accession>
    <name>A0A133UZJ0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000040">
        <property type="protein sequence ID" value="KXA99601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99601">
        <property type="protein sequence ID" value="KXA99601"/>
        <property type="gene ID" value="AKJ40_02765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="336" mass="38501" checksum="E5FA985688F6D979" modified="2016-07-06" version="1">MNRYIGIDVHQDKCHGTVLDEDGITARQGYFQNSPSGFKDFFDGTGTGKVAIEATDAWQPVYDWLTEKGFDVKLAHPHKTRIIAEVKIKTDCRDSEALADLVRADLIAEVYVPCDDMRELRGIAKQRGKLVQERSKYKNRTKAQLRKRGIEYKDRNIWTKSGKQWLRDLEINAVNDFLEVLKTLNDRISKLEEEIEEIAGDMEEARLLMTIPGVSYYTALTIIAEIATIERFPSPEHLCSYAGLVPSVKQSGSKEVHGPISGGRPLLRWIIYQATHNHKNNAPNSHVTEFYKRLEQRKPKKLAKTAAARKLTTVIYWMLKLKEEFHPKGYDPRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZQ0</accession>
    <name>A0A133UZQ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000038">
        <property type="protein sequence ID" value="KXA99652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99652">
        <property type="protein sequence ID" value="KXA99652"/>
        <property type="gene ID" value="AKJ40_02685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="70" mass="8193" checksum="DD69D0E615EC906B" modified="2016-07-06" version="1">MSLEDFFLEKIGISEEYWEDSEGELREASEKSGASKFGNIYGRGRLDRFSPGLRRGLPRESRERTNTWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZU3</accession>
    <name>A0A133UZU3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARDB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000035">
        <property type="protein sequence ID" value="KXA99701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99701">
        <property type="protein sequence ID" value="KXA99701"/>
        <property type="gene ID" value="AKJ40_02570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="144" mass="15830" checksum="99C72B8B96E7856E" modified="2016-07-06" version="1">MKRKIILILIIIAAIIVGLVSFPYLKNRISDSKEISIDNARLDKAKISPGEEAEIYVSINNKSKENDAKGVSVRVVSPSKNIVLSKDYIDLGIIGAGGSRSVSFSISVLKNAYEGKYRIKIKADAEKPFRESTEDVYLEVKAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZU8</accession>
    <name>A0A133UZU8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000034">
        <property type="protein sequence ID" value="KXA99725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99725">
        <property type="protein sequence ID" value="KXA99725"/>
        <property type="gene ID" value="AKJ40_02555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="94" mass="10853" checksum="E4DB5C8BB6FF5130" modified="2016-07-06" version="1">MDLLIILSISLGSLLGLYSIYNVYKAMKLFRFQKIWRVMGLGFISNTILFIIILLLHLFGLLNKIGWAMFIHPAIFGSLTIWAIFILRRKLHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZV2</accession>
    <name>A0A133UZV2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000035">
        <property type="protein sequence ID" value="KXA99700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99700">
        <property type="protein sequence ID" value="KXA99700"/>
        <property type="gene ID" value="AKJ40_02565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="387" mass="43014" checksum="DBF15C6A46CCB951" modified="2016-07-06" version="1" fragment="single">MKKVLAVIILVSLLAATIIVIGFTRDQTDRTQEIPKLLWKKKVVGTFDEFAGVTVVNKTVYTVGKTMDNAPVTALEAETGEIIWQTEVGSCDSTPMIVDNRLFVINCMWDDFTVRDVDQPVDKERIWCLNKEKGTVIWFNDSVLPDGGGPVSSAPAKNRIFACSTKDIYAKKPIGRVQSFRSDNGGLVWTSSYVGASTGGIFFENRYIVSGTNKLAAYDADNGERIWANKEIKSWDSLPVVAKDGVLYIGGGYGKLPLTLFAVNPNNGDTLWSWRAENNRELTLTTPVIHNEKVYFGGYSNLYCVDLKTHSLVWKRGGGGEGPYSTPVIANEIIYYGSTTLEEGEPDYIFARDIDTGNLIWKYEIDTTGRLQGIFSQPTISNNRLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZX8</accession>
    <name>A0A133UZX8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable 6-oxopurine nucleoside phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="LHXU01000033">
        <property type="protein sequence ID" value="KXA99737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99737">
        <property type="protein sequence ID" value="KXA99737"/>
        <property type="gene ID" value="AKJ40_02490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.566"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="51"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="264" mass="29218" checksum="CC1D102419D979F8" modified="2016-07-06" version="1">MVEVAVIGGSGVYSLDFIENPEKTRITTPYGESPKVITGELENREVAFMPRHGKGHATPPHKINFRANLWGLKELGVERIIATTAVGSLNRKIEPGDFVLLDQFLDFTKKRPSTFYDGEDDGVVHVDMTDPYCSELRKVLLNKAKELKFSVHSAGTYACMEGPRFETAAEIKMLKKLGGDVVGMTNVPECVLARELEICYSTVSVVTNLAAGISEEKLTHDEVSEIMERNIEKVKKLIFSSIPEIPKTRSCKCDQALEGAKVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V005</accession>
    <name>A0A133V005_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000032">
        <property type="protein sequence ID" value="KXA99765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99765">
        <property type="protein sequence ID" value="KXA99765"/>
        <property type="gene ID" value="AKJ40_02480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.564"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08298">
        <property type="entry name" value="CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="331" mass="36347" checksum="DEABC6FECED5D01A" modified="2016-07-06" version="1">MKAMQLKEVKAVDEDPLELVEISEPDPGPGEVKIKVRTCGVCHTDLHTVEGDLDLPSLPLVPGHEVVGTVEKLGPETGRFEEGDRVGGPWLYSSCGKCKFCKRGMENLCEDPKFTGLHVDGGYEEFMIAKEDFVYPIPENFTDENAAPLLCAGVIGYRSFRLSDVKPGERLGLFGFGASAHIVIQIATALGCEVYVFTRSEEHRQLARELGSAWEGSAKDDPPEKIDSGITFAPAGWVAKEALRVLEKGGTLAINAIHMTPIPELDYELLYYEKNMRSVANVTRRDAREFLKIAEGIEIETEVEVFPLEDANRVLKLLKNSGINGAGVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V043</accession>
    <name>A0A133V043_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Complex1_30kDa domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000030">
        <property type="protein sequence ID" value="KXA99807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99807">
        <property type="protein sequence ID" value="KXA99807"/>
        <property type="gene ID" value="AKJ40_02380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="16"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="140" mass="16090" checksum="E599F179C4A7280A" modified="2016-07-06" version="1">MSDGAKGIKTGQVREVESKELKDVAEELLEEGFDHLESLTGVDRPEDGQIELIYHVSSYSDSDLREQVIVVKTRVDRETPEIRSLSDFWPNIRYMEAETRDLLGVRFKGNKLRAPLLLPDELEGEYPLRKDFEIPEEGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V061</accession>
    <name>A0A133V061_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_IS1595 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000030">
        <property type="protein sequence ID" value="KXA99813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99813">
        <property type="protein sequence ID" value="KXA99813"/>
        <property type="gene ID" value="AKJ40_02410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="146" mass="17084" checksum="37A96F85A8BC4348" modified="2016-07-06" version="1" fragment="single">RKRGLKLRGRGTYEKDKPPIVGAVQRKGRVVLQEARNLSNKFIRTLLGGHVKEGSKVYHDDYTIYNYLPGYEDVAINHSEGEYVKGEAHTNTIEGIFSLLKSWLRIFRGVRKDNLWKYLKIFEFDFNLRELDPFQKLTCLFTSMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V095</accession>
    <name>A0A133V095_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC2_membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_02300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000028">
        <property type="protein sequence ID" value="KXA99861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99861">
        <property type="protein sequence ID" value="KXA99861"/>
        <property type="gene ID" value="AKJ40_02300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="3"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXA99861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="253" mass="27905" checksum="577FE8412AA9991E" modified="2016-07-06" version="1">MPFLTLLKREVFRYIKNPIVTVAPPIISQILYILVFGLVLGPRIGEVGNFSYINFMFPGLIMMALLMNSFMNPSWSIYAGRHFGWIEPILSSPLSYLQIATGYILGGVLRGLFVGVILLGGAFLIPGVQALYAVHFVVIYFLVVAFLASSLGCIVGLWAQKFDHIALVMNFALFPLVFLGGVFYSLKMIEGISSLEIIVRLNPVTHMINGLRYGMIGLSDINLAPGLLFLPLLALGLFAISIKLIQNGYNLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V097</accession>
    <name>A0A133V097_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000028">
        <property type="protein sequence ID" value="KXA99853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99853">
        <property type="protein sequence ID" value="KXA99853"/>
        <property type="gene ID" value="AKJ40_02285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="225" mass="25918" checksum="10BA51ECF6546D3B" modified="2016-07-06" version="1">MKGWLFDVYPTGEDQIAVCFKTDNGELRIFKDGYIPNIYVYGGRGDLENLESELEKDTLVKSCSFEEKRVKLRDLEKKKALKIECGSMNKVPRLVQKIAHLGEHRKYDLYNVDLSYAQAYLQENNLFPLARSKLSDISNLQFELIDSAESSEYILPPLKFVKLSVKSEKPRPRSGFRDPISEVRLSFEDENISIEGRNEKENILRLVSVIREEDPDIIFTSTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0D6</accession>
    <name>A0A133V0D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000026">
        <property type="protein sequence ID" value="KXA99908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99908">
        <property type="protein sequence ID" value="KXA99908"/>
        <property type="gene ID" value="AKJ40_02220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="71" mass="8488" checksum="5AF9403438F592F3" modified="2016-07-06" version="1">MNSSYRVSIREGLILGKGLEMPDKEREIDRFYELLRKGWMPRPLKIFLILVSMLFAPIFFLIDKILEEQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0H4</accession>
    <name>A0A133V0H4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="LHXU01000025">
        <property type="protein sequence ID" value="KXA99939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99939">
        <property type="protein sequence ID" value="KXA99939"/>
        <property type="gene ID" value="AKJ40_02165"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="155" mass="18102" checksum="C764F693996B9F67" modified="2016-07-06" version="1">MNEVDIKILRRIQSNFPIQEKPFESLSKELGIDRGKLIRKIQQYESNGYIRKISPKLASSEIGYKASTLVAMKVPEGRTERVAKIVNEYNGVSLNFERECGYNLWFTLHAKSEEELLETIDEIKERTDPIDLLNLPKRKKFKLDVEFEPLKEDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0P3</accession>
    <name>A0A133V0P3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_02045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000023">
        <property type="protein sequence ID" value="KXB00003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00003">
        <property type="protein sequence ID" value="KXB00003"/>
        <property type="gene ID" value="AKJ40_02045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.414"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="240" mass="26634" checksum="C559BE35A89237CA" modified="2016-07-06" version="1">MSEELLRAEDIVSGYTRDLDIIKGASISVSEGQLTALIGPNGCGKSTFLKTILGYIKPRQGKIWFKGEDITETDPYELVESGISYIPQGRTVFRNMSVEENLDMGLWPMRGESKKKKEAIETVYEMFPFLAERKKDSADHLSGGQRQMLSLARAVALQPDLLMLDEPSLGLAPSLVDEVFEHIRNVNEQGITVLVIEQKAAEILKVADYGYVLDEGELAFSDAAEDLLENDEVKKLYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0R6</accession>
    <name>A0A133V0R6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000023">
        <property type="protein sequence ID" value="KXB00006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00006">
        <property type="protein sequence ID" value="KXB00006"/>
        <property type="gene ID" value="AKJ40_02060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="284" mass="30568" checksum="B732145546C6917C" modified="2016-07-06" version="1">MIYYIVQGILVGTFYAVLALGLQMVFGVMEVVNFAHGDLMVMGGMIGWLLITTYSLPVGLIFPVVFASMFITGLVVFRVLFKRVRNVPVVQSLLIAFGLGFIIRDAVRYLFSPKIRTIRLWPGSVSFAGVSFSNDLFLTGLVCGSILVIMLVFLERTNWGKGIRATSEHTDLAQACGINIDRVQMLGSGIGIGLAGIGGIFLGVNFQINPYVGMEFLFKSFAVVVLGGMGSMRGVIIGGLIIGLVESIGTLFIGPQPAAAASFITIILVLLIRPTGFFGREVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0X3</accession>
    <name>A0A133V0X3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000020">
        <property type="protein sequence ID" value="KXB00097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00097">
        <property type="protein sequence ID" value="KXB00097"/>
        <property type="gene ID" value="AKJ40_01915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="596"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="1">
        <location>
            <begin position="791"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="999" mass="112048" checksum="27A15FC9C5293226" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V101</accession>
    <name>A0A133V101_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate 5-kinase</fullName>
            <ecNumber evidence="7">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-glutamyl kinase</fullName>
            <shortName evidence="7">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proB</name>
        <name evidence="9" type="ORF">AKJ40_01900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="7"/>
    <dbReference type="EMBL" id="LHXU01000020">
        <property type="protein sequence ID" value="KXB00095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00095">
        <property type="protein sequence ID" value="KXB00095"/>
        <property type="gene ID" value="AKJ40_01900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.345"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB00095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="268" mass="29024" checksum="79039AD344E7FB78" modified="2016-07-06" version="1">MSDPKKAREKLSGAKRVVVKIGTNCLTDEDSKLEEKSIEKLADDIADLKEDGREVILVSSGAIGAGLGRLSFGEMPEDMKSLQAASTVGQGALMRRYSECFEEHGIHVAQILLTQEDLTAPSRFQNFKNTIRTLFKWSVVPIVNENDAVAVEEIRMGDNDPLSAFTASGAGADLLIMLTDVDGLHTGDPKEEESAEPIRTVEKITPEIEKLTEKSSESKFGGMYTKVQAAKIATDEGIPVVVADAEESNVLKKILAGEEIGTLFLAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V132</accession>
    <name>A0A133V132_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_01840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000019">
        <property type="protein sequence ID" value="KXB00125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00125">
        <property type="protein sequence ID" value="KXB00125"/>
        <property type="gene ID" value="AKJ40_01840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="130"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="288" mass="32109" checksum="74D64847C65FA7B5" modified="2016-07-06" version="1">MSKKFREEGRIYRDVGRSEREEEEEESPPPLSRDAIFRIGRKSEDGQRERRPQRSPSGSSGGLFSIFGNLFFKRATIILLLLMFALYIVQTGAQVALGGSYYQPRTPNHPADFDTFLYYLAPSQSTFLTRPWTIITGIFSHGEFFHFFINGLILFFIGLALERRIGRERFIYLFLTAGILSSIAQILVIPNETTVALGASGAIFGVLGALTVMAPRLPILLFFFIPMPLWMLTLGYGSIEAILAISGAGGAIGHMAHFSGLLIGLAFGYHFRKEALRRRSSSSYSIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1N4</accession>
    <name>A0A133V1N4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_01490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000013">
        <property type="protein sequence ID" value="KXB00335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00335">
        <property type="protein sequence ID" value="KXB00335"/>
        <property type="gene ID" value="AKJ40_01490"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.220"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="4">
        <location>
            <begin position="267"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="6">
        <location>
            <begin position="586"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="MCM" evidence="4">
        <location>
            <begin position="856"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="5">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="1234" mass="139553" checksum="0589AC091718C9FB" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1Q9</accession>
    <name>A0A133V1Q9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00380">
        <property type="protein sequence ID" value="KXB00380"/>
        <property type="gene ID" value="AKJ40_01385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.159"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="337" mass="38361" checksum="07F98B5F31EB3FF6" modified="2016-07-06" version="1">MVEFGINRKEHPPSVFLWGGPGIGKSAIIRQIVEELGMNPQESFIDLRLTQLDPVDLRGLPRLESKDYVEWATPHFLPREGRGVLFLDELNLAPGAVQNAAYQLILDRKLGDYELPDRWVMISAGNRAEDRAGVHPMKAPLSNRFIHWEVETDLEDWKDWAYDNGIDRRVIGFLNFKPSMLYRFEEEKGRHAFPTPRTWERVSDLLKMGLSDTEDIASAVGLGAAREFKAYVRMKDDLPDVDAILEGKNEVPEDLDKLHALVSSMVQKASEMGGYEERIVEYANLLPAEFAVLLVKDSLRAGIPVQTTQKFKEFSEKHKDLILDEESKRKTEGSENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1S5</accession>
    <name>A0A133V1S5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00381">
        <property type="protein sequence ID" value="KXB00381"/>
        <property type="gene ID" value="AKJ40_01405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="72" mass="8032" checksum="7C41DD574936E4AA" modified="2016-07-06" version="1">MTTKIEAPTEESPYLVWKEGDLWIAKDHETGVADQGETPDKALKNLEKGLKLRAEALEQDDAIPVSDAPWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1W4</accession>
    <name>A0A133V1W4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00421">
        <property type="protein sequence ID" value="KXB00421"/>
        <property type="gene ID" value="AKJ40_01350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014858">
        <property type="entry name" value="BrxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08747">
        <property type="entry name" value="DUF1788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="187" mass="21801" checksum="E20EC3CCAADAC0E6" modified="2016-07-06" version="1">MKSLEDRFDELREELEQDYDSFNKVQGVNIALFVYSPRREKKVISEVQRLSHKLSDSFLQSETLSLSKIVFEAFEELLGIDEVIEREKEAPNRLLEEANQPLLDYITSKILDLDESMDQGVTLIHRCGGIYPFLSVHALTARLETELNNPTIFFYPGKRKRNYMRFLNGSEEHVGNYRAKIYEVDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V234</accession>
    <name>A0A133V234_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor C small subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_01295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00475">
        <property type="protein sequence ID" value="KXB00475"/>
        <property type="gene ID" value="AKJ40_01295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rep_fac_C" evidence="7">
        <location>
            <begin position="259"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="351" mass="39752" checksum="6A26C7C91A973223" modified="2016-07-06" version="1">MPKSSLWVEEYRPTSLSDVPVQEKIIKDLKGFVKKGSIPHMIFAGPVGSGKTMAALGLAGDLYGGNQDQYFLKVNCSNEGVMVRRKPLPGEGGGEIQKAKRRKRVTGTNKRLRLREEILNHIRSPAMGKIAHKLLYLLDFDEEDSQTQNALRRPMETYSENCRFVFSVENTSNIIDPLLSRCAIFRFGRPSVEDISKMLKNIARKEDVEFTEDGIEVVIEVSNRNLVYAINLLQAVFSVEKKVDKKLVYESIDSFRTGELKNMVITAFRGDFQGARKSLMDILIKGGSNPGELLHEIQKEIYDLDAPDPVKIKLIEKIGKYDHNLTQGKNKRIQLENVLAHIARIGERIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V241</accession>
    <name>A0A133V241_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00518">
        <property type="protein sequence ID" value="KXB00518"/>
        <property type="gene ID" value="AKJ40_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="150" mass="16919" checksum="58D0BB13CD84F64F" modified="2016-07-06" version="1">MKSRDSEGLTHFPRRLVLSFFLHIFGFSTVVNCSTTETGSGAGPIKTSFLPKDLPYPAVLLFFLIEGVGWLVALTYFYHRFVVKGRRFSVPLFKKVEEQTIDQALNIKVVEGVRWLGQTLLEIDRGSISDYLLWLLLGLLVVIAGIILML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2B0</accession>
    <name>A0A133V2B0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00587">
        <property type="protein sequence ID" value="KXB00587"/>
        <property type="gene ID" value="AKJ40_01135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1015"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="146" mass="15689" checksum="58CE15F13A8E4970" modified="2016-07-06" version="1">MLIVSACLLGVNCRYDGENSKSERVLKFLKKGNKKFIPVCPEQLGGLPTPRSPSILPDGGEKVLDGEGEVIMRGWGDVSSKFLRGAEETLKLAKIFDVDKAILKSGSPSCGSKKIPKDFQGKSEGIGVTAALIQRNGIEVLSEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2C4</accession>
    <name>A0A133V2C4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="3">DHBP synthase</shortName>
            <ecNumber evidence="3">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3"/>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00592">
        <property type="protein sequence ID" value="KXB00592"/>
        <property type="gene ID" value="AKJ40_01115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1011"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="238" mass="26789" checksum="B0AC0137CF38C4C5" modified="2016-07-06" version="1">MEKAIKEIRKGNFVLIHDASDREDETDMVISAEKTKPDHVAQMRQDGGGLICVAIHPKIAENLDLPYISDIYKKASSDFEILNQAKADDIPYGERSSFSITVNHRKTFTGITDKDRALTIRELGKLSSRAYNGASVEDFGKNFRTPGHVPILRAAENLLDERRGHTEYSIALMEMAGVAPAAVVCEIMDAETKRAMNKEKVKKYSKKKNLVYLEGKEVLEGYEKWKRSKGETKWHVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2C9</accession>
    <name>A0A133V2C9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Riboflavin kinase</fullName>
            <shortName evidence="17">RFK</shortName>
            <ecNumber evidence="5 17">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ribK</name>
        <name evidence="19" type="ORF">AKJ40_01120</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 17">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5 17"/>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00593">
        <property type="protein sequence ID" value="KXB00593"/>
        <property type="gene ID" value="AKJ40_01120"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01285">
        <property type="entry name" value="Riboflavin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023470">
        <property type="entry name" value="Riboflavin_kinase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 17" id="KW-0288">FMN</keyword>
    <keyword evidence="12 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP-dep_RFKase" evidence="18">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="92"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KXB00593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="211" mass="24157" checksum="2DA64DAB0026587B" modified="2016-07-06" version="1">MKIARMNIGIESEGISKEKITKESEEDPNTVSRQLTELYEDGLIEKKSDNERGLWTLTSEGVRLLRSLWFNLRGVFGGLPEKIKLTGRVVSGLGEGSYYISKEGYQKQFRKKLGFEPYPGTLDLKLNTDSKTLKKWLELEKGIEIEGFSTKERSFGRVKCFPSKINGEEAAVVLPFRTHHEEDILEIISPLKIRDRFDLEDGDELEIEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2D2</accession>
    <name>A0A133V2D2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00589">
        <property type="protein sequence ID" value="KXB00589"/>
        <property type="gene ID" value="AKJ40_01155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="74" mass="8487" checksum="AF77B04EA9A758DC" modified="2016-07-06" version="1">MTSKRQLERRVSDIEGEDSEEGMEEFRFHMTFVDKDLNVTGGRILRTFMDGSESERYELGPEEAKLIAGDVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2I1</accession>
    <name>A0A133V2I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00652">
        <property type="protein sequence ID" value="KXB00652"/>
        <property type="gene ID" value="AKJ40_00990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="74" mass="8211" checksum="EE3B0CA989283956" modified="2016-07-06" version="1">MDFSSTLILFWKRKNEGRLGVEVYQTFFILGISLTPVGIVLMVTTGNPVLIGLAGLGIIYLIIGLANRTKWNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2I5</accession>
    <name>A0A133V2I5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00650">
        <property type="protein sequence ID" value="KXB00650"/>
        <property type="gene ID" value="AKJ40_00980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="65" mass="7656" checksum="42B7CB90B6C0F804" modified="2016-07-06" version="1">MIIFLFGFLLTDKLNGFIMLLLFFIALIFSIVLAFEKSEEKTEEDKLLEKVRKLEEKIEDVEKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2J0</accession>
    <name>A0A133V2J0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00649">
        <property type="protein sequence ID" value="KXB00649"/>
        <property type="gene ID" value="AKJ40_00975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="103" mass="12184" checksum="681A38EA834FBDDE" modified="2016-07-06" version="1">MRKVMSEKEFFEYWKNVSLISAVFASVSMWITIYLTATHSYYYKNSAALFPFFFIASTFSSLCVLKWREKNPTLVKTFKWSTGILTLLGFLWFLNILTDMIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2J2</accession>
    <name>A0A133V2J2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00662">
        <property type="protein sequence ID" value="KXB00662"/>
        <property type="gene ID" value="AKJ40_01045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="80" mass="8728" checksum="17F1FD95642B28D3" modified="2016-07-06" version="1">MKESREVIPSEIEKFSMSKDSLKSILGKNLGATVESFDVSDGEVSISFSDSILDEVLGNIYQREIDSVDLNGEEAKITVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2L7</accession>
    <name>A0A133V2L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00697">
        <property type="protein sequence ID" value="KXB00697"/>
        <property type="gene ID" value="AKJ40_00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="126" mass="14381" checksum="ADF9321E92C20E1A" modified="2016-07-06" version="1">MYWQLKKVLDFEEEIVADGEEGEENTVTYYIPDPKPVLAKFLNQVDGKWLLMSAKNWLESFTFNSNLLPIFPHTSRPYPCTRGAFYPASKSFQHVRNTLPGEKRRIGDTRGMKYTRACGGTGKAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2N7</accession>
    <name>A0A133V2N7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc-hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_00875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00685">
        <property type="protein sequence ID" value="KXB00685"/>
        <property type="gene ID" value="AKJ40_00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="6">
        <location>
            <begin position="343"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="762" mass="87658" checksum="A1ECECC0D6A1F016" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2N9</accession>
    <name>A0A133V2N9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00693">
        <property type="protein sequence ID" value="KXB00693"/>
        <property type="gene ID" value="AKJ40_00920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="136" mass="15020" checksum="45B62E61FFACF1F5" modified="2016-07-06" version="1">MGRMRAYRRGGRGKGAVLPGSSPQTGGKTGKKRKTWKAPVPCRGGRPGGSRLRASSLSPSLPLSRKIKSNYGNLPFAERWLTRDLSRIRLQVTLRDLLSANVLRPYYVLKEVEDGLVAQAEHTMIVTEEGCEVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2R5</accession>
    <name>A0A133V2R5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00730">
        <property type="protein sequence ID" value="KXB00730"/>
        <property type="gene ID" value="AKJ40_00795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="106" mass="12119" checksum="40EA5FBAC8AA7900" modified="2016-07-06" version="1">MSKEKVKEMPTSGTLERLTNDRGKHNPACHPPNSVRFKCQCGVVHKWPQNSRGHVYRCKNCGRKHGHQYGPWDYPSFGSKYGRNGCPGLGVYREKMESLLSEEEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2S5</accession>
    <name>A0A133V2S5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00725">
        <property type="protein sequence ID" value="KXB00725"/>
        <property type="gene ID" value="AKJ40_00770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="93" mass="10563" checksum="EB1097454CF81589" modified="2016-07-06" version="1">MSTGKEKEEEKEEEIVFETKLVREKEGGYRLKFTDYTLGHPDFGEPWTDIEKGKELMAMAARAITSISKLVERQTIKRMGETDNHSAHSESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2T9</accession>
    <name>A0A133V2T9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00767">
        <property type="protein sequence ID" value="KXB00767"/>
        <property type="gene ID" value="AKJ40_00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="284" mass="33550" checksum="CF590D2BEC345F12" modified="2016-07-06" version="1">MPERRAWSIDIRWKDVMNELPSTVFPIRVSIQCDRSVKDDENWGPWDGVTKTFEVRQPDSIPYIPRQTIYFYNPVEEKRLPGEGSPQTRPGSHIQYKDMCEAEAFFEEFEEFLRTVETDYPEVPERIYIQNLKLVEIPEGYIENGKLQRRDLIEEEQRVSIAEFGRPTKISKKKVRTEIREILADRCLKPLDLTEMLSVVMKPVGKAHVPKRYYTKKKALKHNRPDLQPEIFNEAELENMPREELKGYLEQLIEENILKQVVYEGETVEKKEFVEQTARIEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2U9</accession>
    <name>A0A133V2U9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prok-JAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_00610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00760">
        <property type="protein sequence ID" value="KXB00760"/>
        <property type="gene ID" value="AKJ40_00610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prok-JAB" evidence="6">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="141" mass="15972" checksum="9A801CA4DA6AFDC9" modified="2016-07-06" version="1">MPIREIHKEVLNLILHSSRSSHPNEFAGILRAEEKRVTEVLVLPGTYSSDRSVLMRLDMLPISSRACGSVHSHTSTNIRPSRADLNFFNKLGEVHVIVTPPYDETSWKAYNSRGSEISLDVVESENRELVSRKFSEDFFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2W1</accession>
    <name>A0A133V2W1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00774">
        <property type="protein sequence ID" value="KXB00774"/>
        <property type="gene ID" value="AKJ40_00620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05126">
        <property type="entry name" value="Mth938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034096">
        <property type="entry name" value="AAMDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="SSF64076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="112" mass="12702" checksum="406ADB8B22A560A1" modified="2016-07-06" version="1">MIDSYSFGKIVIDGKEYTNDVIIFPDRVKSGWWRKEGHSLYPEDIEDITKESPEVLVVGTGAYGRLSIPSKTREYIKSDGIEIIAEKTEEACKTYNDLKDEKKTIAALHLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2X0</accession>
    <name>A0A133V2X0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00797">
        <property type="protein sequence ID" value="KXB00797"/>
        <property type="gene ID" value="AKJ40_00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="187" mass="22218" checksum="F02AF32A46D5A485" modified="2016-07-06" version="1">MENFGLSQIESVWTKERTNKDLTELPEDFYDKSANYATEIRKEKQSSREIREELLEEELSYILEIIQEIYLLRITKITNNLYEKKNENLLKKERKTFEKMREELDDLREELIKPVLEKEVEMKPPEEKSNTLVLLSSKISEPITASDLNYYGPFRKGEVANLPRKSAELLIEQDLARRIDIRNIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Y4</accession>
    <name>A0A133V2Y4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_00655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00766">
        <property type="protein sequence ID" value="KXB00766"/>
        <property type="gene ID" value="AKJ40_00655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="410" mass="47198" checksum="B6B4FC8F09108F18" modified="2016-07-06" version="1">MTTKEVSLGKLKENDYNPRKRFDDAKMEDLKKSIEKVGLAQPLTVRGLENGDYEVVCGVRRLRALNELYSGNKKIPVNELELSDQEAKVLSLTENVARDNLTKIEEARAYAKYITSNGYETNLLDEIEKNVHLVDIPSKSHKQVKELANQIGKYTSPSTIGKRLKLLILPEEIQNAVESGEIKIKVAQVITQLRKLDDSEFAERKMKELANDPNYRGSSPNLEGLRKEVGKILEKQEEQKEKSEQKLKKFKTRARERKTAVEEQVEEIKEKFDISELEKVDSEDVVEIGEKYLEILQNEINNLTTGDRFDNLQDEQLELEDREEKLKRNLKEVTNNNLSRCPYCDAPVSADDLKNRIGIIEDQITGIQEERSELSETKTELTEARRGLRKEVKSHNQLSEKIENLQEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V308</accession>
    <name>A0A133V308_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Methionine aminopeptidase</fullName>
            <shortName evidence="6">MAP</shortName>
            <shortName evidence="6">MetAP</shortName>
            <ecNumber evidence="6 7">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">map</name>
        <name evidence="10" type="ORF">AKJ40_00260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="6 7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6 7">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6 7"/>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00832">
        <property type="protein sequence ID" value="KXB00832"/>
        <property type="gene ID" value="AKJ40_00260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.58"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
        <property type="entry name" value="MetAP_2_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="9">
        <location>
            <begin position="12"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB00832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="320" mass="35973" checksum="BE02EC5C284B4CD7" modified="2016-07-06" version="1">MSEKLSEEEIETYREVGKLTSEVREEACEMIEPGEKLLTVAERVEEAIREKGAKPAFPCNISINEKAAHYSPPEEDETEFEKDDLVKLDIGAHIDGYIADTATTVHVGEEDEVEPEKSEETEKKEEPDKRREMVQAINLVLERAIDTVEPGINVGDIGKVIEDTAKEQGYNPVSNLTGHTLKPWSLHGGVSIPNVEKDTDEELEEGDVVALEPFITDGEGEVEEMPEVYIFRVMKEGGVSGRMAQQTLRKIKSNYGNLPFAERWLTRDLSRIRLQVTLRDLLSSNVLRPYYVLKEVEDGLVAQAEHTMIVTEDGCEVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V330</accession>
    <name>A0A133V330_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_IS66 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00852">
        <property type="protein sequence ID" value="KXB00852"/>
        <property type="gene ID" value="AKJ40_00390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="61"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="132" mass="15402" checksum="2176A8D103C524E4" modified="2016-07-06" version="1">MERPDCPHCGSSWVNKAREVKNKYVTKQGYKCPECGRFFVERDGFEGKTYPKEVIVEALHLYVEGLSLSKIRTHLKQHRGYSPSDGSILNWVREYSELLERFEQEQMEDPEIGRKIHLDEVVVKVGKKSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V341</accession>
    <name>A0A133V341_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ald_Xan_dh_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00845">
        <property type="protein sequence ID" value="KXB00845"/>
        <property type="gene ID" value="AKJ40_00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="777" mass="85854" checksum="28CE896237F5214A" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V356</accession>
    <name>A0A133V356_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00882">
        <property type="protein sequence ID" value="KXB00882"/>
        <property type="gene ID" value="AKJ40_00145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="219" mass="23390" checksum="1F52F27956054D33" modified="2016-07-06" version="1">MSLSLLFVDELRGFYKSKVMLFLWVGLPALTVILRLLDPATEGMPFTMVSALLVSSIGGTLAAVMLAVSIINEKEKDVYDLFLIRPIKRRDLIISKFGSVYLCIGIASALALLTGVIIDFIEIGGFPEAIIEDSARYLVTSLSMMAISSSAGVLIGVLAPSVLVGVVLVIYGANQISIIPSLPALANTSNQMLFSLGLGGSLAVVLLGLSIFFMNRKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V367</accession>
    <name>A0A133V367_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">GGGP synthase</shortName>
            <shortName evidence="9">GGGPS</shortName>
            <ecNumber evidence="9">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ40_00130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GGGP/HepGP synthase family. Group II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00880">
        <property type="protein sequence ID" value="KXB00880"/>
        <property type="gene ID" value="AKJ40_00130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.29"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010946">
        <property type="entry name" value="GGGP_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01769">
        <property type="entry name" value="GGGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="171"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB00880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="246" mass="26373" checksum="8CA1B5F47BC8B6A4" modified="2016-07-06" version="1">MSVRGYLNDVISKDKAAHLTLIDPDEQTPEAAGKIASSVDEAGTDAFMVGGSTSAEGEILDETVREIKRNSNLPTILFPGGQRGVSREADAIFFMSLLNSRNPYYITRAQMMGAPIVKKYELEPISMAYLIVEPGGTVGEVGEADLIPRDDTETAVNYSLASQYFGMGMVYLEAGSGAEKPVPTEMIEAVRSSIDSTLIVGGGIRTPELASERVDAGAQIIVTGTLVERAEDKFEKINRLTTAMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V368</accession>
    <name>A0A133V368_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_00205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00892">
        <property type="protein sequence ID" value="KXB00892"/>
        <property type="gene ID" value="AKJ40_00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="266" mass="29919" checksum="594570156B32F69F" modified="2016-07-06" version="1">MSLGLNLRIAYETVKENLKTTFVLSLIFMGMAAMYAGFYPSFKGNLEELMKNFPEMGFIRGFESFASYPGFLNAELYQIFWILILAIIFGYISASLISKEIEGKTMDMLLSNPIHRYRIVLEKFLGLLPLILVVNFATMASVYGITLAIGEELEFFNLLTTHIFSIPYFLAITSLGIFVSTIINKKMKASMVVMAVVIGSYIFESVSLLAPDYEKLGLISLTHYFNPAETLVEGSIDIIGTITLIAVTVVFLLMAMVYFERRDIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V371</accession>
    <name>A0A133V371_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00884">
        <property type="protein sequence ID" value="KXB00884"/>
        <property type="gene ID" value="AKJ40_00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="100" mass="11842" checksum="933BD919F1FDFB84" modified="2016-07-06" version="1">MSKLKTKPQTISGLTLTKKGSWNEIADACTEVEKLLESIEPGDIGEDVTEKELEHVRAEWEKWKPCKDEDYSKEMRKKQPSNPLWKNRLWEKMKKNPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V393</accession>
    <name>A0A133V393_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein AKJ40_00165</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00900">
        <property type="protein sequence ID" value="KXB00900"/>
        <property type="gene ID" value="AKJ40_00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005228">
        <property type="entry name" value="CHP00251"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00251">
        <property type="entry name" value="TIGR00251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="99" mass="11118" checksum="E523DC1AFAB537DC" modified="2016-07-06" version="1">MLKQEDNGVVVNLKVIPNSQKFEIKDVNPWRKKLRISVSSSPEDGKANQELLDGLETVLGSKVDIVSGVKSREKQIVVRDVPIDEVIEKLGLRDFISDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVE1</accession>
    <name>A0A133UVE1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000121">
        <property type="protein sequence ID" value="KXA98100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98100">
        <property type="protein sequence ID" value="KXA98100"/>
        <property type="gene ID" value="AKJ40_04935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="205" mass="23977" checksum="8B46B656011AA552" modified="2016-07-06" version="1">MLEEEVDSLSEKILKEPLPSKPNEEKGSDKKDASEPQKEDNMKISTKPELLYRGPLDGPSLPEEALWILGLLETIFDGKEITTNLCEGKFGSMGMTLRSGRSMYLERALTRVHLRNQDVGTTYRWLVDDYPIEDLGKRGERRDRKQIEVGARYRITYEDRYGVKTEREIEVIERKKKTLDAYCHLREDTRTFRRDRIKNIVPLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVR7</accession>
    <name>A0A133UVR7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000116">
        <property type="protein sequence ID" value="KXA98291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98291">
        <property type="protein sequence ID" value="KXA98291"/>
        <property type="gene ID" value="AKJ40_04855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="190" mass="22185" checksum="AC166C12CF143C48" modified="2016-07-06" version="1">MKNEYEYKNLLVPVKHPDDVNRVTELSSVLLDKGRVTFLTVIKKGSFPSVQKDWRISERAMESHREKITNKRISIFPKIRYSENVWKGVLEQAEEDDSDLILIGWGGKVSFRSLIQSHLEQIFANSNRDVIAFKNRTDSVRNIQKILFPVGYKDYDYSKRLTITSRIIKKISNLFYRRTAVLVVVPLTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVS0</accession>
    <name>A0A133UVS0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000116">
        <property type="protein sequence ID" value="KXA98292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98292">
        <property type="protein sequence ID" value="KXA98292"/>
        <property type="gene ID" value="AKJ40_04860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="88" mass="9763" checksum="6D7DC3FCC4E759ED" modified="2016-07-06" version="1" fragment="single">NKARLESSEYKSKVIIGEDVEKAILKEVQNYDTICIGGTEHSVLSHTIFGSLPEKIGETAEGSVVMVKGYRKKDFLQKIGEKIARLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVU4</accession>
    <name>A0A133UVU4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000115">
        <property type="protein sequence ID" value="KXA98323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98323">
        <property type="protein sequence ID" value="KXA98323"/>
        <property type="gene ID" value="AKJ40_04840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="187" mass="21686" checksum="E732C7035AC2FBAC" modified="2016-07-06" version="1">MPPSAVKTVEDLIFWQYAKIISKSAGMGKKNYGFIMERFKKLQSGEIEWSTSIRECVRESERKDECIYCGEECEDLTLEHILPLSRGGPDTPDNAVHVCQSCNSRKGSKRPYEWFYDEYDFDKAKYDMPRIAEGKYLKLLHKLHEENGTLDLHEDELERLCDQCDLGSKCPEEETLSPLCLEGVFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVU6</accession>
    <name>A0A133UVU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000115">
        <property type="protein sequence ID" value="KXA98321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98321">
        <property type="protein sequence ID" value="KXA98321"/>
        <property type="gene ID" value="AKJ40_04830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009620">
        <property type="entry name" value="UPF0236"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06782">
        <property type="entry name" value="UPF0236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="415" mass="48181" checksum="4F2719984B4A4253" modified="2016-07-06" version="1">MKLDLEVEVEGEDLTLTGMIDQIQGLEKECLKELIYAEEENLLKKVCGERHEETRYQRYGRKDPRKIKTSIGELELEPAKVRDKETGEVFSPIEEELEIPEGKNVNKDLSLESIEQVSEQSYRKAVETVKRLSNSDLSKSTLWRRVQEIDLATEPKGDVDVLLVDDTKVHSQEKEGFHFPNLVLGYNTEEDEYSLLFMGVDEDWTDIREEIGEEVDLSEVYVVSDSDREILDAFRGAKGIQLCHFHVAKYANYCLWKEDAPKNFRKKMRRILKSRLSTLQNSVKKFWRDEDTERLKNRISWFREELDRWAERAEERGFESAADYVRRNGEKFVTFAKAALEGEYVPHTNNKEEREMRELAYRAKKIGGSWSKDGLRNVSLCQTISRLDKSLFGKFKEVYLGEAGTLNYSVSPTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVZ8</accession>
    <name>A0A133UVZ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdB</name>
        <name evidence="9" type="ORF">AKJ40_04850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000116">
        <property type="protein sequence ID" value="KXA98290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98290">
        <property type="protein sequence ID" value="KXA98290"/>
        <property type="gene ID" value="AKJ40_04850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXA98290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="122" mass="14097" checksum="DA3539EFA47CC526" modified="2016-07-06" version="1">MQPSPQDLPPEAQDKIQKLQKQKRKLEQIGEQKNRFKAEDKRLEEGIKALDEADEDKEVFKVVGPVGIKSNREDLKEELSEKKERIKSEIESMENKENEIRESAKENQSKLREMMAGGKGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UW85</accession>
    <name>A0A133UW85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000110">
        <property type="protein sequence ID" value="KXA98455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98455">
        <property type="protein sequence ID" value="KXA98455"/>
        <property type="gene ID" value="AKJ40_04760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="144" mass="16881" checksum="DC9E657D10EB7CC6" modified="2016-07-06" version="1">MTVEIELEEDERDFLRDFVKKGTKKAREIARANILLLVDKGFPVKEIADILEVHRRTVWKIKKRYLEEGLESALKDKPRPGQPKKWTEEDEAEIIATACTSPPKGRKRWTIRLLRDELQKKSGFEDINRETIRLVLKKTRLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWM9</accession>
    <name>A0A133UWM9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hist_deacetyl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000102">
        <property type="protein sequence ID" value="KXA98594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98594">
        <property type="protein sequence ID" value="KXA98594"/>
        <property type="gene ID" value="AKJ40_04640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="1">
        <location>
            <begin position="70"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="276" mass="31083" checksum="6F0FF216C6FD6060" modified="2016-07-06" version="1">MTTGIYFHEILAEESWPIIGNRYSNFSKILKDLEDELENAILLSPQKPSEDLLLKTHSKKYFKQLKSASYFNGATLTVGACVEASLRVWNMDLTNAVVFLAAAGHHAHPNSGWGGTYLSCIGPVLNILRASGLSRLAYIDTDSHHGDGAREILQDDHDALHVCFCSSDRRDEKANVCVDVGRRTDDEGYLEKVENELPLIERFDPEIVIHFFGHDTHRDDYGDRGLSTDFFPRLARRMRDFADDVCNGRYVVIDGGGANSRVGRVIWPEIIRELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWZ5</accession>
    <name>A0A133UWZ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000097">
        <property type="protein sequence ID" value="KXA98702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98702">
        <property type="protein sequence ID" value="KXA98702"/>
        <property type="gene ID" value="AKJ40_04530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="80" mass="9714" checksum="9B5F13172C784194" modified="2016-07-06" version="1">MDEEIEDILSDLPERLAIRIESLDKPDEYKEEIIREFYSEKEKFREEFGEELTEVFKSRIEDVCMDLAILRKKLRVKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX09</accession>
    <name>A0A133UX09_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000096">
        <property type="protein sequence ID" value="KXA98730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98730">
        <property type="protein sequence ID" value="KXA98730"/>
        <property type="gene ID" value="AKJ40_04500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="76" mass="9415" checksum="9BB3A30CA9B60715" modified="2016-07-06" version="1" fragment="single">GIKHFMDHLVDSFSEWWKDMDDWDEMPYTTAKKIIQGMQDYEIVQEKSLEELMDWRDEKLVKLIMELYEDKNQHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXE0</accession>
    <name>A0A133UXE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_04405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000092">
        <property type="protein sequence ID" value="KXA98848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98848">
        <property type="protein sequence ID" value="KXA98848"/>
        <property type="gene ID" value="AKJ40_04405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1211"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXA98848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="215" mass="23529" checksum="83A2D7D75A7963F4" modified="2016-07-06" version="1" fragment="single">MLYFLGLICLIMGGTLLIPVFVALIYWEIGVIPYFIIPASITLAIGYIIVKKLESEELSLGNAMVVVTCTWIIFAFLGSIPYIFSSGLSFLDAYFESMSGFTATGLTVMQGYTGWTIPEPTHTVLFWRSLTQWVGGLGVIVLFLALFPGTASVARKLYASEAREDRIMPSMRATVRTIWNIYLLFTILGVVGLYLAGMHPFAAVNHSMTGIATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXG3</accession>
    <name>A0A133UXG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000091">
        <property type="protein sequence ID" value="KXA98884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98884">
        <property type="protein sequence ID" value="KXA98884"/>
        <property type="gene ID" value="AKJ40_04380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="111" mass="12674" checksum="A7D3BA13A726698A" modified="2016-07-06" version="1">MSLEESLAEFLEDGDDWERKKTSVDGVFILNLPEYKGNPPRLAIELNPTDSSGNPTKKRGLMMFNTGELEKFREMINEEGLDGVMETITEVNPEKGKKKRPEEEEEDVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXL3</accession>
    <name>A0A133UXL3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000090">
        <property type="protein sequence ID" value="KXA98918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98918">
        <property type="protein sequence ID" value="KXA98918"/>
        <property type="gene ID" value="AKJ40_04305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="76" mass="8688" checksum="7E0FF9EFB331B01F" modified="2016-07-06" version="1">MVWQTVVGKKEKNGLIFLKLKSRSGNIYPVQVAPGVDVPDHKGLMFADVLPESWVVREVKTKEEFKNLKSFDLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXL7</accession>
    <name>A0A133UXL7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamyl-tRNA amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000089">
        <property type="protein sequence ID" value="KXA98925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98925">
        <property type="protein sequence ID" value="KXA98925"/>
        <property type="gene ID" value="AKJ40_04280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1171"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asparaginase_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="90" mass="10108" checksum="FF9A29E0C6ADCE4D" modified="2016-07-06" version="1" fragment="single">DLDVPVAMTSQCIWGRTNLRVYSTGRDLLDLGVFSLGDMLPETAYVKMMWVLDKTQNKGEVKSLMKENLAGEITPETRPDVFLKPKTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXR9</accession>
    <name>A0A133UXR9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000087">
        <property type="protein sequence ID" value="KXA98978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98978">
        <property type="protein sequence ID" value="KXA98978"/>
        <property type="gene ID" value="AKJ40_04235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="106" mass="12299" checksum="9004C342B097310A" modified="2016-07-06" version="1">MTERETRETMTRSKNEYPGEGKIAETGRRRDDLYRAHSLVVGVPRRSKAKDMARYYLMDKYRKIDYEDVTFDRVLKKLAAGADRTAVLVEAKVPIKAVRGVHKDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXT6</accession>
    <name>A0A133UXT6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000085">
        <property type="protein sequence ID" value="KXA99002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99002">
        <property type="protein sequence ID" value="KXA99002"/>
        <property type="gene ID" value="AKJ40_04195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="91" mass="10843" checksum="C1774FC940DB12F5" modified="2016-07-06" version="1">MEVRLYGKLREKAPKTDKHSGKIGIIEIDSESFENISEILEYLEIREEEISHIFLDGEYTNPDRKISKENRLAIFPRDMGLLYKWYFSTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXV7</accession>
    <name>A0A133UXV7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000083">
        <property type="protein sequence ID" value="KXA99020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99020">
        <property type="protein sequence ID" value="KXA99020"/>
        <property type="gene ID" value="AKJ40_04150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="98" mass="10519" checksum="C8E490D9884DA3E5" modified="2016-07-06" version="1">MTEKVGGVKMTDEVVCAVPGCDNLLIEKERNGKKAVCSTCEAEGLHLCDLCGKRMSTNRIRSGATLCKECEMNPSGMETTEAEMTEYGLGSDLGSYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXW3</accession>
    <name>A0A133UXW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000082">
        <property type="protein sequence ID" value="KXA99033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99033">
        <property type="protein sequence ID" value="KXA99033"/>
        <property type="gene ID" value="AKJ40_04135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="228" mass="26122" checksum="5670A709AEEF6EB9" modified="2016-07-06" version="1">MVSIDIRDKRRNIEAVIFDMDNTFFDFIQAKIIACEKVTERIGRNDGQELLNYFLRDDVNFEDVECIADYLKDRDSYDEEIFQECCKIYEDIKLNTIELYDGVEETLEDLKNMGLKLAVVSNAGKEHVKSRLNKTGLTRFFETVVSRDETKKAKPDPEPILSALNVLGVSPKKALMVGDSIQRDIKPGEKLGMVTAYAQYGDRNSESEEHVEPDIRLSNIKKLNSLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXX1</accession>
    <name>A0A133UXX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000082">
        <property type="protein sequence ID" value="KXA99032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99032">
        <property type="protein sequence ID" value="KXA99032"/>
        <property type="gene ID" value="AKJ40_04130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="67" mass="7720" checksum="706FA47339F2201C" modified="2016-07-06" version="1">MPKTKFGVTIDEELTKELDKIVGDSEYLDLSRSEVVETILTAFFKSNVDHTKKARELIIKKEKVNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXX9</accession>
    <name>A0A133UXX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000079">
        <property type="protein sequence ID" value="KXA99056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99056">
        <property type="protein sequence ID" value="KXA99056"/>
        <property type="gene ID" value="AKJ40_04075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="163" mass="18406" checksum="1E8F6EDEF2D02E40" modified="2016-07-06" version="1" fragment="single">GEKLGNVSEIPHETREVKRKEKVTLETDGYKITMNLLDMPGISTKVDFEEFMDYGMGEEEAKVRSKEATRGVVEAINWLDNVDVVIVVLDSTRKPYNQVNVTILGNLEAKDIPIILVANKIDLAEANPEAIRETFPQYSFAKISAKEEENINELYSEIIESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXY2</accession>
    <name>A0A133UXY2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase DnaG</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name evidence="2" type="ORF">AKJ40_04055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="LHXU01000079">
        <property type="protein sequence ID" value="KXA99053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99053">
        <property type="protein sequence ID" value="KXA99053"/>
        <property type="gene ID" value="AKJ40_04055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0639">Primosome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="370" mass="40339" checksum="983CB5332EEBF48F" modified="2016-07-06" version="1">MGRKNRRTKYLIMVSIRADGVVHEPDVVDALFNATGGILEDLDLRGLRRNGKIGRVEVDVRTGEGVSKGSISVPSRLGKERTAMIAAAMETVGQVGSCEAEVKVGRIQDAKEAKREFIRKRAGELVEEIEKKRETPSPGRTVTEGGLEKLGGVLAGPTASESDAVIIVQNRSEVINLLSHGIKNVMAIGGSEVPPTIPEICEGRTSTAFLDGDKGGDLVLKELFKVVDLDYVARAPEGEKVENLSEKEARKALKSKVSPYECSFSRDYELGKLAEIMGELRGSLKARILDRRLNKAKETLVRNLLRELSDSRGARAVAFDGIITQRLAELASEKGLKYLVGVRERLAREPEGIEILTKRNAEGRQVEAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXY3</accession>
    <name>A0A133UXY3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEM4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000081">
        <property type="protein sequence ID" value="KXA99042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99042">
        <property type="protein sequence ID" value="KXA99042"/>
        <property type="gene ID" value="AKJ40_04105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="229" mass="25567" checksum="8B61481968A9E162" modified="2016-07-06" version="1">MDIKGRTFAAFRPFQRLDRTKELAMEAGGIPYVYGICKPKIPHNSNLKENISEDWDVIVFMSPTGVEVTENLIDFPEIKAIAVGNTTAKALREQGCEHITVPEKQSSDGVQQLLKENNWDALALRSAIADKSLEGALNVDAYIMEPVNVSKAINDYSNNEPDYTLLTSGGMIEILLTEAEKSGEKRNLIEKINESFVLSLGRKCSEFAESQGIRINYEFPQPSLESFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXY9</accession>
    <name>A0A133UXY9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000078">
        <property type="protein sequence ID" value="KXA99066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99066">
        <property type="protein sequence ID" value="KXA99066"/>
        <property type="gene ID" value="AKJ40_04040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="60" mass="6828" checksum="41334D91113109B8" modified="2016-07-06" version="1">MDPGESGTVRLAVQDLDAGETYRVNLNGRVKQLEVESQKIGGEPLESREKKRKEEFPHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY35</accession>
    <name>A0A133UY35_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PEP_hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000076">
        <property type="protein sequence ID" value="KXA99087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99087">
        <property type="protein sequence ID" value="KXA99087"/>
        <property type="gene ID" value="AKJ40_03975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP_hydrolase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="277" mass="30513" checksum="8BD4D22D19E27502" modified="2016-07-06" version="1">MKNTFTRNEILSRIEEVRENNEPIIGAGCSAGIIAKCAEYGGADFIIVYSTGLSRLKGHPTTPYGDMDTNDITLQMADEISEVVDDTPIIGGICAQDPNYRDLDELIDDYLDAGYSGIINFPTIAMYGDRGDRWREMRESQGFGWTREVEMMKRAHEKDVFTIAYVWSPEDAKEMAEIPADILCPHAGGTSGGKAGYEAAPKEDAAEKVQNMIDAIGVVNEDAICVAHGGPFAEPEDTQYLYDNTDAKGFIGASSIERIPVEKAVENTVKRYKDFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY58</accession>
    <name>A0A133UY58_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_03960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trimethylamine methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000075">
        <property type="protein sequence ID" value="KXA99101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99101">
        <property type="protein sequence ID" value="KXA99101"/>
        <property type="gene ID" value="AKJ40_03960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1066"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015948">
        <property type="term" value="P:methanogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038601">
        <property type="entry name" value="MttB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010426">
        <property type="entry name" value="MTTB_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06253">
        <property type="entry name" value="MTTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="471" mass="52611" checksum="D3471D2B447C442F" modified="2016-07-06" version="1">MEYLTKSEIAEIHDTSLKILDEVGMKWDNEEALKIFDNHGADVDFHEKIVKIPPDMVEKSIETTPSECTLYSRNKEYDIPMEDGEINFGPFGYANFVRDPETGKRREATAEDLRKLTKLVDTIDDWNFQYLQVTPQDVDPKINYLIAHAIQLKNSEKHLVAAGTSKRIVEDTVQIAKAISEDFDERPFLSFDHLTVPPLTEEKSTSAGLVEAAKRGLPVLVSEGVMAGSTSPVTLAGALAQSSAGALGALTLVQLINPGTPTLYGSFARIMDMKRGTVSMGGPEWILLKKAWSDLAEFYDLPNWYGCMLNDAKIVDAQAGYEKALSCLLASFSKKGLMVQCATIDQDRMCDFGNILVNKEISEAVLRIKRGFEVNENTLALNVIKDVGPGGSFMSTQHTLDNYKNIAWEPELSERGSYEDWEKKGEKTLYDKALTESLDRIESHQSPEIPEEKERKINEIIKEAKEDGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYD1</accession>
    <name>A0A133UYD1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000067">
        <property type="protein sequence ID" value="KXA99198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99198">
        <property type="protein sequence ID" value="KXA99198"/>
        <property type="gene ID" value="AKJ40_03730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="200" mass="23240" checksum="1EBFED18715FE3B8" modified="2016-07-06" version="1">MGFQASLLINLSNFSLQKLEIYPITKAKKDIWNEMVLSVLGTKQGNKKSVIADGGFFAYDNYTRSARQRTVPIINPRSGLEEKVKEKLEEASVNIEWFDSQNSKDFKTLLEEFEEIVGEAVEKSLNYDDFKVERSKIEHIFKIANEIFGMKDLHIYSKRTALWRAYAAVYVSTLFYQFLERNEINPHRAMGLLSHKKDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYD2</accession>
    <name>A0A133UYD2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000069">
        <property type="protein sequence ID" value="KXA99177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99177">
        <property type="protein sequence ID" value="KXA99177"/>
        <property type="gene ID" value="AKJ40_03785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="110" mass="12724" checksum="C9231F8FC2EFD5CC" modified="2016-07-06" version="1">MTHRVHCEECKTKTNVTDQVIKILNEEGVSKVYFGDLEVECCENPSLAWITSNTIYENKIEEMKGRIGGRGRGRPKKSEKLDDEKKEKVKKRIENYKNNHIPISEVSENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYE1</accession>
    <name>A0A133UYE1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000067">
        <property type="protein sequence ID" value="KXA99195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99195">
        <property type="protein sequence ID" value="KXA99195"/>
        <property type="gene ID" value="AKJ40_03715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="71" mass="8362" checksum="8DFAE0FFCEEDC5FF" modified="2016-07-06" version="1">MVSFAMWVEKVFIRCGESGFSTFKRHFLSPLRKCIGRRRKTEAFARARDYNLKRVSYVSRQEGLTALWIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYE2</accession>
    <name>A0A133UYE2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000069">
        <property type="protein sequence ID" value="KXA99174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99174">
        <property type="protein sequence ID" value="KXA99174"/>
        <property type="gene ID" value="AKJ40_03770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="68" mass="7550" checksum="70BE748B8D28FE9E" modified="2016-07-06" version="1">MPLGSSAERGDAVGQRTETTETESKRKDGRQAKSKQNRIHGTLQRHHGMEGKDLQSQGNTAETTDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYE9</accession>
    <name>A0A133UYE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_03685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000065">
        <property type="protein sequence ID" value="KXA99218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99218">
        <property type="protein sequence ID" value="KXA99218"/>
        <property type="gene ID" value="AKJ40_03685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="223" mass="24518" checksum="AD5BF7110C0A0FB4" modified="2016-07-06" version="1" fragment="single">MKDIPRSVRNVAGVVEIVEKEFSTHLSSKRFYILFFIIYFLSLGVAYTTIPNIMDGLTRVGDEAIFLKMFTSAPSDVGISLLQFFSIFGPILGFILTFDAINSEISEGTLHVSLSQPIHRDSLVNGKFLAGVLAIAVFLTVSVFSIVGIGLSAFKMPLPTGELLRICTFWGLSIVYFALWASLGLLFSIMIRRPSTSALASVAVWLFFSIFIYMFGGVMGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYF2</accession>
    <name>A0A133UYF2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000064">
        <property type="protein sequence ID" value="KXA99230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99230">
        <property type="protein sequence ID" value="KXA99230"/>
        <property type="gene ID" value="AKJ40_03655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="343" mass="39293" checksum="8BBE519AFF8F1EE1" modified="2016-07-06" version="1">MHLQEGNPKTIQALKNVLDTAKKEKADLVTVSGDLFHSREDAEVLRPRLRDIFTDNPFKVLAIPGNHDEGAYRGNLDWGPDLEVATEKPFEVREFGDHNLVALPFQDELTTELYDRVKEVSEELSGGVLLLHCTLDIGYSAGSFGEEETVRYFPVTSSVLSEWDFDFILAGHFHGSTDVRKLDNGGEFIYPGSPVSLSWSEIGRRRAVLLDLAKGDREEFILNTFYRDMFNRTIRPGGENEFIEEAEDWLRERSEENCHLRVIPEGHITVDETEFRESLENVCKGADISHEGYENVEKVLNHTLFKRFKKTLDSKEEIENEEEVESKVIEAMSRLLARRELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYG8</accession>
    <name>A0A133UYG8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_03565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000061">
        <property type="protein sequence ID" value="KXA99262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99262">
        <property type="protein sequence ID" value="KXA99262"/>
        <property type="gene ID" value="AKJ40_03565"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.942"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="236" mass="26248" checksum="99E73A05D77F2966" modified="2016-07-06" version="1">MIDVNKLNAFYGDIQVLWNLSLKVEENDFVTVVGPNGAGKSALLKAISGLLEKYTGRIEVFSNDISELNPYEVVELGCVLVPEGKNLFTDMTVMENLEMGAYTERAREKKDETLEEVFDLFPILSERRYQLANNMSGGEQRMLAIGRGLMTRPKILALDEPSSGLAPQLTQKMFEKVEEISKEITILLVEQHVRKALALADKSYLLGRGRIVAEGEGEDLLSSGKLEEVYGSSEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYL2</accession>
    <name>A0A133UYL2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000059">
        <property type="protein sequence ID" value="KXA99286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99286">
        <property type="protein sequence ID" value="KXA99286"/>
        <property type="gene ID" value="AKJ40_03505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040506">
        <property type="entry name" value="RACo_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17650">
        <property type="entry name" value="RACo_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="634" mass="70975" checksum="C3A536C405D3722D" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYP4</accession>
    <name>A0A133UYP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000058">
        <property type="protein sequence ID" value="KXA99308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99308">
        <property type="protein sequence ID" value="KXA99308"/>
        <property type="gene ID" value="AKJ40_03480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.891"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="64" mass="7290" checksum="5F4D348017EC1EF3" modified="2016-07-06" version="1">MPKRIRDKEGIEGGDEVVVKDEGGLIIIEKRELTEELAEGYRKTAERDRKISEEMLTASEEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYP5</accession>
    <name>A0A133UYP5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_03430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000058">
        <property type="protein sequence ID" value="KXA99299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99299">
        <property type="protein sequence ID" value="KXA99299"/>
        <property type="gene ID" value="AKJ40_03430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="69" mass="7703" checksum="DAB1FCD2B1DB29F8" modified="2016-07-06" version="1">MVELPIASVDRIIRRVGGQRVSESAARELAEVLEEKGMEIANEATTLAEHAGRKTVRDEDIRLAMRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYQ5</accession>
    <name>A0A133UYQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_03390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000057">
        <property type="protein sequence ID" value="KXA99318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99318">
        <property type="protein sequence ID" value="KXA99318"/>
        <property type="gene ID" value="AKJ40_03390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="339" mass="38197" checksum="C413870D215C543E" modified="2016-07-06" version="1">MEEESKDRDNICKLAIEGSSNGIYVFQDGKFKFVNEALSKISGYSREELKKMNFLDLVHPDYREEIKKWTEQALNGDLSGLPEKHEFEVLMKDGDSAWVQLIPSLVEYEERPAIVGDVVDITERRKAEEREDFLHSLLRHDLRNKAQVVQGYLELMRDFDLNEEAERFLDNAVNALTGGIEIIDKVRTVREVGKEKLGKISIDAVLEDIAVNKKPQASKEGIELEVENFDCDALGGKLLAELFSNLIENSIQHAQCDKIEISGRKTKDECIVTIQDDGKGIPDDIKDEIFDRGFKRGKTGGSGLGLYLVKEIADSYEGSVEVKDSELGGARFDVHLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYT9</accession>
    <name>A0A133UYT9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000054">
        <property type="protein sequence ID" value="KXA99370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99370">
        <property type="protein sequence ID" value="KXA99370"/>
        <property type="gene ID" value="AKJ40_03300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="102" mass="11636" checksum="3B2E36145E373135" modified="2016-07-06" version="1">MSDIKKYIINFGFIKPEGGEEDHFVHASDIESGPLNEGDEVEFDSEQGIKVREQLTLKRFELKSGKVGIMLIAISPTSFSQHYINEMFRLYSFSTHFSNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYV7</accession>
    <name>A0A133UYV7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000054">
        <property type="protein sequence ID" value="KXA99368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99368">
        <property type="protein sequence ID" value="KXA99368"/>
        <property type="gene ID" value="AKJ40_03290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="60" mass="7317" checksum="9159014E9C913290" modified="2016-07-06" version="1">MDGHPSYQDFDHWSCLFHLFRNKTDEDETLKLLKDELPHLVPDYLSEKKTVYLRYFNLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYX2</accession>
    <name>A0A133UYX2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000054">
        <property type="protein sequence ID" value="KXA99374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99374">
        <property type="protein sequence ID" value="KXA99374"/>
        <property type="gene ID" value="AKJ40_03325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="73" mass="8806" checksum="202B329BB2E4A10D" modified="2016-07-06" version="1" fragment="single">KEKVMSEMKDLVSSIIEKSLNYDEYKKKRSTIEKIFKIAKQIYGVEDLHVYHKEGAYWKIFIGFYFSCLLYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ08</accession>
    <name>A0A133UZ08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000050">
        <property type="protein sequence ID" value="KXA99436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99436">
        <property type="protein sequence ID" value="KXA99436"/>
        <property type="gene ID" value="AKJ40_03140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.765"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="87" mass="9851" checksum="065710727AB2B958" modified="2016-07-06" version="1">MKRDPFEEMEKKMKEMMEEGSKTGGRSISVQRVGGETTVNVSGDVSDEEIDRLKKKYPDAEIQVEGESIEEKGEEPVVEVIDEEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ37</accession>
    <name>A0A133UZ37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000050">
        <property type="protein sequence ID" value="KXA99441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99441">
        <property type="protein sequence ID" value="KXA99441"/>
        <property type="gene ID" value="AKJ40_03165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.771"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="233"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="492" mass="54479" checksum="FA172C2500F6E4AF" modified="2016-07-06" version="1">MEFKVLGGAREVGRSSVHVSTSESDILVDCGLKQGETTEYPRVNELDNLDAVVLTHAHIDHSGGLPLLSSLELLDGDVPVFCTPPTGMLLKTLLYDSYSLQRKEWKRNDRDPIYGHEDVAEVLKQVEPVPYQEFSVTDDIQAEFGNAGHILGSAWVQIRSEGRRVLFSGDLGGGRTNHLPRPADPPKSDALFLESTYGATQQHPSFSKQCNELIDAASAEVPVLIPSFAVGRAHEVLRLIKTRDEIDPSRVYFDGMIEETLPAYRSYASTLYMSESIVNSIESSSDPRPFLPEGVEKPDTYRDRTRIAREEDAPIVIAPSGMLTGGWSPLYLREFAESREDAKVILVGHQAEQSVGRRLESAHEAGTDADVTVEALAGPGDAEDAEDFEYRESEVRVPGEWIETFGGFSAHGSATSLLNFARKSLPRRIFVVHGDGDNWKSMEALLKSDSTLKHGRIESPAVGDEFELEARIPKPFEERLEELEEKVSELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ42</accession>
    <name>A0A133UZ42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000049">
        <property type="protein sequence ID" value="KXA99452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99452">
        <property type="protein sequence ID" value="KXA99452"/>
        <property type="gene ID" value="AKJ40_03110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="83" mass="10179" checksum="BFE82C84C37332C7" modified="2016-07-06" version="1">MLQELESVLEEKMELGEREREKRLEEVQDIIENEKVKKLRKDYHQTKTKIDKLKKERKESPLLEKKDRLEESIKSKKSEKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ45</accession>
    <name>A0A133UZ45_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribulose 1,5-bisphosphate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000048">
        <property type="protein sequence ID" value="KXA99463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99463">
        <property type="protein sequence ID" value="KXA99463"/>
        <property type="gene ID" value="AKJ40_03065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.741"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017712">
        <property type="entry name" value="RuBisCO_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00014">
        <property type="entry name" value="RuBisCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03326">
        <property type="entry name" value="rubisco_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_large" evidence="1">
        <location>
            <begin position="86"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="368" mass="40806" checksum="EE51E28F894C1939" modified="2016-07-06" version="1" fragment="single">NGTWSGLEVDERIREMSATTFSIEDNIIRIAYPETLFEPNSMPQILSCIAGNIMGMKAVDRIRLRDCVWPESIVKDFPGPQYGSSVRKKIFDAEDRPITATVPKPKVGLTTEQHAKIGYEAWTGGIDLLKDDENLTDQSFNRFKDRVKESLKMRDKAENETGEKKSYLINITGDTETMLDRAEFVAEQNGEYVMVDIITAGWASLQSVRKKCEELGLAIHAHRAMHAAFDRLDQHGVSMRCIAQFARLCGVDQIHTGTANLGKLENEDTIGINDWLRSDLYGLNDVLPVASGGLHPGILPKLLDILGQNICIQVGGGIHGHPDGTHAGSKAVRQAIDSTIQGRDIQNYAEGHPELKRALDKWGDMSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ96</accession>
    <name>A0A133UZ96_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="2">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphoriboisomerase A</fullName>
            <shortName evidence="2">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpiA</name>
        <name evidence="3" type="ORF">AKJ40_02945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="2"/>
    <dbReference type="EMBL" id="LHXU01000045">
        <property type="protein sequence ID" value="KXA99518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99518">
        <property type="protein sequence ID" value="KXA99518"/>
        <property type="gene ID" value="AKJ40_02945"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.716"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="236" mass="25944" checksum="F7AF81F2304A8046" modified="2016-07-06" version="1">MPGQEEWKRNSAREAAKLVRNDMLVGLGSGTTVAKVVKELVEKGTKARFVTASIATQKLADRLDLNLTTLEKGTGLDLTIDGADEIDPNLRLLKGGGGAHTRERIVTGAAEELVIVADSTKLVEKLGEKNPVPVEVIPFAYEYVAGLIEEYGKRSELRRTETGNPYVTDNGNYIVDLRTDPVNNPEKLREDLDKTPGTVDNGIFTDKPDKALIGHEEGCRAVETKEQHRELRRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZA0</accession>
    <name>A0A133UZA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000045">
        <property type="protein sequence ID" value="KXA99515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99515">
        <property type="protein sequence ID" value="KXA99515"/>
        <property type="gene ID" value="AKJ40_02930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="169" mass="19884" checksum="D9029745CDDDBD0C" modified="2016-07-06" version="1" fragment="single">MEVSDIRKRMRSFKKDYIMPIYLPFIPAIISFLGMFFAVVLAVLGWRARFPFGAWPPMRFPWSIAGIVSIIVVLALVSLAAGIIGIYVLYKWIDRRNEHFKRVRFLYEDIIDFLKEKGAEKEAKGIQRELREMESQMDVKSAPLWIVLTIVFPPVIFYVLHFLTRDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZB9</accession>
    <name>A0A133UZB9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000044">
        <property type="protein sequence ID" value="KXA99531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99531">
        <property type="protein sequence ID" value="KXA99531"/>
        <property type="gene ID" value="AKJ40_02880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="100" mass="12101" checksum="514E2128DF4E993A" modified="2016-07-06" version="1">MVNKTEKRTEEFFEHMKGKKNKPQNSEKTKENDWEKRAKEMKPKQRSFLLLPNDWKELDTLYAKFMQETGIQKKWKFYRAIIKAGISNWKDIIDFAKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZE1</accession>
    <name>A0A133UZE1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000044">
        <property type="protein sequence ID" value="KXA99537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99537">
        <property type="protein sequence ID" value="KXA99537"/>
        <property type="gene ID" value="AKJ40_02910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="41"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="244" mass="27763" checksum="6F83F321B10C2D6B" modified="2016-07-06" version="1">MKSDFHNKVTDSFSHLEDKSVFTVDSSKVACLDLEGTLVEGSVWRVLNRAFGVKESIADELLEMFLNGLISYDQWADTLVETWKLPSGEQPTKNNIEKLTKNFEVLDGAYELVEILNDKGYFTVSISGAPDIFSREVAHELGIDRDIPTQRLVFDNNNMLRKVLVLNDYDFSKDHIIRKLKSNNQLQEVLAVGDGLNDVDMCREADFGCIVIRRGRKDRVDYKRLKSDGVLVDTLQNISQKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZE2</accession>
    <name>A0A133UZE2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000042">
        <property type="protein sequence ID" value="KXA99566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99566">
        <property type="protein sequence ID" value="KXA99566"/>
        <property type="gene ID" value="AKJ40_02815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.683"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="169" mass="18186" checksum="459D46AF58BB3D8A" modified="2016-07-06" version="1">MVWEIIIGRNWSQRAIILGTFVLYIYMFLVRRDDAKKGLKKGLNTFKGLLTLIFAAILLASAIRILLPTNLVKIYLGPESGFSGVITGGLLGGIMQGGPYAVYPIIRGLQQTGVSLAIVIAMMVGYGAIGTGKIVYGLAFFNTKTISIRVAVGIGLTTLASIILYLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZE3</accession>
    <name>A0A133UZE3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000043">
        <property type="protein sequence ID" value="KXA99551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99551">
        <property type="protein sequence ID" value="KXA99551"/>
        <property type="gene ID" value="AKJ40_02860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="169"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="546" mass="63253" checksum="093F3B718A9865B5" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZK1</accession>
    <name>A0A133UZK1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000039">
        <property type="protein sequence ID" value="KXA99628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99628">
        <property type="protein sequence ID" value="KXA99628"/>
        <property type="gene ID" value="AKJ40_02725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.626"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019016">
        <property type="entry name" value="Csx1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09455">
        <property type="entry name" value="Cas_DxTHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="162" mass="18322" checksum="3C6C9EA131377EFA" modified="2016-07-06" version="1">MEVYITLLGRSTWALLNTFYAVVNEGNKPDSVHIYVEKSYEDELEAVEKGLKIIANGFNFSPEIKPHMVNDASFAEAVAGIRKTLQGLIKGDNKVMIDITPGRKALVAGALLSAFDLSTREDLKVDRIFYLAIETTEDVEKPYFMIPMEIQELTEMREEMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZM7</accession>
    <name>A0A133UZM7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000038">
        <property type="protein sequence ID" value="KXA99648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99648">
        <property type="protein sequence ID" value="KXA99648"/>
        <property type="gene ID" value="AKJ40_02665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="151" mass="17201" checksum="F110E8CB27250391" modified="2016-07-06" version="1" fragment="single">RVGRPAKVTPAKAAFLIVVKERGKETTYRDLASSDYVKKLGISEVHYTTIHKAVKRLPPGFLETVMRLFGERVSKDEMDCVFDATGVKIRRYEKKIHAGEERRERQGVKLNAVWNADEKVFHASEVLKGKAHEYPGSEGMFKRINTPIETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZY2</accession>
    <name>A0A133UZY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000034">
        <property type="protein sequence ID" value="KXA99721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99721">
        <property type="protein sequence ID" value="KXA99721"/>
        <property type="gene ID" value="AKJ40_02530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="70" mass="8386" checksum="72715BC217A58519" modified="2016-07-06" version="1">MTYYYLDRNGLVYRETIIIDEKLFQEAPRDPYTLKNVEIEGDILKIELDYFGGCKEHEFKLIGTKNFMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZY3</accession>
    <name>A0A133UZY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_02520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="LHXU01000033">
        <property type="protein sequence ID" value="KXA99742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99742">
        <property type="protein sequence ID" value="KXA99742"/>
        <property type="gene ID" value="AKJ40_02520"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.573"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="82"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="307"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="438" mass="47655" checksum="7A6CC6720860825A" modified="2016-07-06" version="1">MSEPVIINGVRTPIGRFGGTLKDLKVTELGSTAIKGVFEDIGLKPEAPEKRKNYRPSKFSDVEICSLEEEQMDWGEGSKEIEIDEVIMGNVLQGGQGQNTSRQASIKAGVPREIPAYTVNKVCASGMKAVSSAAERIESGNAEAIVAGGMECMSNAPYILPKARWGYRMNVDGRGDVLDAMVYDGLYEIFYDYHMGITAENLAEIYDISREEQDRMGAESERRAVKAVENGVFENEIVPVEVPGKREPETFDTDETPRKTSFESMSKLPPVFKKDGTVTAGNASKISDAAAALLVTSREFAEENNLEIRASIKGYESSAIDPQYMGIGPVPATKMLFDRLDYKLEDMDEIELNEAFASQTLAVMEELDMPKYGIDMMEEGGERINPHGSGISLGHPIGCTGARIIVTQLNELERKGGGLGLSHLCIGGGQGMAIIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V041</accession>
    <name>A0A133V041_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_02390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000030">
        <property type="protein sequence ID" value="KXA99808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99808">
        <property type="protein sequence ID" value="KXA99808"/>
        <property type="gene ID" value="AKJ40_02390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.496"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="341" mass="37312" checksum="D26C567BE1FA5D0C" modified="2016-07-06" version="1">MIDLRWGLNFIIRPEVFVPLIFPGLAVGGLTLLGIIWLERKAVGKIQLRYGPLLVTPRLGGILQLLADGIKFFFSEPIIPRNVDKLSFIFAPILIFAFSILPVIGIPLSESYIAIASSMSLLVVLALLVITPIFFWVMGWASNNKFSFLGGVREGYLTVSYEIPFILSVIAMAGLYNSVDLIEIVNSQVGGWGGLINPIAALTFFLTTMISTGKFPYEIGEADSEIIGGVGTEYSGILYMCVMGASYLRLYVMSLLFTVLFLGGWNPLPSFVPSSGFLPGILIFIKSFIVMGVMVLFRGVYPRLRIDQAVRISWQKLFVLSMASVAFSVGLVMMGFGGIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V094</accession>
    <name>A0A133V094_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_02305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000028">
        <property type="protein sequence ID" value="KXA99856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99856">
        <property type="protein sequence ID" value="KXA99856"/>
        <property type="gene ID" value="AKJ40_02305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="310" mass="35130" checksum="05962F79B54A95F9" modified="2016-07-06" version="1">MSDVDSYPVVLEDLTKEFGDLVAVDSASFNIFEGEFFGLLGPNGAGKTTLINMLIGLATPTSGTAYVYGNDITKEYRKVHSRIGFAPSEGNFDREYNTMENLEYHAGYFGVSREERERRAEKYLNMFDLWDKRDKKTYQLSTGMKTKLLFARALMSEPDILILDEPTSGLDVETRKKVHTYLEELDRTILLTTHQIEEAEKLCDRVAIMNDGEILAVEPPEKLKRKGGTDVVEISLEERIDQVPEFLSREEFQTSLVDGGTKIRTVAPDGNEIAAEVSERLFRSGLEVKSIDIEKSSLEDIFLRLTERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0A2</accession>
    <name>A0A133V0A2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000028">
        <property type="protein sequence ID" value="KXA99860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99860">
        <property type="protein sequence ID" value="KXA99860"/>
        <property type="gene ID" value="AKJ40_02330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="69" mass="7664" checksum="58874C4718C79E42" modified="2016-07-06" version="1">MINILLGIWILFGSYLSFGSIEHEIGIGVLEEIERNFWAVKSFMNTVMMPAAVGQILTGIALMIIGTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0C1</accession>
    <name>A0A133V0C1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_02270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000027">
        <property type="protein sequence ID" value="KXA99886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99886">
        <property type="protein sequence ID" value="KXA99886"/>
        <property type="gene ID" value="AKJ40_02270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="4"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="311" mass="33961" checksum="E6D61658F30C362A" modified="2016-07-06" version="1">MYAVTLGEFLAEFYRKEVNVPLHQVGEFRGPFPAGAPAIFADTLAKLGSSCGFIGVIGEDDFGKIAVERFEKDGVDTSHLVSSKEYTTGTSFVSYFEDGTRKFLFHLSNAAAGQLSKSHIDSSYISEAEFLHVTGSTIAINESCREAVYEAVEIADINDVEITFDPNIRPELLKDETIREVSEPILKTCSYILPNENELRNLSRNNYDDITSCARELLEKQVKAIIVKRGKEGALIITESKEIVSPPFSVDEVDPTGAGDSFNAGFVHSLLEGKNLFKAVEFANGVGALSVTEVGGMRGAKNAESLLKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0E4</accession>
    <name>A0A133V0E4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000027">
        <property type="protein sequence ID" value="KXA99885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99885">
        <property type="protein sequence ID" value="KXA99885"/>
        <property type="gene ID" value="AKJ40_02265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="391" mass="45124" checksum="1D937382A41C3CBA" modified="2016-07-06" version="1">MRFLNRREMILKTFGEEDPGGVVWQPRIENWYDVNKAQGDLPERYQNMDLLEVYDDLDASPRPYLIPYPSPEDLRGEEGWGGFCPQYAPPVIKIKSKGNVEGEIRKEEGEIIERWDTPKGRLTRRWKPPQTSISARVHEYPIKDIEDLDTLEYILEDQQWEFDLDAWKEVKNRIGDRAPIAAIAGRAPLQELHMFFMPYEKAINRLLKSNPKKVKNFLKKALELKSEAFDTLAESPVELICLADNLDGRLLGPSLFEEHILPYYQRYAPELKDVGKLIYAHWDGSLRGILNYAQDTKLHGLEALTPKPQGDVTLEEIKEALGDNMVLLDGVPAQLFMPNESEKALEKTVKKILNMFYPNIVLGISDELPPKANIERVKLVSEIVRDWNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0F7</accession>
    <name>A0A133V0F7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_02250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000026">
        <property type="protein sequence ID" value="KXA99913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99913">
        <property type="protein sequence ID" value="KXA99913"/>
        <property type="gene ID" value="AKJ40_02250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.461"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="257" mass="28089" checksum="1B196D8403244C21" modified="2016-07-06" version="1">MNILEVRNLELWVNSNKILDDVSLDIEENRVYAIVGPNGAGKSTLAYSIMGLEGYTGYSGDILFKGESLNGLDISERAEKGITLAWQEPARFEGLTVRKFIKSAASEKSDESVRSAIEKVGMDPDQYLDRAVDKGLSGGERKKIELASILAMEPELVLLDEPDSGIDVASLDRIFEGIELLKEKGSTVILITHSATAHRQAEYAYLMCRGAILDEGPIDDIGSYFEERCIPCDHKNAPEEKEGGIEVDGSQTTVQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0F8</accession>
    <name>A0A133V0F8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="5 10">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AKJ40_02235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:61292"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:61294"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:16235"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="5 10"/>
    <dbReference type="EMBL" id="LHXU01000026">
        <property type="protein sequence ID" value="KXA99914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99914">
        <property type="protein sequence ID" value="KXA99914"/>
        <property type="gene ID" value="AKJ40_02235"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.458"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="11">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="12">
        <location>
            <begin position="179"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXA99914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="307" mass="33405" checksum="5578B266350240EA" modified="2016-07-06" version="1">MNITVLGSGAMGSLFGGLLTADGHDLTLVDVWKEHIETMKERGLVISTPEGTERNIEVEATADPSSIGNADLVIVFVKSYQTKEALQDTSGFFDENVDVLTLQNGLGNPETISEYVPEKNIIAGVTAHGSTLKNPGHIIHAGVGPTKIGRYFTENDEKVSQLSKILTSAGFETEVTERIREEIWEKLLVNVGINPPTALARVRNGLLVETEAGEELIETIVNEALQVAVEEGVNVREDIVNHVKNVASSTSANKSSMLQDIEAGKKTEIEYLTGSIVRRAEKHDIEVPINRTLKHLVELSERTQNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0H6</accession>
    <name>A0A133V0H6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CcmB/CycW/HelB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000025">
        <property type="protein sequence ID" value="KXA99937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99937">
        <property type="protein sequence ID" value="KXA99937"/>
        <property type="gene ID" value="AKJ40_02200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003544">
        <property type="entry name" value="Cyt_c_biogenesis_CcmB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30070">
        <property type="entry name" value="PTHR30070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03379">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="198" mass="21764" checksum="A277C83B6AE027F3" modified="2016-07-06" version="1">MLMFALLVILAFRFAFGDGDVKPNQISSIMWSTFLFTGLFALFNSFSREKDTQCLEGLLLCPGDRGGIYLGKMISTLIQIYVVELFGVAMMEIFFQFEFLTHVFPLLVILFIGSIALVSAGTIISAISVSADNRELVLPILFIPLVLLTVVVPVVSTTSGVLSGDPLSLYSDYLELLVGFSVIYIALALILFDEVIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0T4</accession>
    <name>A0A133V0T4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000021">
        <property type="protein sequence ID" value="KXB00058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00058">
        <property type="protein sequence ID" value="KXB00058"/>
        <property type="gene ID" value="AKJ40_01920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="290" mass="32884" checksum="BAE885BDF6628289" modified="2016-07-06" version="1" fragment="single">IWEWLYPDEDYRREITEKVGDILKGEEIERYETIIQCKSGEEKVISWTSHPLRNEEGEIIGSIALGSDVTEQKEAEERKEFLNTLLRQDLRSKCQTLSGYLQLLEDADLSDEHREYLRKAVAAGREADEVLELARELEEIEETKWVAERDLVKVLEQVMEDISNLAESGNIEIEKNYSESIGSVKGDYSLNTLFSQILKTRIQTSGCDKIEIEAEKKNGKILVKVEDNGAGLSQDIVDLFSRKPYRGVTAGAGGARYYMIGEIGKHNQAEIEAHDSELGGARFDIHLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0W8</accession>
    <name>A0A133V0W8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000021">
        <property type="protein sequence ID" value="KXB00061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00061">
        <property type="protein sequence ID" value="KXB00061"/>
        <property type="gene ID" value="AKJ40_01945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="80" mass="9375" checksum="43E23E012548B10B" modified="2016-07-06" version="1">MSDILETVKSEENCKKTTIIRLANLDWDMTGRYLNYLLDNSYLETYDEGSKGKDSYRITEEGEELLRSMKIVKNICEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0X5</accession>
    <name>A0A133V0X5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000021">
        <property type="protein sequence ID" value="KXB00065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00065">
        <property type="protein sequence ID" value="KXB00065"/>
        <property type="gene ID" value="AKJ40_01970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_7TM" evidence="3">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PAS_4" evidence="2">
        <location>
            <begin position="121"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="441" mass="49516" checksum="2F1029C1D6A8EAE5" modified="2016-07-06" version="1">MGGVNRELVIKDLGGVTYFYSVFGPFFWLSAVYDYILVFSGVVLILYSLADLHRTYWKQATVIAVGVLIPLLGSVLYVSGPSPGLDITPVLFLPASISLTFGVRNFHFLDAFLIGRKTVFQKISNAIFVLDQDRNIIDLNRAGEELAEETERYGDIIGRDVGDVFSEKFDFSEVIDSEGEAVTEFKLAKNGEERHFQAQIGPLPENGENQVGWIIIVRDVTEHEKTRERKDFLNNLLRQDLGGKYRTIQGYLQLLEEVDLPDEHREYLRRAVKAGGEADEILELAKKLEEIEEVGWVAERDISKIVEHVVEQISVSAEREEVEIVEAYPEAVAGVRGDYSLDVLFSQILKTRILSSECSKIVIEVEEREENVLVSVEDDGERLVDAIKNLFSGEVYRGGTAGAGGARYYMLRQIAEHNNADIEVRDSELGGARFDVLLQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V103</accession>
    <name>A0A133V103_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-L-AF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000019">
        <property type="protein sequence ID" value="KXB00127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00127">
        <property type="protein sequence ID" value="KXB00127"/>
        <property type="gene ID" value="AKJ40_01860"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.338"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="284"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="482" mass="55563" checksum="42FCC9372871EF30" modified="2016-07-06" version="1">MAKIKLDIDRKLGKIDRRIFGSFVEHLGRCIYGGICGEDGPKCDESNFRKDVIEAIQDLNVTQLRWPGGNFASGYHWIDGVGPVEDRPSKMELAWDSVETNRFGTDEFLDFCDKVGVEPHICTNMGTGTAEEAQNWVEYCNGSEETYYADLRRENGRDSPYKVKYWGLGNEMYGEWQIGQLDAEDYAKKARKYAKLMKRIDPSIELIAVGWDEDPEWNKKVLSELEDYIDYISIHMYVGNEEDDYYSYMGTSKKIESRLDMLEGVIDSVMSEVPKDERVKIAFDEWNVWYRAFKEDLLEERYNLEDALVVSMFLNSFLRHCDYVKIANQAQLVNVIAPIMTKKGDLFLQTIYYPFSILANYNKGVGLDVHVDCDSYKLEDEKEVPYLDVSASYDEEEGSLTLNVINRHREDSISTVIENQKGEVGNKVDIHELSAKDIKSQNNFEEKDNVGVIERTFDDASNRFSYEFPPHSLTTLELEVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V135</accession>
    <name>A0A133V135_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_01805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000018">
        <property type="protein sequence ID" value="KXB00158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00158">
        <property type="protein sequence ID" value="KXB00158"/>
        <property type="gene ID" value="AKJ40_01805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.325"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="468" mass="50567" checksum="56768E57A108C882" modified="2016-07-06" version="1">MRDLFAFIFLLIAGILLVPVLVAAIYMEFSHIPSFVLPAAISGGIGIIFRKKYDEEGNLRLGEAMLLVAIAWVLMSGFGAVPYIISLNLGPLNAMFESAAGFTATGLTILQGAEGWLVEVPPHSMLFWRSFTQWVGGVGVVVLFLAIIPRTGRFARLLFESEAREERMLPRIKDTARYIYKAYLLFTILGIIGFVLGGMGLFAAVNHSMTGIATGGFSVTADSFAGYGGPILAVAIFLMIMGAISFALHRKAFDGNWRALLNSWEVRLMIGLIALSALALALDVGIKNSIFQTTSALTGTGFSTTGLIPGDWSSFQKGVLTVLMVLGGGYGSTSSAIKLIRSIIIIGTLLWIIKRAFLPDRAIVPLKIGGVEYEEKDVMEASMYAFIYIGFLIVSSLLIMILMPDWSGIDVIFESASAQGNVGLSVGITEVAPSPVKWILIGQMLAGRLEILPYVALFYKITQKIGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V138</accession>
    <name>A0A133V138_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_01870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000019">
        <property type="protein sequence ID" value="KXB00131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00131">
        <property type="protein sequence ID" value="KXB00131"/>
        <property type="gene ID" value="AKJ40_01870"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.340"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="196" mass="22598" checksum="46EDF3F89AF67A16" modified="2016-07-06" version="1" fragment="single">KILPDLLKAFESEKIYKFLHLPVQSGNDSILREMRRGYTVEDFKKIVESFEERYPDLYLATDVIVGFPEEDEKAFKDSCDLIEEVKPDKVNLTRFTPMPGTDAKEMEQIRSEEKKRRSRKMTDIVQEISYDKNLNYLGTVTEGLVVKEGRKGGYVARLPNYKPLIVEDANPGDFVRVKVTGAEPTYLRGELLKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V159</accession>
    <name>A0A133V159_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00190">
        <property type="protein sequence ID" value="KXB00190"/>
        <property type="gene ID" value="AKJ40_01715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="62" mass="7161" checksum="3F04AF2E10E1DE51" modified="2016-07-06" version="1">MARPRSIEVKKQLACEELEQLISQESDSRLKERLIFIRILYDGERIKDAASKVGRSKPPGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1A0</accession>
    <name>A0A133V1A0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000016">
        <property type="protein sequence ID" value="KXB00230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00230">
        <property type="protein sequence ID" value="KXB00230"/>
        <property type="gene ID" value="AKJ40_01670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="131" mass="15066" checksum="D5533AEEE07D8434" modified="2016-07-06" version="1">MDEEFTEQDVADELGISGGWVNNAKQELINSNILSNENIRTRKQKRKEIKQELIDSNIGNIANIRTRAKKREQVKEALEENPEKSNVEIAKELDVSDPFVGKVRKGTPPVVFLKIFDLKYLRLLMIRLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1A5</accession>
    <name>A0A133V1A5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00195">
        <property type="protein sequence ID" value="KXB00195"/>
        <property type="gene ID" value="AKJ40_01745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="52"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="292" mass="32770" checksum="2A0C0081D327017F" modified="2016-07-06" version="1">MSEEAAKGKIGIDVWTPMARKASKEVFPNAEFVGTDVLDEAKMVKTEDELNCLKIAYAITEAGMREGLDFLKPGVRECEVLAKVWEKMTALGSEWTQCSNIVCSDPYTTPYRRFTSDRLIQEGDLVIIDVGGYYNGYWGDFTRTYLCGDIEATETQKKVHQQAYDALWKATEAAKPGNTNQDLVPEGNLDVDPEYNLGGVWGHGSGVNPWEAPDLSSWSKEAIELKPKMQFNIEPYSGDSEARQGVRLENNIIVKEDGPEVYSTFPFDSRLLDEVHPLDETTGRKDPVKFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1C9</accession>
    <name>A0A133V1C9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00196">
        <property type="protein sequence ID" value="KXB00196"/>
        <property type="gene ID" value="AKJ40_01750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="116" mass="13506" checksum="927562558B3C4711" modified="2016-07-06" version="1">MNPYPEELIFDMNLGREESKIVVKTEEGGFDSPSAPAVYSNLRNFLPWLRLGGGIEKLTFELKEKGSSNVGIFLIMLFKRCQEILQDRQLSPRFRRYTDKSSYTGWQMIKRNKLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1D3</accession>
    <name>A0A133V1D3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000015">
        <property type="protein sequence ID" value="KXB00260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00260">
        <property type="protein sequence ID" value="KXB00260"/>
        <property type="gene ID" value="AKJ40_01610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.277"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="333" mass="37015" checksum="86A47754EF53A5A9" modified="2016-07-06" version="1">MSTNNTDVWTFVEQREGKIHPVSYEILSKGREIADELGANISSVFLTPDGEDAEELLYRGADRVFLFESPVFGLPKEMIFKENINELVRRETPEIFLIGATRFGRSLAPRISASLKTGLTADCTGLEVDEAGEFIQIRPAFTGNVLAHIKTSTRPKMSTVRFGEFEKPDRDPNRSGEIIEMDPFVEESKDVEISERVEEEDVNLENEKVIVSGGRGLKEPSDFELLRELAELLGGEIGSSRPLVDEGWLDRCYQVGYSGKRVKPDLYFACGISGASQHLAGMKESDTIIAINSDPSAPIFDVADYGIVGDLYEVIPKLIERIKEVSDDEKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1F1</accession>
    <name>A0A133V1F1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000015">
        <property type="protein sequence ID" value="KXB00262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00262">
        <property type="protein sequence ID" value="KXB00262"/>
        <property type="gene ID" value="AKJ40_01620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="88" mass="10092" checksum="C16BF9A13A0EFC6D" modified="2016-07-06" version="1" fragment="single">MCETKNNMNLTKTVVLKLKETDDSIQETMERYTEGMNFASKVVYENGEPLSANRLQKLTYKHLRENLDLPSQMSCNVARQVSGTYKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1H6</accession>
    <name>A0A133V1H6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000014">
        <property type="protein sequence ID" value="KXB00298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00298">
        <property type="protein sequence ID" value="KXB00298"/>
        <property type="gene ID" value="AKJ40_01545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="433" mass="48060" checksum="2F7F6F8496429C73" modified="2016-07-06" version="1">MNKKNSLFVPVALIFSAILIVSSCAVALGDTSISVDKHLISIVPGKSGRTFRITELLKIRNSEEEEFEGVLSLPIPENSDNVHGDVLRDNVTCLAMNSGKGEVIIKPFSSSGVTHSPERAVPLSYVGQRENVTLVVQVDNSLKKVHLKMVSGESYKLEWESKKINRVIFKYPKLIRSRLLANSAAGTPTYLFARENAFLFNLDNDKKQVGVKIENSSSEGWGLRIGGFENKTRKYELGSHENSLVKLLGWSPNYEAVLRLTYSIERTPNGSTSFGKEINHPTSELQFWILKIENEPAVSTDLKDFERKRKSENAVWQIFHVKDLSPGAEYNFNLVSKSADKSGVSGWLLVIISVVVFLSVYGVYRVVGTTEVSNSAEEVGGTVKPEAPSNVEMMAEALADLRSDYENGDISEDVFKKLEEKYKETARELAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1I4</accession>
    <name>A0A133V1I4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000014">
        <property type="protein sequence ID" value="KXB00299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00299">
        <property type="protein sequence ID" value="KXB00299"/>
        <property type="gene ID" value="AKJ40_01550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="268" mass="30898" checksum="00BEE25230E7A6A5" modified="2016-07-06" version="1">MKGGKKNIKRRYWVGEKVKPVRVVAITVLILTLLSPVATGQHPEKDFSISWRRIGLKRVDNFGFIVTENFSAFSKRGNAENIVFMADRNVENLTVNRDLEKTREGFFYKFRLEEPVPENQSLVLQVKYYSSDLSFSRPVYYSCENVVVSLKNFEDVEIESSVPVGRKFSIQFGDNVSIRVKNEEGQSETPPTPDIDIEWVLLIALSIFLLLLIVSYFNGWGMFGSTPTDRAPTRRGVLERLEEDFENGKIPEKAYENILERLREEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1K2</accession>
    <name>A0A133V1K2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anth_synt_I_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000014">
        <property type="protein sequence ID" value="KXB00295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00295">
        <property type="protein sequence ID" value="KXB00295"/>
        <property type="gene ID" value="AKJ40_01515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="177" mass="20504" checksum="C85191A8AD17CA34" modified="2016-07-06" version="1">MVDPSQIFLEVRKNFDLAYLLESLDGFRPGSRFSVIGCGSLFHLKFSGYQREVEGGTDFVDLSSERLEDMDADLDPLEAMKRAMFMDEMQVLGLNLPRYILGVTGYLSYDYVRKRIELESNTEEDLNHPLLEFALPESVIVFDHQRERTYHASLMLLTERDDFDETSFRSMEMSNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1P7</accession>
    <name>A0A133V1P7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_01450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00378">
        <property type="protein sequence ID" value="KXB00378"/>
        <property type="gene ID" value="AKJ40_01450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="340" mass="36863" checksum="0838BB73C35DE102" modified="2016-07-06" version="1">MLLLIFGSVFGGNPGGGYTLYVQNNDLEGGKPTSLSEVLVSALDNIEALDIKELPAGVEIEKYRKENPSLSIDRALVIPKGFQSSAMDGNVTVSLLTSGEGPATSMVQGVIDSVINMFNYQMSGVEPIINIDMGSLEKEEELSAVDYYLPGYIAAFIMINGIMAVTTYISEFRRNGIIKRLAATPLKKSSWILGNLTLQAVLGFLLTLVMVVVAMMVFGVQAIPGPYALILIFLGSVTFCSIGIVLGGVIKDTEAANTAGSAIAFPMMFLSGAFWPIEMVPSFMQTIAKFLPVYYFHEGLREIMIKDSPSQALVPFLIFTVLAVVFTFVAVKVTKWEEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1Q5</accession>
    <name>A0A133V1Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00369">
        <property type="protein sequence ID" value="KXB00369"/>
        <property type="gene ID" value="AKJ40_01390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="2">
        <location>
            <begin position="278"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="414" mass="47890" checksum="CD4D422517565518" modified="2016-07-06" version="1">MKAKKKMEKARVQLLLDNPFFGYLGSYLQLEESDSLNNPISTDHKKLYYNPDFIEGLNETVLKTCIAHGILHTVLGHQWRRENRKTKTWNSATDLATNWLLKQSGFEIPPDSELRPIFKDKSAEEIYSLLNLEEERKKQKAADKNSQKEGRERKDETGGEESKSEKENTGQLKQDSMDDHRIWENVAVDQDLDQEEIAEEWKRRAAESYASARGEGKMPEALERLVDEILEPTLNWRRILRRYILQHAREDYDWMRPDRRLLQYGVYYPSPHSERLDLAVAVDTSGSIRDDDIELFLSEVKGILESVDSYRARLLACDAKLHTDISVGRDTGLDVERTIDKFSESLKGRGGTKYSPVFEALDDEGVQILVYLTDGRCSEEIEEPNFDVIWVINEGGTKKHIEFGKIIKLEEKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1X2</accession>
    <name>A0A133V1X2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TerB_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00415">
        <property type="protein sequence ID" value="KXB00415"/>
        <property type="gene ID" value="AKJ40_01320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025266">
        <property type="entry name" value="TerB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13208">
        <property type="entry name" value="TerB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB_N" evidence="3">
        <location>
            <begin position="243"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="829" mass="97164" checksum="6F99EED8EB72D003" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V200</accession>
    <name>A0A133V200_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_01280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00473">
        <property type="protein sequence ID" value="KXB00473"/>
        <property type="gene ID" value="AKJ40_01280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1183"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="540" mass="58294" checksum="8E9C1A3A57846622" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V244</accession>
    <name>A0A133V244_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00527">
        <property type="protein sequence ID" value="KXB00527"/>
        <property type="gene ID" value="AKJ40_01235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="251" mass="28995" checksum="21836ACD13ACDBF7" modified="2016-07-06" version="1">MPIRLLKRQQERQIEGTKSGTEKHLADYWKKQEKKAEVRKEFLNTLLRQDLRSKFQTIQGYLQLLDEVDLPDEHREYLRKAVKAGGEADEILELGRKLEEIEETEWVAEKHIVKVLVHVIEDISDLVERQGVEIEEDYPEGIGRVKGDYSLSTLFSQILKTRIRTAQCDKIKISTERKDGKLLVKVEDNGKRLPVDIKNLFKGEPYTGETTGAGGVRYYMLREIAKHNNAEIEVQDSELGGGKFNIYLQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2A6</accession>
    <name>A0A133V2A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_01145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00588">
        <property type="protein sequence ID" value="KXB00588"/>
        <property type="gene ID" value="AKJ40_01145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1017"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="301" mass="32086" checksum="02B2C38ADC4109F8" modified="2016-07-06" version="1">MIGRIIFVIFALLGAGFVSRKVSLLTSGRVDILNKLAFYVALPALVFHSIYRLSLGEIFSPLLVMGFLIVVFSTSGLGWFTFRKVESAPKKSISIVQSYHGNLGYMGLPIVTFALGEIGGAKASFLLGFSTIVQILLTVSLLVNMNQIGGELRGEIKKVAFNPVLLALVTGLLFSYLNISIWTGVEEIISLIGKAALPLALIGVGASIELKGWSEDLKTISSVTFLKIVFMPILGFVILTGLGVETISLKTGVLMLAMPPAASTYIYASELGGDKRLASLNISITTIASLLTLSVLLVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2B6</accession>
    <name>A0A133V2B6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ40_01140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00594">
        <property type="protein sequence ID" value="KXB00594"/>
        <property type="gene ID" value="AKJ40_01140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="153"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="254"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="380"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB00594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="452" mass="49346" checksum="9E768500A38D5E01" modified="2016-07-06" version="1">MGKLFGTFGIRGIANEEVSPELAYELGLALSTMLGDENRKIAVGYDPRTSSVMLEHSIVSGITSGGCDAVRFGLVPTPVLSYGISHFDCDAGIMITASHNPPEYNGIKFWDGNGAGFTRERENELEKIFREGGKTAAWNEIGDTKKVDALSPYKKALLDRVTEVEGSIKVIIDCANGAGSVIAPQILRELGCKVVSLNSHPDGHFPGRLPEPTAEHITDLTSAVTAMNADIGIAHDGDADRTIIVDENGEILSGDLVFALAGVNYLRDTENPRIITTVATSSVLDDTAGRLGGKIVRTKVGEPELVEEYRKNGGDLAGEENGGVIFPDWTFCRDGIMTDAQIIDYLSTTGKTVSELRKTLPEYQQIKRKTECPNDLKQKVVDDLAHEFKDYNPDRTDGLRIELEEGWLLLRPSGTEPIFRCFSEAKNKKNAEELADKGMKAIKESIEKLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2M7</accession>
    <name>A0A133V2M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00689">
        <property type="protein sequence ID" value="KXB00689"/>
        <property type="gene ID" value="AKJ40_00900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="144" mass="16869" checksum="A50714EB510D028E" modified="2016-07-06" version="1">MTVEIELDEEERNFLDDFVKKGTKKAREITRANVLRLADMGRPVTDIAEMVGIHRKTVWEIKKRYKEEGLESALKDKPRPGQPKKWTEEHEAEIIATACSSPPEGRKRWTIRLLRDELQKKPGFEDINRETVRLVLKKTRQNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Q7</accession>
    <name>A0A133V2Q7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00732">
        <property type="protein sequence ID" value="KXB00732"/>
        <property type="gene ID" value="AKJ40_00805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="91" mass="10776" checksum="727A7E5552B638C7" modified="2016-07-06" version="1">MKVNTELRFEHCPHCGGNVKRIRSHRKKCEKCGTVYFFRNSPVEDGKLKVEEIDRSEYKKEAEKRLVAARLRGDLGEDRQRDHQNHRLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2S4</accession>
    <name>A0A133V2S4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00752">
        <property type="protein sequence ID" value="KXB00752"/>
        <property type="gene ID" value="AKJ40_00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="76" mass="8372" checksum="CE630FE68AE287E9" modified="2016-07-06" version="1">MAGALIMIVAEVGSMRDVFEEIESLPMVREAKMLAGPYDIMAVAESDKLSEIMETLIEKIRSIDGVGETVTHIFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2T2</accession>
    <name>A0A133V2T2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Meth_synt_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00758">
        <property type="protein sequence ID" value="KXB00758"/>
        <property type="gene ID" value="AKJ40_00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="307" mass="35641" checksum="EE7D3E3D4068F3A6" modified="2016-07-06" version="1">MRLREAYQEWELGKITDEEMEEIYRDYAKEVIKEQEEIGLDVVTDGLIRWYDPISHFARDIEGCEIDGLLRYFDTNFYFRKPVIKGDLSRDKPILKKEFIPAKKNASKILKPVLTGPYTLAKHSVDKFYDNISELVFNFADIISREVRELVNEGAEEVQINEPAILENEEEFSIFSEAFRKIAKSKKDTQLDLSFYFGDIAPLYEYLQDLPTDLLGLDFTYSPDLLDMITEIGSEKKLGLGLIDARNTKMEKIEEKVSIVRKIVPYVDADEIYLQPSCGLEFLPRRRALEKLDRIVEIADRAKGVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2U1</accession>
    <name>A0A133V2U1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00768">
        <property type="protein sequence ID" value="KXB00768"/>
        <property type="gene ID" value="AKJ40_00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="77" mass="8732" checksum="979E66B4AB2D4681" modified="2016-07-06" version="1">MLRKRNEKRRMIIVSEKVSQEVLNQLGKPQRTVVKICEDNWDRIKKPCPDVDGNICGVTGKVCAFSNCIKLKEAGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2U5</accession>
    <name>A0A133V2U5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose 1,5-bisphosphate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00772">
        <property type="protein sequence ID" value="KXB00772"/>
        <property type="gene ID" value="AKJ40_00685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="77" mass="8805" checksum="DEB5424254265F9E" modified="2016-07-06" version="1" fragment="single">MVSIEYEDFLDLEYKPNETDLICEFYVEPAKDMSMEDAAGRVASESSNGTWSGLEVDERIREMSATTFSIEDNIIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2U8</accession>
    <name>A0A133V2U8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OrfB_Zn_ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_00560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00751">
        <property type="protein sequence ID" value="KXB00751"/>
        <property type="gene ID" value="AKJ40_00560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="248"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="352" mass="39819" checksum="204835D05F0F3E4E" modified="2016-07-06" version="1">MKKVRKTVQCGIVNLTDVKESLLGREFENLQRFLHGEEGVELYSANKQQAERYYKKIKDGKKYPISIRKDLIDIRECDSDVGDYFVRIPVAGRRGGVNVPVNTHMGIEEDWEICESKLFRKDGSFYLNVTVEIEVGEVEEYEGVLGIDLGLRNPVVSVALPSRESEFRGLGVKQVQSKYFYLRRQSETGKGWHRRERDKVRDQLHKTTTKIANYAEENKVVVAVGDLSGVQNQDKGREMNRKLHRFPHYSFRQMLEYKCRERGIEYIEVNEAYTSQRCSRCGEEGNRNGGEFKCPNCGLEIDADVNGARNIVSRALDKSEIRPLVNAGAPVAAPGTLSVEATSGASPEAISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2V7</accession>
    <name>A0A133V2V7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="5">HPPK</shortName>
            <ecNumber evidence="5">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="5">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="5">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mptE</name>
        <name evidence="7" type="ORF">AKJ40_00615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="5"/>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00761">
        <property type="protein sequence ID" value="KXB00761"/>
        <property type="gene ID" value="AKJ40_00615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.519"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAF_flag10" evidence="6">
        <location>
            <begin position="32"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="247" mass="27772" checksum="9CE6DED9A093EDDB" modified="2016-07-06" version="1">MEWSKWKPKYEGIVKKLKLNRTEDERAAKILNRLINSSKLPDLKKLIEGNECIVFGAGPSLEKDLEKLDEAGWLNKVLISADGATSAVKRYRLPDVIVTDLDGDVEDQLDAWQKHSFLVVHAHGDNIQKVKEIVPRLTERVIGTIQVNKPAQLYNFGGFTDGDRAAFMAYELGAAKIILSGMDLGEEIGEYTGHTNKEVKKMKLEICENLLSWLSKEFGAKIVNVTSEGREIPQVPREDIVENQQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2X9</accession>
    <name>A0A133V2X9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="6">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aspC</name>
        <name evidence="6" type="synonym">aspS</name>
        <name evidence="8" type="ORF">AKJ40_00415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00791">
        <property type="protein sequence ID" value="KXB00791"/>
        <property type="gene ID" value="AKJ40_00415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.352"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="145"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="6">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="439" mass="50419" checksum="E70042BB2AD8F95F" modified="2016-07-06" version="1">MSYERMGNWRKTHTCGEISLEQRNEEAILMGWVEDIRDLGGIKFFTLHDSEGMIQITAPEGKVEEEIFEKIDSISKESAVAVKGKITEAEQAPGGVELIPEEIRELNPAKTPLPLDPTGRVKADLDTRLDARLLDLRRPKPSAIFKIKHLALQTFRNYLTSQGFIEINTPKIVGTATETGAILFPISYFEKEAFLSQSPQLYKEVLTGSFEKVFEVGPIFRAEEHDTRYHLNEVLSADIEMAFATKEDVMEVLEDVIVEIFERVKTQASEELEALDHDIEVPEKPLPRLTYEEAIEKLQEKGEEIEWGEDFSIPEQRLLGEIIEEPYFIIDWPTREKPFYIKPHEDNPELSHAFDLLCREIELVSGGTRIHEKDLLKKRLKENGLSPQQFQYHLKNFEWGLPPHAGFGLGVERLLMILTGAKNIRETVLFPRDRKRLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Y5</accession>
    <name>A0A133V2Y5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvate, water dikinase</fullName>
            <ecNumber evidence="6">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AKJ40_00530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6"/>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00808">
        <property type="protein sequence ID" value="KXB00808"/>
        <property type="gene ID" value="AKJ40_00530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.376"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="12">
        <location>
            <begin position="526"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="11">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB00808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="1187" mass="132693" checksum="0AA282708E50EC41" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Z1</accession>
    <name>A0A133V2Z1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo11</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo11</name>
        <name evidence="4" type="synonym">rpoL</name>
        <name evidence="7" type="ORF">AKJ40_00505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00804">
        <property type="protein sequence ID" value="KXB00804"/>
        <property type="gene ID" value="AKJ40_00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="93" mass="10778" checksum="4DD9C0A680710FE4" modified="2016-07-06" version="1">MQVELMEKEGTEMKVKIVGEGHSFTNVLRKKLHEDERIEIASYNIDHPLLSDPVLRVKTSEKKSPKRALIRAAKSLSEEYEEIKMKLEKALEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V324</accession>
    <name>A0A133V324_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flpA</name>
        <name evidence="5" type="ORF">AKJ40_00265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00833">
        <property type="protein sequence ID" value="KXB00833"/>
        <property type="gene ID" value="AKJ40_00265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.60"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="226" mass="25772" checksum="F2790CF5047D2E5E" modified="2016-07-06" version="1">MRVEKHEKFDGIYWVELEEGKRNLATRNISPGNKVYDERLVESQGNEYRIWNPYRSKLAAAVLRGLKNMPIKPKDKVLYLGAASGTTASHISDIVGSEGMVYCIEISSRPLRDLLVTCEQRQNMAPILADAQNVEEYRALVEQTDIIYQDVAHPEQTNIALKNIESFLRKGGDALIALKARSIDVTKDPREIFRAEMEKLEKKVEIVDSQLLDPYEEDHAMILIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V344</accession>
    <name>A0A133V344_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00868">
        <property type="protein sequence ID" value="KXB00868"/>
        <property type="gene ID" value="AKJ40_00055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="174" mass="19954" checksum="9A5A3ABC7936674F" modified="2016-07-06" version="1">MFAAFRCEICGETYLGYSKPENCPYCGAHEEYLKSLENYERVMPKKVTDESHENVLKAIDLEIDNAKFYACAARETEDELEAAVFKRLGKIEAEHAEALAEVIDVPEKDIPSYEECSTDSLENYREAHEREERAIKAYSKFASEAKEPEIKELFEAIVEIEKDHLALSERKTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V349</accession>
    <name>A0A133V349_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="10" type="ORF">AKJ40_00110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00877">
        <property type="protein sequence ID" value="KXB00877"/>
        <property type="gene ID" value="AKJ40_00110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.24"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB00877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="285" mass="31233" checksum="3F60CB7C02458F35" modified="2016-07-06" version="1">MITPFDENYELDEEGLRENIRSQIEGGIDRIVPVGTTGECATLSHEEHKRVVEIAIDTAGGEVPVIAGTGSNSTREALRLTRHAAEAGADAAMLVTPYYNKPTQRGLYEHYKKIAQEVDIPQIIYNVPSRTGRNIDPETLVSLSEFENIVGVKEAIGDLQQIMYLVENTGEDFNVLSGDDHLTLPMLSLGAVGVISVASNIVPGEISKLVHSYLEGDTKTAMEQHYEFLPLFRSLFLETNPGPVKAAMGILDRPAGKPRLPLVEVTEETKNQLREVLSNLAITPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V357</accession>
    <name>A0A133V357_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00871">
        <property type="protein sequence ID" value="KXB00871"/>
        <property type="gene ID" value="AKJ40_00075"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.16"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="250"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="946" mass="107367" checksum="4D42376C6DABFDBA" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V369</accession>
    <name>A0A133V369_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PK_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00873">
        <property type="protein sequence ID" value="KXB00873"/>
        <property type="gene ID" value="AKJ40_00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PK_C" evidence="1">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="196" mass="21808" checksum="39AC0461E2D6577E" modified="2016-07-06" version="1">MNRKDLQKELTLFKEKGSVNTRACFEAVADRINDLGLQYVIVASTSGETGAKAVNFFKKHDVKIVVVSHQYGFKKDGEIEFQDRYRRRIENSDNASLVITPDLLTRVPKITRGKYGGYNPLDLVADTLRIFSQGMKVCIEFTIQAADAGKIPVNEEIVAVAGTSSGADTGIVLQGQHSHKLFQMDVKEIICMPRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V384</accession>
    <name>A0A133V384_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00889">
        <property type="protein sequence ID" value="KXB00889"/>
        <property type="gene ID" value="AKJ40_00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="293" mass="31828" checksum="C6A9BA49FB5EF39F" modified="2016-07-06" version="1">MVILVIAGAIIGSVGSSGEGQGPGQEQGPGVGSSDFRVGLGYVLGVSIVAFAVMALTDFDNRIRVGLLFLTFFVFFFIKGGHLITLVPRLLGSEGVRAAAGEVDWRHFLRFSFPLAVAGLVLTLGATFFIGRALCGYGCPVGVFQELLYSVQDYREKARRFVLSTQWAFGVRLIVLGLIVVLYLGAGLDLVQVVSPYQLWRLEIAIPGIFVMIGFFVGAVFLYRLFCKLFCPFGALASLVAKFSILKIGKEESCTECGLCEKECPMQDCEKYGECYLCGRCARICQRESIGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUY3</accession>
    <name>A0A133UUY3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMC_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_05025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000127">
        <property type="protein sequence ID" value="KXA97936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA97936">
        <property type="protein sequence ID" value="KXA97936"/>
        <property type="gene ID" value="AKJ40_05025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA97936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="684" mass="79385" checksum="22AA016FD01A90C8" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVA7</accession>
    <name>A0A133UVA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000120">
        <property type="protein sequence ID" value="KXA98135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98135">
        <property type="protein sequence ID" value="KXA98135"/>
        <property type="gene ID" value="AKJ40_04925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="117" mass="13449" checksum="554685E429045A24" modified="2016-07-06" version="1">MKGMIYSFFSRKASVSVAEEMNEMIRQPSTFSSIFLFLRFHIFCKSKWIQPGPEGNAPKVASWEKGFTNPTSERDPSTIALSCRWIHGKFRNESTRFLKCLSKKVSGGAEISFIFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVI8</accession>
    <name>A0A133UVI8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_04905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000119">
        <property type="protein sequence ID" value="KXA98166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98166">
        <property type="protein sequence ID" value="KXA98166"/>
        <property type="gene ID" value="AKJ40_04905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="264"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA98166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="552" mass="61891" checksum="1D08147AF8AE7CDF" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWH6</accession>
    <name>A0A133UWH6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000105">
        <property type="protein sequence ID" value="KXA98536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98536">
        <property type="protein sequence ID" value="KXA98536"/>
        <property type="gene ID" value="AKJ40_04675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="85" mass="9941" checksum="1EFDD9EC597C079A" modified="2016-07-06" version="1">MEKRHHRVLHCELLYLVMWDKPGTNSAPGRFYNKIRKEFGDEVRFIQQSVYGTETFETAESLTELAKNYGLNVLVFRVVEHPNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWP3</accession>
    <name>A0A133UWP3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000102">
        <property type="protein sequence ID" value="KXA98595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98595">
        <property type="protein sequence ID" value="KXA98595"/>
        <property type="gene ID" value="AKJ40_04635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="71" mass="8031" checksum="A46D8D890477580C" modified="2016-07-06" version="1">MLVNTKTDVTENVYNNVKKLKEVQRVAMLTGPYDIMAIVKTDDIKKITNALMNDIRKMNGVERTTTCVVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWS4</accession>
    <name>A0A133UWS4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000100">
        <property type="protein sequence ID" value="KXA98639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98639">
        <property type="protein sequence ID" value="KXA98639"/>
        <property type="gene ID" value="AKJ40_04585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="101" mass="11376" checksum="11B78D78D00B5D96" modified="2016-07-06" version="1" fragment="single">SGMRFEYRTPDPLCNPYLLFTGLLAVGMDGVDRELDPGPPASENIFEMTEEERESRGITILPDSLHKALDALHADDVIRGALGEKMTETYIDRKREESFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWU2</accession>
    <name>A0A133UWU2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000099">
        <property type="protein sequence ID" value="KXA98664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98664">
        <property type="protein sequence ID" value="KXA98664"/>
        <property type="gene ID" value="AKJ40_04580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="470" mass="55388" checksum="865FC380FB123674" modified="2016-07-06" version="1">MVNGTVVGAVEEKLRDRLNRFPLVVWFDPTGQYLDVVDHLELSENFLKYDGSFLEIRHKIEREDPEFKKSWAIYVPESKKNSQWLREFWQIGTEMEIPAKSLLRELGFIIGRKHRKDLENEKLNTDIVNFPNEYLNREDYDSKRIVKAHIKNALGIDSFDFFLVTAKFLDDPDLVGKKLREKGKVIDFIKLLSEKYGIATETEDLADFRSELIRSLFLGEFVFRSKLGLRRFEKILPAKDKRSNCAHFIRRWQDTKKYEEAFLKAHREFQEKYDDITEPEHSIGKLTKVSGLKSVDDFLLKRVDKKFENGEKVDIEELSKIVEKRKKLFWGQREPGRNGGDWDYLYHVSECLKMIDNGYPKNEFGKIIDYYTDEGWRIDHEFRKAAEIRNSISLIEKAKSHLESKYYQYLREINDCFSESFSISNSSIPPQSKVFETIEEGSAIIIVDALRYELAQDLIGDKEVRPYLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWV0</accession>
    <name>A0A133UWV0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000099">
        <property type="protein sequence ID" value="KXA98663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98663">
        <property type="protein sequence ID" value="KXA98663"/>
        <property type="gene ID" value="AKJ40_04575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="128" mass="15440" checksum="26EB53DC69C0FF7E" modified="2016-07-06" version="1">MEKWIEKYFFKNFHYKMYKKRPVVWQLQTPDKHFSAFIYYHKLDEDTLPKLDSIYINPLISYYSSQKEIAEKNEDAVEAKKMDDKVQDLKEFQNQIGEIIDSGYEPDLDEGVKHNFKPLEHLTPVEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWZ8</accession>
    <name>A0A133UWZ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000098">
        <property type="protein sequence ID" value="KXA98687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98687">
        <property type="protein sequence ID" value="KXA98687"/>
        <property type="gene ID" value="AKJ40_04560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="91" mass="10234" checksum="7FEDB482310996E0" modified="2016-07-06" version="1">MVIFAEALFLINTRSNATKDVFDSIGNLKGIRKMEILTGHHDIMALAKTKDMREIKHKLIREIRSIEGVRNTVTCLFIEYGSCEATIPPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX08</accession>
    <name>A0A133UX08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000097">
        <property type="protein sequence ID" value="KXA98701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98701">
        <property type="protein sequence ID" value="KXA98701"/>
        <property type="gene ID" value="AKJ40_04525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1241"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="87" mass="9532" checksum="A824434E438149CA" modified="2016-07-06" version="1" fragment="single">CAHSGIVNVLTHFLKKTDNDRIYAVIGGTHLGSASDKQVEKTLEFIEKRNIQKIGVSHCTGLANSAKLYNRLGDRFLFASAGETIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX83</accession>
    <name>A0A133UX83_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000094">
        <property type="protein sequence ID" value="KXA98781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98781">
        <property type="protein sequence ID" value="KXA98781"/>
        <property type="gene ID" value="AKJ40_04445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038215">
        <property type="entry name" value="TN5-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014735">
        <property type="entry name" value="Transposase_Tn5-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14706">
        <property type="entry name" value="Tnp_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DNA_bind" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="309" mass="34526" checksum="20CCC0035B505806" modified="2016-07-06" version="1" fragment="single">MVLDFSGDVGLVGGFCYADVSQYMKDEFQFTDFGDKRLDDRLLRIGVALGGAPSESIPRACGDWASTKATYRFFDNENVTPEEILSSHKEEMKSRLKWVKKVPVVSDTTYLTFPSHPSKEGLGDIGNSKTDVEGVLVHSTIGVHPETRRMIGVMDQQVLVQDQEQDPTETCDTNGKDESIQLESEQDKWIRGDKEAIKMLPEETRPIFVHDRGADDFSLFKKLKEEGSGFVIRASQNRCIKTPSGQGNYLLDWSKNLPEIGQTEIHIQQQGNRKGRDATLSIQTGTCELLPPEKVPQDTSPCQVNVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX94</accession>
    <name>A0A133UX94_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000093">
        <property type="protein sequence ID" value="KXA98812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98812">
        <property type="protein sequence ID" value="KXA98812"/>
        <property type="gene ID" value="AKJ40_04415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="73" mass="8665" checksum="FEC8B259C0BD34AE" modified="2016-07-06" version="1">MKSMENDEEVLVVPVDDYSFSKAKSELIYAFPKSYNRHVPEYIAFYRKRPISAITHYGKVKKPWRKIRVANID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXT0</accession>
    <name>A0A133UXT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000086">
        <property type="protein sequence ID" value="KXA98996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98996">
        <property type="protein sequence ID" value="KXA98996"/>
        <property type="gene ID" value="AKJ40_04220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="67" mass="8033" checksum="7FFE0D6ABE2798B6" modified="2016-07-06" version="1">MKEYQELGYEDWRDETGYGERFPNEGQFGSLVSRFSKEANVRSTHMAKRVVTARLAFHNFFQWLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXV0</accession>
    <name>A0A133UXV0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ub-Mut7C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000085">
        <property type="protein sequence ID" value="KXA99001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99001">
        <property type="protein sequence ID" value="KXA99001"/>
        <property type="gene ID" value="AKJ40_04185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="1">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="87" mass="9874" checksum="98F57B048238CEBA" modified="2016-07-06" version="1">MTVELKLFGDLKIKSPISEKRNGYPAISKSDLSKARTGKDLIKIHGINRAEIGHFFLNGKFAKLEDELRDGDSLTVFPRNMLMPCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXW4</accession>
    <name>A0A133UXW4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000082">
        <property type="protein sequence ID" value="KXA99034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99034">
        <property type="protein sequence ID" value="KXA99034"/>
        <property type="gene ID" value="AKJ40_04140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="321" mass="36962" checksum="DCBF5179FB6EADCE" modified="2016-07-06" version="1" fragment="single">KKSGREVYRDFNTFRTGDILDMENLKIEPVHVDHSIPAAYGFIIHTTSGKVAYTGDFRMHGPKSNMTRDFLDKASDYDIDYLIIEGTNITGAEISSESHVEQITDKLIKHTDGLVVISFSDRDVDRLNSIYRATKRNNRKLALSTKQAFLLRDLYKDPNIKVPDLRRDDIFVFGKEKSWLRAWEEEIHNEFNVLYGSDINSIQDRIVLAASYYDMNELMDVNPQAGSIFILSKSEPFDEAGEIQHEKLLNWCNHYGMPQYHVHASGHAMPHELKSVIKEISPNTMIPVHTERPLLFEKYVADLDVNFKSPILKEKISLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY18</accession>
    <name>A0A133UY18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000078">
        <property type="protein sequence ID" value="KXA99067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99067">
        <property type="protein sequence ID" value="KXA99067"/>
        <property type="gene ID" value="AKJ40_04045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014931">
        <property type="entry name" value="DUF1805"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036493">
        <property type="entry name" value="YunC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08827">
        <property type="entry name" value="DUF1805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102891">
        <property type="entry name" value="SSF102891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="106" mass="11269" checksum="9915F033EC14C4EC" modified="2016-07-06" version="1">MPKIVTETVEVETGYATGLSVQWADGQFVVIVSDNGVLACGAIDVEVMEEFDNVIAVAEGTPEKPLVMPEDLLNAKISRTTGKAEAMGIKPGMSGKEALEKMLKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY22</accession>
    <name>A0A133UY22_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000076">
        <property type="protein sequence ID" value="KXA99092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99092">
        <property type="protein sequence ID" value="KXA99092"/>
        <property type="gene ID" value="AKJ40_03985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="140" mass="15569" checksum="360F2B0C73049088" modified="2016-07-06" version="1">MSEKKGNVYRPDDLESLVWEWGTQQFVKGENFSLGVTVITPGQEHAKHNHPGVEEMFYVVSGKLGVNFYYDDGEKESFEAPAGSWVHIPTGVKHDGKCISVEPAKFLVIYSPAGPETDQLRNVPESTILEPGEKPEYTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY26</accession>
    <name>A0A133UY26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000075">
        <property type="protein sequence ID" value="KXA99102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99102">
        <property type="protein sequence ID" value="KXA99102"/>
        <property type="gene ID" value="AKJ40_03965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="92"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="215" mass="23630" checksum="4CF2E3D851C249C7" modified="2016-07-06" version="1">MNKKLYADAENSITNLEEEKALEIAEIAKKEGIELSELIEKGYAKGLKQVGQQFEEGLLFLPELSRAGEIMEKVMAILEPVIEKQGGELSKKGIVVIGTVKDDLHNIGKNLVKALLTAYGYDVYDLGMDTPAEEFLKKAREVKADVIGASCLLTSTKAELKNIVDYLEEKESRNDYLFVIGGAATSLEFANEIGADGYGENAQKAVKLIDKLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY47</accession>
    <name>A0A133UY47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000074">
        <property type="protein sequence ID" value="KXA99115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99115">
        <property type="protein sequence ID" value="KXA99115"/>
        <property type="gene ID" value="AKJ40_03935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="115" mass="13648" checksum="CEEF81869B295169" modified="2016-07-06" version="1">MVEILVVDALCRSQEDFCEQEVEVEVPYYGRGEKTVRWNVGERGAKTFRKRYFFLPFELPPPVFLLHLLLRTLFRWIRFVGTGLEKLLPPLLLQLFNCPTIKQGFYEVHPDRLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY49</accession>
    <name>A0A133UY49_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000075">
        <property type="protein sequence ID" value="KXA99100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99100">
        <property type="protein sequence ID" value="KXA99100"/>
        <property type="gene ID" value="AKJ40_03955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="81" mass="9025" checksum="A6B3DF07E9B99E07" modified="2016-07-06" version="1">MDMEKDKISFGIRIKDDLVKELENIVEESEYLDVNTVYWTYKKTPGPILFTGVLSEEGKHVRGTPGGSPPFGLPLGGQRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY83</accession>
    <name>A0A133UY83_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000073">
        <property type="protein sequence ID" value="KXA99129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99129">
        <property type="protein sequence ID" value="KXA99129"/>
        <property type="gene ID" value="AKJ40_03910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="69" mass="7753" checksum="5FE087A6958344DD" modified="2016-07-06" version="1">MTLRIGLIRFISRIHSVNLEPLRPSEASEASEANPKRISEKDPGNSSGGMKPDKKELVRLFCELFAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY96</accession>
    <name>A0A133UY96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000071">
        <property type="protein sequence ID" value="KXA99154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99154">
        <property type="protein sequence ID" value="KXA99154"/>
        <property type="gene ID" value="AKJ40_03845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="137" mass="16091" checksum="49B278B2E364EDFA" modified="2016-07-06" version="1">MLKQFPRDEHYENLGDYYLVPLWENEKIKGVVIVYVNTWETGGYVRTTDEFRPEFPPFSLEEASKVAAKNLENYDARSLEKVGKLGWKLCEQTHDREFPLWVFEVGDEEYYVDWVGEFYEELTSVHDKLGGGVGNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYE4</accession>
    <name>A0A133UYE4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000066">
        <property type="protein sequence ID" value="KXA99208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99208">
        <property type="protein sequence ID" value="KXA99208"/>
        <property type="gene ID" value="AKJ40_03700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="75" mass="8586" checksum="72935974277C3154" modified="2016-07-06" version="1">MDESSGCEIFVLLVFRGLAEILTRSGTYSSLWFSQRSEKIIETLWGLFFGSRVFSIFFDPDFGDQGGLLVIEYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYG7</accession>
    <name>A0A133UYG7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000064">
        <property type="protein sequence ID" value="KXA99229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99229">
        <property type="protein sequence ID" value="KXA99229"/>
        <property type="gene ID" value="AKJ40_03650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="338" mass="38700" checksum="F978029C460C3ECB" modified="2016-07-06" version="1">MSVFGEIDEGDIISSNLLEELINGALSEGVEIFSVRACLQDYMVDEFVKVCKVKNSGNKLKYSLQLEWPEEFDDKESRGQERGRLRDTFIRAGIAKHSNLPEIMSRLREHDDVIVGLDTNVLLDCAITSVLIDELYAEQFPNWILFAIPKITTAEIENKANQKFTGPSDHPRLGWPQYDGRIGQRALQEILELDKEDPDRPGLSIMTIGDLKDPDTVKTTDNWWKDSEIRSQFQKFLRSISFHKGTYFLSQDRVNVMMSGAEGAEGLYLQKPAFEEFEKGKISRKKFISFLYELCIQFGGVEVNSVCGPCPTFQLDIFWPGKHVSDWRESKLKVKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYH7</accession>
    <name>A0A133UYH7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000063">
        <property type="protein sequence ID" value="KXA99239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99239">
        <property type="protein sequence ID" value="KXA99239"/>
        <property type="gene ID" value="AKJ40_03630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="488" mass="56321" checksum="5D4584E65CE2EA24" modified="2016-07-06" version="1">MLELNGVTVFVKDYKYKFLQIGVFLSVFTLLIFKLAYNVPKFALFLPFRDFIIFLEFFSLIAFLFLACSYFAYKGVYKKVRFSIFGLIFVFFLLLSLLEPWYLLICILSGASLVSMSMERRNGNTFRKEVSLVLIVLVLLPFLTSMIFALFPVNVGTTQQEFEVSFWAEGVPPSKERVLEGPGRPSRLIYSENIVNETDIEILNRHNSKISLAVHQDMLHDNSPAEKVAEKLNRGDVPVQAWLLTHPENYYWANNLNYPIFDNLYDRYLEWKKDLTFNGLVLDQELDVLETGKSLPKTLRTLYRTDIYEKSVENYKGLVDRISSRKKAILTTWGTPCLDDFLDLDPSLQKMLGVSAVPPETWGKHSFQVYRVIPYRTIKLDLGPYLVYSYSVTAREIFGNDTAIGLSHAGYLGYSDISKIVKDVRLVSALELSEAQVYSIEQVKRFFGPEGLEKILEDGKKPDEQVSIRYNPIVPFWRFPITFFDLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYK2</accession>
    <name>A0A133UYK2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YrdC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000062">
        <property type="protein sequence ID" value="KXA99251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99251">
        <property type="protein sequence ID" value="KXA99251"/>
        <property type="gene ID" value="AKJ40_03605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.953"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="197" mass="20822" checksum="872C2ADF8FCA565D" modified="2016-07-06" version="1">MNELQEAIKAIRSGKMVVYPTETVYGLGADATSDEAVSRVFEAKSRSFDRPVSIAVDSLSMCYRVGKLYREEETLIREFLPGPLTVLVEPRPVLSDVLSADTGKVGIRIPDLSVTRKLIESVGGPITSTSANVSGRPSPTTVADALNQLGGSVAVAIDIGESTLGTSSTVVEVLEGDVEIIREGPVSRSQIVSALSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYL4</accession>
    <name>A0A133UYL4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000060">
        <property type="protein sequence ID" value="KXA99273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99273">
        <property type="protein sequence ID" value="KXA99273"/>
        <property type="gene ID" value="AKJ40_03520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="249" mass="26901" checksum="845F54353340CD77" modified="2016-07-06" version="1">MSVQAIGGSLGVGLAPFVLAFLASIYGWRTPLQILAVAGLPFLLFFLLRTEETKGTKPGRVERSFPKLSLAVAFAIFFFLRAFVFKSITTFLPTYLVEVKGFSLGLGGFTTSILLLPGVFTLPVAGVIADRFDRVLIVVLSSLSSALVLFLVVTYFPSGVLLYVLLISLGVFLYLSFPAILSLVKEVSPGDEYGRTFGINFTMTAASGTVAPVIVGYIGDLFSLGFAFRFLPILLFIAPFSILVVKNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYP7</accession>
    <name>A0A133UYP7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000059">
        <property type="protein sequence ID" value="KXA99287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99287">
        <property type="protein sequence ID" value="KXA99287"/>
        <property type="gene ID" value="AKJ40_03510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009620">
        <property type="entry name" value="UPF0236"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06782">
        <property type="entry name" value="UPF0236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="201" mass="23208" checksum="7FA4169F680C5252" modified="2016-07-06" version="1">MKKTTIKITIEHENLNLVGLIDQVKGLEREIVEKVIRDVEKEEVESLCGGEYERTRYQRHGSKLRSFKTSVGPLDLDLTRVRDKETGEVFTPVEEALAMPKRKVILEDVSLELIEQISKLSYRKAVETVQELSHSNLSKSTLWRRVQELEIEAKLRSDADVILVDETKVHNQGEEPFNYLHFFLGYNTEEEKYSLLSAGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYR5</accession>
    <name>A0A133UYR5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000057">
        <property type="protein sequence ID" value="KXA99319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99319">
        <property type="protein sequence ID" value="KXA99319"/>
        <property type="gene ID" value="AKJ40_03395"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.872"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="154" mass="17610" checksum="81B4B73D1552C164" modified="2016-07-06" version="1">METLIVYKSVHHGNTEKVAKSIAEVLEADLCEPEEFEVKELRGKDLVGFGSGIYNISFHESILELLEELPEMESKKAFIFSTSGLPRIPIVHDYESEVKEKLTEKGFEVVDSFSCRGHDTYFPVFRLFGGIHKDRPNEEDIDKAKKFAKQLIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYR8</accession>
    <name>A0A133UYR8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000057">
        <property type="protein sequence ID" value="KXA99321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99321">
        <property type="protein sequence ID" value="KXA99321"/>
        <property type="gene ID" value="AKJ40_03410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="349" mass="40382" checksum="CCADC1652DBAA7AB" modified="2016-07-06" version="1">MPFLTSFAFYLFPVDVGTTRNEFEVSFWAEGVPPSRERVLEGPGRPSELIYSENIVSETDIEILSRHNSKVSLAIHQDMLRENSPAEKVVKKMNQGNVPVQAWLLTHPENYYWANSLNYHIFNDLYDKFIDWRKELNFHGLVLDQELDVREPGKYLTKTMRRLYRTDIYEKSVESYKQLIERISNQKKAILTTWGIPCLDDFLDSDTSLQKMLGVSAVPPETWDVHSFQVYRVIPYRTIRLDLGPYLVYSYSLTAREILGDDVAIGLSHAGYLGYSDVSGIVKDVRLVNALGLSEAQVYSIEQVKRFFGPEGLEKILEEGKKPKEQVTIRYNPIVPLWRFSITFFDLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYW1</accession>
    <name>A0A133UYW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000053">
        <property type="protein sequence ID" value="KXA99386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99386">
        <property type="protein sequence ID" value="KXA99386"/>
        <property type="gene ID" value="AKJ40_03245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="67" mass="7299" checksum="739741440B414457" modified="2016-07-06" version="1">MVGVGICTPVQIAPRSLFSPKRVDGPHGIVAIVETEAIVEIREALIDEIKNIEGMKETTTNLIISKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYX9</accession>
    <name>A0A133UYX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000052">
        <property type="protein sequence ID" value="KXA99402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99402">
        <property type="protein sequence ID" value="KXA99402"/>
        <property type="gene ID" value="AKJ40_03215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="193" mass="20940" checksum="7D34C98CDE36CBC9" modified="2016-07-06" version="1">MLSFEKKELRDITISVCVLAVAVSGIGPNWRGLGRILVNLVSVSLPLVAGFFIHEMAHKAVAQNYGYRSFFQMWIQGLLFALIIGILSSGRFLFAAPGAVMIRAGHASIEENGKISLAGPLANLGVASLFSPLTLFSGLIASIGHFGVFINLWLALFNFLPIGPLDGRKIFDWKPKIGIVMLILIAILVFFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYY5</accession>
    <name>A0A133UYY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000053">
        <property type="protein sequence ID" value="KXA99389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99389">
        <property type="protein sequence ID" value="KXA99389"/>
        <property type="gene ID" value="AKJ40_03260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="64" mass="7125" checksum="0E2831B279745219" modified="2016-07-06" version="1">MTRLKGRVSLHFATSQGVREVKTGGYRDHGEKTKTADGTLTSPIERIVGIDDDYVFIPPDLQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYY8</accession>
    <name>A0A133UYY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000053">
        <property type="protein sequence ID" value="KXA99391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99391">
        <property type="protein sequence ID" value="KXA99391"/>
        <property type="gene ID" value="AKJ40_03270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="107" mass="11553" checksum="DCD4E0045F78C54D" modified="2016-07-06" version="1">MGINPNKRRTKEGSGLMAFALLGALIAVKLFGMSGFFVMNIQGKEFPDLIVWFVFSLIGGTIIGRVVTIVFIELANVTGIDFTGLWAFCSAVSTLALFIAFAKELSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ18</accession>
    <name>A0A133UZ18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000050">
        <property type="protein sequence ID" value="KXA99438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99438">
        <property type="protein sequence ID" value="KXA99438"/>
        <property type="gene ID" value="AKJ40_03150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="72" mass="7798" checksum="07C02775D55A30B4" modified="2016-07-06" version="1">MTDKSEGKLPSGIVKFTIARDELKNILSKKYNVDVESFSAGEEGVTISLQTSGKGELEEEAEEKGETNISGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ73</accession>
    <name>A0A133UZ73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000046">
        <property type="protein sequence ID" value="KXA99494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99494">
        <property type="protein sequence ID" value="KXA99494"/>
        <property type="gene ID" value="AKJ40_02980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.723"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="104" mass="11049" checksum="77BBF29FBBA79245" modified="2016-07-06" version="1">MEPTLKEATPGDIFMALPGRIVTGLRESLDQLDQIGPGTASNSTLLYAPEVKFYARTIGVGRKMQTKIRNIFVAGDGAGVSRDIVNASATGILAAREIVEESRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ86</accession>
    <name>A0A133UZ86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000047">
        <property type="protein sequence ID" value="KXA99477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99477">
        <property type="protein sequence ID" value="KXA99477"/>
        <property type="gene ID" value="AKJ40_03025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="70" mass="7972" checksum="BE2C384CAB8456CB" modified="2016-07-06" version="1">MIPMDLWKIGFALLIIGIAIPIGYGLYQFVLTSIEWYWRISILFIIAGIVTLLASAVQDKLRSTPPEEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ98</accession>
    <name>A0A133UZ98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000046">
        <property type="protein sequence ID" value="KXA99499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99499">
        <property type="protein sequence ID" value="KXA99499"/>
        <property type="gene ID" value="AKJ40_03005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="191" mass="21733" checksum="66D30948B73DD915" modified="2016-07-06" version="1">MDEGEIQSYIAKTRGANTHSSKASLFSKLVESLFGGEVDVALAPDVFPELEEHLIAEKGTLAVKKEEDTPEPNLIIEFRTTKLDPLRSGEIIERAKDQLRRFAYAIWRERQPELRCLLTASDGVHNFVYRPSLKGDLDSVDLEGVSPFTIDKKLREIIDLEEISRQDFSRGDPERVCKWLERIIFGRLSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZG7</accession>
    <name>A0A133UZG7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000042">
        <property type="protein sequence ID" value="KXA99571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99571">
        <property type="protein sequence ID" value="KXA99571"/>
        <property type="gene ID" value="AKJ40_02845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="180" mass="20731" checksum="FD74881F4E5312E0" modified="2016-07-06" version="1" fragment="single">MILKSPDPIRGLEDPTQKIIGKQKYRFNGRKERERFKLCWSARSVVYPELVMKQRPNAQYEPVQLLSFLTYAALTNDFVNDAAENYPLPEDEAPHPNTVFYRTKKLSVDEILDQFNSAMERIIEVAREKGALEGKLDLAIDLTDWRYYGDKNDPMVLRVKPKDGTTKAFVLATVYVIVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZH1</accession>
    <name>A0A133UZH1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_02825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000042">
        <property type="protein sequence ID" value="KXA99567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99567">
        <property type="protein sequence ID" value="KXA99567"/>
        <property type="gene ID" value="AKJ40_02825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="320" mass="35670" checksum="D4C7E12F6B9AAC70" modified="2016-07-06" version="1">MHVSFEVRRGEIFGLLGPNGAGKTTTIRMLCTLLRPTEGTARVAGYDVVDEDDQVREHIGLVSEEMIMYDRLTAYENLKLFAKLYDIPGEILDQKIGELLDLVKMSEWRDEQVGRFSSGMRQRVNVVRGLLNEPEVLFLDEPTLGLDPQSTAEIRGLIEQINGGRDTTIVLTTHIMTEADALCDRVGIIDKGKIAALDTPSVLKRKVSGRSSKVLELEVPGLDEQLLSVVESLEPVQEVTMESSSRLKIIGEGNDVFDRVIDAVRSKGRKITSIKDREPTLEDVFLELTGRELRDQVSEKVETTRRGGPHGGSDRSRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZJ6</accession>
    <name>A0A133UZJ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000041">
        <property type="protein sequence ID" value="KXA99579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99579">
        <property type="protein sequence ID" value="KXA99579"/>
        <property type="gene ID" value="AKJ40_02810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="74" mass="8399" checksum="9EF18EA758DB87F0" modified="2016-07-06" version="1">MGEKSEKTKFTTVSIPIPLFEKLKEQIEGTGFNSVSSYVGYILREIVAEKGKAPFTEEDEEKIRKKLKALGYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZP0</accession>
    <name>A0A133UZP0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000038">
        <property type="protein sequence ID" value="KXA99650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99650">
        <property type="protein sequence ID" value="KXA99650"/>
        <property type="gene ID" value="AKJ40_02675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="67" mass="7573" checksum="6B2A1B3F87C16AA4" modified="2016-07-06" version="1">MRRAGFPRPKGSSKRLCMGMNLNSNYNYENNQIKALLKNSPLKKFTQGREVETGKTQPPGLSTEMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZP9</accession>
    <name>A0A133UZP9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000038">
        <property type="protein sequence ID" value="KXA99654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99654">
        <property type="protein sequence ID" value="KXA99654"/>
        <property type="gene ID" value="AKJ40_02695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="444" mass="51498" checksum="1D1253EA9649BEA2" modified="2016-07-06" version="1">MKMVFDKLKSIFGGGGEEEEVEEGREREREKLSLEEVRKRIVDRKSHPLQEIEKDYQPILEKVSNIRGKIESLNKDLVGAEPGGEVHPNIYKSAKEGKRLLTDKADRAVEKMKAPQGPTWNGLLDLNESLKGAVNLLRNARAAHGRQVGAVFENEMSRLGRLTDSLQSVSRELDDSLRKGKATVDDLDETMEKIKERKNLLGRKNDLEKKLGEFRGKKEEIEGELDKERESLASLEKSERFEELEEVKDRIEELTRKKEEIRKRIGSKISELARPLRKMSKMIERDKHMVSSTVLEAIDLYQKDPVQTALEEEEGLPKLNAMLQELESVLEGEMKLGEREREKRLEEVQDIIENEKIEKLREDYHRTETKIDKLKKKRKKSPLLEKKEKLEGSIQSKKSEKSEIEERIEKKEEELEEVSEQIDEKSLEIRERVESALNAQVENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZQ5</accession>
    <name>A0A133UZQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000038">
        <property type="protein sequence ID" value="KXA99649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99649">
        <property type="protein sequence ID" value="KXA99649"/>
        <property type="gene ID" value="AKJ40_02670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="93" mass="10769" checksum="0FB780FC0484F646" modified="2016-07-06" version="1">MKTTEAVRIPQKGKFIVSFSLDEPEGRKENFSSIMSPLPLLAMIFRSEKKNIPLYPPIFVVKHCSPLKRCFVDCTNQKDQMDVRKENITVRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZS3</accession>
    <name>A0A133UZS3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ORF">AKJ40_02620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000036">
        <property type="protein sequence ID" value="KXA99681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99681">
        <property type="protein sequence ID" value="KXA99681"/>
        <property type="gene ID" value="AKJ40_02620"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.599"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="215" mass="23491" checksum="28505D67C05C4470" modified="2016-07-06" version="1">MVKVKVCGLTSAEDAQMVCNNGADFVGAIVDVKVPTPREISPTKARKILEIVPEDVEKVVVTMPENVQEVKNLEKMIDSDYLQIHSHLSESQLREIREETGRKIIGVTSIPQNSPEPEKIINRAKRIGEATDLLLIDTRGEGGGTGKTHDWEISSKIRDSLKTPIILAGGLNPSNVGLAIEKVKPFAVDAASGLESDPGRKDSRLVRKFFDKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZW5</accession>
    <name>A0A133UZW5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000034">
        <property type="protein sequence ID" value="KXA99724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99724">
        <property type="protein sequence ID" value="KXA99724"/>
        <property type="gene ID" value="AKJ40_02545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="122" mass="14030" checksum="054510B29FF18CD3" modified="2016-07-06" version="1">MEGRIMVVDDVPGVLKLTKRVLESEGFQVITADSGQKALKKLRKKEVDLALIDVFMPKMDGRELIEKIRDDPSLKDLRIALLTIAKSWEVEKDKLEKLGVQDFIQKPFDNKDLIQRVRNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZX0</accession>
    <name>A0A133UZX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000034">
        <property type="protein sequence ID" value="KXA99722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99722">
        <property type="protein sequence ID" value="KXA99722"/>
        <property type="gene ID" value="AKJ40_02535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="59" mass="7147" checksum="89F77EB5B2DC374E" modified="2016-07-06" version="1">MKVWLINLFNALIFTFVTIYWFFKHLEDTFGIIIFIIAGFLFYLLAVVNWRKDKQVNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZZ6</accession>
    <name>A0A133UZZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000033">
        <property type="protein sequence ID" value="KXA99741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99741">
        <property type="protein sequence ID" value="KXA99741"/>
        <property type="gene ID" value="AKJ40_02515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="186" mass="20183" checksum="2C470D604060FE58" modified="2016-07-06" version="1">MPWWDPLIALGYPGIFVLNFLGASSIVFPIPYTVALLVAGTSHSFNPLLLAAVAGLGSALGEFVGYGAGYAGRKVVGGDYERKFEAMLKIFERYGTPAIFLFALTPLPDDLLFIPLGLARYSFWKAFIPCVAGKFLMALILVYIGSAAGWAFGTNWITALITGIVLIVIIYAVLRLDWVKLADRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V019</accession>
    <name>A0A133V019_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZnMc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000031">
        <property type="protein sequence ID" value="KXA99780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99780">
        <property type="protein sequence ID" value="KXA99780"/>
        <property type="gene ID" value="AKJ40_02435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.553"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043725">
        <property type="entry name" value="DUF5667"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18915">
        <property type="entry name" value="DUF5667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ZnMc" evidence="6">
        <location>
            <begin position="334"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="508" mass="56694" checksum="50D16B00D310F131" modified="2016-07-06" version="1">MLNEQFGIATIASAVVVLAIAGGAVGIPVAVDSAVDQKPGDPLYGLEKAGESIKGVFVREDQDWHLERAEERVQEFRSVAGNGNSEKYRGVLDEAGERASEAMKKSGDVEGLERAAQTIRRNIQVLENVKNQVPENAKPAIDRAITRSRMQVKALTQTSEEVEDGKIPPGRLKEELENNVESIENLIDALDNKELPPGILKEVLENREITLDNLENIIDGRDLPPGILKEILSGMDVPKEELEEFLKDKDLPPGIEKEILEGDDSEDDEESEEDREEEDEPEEDDEEEETEEEPERFVHEEGELPEWAPGKPPWAGEDDEEEMEEDEGFELLEDGVKITNPPANYKVNPAAYEDLSTENVVREIKEAFETWDSHTSTELFDNNVDVTDKSGFERDGENVISFAPMEDSEEVAITEVWYENGEVLEFDIVLNSNVDWGIDPDGEGPATINAYDIQNIATHEAGHTLALQDIYDDDYANLTMFYRSEIGSTNKISLENGDINGLQTLYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V042</accession>
    <name>A0A133V042_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000030">
        <property type="protein sequence ID" value="KXA99809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99809">
        <property type="protein sequence ID" value="KXA99809"/>
        <property type="gene ID" value="AKJ40_02395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="152" mass="17076" checksum="4C15E0050795D4E0" modified="2016-07-06" version="1">MLIGENILKHLKAIATGIKYLFSSKRQTCSYPAARQKVNERYRGMIKFNGELCVSCGICARVCPANAIKLRTDVKEEPSLDYARCIFCGFCVESCPASALENAPLHDLVYTNYDQQFFEPEELTGADKDPYEVPDGVVEVKIDEDEGFLYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V044</accession>
    <name>A0A133V044_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_02385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000030">
        <property type="protein sequence ID" value="KXA99812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99812">
        <property type="protein sequence ID" value="KXA99812"/>
        <property type="gene ID" value="AKJ40_02385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.495"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="5">
        <location>
            <begin position="114"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="364" mass="41260" checksum="F44BE9CF9A4B0DFB" modified="2016-07-06" version="1">MTLFFGPQHPGSGHLRFDVILDGDVIVDLIPDVGWVHRGVEKIAETKKFVQAIPLVERPGLPDSANMNIGYVRAVEEILEIECPARARYIRTLLCELSRIASHLYGIGIFGNMIGSSTVYMWSFSDREIFIELLQEFTGARLTYSYFLPGGVRGNPPQDFEEKVERGLSYFENRVSDYRSLVFDNPIVRGRLEDVGIISGEKAKELGITGPNLRASGVGYDVRSFVDYGAYRELDFEPALRREGDSFARLMIRFDEIEESIRLIRKSLEKMPKGKIMHEKTRSINNLITMNMPEGWAFSRVECGRGELTYFIESDGGDKPNRMRLITPSFRNLVAFREVVVGHRLADLPAIYGSLDYFPPGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V084</accession>
    <name>A0A133V084_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000028">
        <property type="protein sequence ID" value="KXA99858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99858">
        <property type="protein sequence ID" value="KXA99858"/>
        <property type="gene ID" value="AKJ40_02320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="34"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="186"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="324" mass="35149" checksum="FED38F8990E165D7" modified="2016-07-06" version="1">MFLTRGQGRLFPILIENPMDNKQSWCSMIGGSFTGATLAVLGAICFGVNILLVRKITVTGEALDAVMATVWMNVIVFSLLSFIFYYPKFEFTRVSLFAFSFSGLLGTFLGRLCWYSGTKEIGASRTTPITQANLLVATVFSVLVLGELVTLGHWIGVCALLGGVIIVSYEIESDDDKSSFGLDLRILLPLGAMTLFGLEAPLGKIGLLEETPVLAGLALKSFAAFLGLTGLFLAKGDSPLRPFRAEQKNLYILSGLIQTTGFGLVYLALSISRVVVVVPFRSMTPFFVMILSYAFLRRLEEINKYIVLGSLLVVGGATVVGLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V089</accession>
    <name>A0A133V089_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000028">
        <property type="protein sequence ID" value="KXA99857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99857">
        <property type="protein sequence ID" value="KXA99857"/>
        <property type="gene ID" value="AKJ40_02310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="112" mass="13081" checksum="2D61BE41121D68B7" modified="2016-07-06" version="1">MSSKKIPDFSIEKSEEYREIHLDGVFGGLNPNGAKMVIYTEEHVPKINPRGKPGNMELDQIVRELQTELHMSPVQFKSLFNWMKKHLEKYEEKFGEIEIEAKGEERPEKMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V093</accession>
    <name>A0A133V093_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OrfB_Zn_ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_02325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000028">
        <property type="protein sequence ID" value="KXA99859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99859">
        <property type="protein sequence ID" value="KXA99859"/>
        <property type="gene ID" value="AKJ40_02325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="321"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="410" mass="46749" checksum="4626DF64803A8C3D" modified="2016-07-06" version="1">MKLTFEVPVSNPTRRKQCFLERVSDKFPKMVQWFLTVFEREGLDFGGKSLNRARKIVKELCYPTLERDSKYNCKGAVRFPHSHYYDTVITEAIQKWNSFLTWKEKSGTVERFPEIEHYAPVLDSQMFELDLEKGWITVKTGRGQENIHIPITVPNKSHYRGLDEARISSIRFEKKSKGFVFLLVQKSDSPETPSPSELGEGSVMGVDLGERNLASFVTIRPDSQQVEIENAHFEKGKKAKKLEYREENIRKTLQMRGRASEIPKRKWKTTNKKKNLCEKIANKIRKIAKKNNVKAVFVGDLKAPTPKNSGALSKRLNNFPFAKLKEAIKRHLNKAGIFVKTIYEGKTEKHDLGTSQKCHKCGSEGERYKGKFSCPSCSLKDYNADLNAAINITERGIKSLGKTEGLGAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0H0</accession>
    <name>A0A133V0H0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_02195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000025">
        <property type="protein sequence ID" value="KXA99936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99936">
        <property type="protein sequence ID" value="KXA99936"/>
        <property type="gene ID" value="AKJ40_02195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="237" mass="27311" checksum="DA180351AD05E0E3" modified="2016-07-06" version="1">MTFLKVSNLEKRFEKKEVLKDLDLFIEETEVFSLLGPNASGKTTLLKVISNIYRPTSGKIEVVGAEVQMNPNSVRERVGFVGHETYLYPELTARENLKFYTMAYGVRNQEEKIKEKLKLVGMYPRMNDTVKEFSRGMKQRVSIARALIHEPKLLLLDEPFTGLDFEARKVFVNIIEDFTDESGPVLMSSHDPEIAWRVSQRVGILEKGRIKYILSTQKNEYSNLEDAINSIKWKVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0J7</accession>
    <name>A0A133V0J7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99968">
        <property type="protein sequence ID" value="KXA99968"/>
        <property type="gene ID" value="AKJ40_02100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="186" mass="20721" checksum="80E82508C81A041E" modified="2016-07-06" version="1">MLKEYVTSLRWYLALSSTLFLIMSILGYFFGGEFSYLWESLQETFEGFIDLHPLFLLVFIFVNNSIASIVSILLGVILGIVPLLASAVNGLIIGLVGFHILQTEGLKFFVLGIMPHGVIELPMFLLSTAIGIRIGVEAIKKILGKESAVKKRLKNDLEFYAVRILPLLFLAALIEIFITPSILLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0K6</accession>
    <name>A0A133V0K6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99976">
        <property type="protein sequence ID" value="KXA99976"/>
        <property type="gene ID" value="AKJ40_02150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="168" mass="19694" checksum="E1ED5CEDF1F8C9BB" modified="2016-07-06" version="1">MELSEEAEANLARFERRITGRKWSSKTTRQYLLWAERLLLWAETQGELDSAEGVMFDFDEYLSSLPEDPPWSGNKREGEGFSYRTRIQALSAVKLFLELMVGARIDRDVDEFVSGEEPEFEPEWYTKEETEKIFREAENCSYPHCLVMTRLGYDCILRVRDGMLIFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0K8</accession>
    <name>A0A133V0K8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99972">
        <property type="protein sequence ID" value="KXA99972"/>
        <property type="gene ID" value="AKJ40_02130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="101" mass="12062" checksum="DCCC48B9974741E1" modified="2016-07-06" version="1">MISKIAELVGEEITDRTSKKFEDLEEALEHLYWWEEEFSVEETEDVITSRGICPIYERYSDWCEDGCVSFAEEIAEEYGYSVERAKRRPDNEICEFKFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0L2</accession>
    <name>A0A133V0L2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99970">
        <property type="protein sequence ID" value="KXA99970"/>
        <property type="gene ID" value="AKJ40_02115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="67" mass="7633" checksum="A87A02DDF3AACD21" modified="2016-07-06" version="1">MSILNRRSSEAERCGIRSRRRGWKMKRKIELTMEINLEEIAKKRRGAPAPGGLPSRTGVRPGQPTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0N6</accession>
    <name>A0A133V0N6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99975">
        <property type="protein sequence ID" value="KXA99975"/>
        <property type="gene ID" value="AKJ40_02145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="83" mass="9547" checksum="0ABA85FCB6A0246C" modified="2016-07-06" version="1">MNEGEDLRERGILQVGRLARIYLCLRVSPGEWKSIPQIAKETGLSKKTVRNALGKLANLPRIERRKREGKVQVRFRRLLPPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0P0</accession>
    <name>A0A133V0P0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000023">
        <property type="protein sequence ID" value="KXB00001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00001">
        <property type="protein sequence ID" value="KXB00001"/>
        <property type="gene ID" value="AKJ40_02025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="121" mass="14502" checksum="29B66859D0175CCB" modified="2016-07-06" version="1">MIFRTSSPSDCEATCPRVGGLEKKVEELKEENTDLRQEKREVEKKLNYWKERHARLWDKYRKVTSSNKPSSKKTRYEKEEEKRRKRERKKRRKGDEDTGGEEEDEEKGKPGRKPESRSSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0T5</accession>
    <name>A0A133V0T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000021">
        <property type="protein sequence ID" value="KXB00059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00059">
        <property type="protein sequence ID" value="KXB00059"/>
        <property type="gene ID" value="AKJ40_01930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="178" mass="20184" checksum="079BCC68ED1800CF" modified="2016-07-06" version="1">MEKILVWLTENLSPGIYFREEEAKAIIGSVEDPALLIDEKHTIRSYNEPLIELLNSSDEGSGGSKCFEVIHKGEEPIDNCPLEDSIEGDSVESEVISEPQLGDGYYLVKAYPLHMGKDSELYLHLVVEIPTECPDCGGELEKIAEDWPDDWFYCPQCTYTERVEERIPKRSDNVKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0U7</accession>
    <name>A0A133V0U7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000022">
        <property type="protein sequence ID" value="KXB00041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00041">
        <property type="protein sequence ID" value="KXB00041"/>
        <property type="gene ID" value="AKJ40_02020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="157" mass="18115" checksum="BC487CFC69A33D29" modified="2016-07-06" version="1" fragment="single">MKVETIHKINEGELDGESTLDFALSHAEKVKEDILQSWFKKGASRNDKALNEFLLIEIIRSILGAEPRGFFVLLSVSRRLRALLDLKYVDDLERYKYFKRKIKNLKGRLREISKRSLGTEGDESFAFDSSIVTADLNGYRNGKKVKKGEYDARFTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0V9</accession>
    <name>A0A133V0V9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000022">
        <property type="protein sequence ID" value="KXB00036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00036">
        <property type="protein sequence ID" value="KXB00036"/>
        <property type="gene ID" value="AKJ40_01995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="84" mass="9621" checksum="13F89E7C73AEDE51" modified="2016-07-06" version="1">MKIKIENSTQLRELRLKRNIEVELPENSTVEDLLLELGLNDLMNEDETLSKYMVMLKNKKTVRSTDTELKDGDTIRLLPMASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0Z9</accession>
    <name>A0A133V0Z9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000020">
        <property type="protein sequence ID" value="KXB00091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00091">
        <property type="protein sequence ID" value="KXB00091"/>
        <property type="gene ID" value="AKJ40_01880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="349" mass="40307" checksum="FE7F306DDED378F8" modified="2016-07-06" version="1">MIDENRKDRKVVEINQRGCEILGYDKEEIIGKDWYENFVPERVRKDVLEDTRKPLMNGRVEEGKKYENPVLTKDGEERIISWENTVLRNDNGKIIGTLSSGMDVTERKKAEEELRKSEREKSLILESSPNLIVYQNLDHEIIWANESAGESVNEKPSDLVGQKCYEIWQDREEPCENCPVEKSWEKGEVEREEVESPDGRVWLITGGPSRNEQGDITGAVEIILNITERKKAEERKEFLNTLLRQDLGSKYQIIQGYLQLLEDKADLSDEPEKYVEKAMKAGREADEILGLAKKLEKIEETEWTGEKDIAKVLEHVTDDIFDLVGREGVEIEKDYIHILRGINFGLTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V133</accession>
    <name>A0A133V133_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000018">
        <property type="protein sequence ID" value="KXB00154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00154">
        <property type="protein sequence ID" value="KXB00154"/>
        <property type="gene ID" value="AKJ40_01785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="154" mass="17623" checksum="6B1BFE42E711E87F" modified="2016-07-06" version="1">MKKGLILGIVASIIFDEDILLKKYEEDKRKEKEDQFLKPDTTLSAALNKLPAVWINAICKKLGIPVEGRKREKAKKIAGKLEEDLEEIVERLPSDSLDAINFILERDGWVKSGAITRKFGKEDPGWFWASPTSFFSLFLIKGSPFWLSILNFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V174</accession>
    <name>A0A133V174_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diadenylate cyclase</fullName>
            <shortName evidence="6">DAC</shortName>
            <ecNumber evidence="6">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="6">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dacZ</name>
        <name evidence="8" type="ORF">AKJ40_01795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate cyclase family. DacZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="6"/>
    <dbReference type="EMBL" id="LHXU01000018">
        <property type="protein sequence ID" value="KXB00156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00156">
        <property type="protein sequence ID" value="KXB00156"/>
        <property type="gene ID" value="AKJ40_01795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00840">
        <property type="entry name" value="DacZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014499">
        <property type="entry name" value="DAC_DacZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="7">
        <location>
            <begin position="120"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="287" mass="31115" checksum="363F6C90B3429169" modified="2016-07-06" version="1">MTIQEHLVSSATELAKRVEADSILVLTESGKAYELIREKFEDLDVIALTPNEETYKKLEQNPESKVIDFSVRDSTRTGQIRHAVWRGIGTDLLSPGDLLVCLTGEMGAKGGIDTISVYLVSEAESTLAGLIESDPVMNAVVEIATELGWAGREGEPLGATFVVEDTEKVMNLSHQLGLNPFRGYDDINVTDEDNWELIKRYAFLDGAFIVDRSGNIVAVGRYLDADSDIKVPSGLGTRHIAAASMSAATHTKCVTVSGTDGVIRIFSNGKIVGKIDPRSKMLEEVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V175</accession>
    <name>A0A133V175_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00194">
        <property type="protein sequence ID" value="KXB00194"/>
        <property type="gene ID" value="AKJ40_01735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="71" mass="8314" checksum="5F6193DADED4E4A2" modified="2016-07-06" version="1">MCYLALLTKRLITEGSYSNKRLKELKSLKVHELNTDNETMWMRNETSHEQQEILESLNLQKPPKITPETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V177</accession>
    <name>A0A133V177_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alba domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00198">
        <property type="protein sequence ID" value="KXB00198"/>
        <property type="gene ID" value="AKJ40_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alba" evidence="1">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="88" mass="9684" checksum="C2BD3BEC8B9BD7A3" modified="2016-07-06" version="1">MKENEIRVGNKENSAYLNAVLHIFNNNSGSTIHIRGLGSQGEKAIEVAEKESELVPALDFDRIESIKVDGVQGHDAILRSKGGEPRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1D2</accession>
    <name>A0A133V1D2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000015">
        <property type="protein sequence ID" value="KXB00258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00258">
        <property type="protein sequence ID" value="KXB00258"/>
        <property type="gene ID" value="AKJ40_01595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="166"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="363" mass="43095" checksum="ED8D2B84ECBBD862" modified="2016-07-06" version="1">MKQVNIEKINNGTWDDAVLRDFVFSFAENMKEKILQRFYREKRGSEEKKFAEYLLVELVRTLLCMPPVTFYYYLKHDADLRELLGLEKLKTIGNYEDFDRKRKYLKFHLDRIVKRNLKTEAGSFFVLDLTIGEADVNKLRKGKAIKEGLIDSEFLHSLTKGTVVGFQVAYLINLSKLSFEKLKIYSKHAEKKRIWNEMVNDELGTKQGKIKTVLADAGFFAYDNYLDSIRLRVIPVIKARSNCKEKLMRKLENCDSNLFWFGKKYRTQLKELLEEFEEILQKTIKWVENYDDFKDLRGQIEHIFKAAKMIFGMNEMHVYYRKHCFWKAFIILYMSSLLCQFINLNGINKNRAIPLLAQNRHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1J5</accession>
    <name>A0A133V1J5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Paired_CXXCH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_01565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000014">
        <property type="protein sequence ID" value="KXB00302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00302">
        <property type="protein sequence ID" value="KXB00302"/>
        <property type="gene ID" value="AKJ40_01565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010177">
        <property type="entry name" value="Paired_CXXCH_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09699">
        <property type="entry name" value="Paired_CXXCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="4">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="378" mass="41548" checksum="1A8E65060CFDFF9F" modified="2016-07-06" version="1" fragment="single">PHGNEAPEVNLSAELCGNCHTDSHHPTIDEWNEYESEDFDSETEASHSEPTESYAKSEGCVACKSTDGAIKNLEKSGVFNLNEEELPSPDVVKEWRITCVACHEPHAAELRVEDESKLCGNCHNSEMEKLEPDGETTTVHHSQWGMYKDSDWTTGRGHPQLGCPNCHMATRSIDEEAGIPANTGHTFDVNAELLGSEYLTGEVKCENCHQDLATTIEEKQAIVEEKISSIESLKEEATSAIKAENNSELVSTYNNGLFYLSFVEHDASTGIHNFSKTISTLQKSYSMLHQAKNGAEKLTLQSELSDKEDKVSNLQSELSDKEDKVSNLQSEVSSLQSDVSNLKSKLKDKYGLPSVIGALVIGLIVGAVAVWLSKRESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1N7</accession>
    <name>A0A133V1N7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00368">
        <property type="protein sequence ID" value="KXB00368"/>
        <property type="gene ID" value="AKJ40_01380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="59" mass="7093" checksum="FCC2F3DA96023C8A" modified="2016-07-06" version="1">MKMSDGFEDMTEDENWRKDLDKPLDKRMEKFTDYLKFLAEHFGKASIESKNYIRGSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1P5</accession>
    <name>A0A133V1P5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00370">
        <property type="protein sequence ID" value="KXB00370"/>
        <property type="gene ID" value="AKJ40_01395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="253" mass="28037" checksum="3F6FC998E1517238" modified="2016-07-06" version="1">MVFKDDFDGSIIDSSYGQVGYRVFGQGKSVVLVHGAGGSYGFWSEQVGNLDCKIITVTLPGHGGLSREGDVSVEVYAECVDLVVEELNLDEPVVIGHSMGGAITLTYALIHDVEKIGLISTGARLPIRENLLRRSRENKEVIMEFVLNWGFAPGVDERIKEDFRRIMLNVSVDTLYQDLKACKDFDLRGDLDHIRAPSLILYGSIDKMTSPSLVRELERLPNSKSEVVEGAGHMLPLERPVETNSILNNWISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1Q4</accession>
    <name>A0A133V1Q4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00373">
        <property type="protein sequence ID" value="KXB00373"/>
        <property type="gene ID" value="AKJ40_01415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="138" mass="15410" checksum="6F9CE2B537EDC07A" modified="2016-07-06" version="1">MLNRVAEKADIDKPVNPHHFRHSRATFLANRLTESQMCEWFGWVQGSDRPSVRGTTAAFIFPGPLAFPLSPQAQIKKGGEPRSETHGGTSTPLQSSINTSKRDPIRTCRRDRFEVRIGLADLLLRDAEGLSGFCRSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1R5</accession>
    <name>A0A133V1R5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00372">
        <property type="protein sequence ID" value="KXB00372"/>
        <property type="gene ID" value="AKJ40_01410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.164"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="79" mass="9163" checksum="0509C64C9E65B967" modified="2016-07-06" version="1">MIFSGEEVIRALQKRKFVPVRQSGSHVILKYRSPVNPEDVRVVTVPLHDELNTSTLRSIAEQAGAKDFQKFKKWIDRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1R8</accession>
    <name>A0A133V1R8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000013">
        <property type="protein sequence ID" value="KXB00336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00336">
        <property type="protein sequence ID" value="KXB00336"/>
        <property type="gene ID" value="AKJ40_01495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="184" mass="21138" checksum="B6518AF89F54546C" modified="2016-07-06" version="1">MKKVEVIQDFPEVELVGRKLGPFKEGEEVEVRPWEASILEERDFARPVRDFSLTGIRKVLIREEKSSRLEELPSSFYRTVSREVRRLRERGEIEKAGEVEEAVESLVNFRIQKLARMIISSVDPGEIPAEEQVLANLLAQTLSFWEHSVGRVFEKNIDKEAGIHAKKVWRNIQGIVGEQADIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1Y3</accession>
    <name>A0A133V1Y3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00468">
        <property type="protein sequence ID" value="KXB00468"/>
        <property type="gene ID" value="AKJ40_01255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="336" mass="38168" checksum="AEE91BF6168E6428" modified="2016-07-06" version="1">MLDSYGISPTGIKSKGRVSNHAVLMGENFTCDGHFDRPIRVVTHAHSDHISGLKKSLTECELVIMTPTTQGFLKALYMEKYGDLEGVVALDYGESFQYRGEKITLYDANHIPGSAQVLVETREGDRLLYTGDFKLPGAWIVPADLLIIDSTYGKPSQTRYFQKRMEDIFVEFVKDKLVEESVNIYAYHGKIQEALKILRSNGIKSPAVMPEKIYEATKFCAKKRDIFGHFYSLGSQKGKKTLTKKHIGLFHKRKNAIDNSCFSVRLSGWIFDRPIRYFDKEYKVGLSDHSDFRRLMQYVEESDPKCVITDGSRGGSSKCLAREIRKKFKKSAVSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V252</accession>
    <name>A0A133V252_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00519">
        <property type="protein sequence ID" value="KXB00519"/>
        <property type="gene ID" value="AKJ40_01195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="158" mass="17139" checksum="237770A7A7DC7F1C" modified="2016-07-06" version="1">MIDIIVFTVLAVLAIVFSSLVVFHRSLVYGAVALGFLGMVNSSFFIILGFPFVGLFHLMVYIGATVVFILFTVTMLRSGPIIGISAKKAAVIVSLLAAVSIAFAFTPYSEGFTSTAYFSLQSFSQLFVEKYWFPIIVTALALATTLIEGITLARMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V260</accession>
    <name>A0A133V260_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00476">
        <property type="protein sequence ID" value="KXB00476"/>
        <property type="gene ID" value="AKJ40_01300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="180" mass="22068" checksum="B3AE53BC9110852F" modified="2016-07-06" version="1">MPKWCTHRKWAKRFLEREDSEHGEIENEPLIEFPNNFKFLFHDHDFNRRTWRDYDNRIMAYNTFGHKGLQIMDLHYCLDFLKEETDPQKIEQRLEFWKVKFLDTERNIYKFYPSVKDLARHLAGKSKHLSINKKIFKFIIVNFREILTDLTHEHGYSSDKLNNWETSCFNKLLEDLTTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V268</accession>
    <name>A0A133V268_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00521">
        <property type="protein sequence ID" value="KXB00521"/>
        <property type="gene ID" value="AKJ40_01205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="144" mass="16377" checksum="113142AE5DF558D9" modified="2016-07-06" version="1">MTPPQLFFNPLGPQIGGVSYSLAVILFLIIEGLAYFLASSYFIYRFAWKGRRLTIDIFKGFERGVIDKVYHEIIPRGVDIAVRKTFDDFEVSVLDSMYNEKLVSAILSIGELFDKTQTEKINHYLIAFMLGIILFLAVLMGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2B4</accession>
    <name>A0A133V2B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00582">
        <property type="protein sequence ID" value="KXB00582"/>
        <property type="gene ID" value="AKJ40_01100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="216" mass="23686" checksum="257D07485DBFF7F6" modified="2016-07-06" version="1">MNIGIIALGSHEENHGAALPPDTDAQIAEYIAEKTAAQTDMEFLGVLKSAYEFPEINTGNHDSLDQVIADLKNQLRKAEKQGFEGILLVNAHGGNQELSDHLGDIARETDLVIKMDSTVCKIEGPHAGTGELSIGSVLGITDETKVTDHLNSEKYPEVGFVGFDKAREKYEWAEEHANEIIENGVKIDPQLGEKLLKISIENSVEKIRDLKSEIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2F9</accession>
    <name>A0A133V2F9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP_bind_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00586">
        <property type="protein sequence ID" value="KXB00586"/>
        <property type="gene ID" value="AKJ40_01130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="47"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="294" mass="33639" checksum="FD4E8165DEBD64FD" modified="2016-07-06" version="1">MECSNCGKDAVIRINWKEKNYCVNHFKRYFLGHVGKVINKYGVSGRVMVAVSGGKDSSTCLEALTHFENIEVVPFHINLGIDEYSEKSLEVARQACEGIGLDLNVLDLKEKYGKTIPEINDQRDAKVCGICGMIKRYLMNRYADEKGYDYVATGHNLSDEVASTFNNLANVYLTPFRGLKPVLEEKKEYNLVARVKPLYFLKDRECLVYAETNNITFFSEECPLSSGSPTNELKEWLHKLDSERPKILRNFAKSFMRIEERMDTDHEELKRCDNCGYATATEVCRFCRVLDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2J8</accession>
    <name>A0A133V2J8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00659">
        <property type="protein sequence ID" value="KXB00659"/>
        <property type="gene ID" value="AKJ40_01030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="188" mass="21657" checksum="7787F1A39E52840B" modified="2016-07-06" version="1">MRNSQLREYISKTRSASTHFSKSRRFLDFVENIFGGKVEIGFAKEIFPELEKSLVNEQGTVAVRGEAGAPLGNLIIEFKTSKLDPMRSEEIIEKAKDQLRRCICILWKKHGQGLRYLLMASDGLRNFVYRPSLEGSIEDLEVGEEIHAGELDEKLRETINLEQIDEIDISKADSEHVYAWLERYLLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2K6</accession>
    <name>A0A133V2K6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_01040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00661">
        <property type="protein sequence ID" value="KXB00661"/>
        <property type="gene ID" value="AKJ40_01040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.933"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="232"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="553" mass="58627" checksum="751228393EB31AAB" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2M1</accession>
    <name>A0A133V2M1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00698">
        <property type="protein sequence ID" value="KXB00698"/>
        <property type="gene ID" value="AKJ40_00950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="78" mass="8660" checksum="DB6C347618AF2BA3" modified="2016-07-06" version="1">MLQHILLFVGIGFTNPFVPDFGTQFITATIIGTVVPKVIVSPLHCFLLKVPLLGAGICKFEQKLEDTGLWDKNISFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Q4</accession>
    <name>A0A133V2Q4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00737">
        <property type="protein sequence ID" value="KXB00737"/>
        <property type="gene ID" value="AKJ40_00830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="174" mass="19703" checksum="FF33FC2EB2508442" modified="2016-07-06" version="1">MGSLMFLALRIKLPKKVKRNLDKLEEGYVPYDGSAAKHKIPHVTVVPPRGIFGLEDWKRAIRGVENIPTEFKVTGFGSFWDSSKLGFWGNLNADIGIDSPHLTLFDCKENEREVKRALEEYGDLFEGYIGLRLEVSSLAVIERDKGIIYEAKAPSRQTSLQDILERPNHESDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2S6</accession>
    <name>A0A133V2S6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00731">
        <property type="protein sequence ID" value="KXB00731"/>
        <property type="gene ID" value="AKJ40_00800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="69" mass="8141" checksum="33E1A921642415FE" modified="2016-07-06" version="1">MNGLNEKDLEKIGREWGRLELVFYPHFEESRRWILRNQTDEGLGPEPRKEFEGASPEEVIEKAKKGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Z2</accession>
    <name>A0A133V2Z2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00803">
        <property type="protein sequence ID" value="KXB00803"/>
        <property type="gene ID" value="AKJ40_00500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038133">
        <property type="entry name" value="Ribo_III_sf_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021568">
        <property type="entry name" value="Ribonuclease_III_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11469">
        <property type="entry name" value="Ribonucleas_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="150" mass="16727" checksum="F6EC55DCAEF87D4D" modified="2016-07-06" version="1">MTFETFFSYSDPEEAFLDQNLAKLGDCLVNLIYSLARSVARETPDGAKAPNRVLSESLNKAGLRDLAPSRSDRHDLGDVAEAIIAYAWLQGKIDIEEAAEILSESFHGVNFDNRKKIFNAAEKGFENLLKTIAERISFEKEKISRNKAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V302</accession>
    <name>A0A133V302_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nop10</name>
        <name evidence="8" type="ORF">AKJ40_00435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00813">
        <property type="protein sequence ID" value="KXB00813"/>
        <property type="gene ID" value="AKJ40_00435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.357"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00803">
        <property type="entry name" value="Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023532">
        <property type="entry name" value="Nop10_arc-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="PTHR13305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="SSF144210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="53" mass="6122" checksum="650F1310BCA4162D" modified="2016-07-06" version="1">MKKCKNCGIYTLQEKCPKCGEETVTPHPAKFSPEDPYGEYRRKLKKEKMDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V312</accession>
    <name>A0A133V312_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L44e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl44e</name>
        <name evidence="4" type="ORF">AKJ40_00450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00796">
        <property type="protein sequence ID" value="KXB00796"/>
        <property type="gene ID" value="AKJ40_00450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="PTHR10369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="92" mass="10287" checksum="1E8A1C6A2087F7FB" modified="2016-07-06" version="1">MKFPKKIRTHCPKCNAHTEHKVQKESSGQARSNSWGQRQFKRVKAGYGGQPRPKQKGGPKVSDKAVIVLECTECGKKQVRTGPRTTKLQIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V315</accession>
    <name>A0A133V315_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00815">
        <property type="protein sequence ID" value="KXB00815"/>
        <property type="gene ID" value="AKJ40_00485"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.367"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="131" mass="14613" checksum="D5F9837C1CAFA9A1" modified="2016-07-06" version="1">MGKKKFPSLTVDIIIEKDGGIVLVKRKNNPFKGSWAIPGGFVEYGETVEDAARREAKEETGLLVELKGLVGVYSDPERDPRGHVVSICYSAREKGGSLHPDTDAADVKVFKEIPWNKLAFDHEKILKEYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V322</accession>
    <name>A0A133V322_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">csl4</name>
        <name evidence="6" type="ORF">AKJ40_00515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CSL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00806">
        <property type="protein sequence ID" value="KXB00806"/>
        <property type="gene ID" value="AKJ40_00515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00975">
        <property type="entry name" value="Exosome_Csl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030850">
        <property type="entry name" value="Exosome_Csl4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="PTHR12686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="68"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB00806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="193" mass="21138" checksum="8B1978D8A14E49D2" modified="2016-07-06" version="1">MEKEVKSGDFVVPGDFLATAEEFIPDEGVYEEDHNVYSTRTGIVLKDTDSKKISVHPKTGNPPILKKGDIIIGSVDQIRGQIASIAIAAIRGNEDRELSFSGDSIIHISNISDDYVENIEDELKPADIVRARITDVGKNSAKLSIVDDSLGVLVAYCSECRSVLEKKDSKLKCPNCGSVEKRKIANDYRQGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V323</accession>
    <name>A0A133V323_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00848">
        <property type="protein sequence ID" value="KXB00848"/>
        <property type="gene ID" value="AKJ40_00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017695">
        <property type="entry name" value="Se-dep_Mo_hydrolase_YqeB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03309">
        <property type="entry name" value="matur_yqeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="266" mass="28510" checksum="BE4FC4AD0C6C5985" modified="2016-07-06" version="1">MEVVIKGAGEVASGIAHFLFSKNLEILMTEIPRPTTQRRTVAFAEAVFSGETEVEGIKAEKATNIRDIHEILKNNKIPVLIDPEGEILDNFSPEVLIDGTMAKKNLGTDIDDAKLVIGVGPGFKAGKDVDIVIETAEEAEPGRIISKGGSYPNTGIPCDIMGYTTERVLRAPADGVFKSDREISDPVEEGDIVGKVDGKELRAGITGTVRGLVKDGLEVVEGQKLGDIDPRGLREFGISDRSIEIARGVWKAINDFGPANMNRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V327</accession>
    <name>A0A133V327_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gatE</name>
        <name evidence="8" type="ORF">AKJ40_00305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00839">
        <property type="protein sequence ID" value="KXB00839"/>
        <property type="gene ID" value="AKJ40_00305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.69"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="7">
        <location>
            <begin position="482"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="627" mass="69890" checksum="99F55B361F7037C6" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V337</accession>
    <name>A0A133V337_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_00375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00849">
        <property type="protein sequence ID" value="KXB00849"/>
        <property type="gene ID" value="AKJ40_00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="4">
        <location>
            <begin position="95"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="185" mass="20864" checksum="5E103B1FC5F9FBC7" modified="2016-07-06" version="1">MPRSFIAIEANEEVRNSLNEVQKELEQTGADLKLVRSENIHMTLRFLGDISEDRVGLFEDVINKASKTDPFQIRVKGLGVFPDPGFIRVVWAGVSEGSEKVTSLRREVDKELDKINHPPDDKEFTPHFTIARVKSGKAKSEINSIVENKSDEEWGIVKVDRIELKESELTSKGPIYTTLEKAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V339</accession>
    <name>A0A133V339_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00867">
        <property type="protein sequence ID" value="KXB00867"/>
        <property type="gene ID" value="AKJ40_00035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="230" mass="26268" checksum="FA99BB9652D1B1CD" modified="2016-07-06" version="1">MDKLGKFKDKIWEFRLWLSKKLWYGRDPDETMAKRFKLFLIVGISLIASGKFLHLAGFPIPNIEPIIPLIVVMGAFSLYMGKSEKWDRIRKYAGIIAIASVFVIDLIFWGVQKIYLFTWPGFIMILLIAKMKDLSFFDKFSDIAVEATITAAVAIILFDIFTAFGFWLLWRPLTLGALYGVFIAQIPFTFYHLGSLIFVPPVVGFGKMVSRVKMRVPVAVKAGAKARERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V346</accession>
    <name>A0A133V346_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00864">
        <property type="protein sequence ID" value="KXB00864"/>
        <property type="gene ID" value="AKJ40_00015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="327" mass="36991" checksum="A1D182B23811BAA1" modified="2016-07-06" version="1">MIKYDDVGSLPLPDTVDREGFERAFVNFEGWALDIYRDLLELKIDAGVQVPCYPQVRDMNGQFLKILNDSESVEEPYLVHEDNAVLPEFEALEMLDLNLPKMKICVTGPLELSVSEFEGRIYSDIMMNIARSLNRFIRKAESLKGFDIEVISIDEPSLGTNPSLEFDKSTFIEALNIVADTDRKLQIHLHSPTFYETVCRAEKVDIIDIGAAATPEYLDSIDPEILERYEKGIRVGVSRTDALSLSAEFNEKYNVNVWTDESAWNNFLEQVEPPSRIAERIEGVYNRFGNFLEYLGPDCGLGGAKKLELAKVILKNTTSGIERFLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V374</accession>
    <name>A0A133V374_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein AKJ40_00045</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00897">
        <property type="protein sequence ID" value="KXB00897"/>
        <property type="gene ID" value="AKJ40_00045"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.8"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="278" mass="29757" checksum="D16B734C13AC9F82" modified="2016-07-06" version="1">MRDPVVAGQFYAGSANGLRSQVEECFTDAHGPGEIPGVSKGPRKLLGLVSPHAGYPYSGPVAAHGFSKLAEDGKPESVIIIGPNHTGAGPDISFDPSDGWRTPLGEVDIDKDLRDSILDKVEMAELDSYSHSREHSLEVQLPFLQYLFDDDFQIVPICMKGQNVKSSEALGNAIGESVSSDVLIIASTDLTHYESPDVAESRDRKVIEKIEGMDWKGVVELVTEKGYSVCGYGPVSSTLLATENLGAERTELFKYATSGDTAGPSGEVVGYCSLGIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V378</accession>
    <name>A0A133V378_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-glucan phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00885">
        <property type="protein sequence ID" value="KXB00885"/>
        <property type="gene ID" value="AKJ40_00160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.35"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="555" mass="63344" checksum="5988139675C1F51E" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V394</accession>
    <name>A0A133V394_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartokinase</fullName>
            <ecNumber evidence="5">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_00115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="5"/>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00899">
        <property type="protein sequence ID" value="KXB00899"/>
        <property type="gene ID" value="AKJ40_00115"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.25"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="351"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="411" mass="44739" checksum="CEFFEB1E467B1DB4" modified="2016-07-06" version="1">MRRIVAKFGGTSLENGHLIRKAAKSVKKEVEKGDTEIAVVVSAMGGTTDVLISETRESTEGELSQEDLDAIMAMGEKTSAKIFAASLHSLGVKSKAITPDDPEWPIITDDSAGNATPDLKKTRQLVNKKIIPLMEENIVPVICGFLGKDEEGIERTLGRGGSDITAFLMGNCLNATDVILVTDAEGIMSADPQRIKNPKILERITAEELVDLARYGAKIVQHSALRYKDPNINAKVIHFRHGNLSKEGTIIEGSTPEKENTNVELFPKPLAMITIVGEGMQKTPGILVENLKPLKKSEINIFGVSIGPRSFSIYVTEEKSQEALELIHEIVAGSPVMRSATSESGVAMLVAESEKFIDTPGIISKLSDPLAEEGINVIEIYSSQASISFFVNWKDRDKAFELLKKSIREVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUS4</accession>
    <name>A0A133UUS4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_05015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000126">
        <property type="protein sequence ID" value="KXA97964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA97964">
        <property type="protein sequence ID" value="KXA97964"/>
        <property type="gene ID" value="AKJ40_05015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA97964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="238" mass="27394" checksum="D454BDE4DA319DCD" modified="2016-07-06" version="1">MCEKWHDPDLTRRDTTKFRFSTYTSHEAYKVYQDFLTEALTLMTTCEGTLEGIAKYLNISKHMVELGEHTLLDYLGDSGKDMIEVDGDLIVIYADFSGTAISKNSGMIMSKVGDEVAYQVCPTINYMTAWNFVKRLKKRLETSDDTTVVFVTDGGLAWLDPIQSLFPDAVHIRQFHSKNTRGIIYVHLRHEGEPYTVRFPWDAVLEEGEASEDARRMRERRKLDESSRSEGERTNRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UV34</accession>
    <name>A0A133UV34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000122">
        <property type="protein sequence ID" value="KXA98073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98073">
        <property type="protein sequence ID" value="KXA98073"/>
        <property type="gene ID" value="AKJ40_04955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="335" mass="37967" checksum="16C6D5A37B9A6F55" modified="2016-07-06" version="1">MYGHALYQQWYETDAVKEFDEVDLAINDYEKLVGKLKAHRAVKNLEESKILCIGEPNEFFKGGLAARAAVDKFRPGIDYMSFETFQEKLEEKSLESEEIVKVKNQFLENAETVSDEIDEETSLKSARVYVVLKELIGERGYDGITINCLSGILDLVDTTPCLAFQRLRDEGTPAVCEADIPQLVTTILLRYIADRPTFINDPVIVPDENRVIVAHCTAPTRMSGFDEEAERYDVSLHHETKLGLAPSVEFKEGQEITLAGVSHSFDEMTATSGRITRNTDYHVCISQAEIEVEDAQFLFNNFKGFHWVLVYGNWMEELKKAVDLLGMELVFPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVB9</accession>
    <name>A0A133UVB9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isochorismatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000120">
        <property type="protein sequence ID" value="KXA98134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98134">
        <property type="protein sequence ID" value="KXA98134"/>
        <property type="gene ID" value="AKJ40_04920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="199" mass="21736" checksum="B572EBCA1C95DB37" modified="2016-07-06" version="1">MRVASTAVLLVGFQNEFCSEGGAFHDIVKGEIESSGAVKNAADLVEQGRERGVKILHVPMQFSENFREIPPDRTGMLGDIRKANAFVMGTDRADIVEELGPEPNDVVISGKSTIAAFKSTNLDHVLRNFGIKNLALAGLLTDVSVESTARAAYDLGYRVVLLRDCTATRSKEAHLASERVIESSFGRVMSHREFLNNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVE5</accession>
    <name>A0A133UVE5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000119">
        <property type="protein sequence ID" value="KXA98165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98165">
        <property type="protein sequence ID" value="KXA98165"/>
        <property type="gene ID" value="AKJ40_04900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="140" mass="16271" checksum="C5C54D51FAB72F49" modified="2016-07-06" version="1" fragment="single">MVIDKLGTYRGKKKKVIADAGFFAHDNYTRSVLRRIKPIIKIRPGCEDKLEKKLKNVNTEIEWFDKVQSDLIDELMVDFREIISSTIEGAKNYDEVKKIRGEIEHIFKAAKMLFGMENLHLYDKEKALTKSFVAIYVSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UW62</accession>
    <name>A0A133UW62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000111">
        <property type="protein sequence ID" value="KXA98444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98444">
        <property type="protein sequence ID" value="KXA98444"/>
        <property type="gene ID" value="AKJ40_04785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="157" mass="18109" checksum="9933DB39E42AEA28" modified="2016-07-06" version="1" fragment="single">LLNFAQRGKEGGFEFGIETNGSNPEMLEDLLGGDLLDRCALDIKAPLNGEKYKAATGTDDGKLPEKVEKSMNLLRESEVSYEYRTTVVPKLLVEKDLIDIGKEIQETENFYLQQFIPENTLKKEYEKVEPYSENKLKRIRKRLKDKFGLKFCKIRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWD6</accession>
    <name>A0A133UWD6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase II large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AKJ40_04710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal DNA polymerase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000107">
        <property type="protein sequence ID" value="KXA98496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98496">
        <property type="protein sequence ID" value="KXA98496"/>
        <property type="gene ID" value="AKJ40_04710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.144"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00324">
        <property type="entry name" value="DNApol_II_L_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004475">
        <property type="entry name" value="PolC_DP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016033">
        <property type="entry name" value="PolC_DP2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210">
        <property type="entry name" value="PTHR42210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03833">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016275">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00354">
        <property type="entry name" value="polC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolC_DP2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXA98496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115696" checksum="4633A1E5AAF101D8" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWG8</accession>
    <name>A0A133UWG8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000105">
        <property type="protein sequence ID" value="KXA98538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98538">
        <property type="protein sequence ID" value="KXA98538"/>
        <property type="gene ID" value="AKJ40_04690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="255" mass="28582" checksum="FF278E328B2718AA" modified="2016-07-06" version="1">MIRTEDSGYLISEHTLSFGAGEGDFWLVKTDSEGNEEWSKAFGGENDDWARSVVQAEDGGYAMVGETESYGPGKIDIWLVKVGGEGGVQYSVSATAQMHIDFLNGYYSQDVLWDYIQDYNTEPNLWATDPNGLAATLNHYISSYYFEDKKDDGCKEGTINLVMSLHNYGTPSPTLVNEGAHWVLVIGAYYEKDGMNVLDVGGVWRHDPAGTGYYYENKYIQYTDWDDDFTAVDISNSEWDGYWVHVHGSGLKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWH3</accession>
    <name>A0A133UWH3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_04680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000105">
        <property type="protein sequence ID" value="KXA98539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98539">
        <property type="protein sequence ID" value="KXA98539"/>
        <property type="gene ID" value="AKJ40_04680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA98539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="190" mass="20558" checksum="0CAA83D2012821B6" modified="2016-07-06" version="1">MNLTPFMSTLAIIALAELGDKTQLTVVTLCAKHRPGIIFLSSFFALLGIGSASIFIGSAITHFLPMFWIKMGSGVAFIIFGLHTFIEEEESSYSCEETTFVASFSLVALMELGDKTQLATITLAARFASPLLVFLGMGVAFLLITGAGVIIGTKLRDYLSKEYIRIGSSIIFISMGLIFILDTIIGIRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWR8</accession>
    <name>A0A133UWR8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000100">
        <property type="protein sequence ID" value="KXA98643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98643">
        <property type="protein sequence ID" value="KXA98643"/>
        <property type="gene ID" value="AKJ40_04605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="299" mass="34937" checksum="CB7D5B6FACA78428" modified="2016-07-06" version="1" fragment="single">GSDLEEVTIVFDRGFDDGDNYDLSRLSESHIVAGVKKNWKSVKAKIDAADLDEFQLSHETEHGKCYVKDSGRVQIGKGKWRIVLSYHDTTREKIRKKMEEARSETEDLLEHLREKIERRRRGRPITKGGIEKELKKVLGKWYGCLDWSFDSGERSLEFEGWNEEWNRYYETAGVHAIITEHEDWSPSKVARTYFGRKNIEDMFHLTKKALVVPVEPPYVKEDHLVRAHLFLVFVGLLCYQYLRRKLPNDMSEKDVKRAFDKLDMTVAIEENTPQFKLSNIDNDTLPLLESLELGKFLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWX8</accession>
    <name>A0A133UWX8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_04540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="LHXU01000097">
        <property type="protein sequence ID" value="KXA98704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98704">
        <property type="protein sequence ID" value="KXA98704"/>
        <property type="gene ID" value="AKJ40_04540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1244"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA98704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="500" mass="58598" checksum="18C57C24A5384B33" modified="2016-07-06" version="1">MPSQTDSEKIYNKLIRKIKRIKNIGNAEGLLRWDQQVMMPNAGTPARSQQLSALSSIQHELLTDEKIGKMLDEIDEEEISKERRSAIREIKREFERAKRLPTELIEKISKASSEAFSKWLKSKEENDFSIFAPNLEKLIELKTKYAEYIDPDVAPYQVLFEDYEPYLGLEIASDTLSKLRKELVPFIEKIKESEVKPDRSTFENNFSGEKQREFAQHVLDILGFKWEYGRLDTAPHPFTSGTQYDVRVTTRFEDNLLDGLFSTIHEFGHANYTLGLPKEKYGTPLGESRGFTFHESQSRLWENHIGRSRPFWEYILPELKKKFPSIDASIEDVYKTVNKVHEDNLIRVDADELTYHMHIILRFEIENDLIENNIEVKEIPSVWNDKMENYLGVRPENDSEGCLQDVHWSHGSFGYFPTYSLGSVLSAQIYNSAKNDIDRLEEKMRNGKFESLKKWLTEKIHRYGKRYTTNELIQKSIGEEFNPSHFIDYIKNKYSEIYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWY0</accession>
    <name>A0A133UWY0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000097">
        <property type="protein sequence ID" value="KXA98703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98703">
        <property type="protein sequence ID" value="KXA98703"/>
        <property type="gene ID" value="AKJ40_04535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1243"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="224" mass="24340" checksum="915CBBF622EB5ABB" modified="2016-07-06" version="1">MYIIVAGLGMLGMRVIKELSEGRHDVIGVDIDKKVCEKAGARTGAIIVNGDATNLDTLHEANINRADICIGLIGRDSANLAFTSLASAFNVPKILVRMNDPSYKEAYLQTGAEKALNTADIYMDSLVMDIERPSFKEVTELGNGEASVVLIEVPDDSPVLDQSIAEIIMLEDFPANCIFAGVFREEEFIVPRGNQEIRAKDRVFLTGDSESLEKAAKCMGVEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX37</accession>
    <name>A0A133UX37_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000096">
        <property type="protein sequence ID" value="KXA98731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98731">
        <property type="protein sequence ID" value="KXA98731"/>
        <property type="gene ID" value="AKJ40_04505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="134" mass="15577" checksum="9BBE639D50BDF408" modified="2016-07-06" version="1">MKATFHHVHLFSSDINKTIQFYQEMFGAKLLFDEEMAGSRNVMISIGNGKINFYDQPPTGEGKRIVHHLGIETDNLEALLDHMKSKGFKLKKKIKDLNTWKYVVVEGPDKILLELFQIVKKKESEKFYRKMSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX62</accession>
    <name>A0A133UX62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000094">
        <property type="protein sequence ID" value="KXA98783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98783">
        <property type="protein sequence ID" value="KXA98783"/>
        <property type="gene ID" value="AKJ40_04455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="229" mass="25660" checksum="88AFB1C85502C3BA" modified="2016-07-06" version="1">MREETKKFESEVKSKEGNGLKVLIEKNFEHEGQTYEPGETVDLPEDVAREAIENGAAKSVEELKKEVEIKPAGEVESGPRPEEVAEREAAGEGGAETEEPPSDEGFPEEVSIPAEGERPGKGEPDVWKELESELEEPSRAPTWRPEEVGDQLLGEVTRTGRGPNGRLLEVRTPEGEKYVLWERIALKDLFDRAEAGDRIGVRFLGVEESSSGRSYHNFRTVLKRRKNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXH5</accession>
    <name>A0A133UXH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000091">
        <property type="protein sequence ID" value="KXA98885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98885">
        <property type="protein sequence ID" value="KXA98885"/>
        <property type="gene ID" value="AKJ40_04385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="256" mass="30175" checksum="5588BA622CCD4D11" modified="2016-07-06" version="1" fragment="single">MKQENIEKINNGVLDDDVLRDFVFSFTKVMKENIFQRFYREKRGSEEKRFAEYLLVELVRTLLCMPPVTFYYYLRHDKDLRELLKLEGLKTIGNYEDFDRKRKYLKMHLDRIMKRNLKTEAGNLFVLDLTIGEADVNKLRKGKAVKEGLIDLEFLRSMTKGTVVGFQVAYLINLSKLSFEKLKIYSKHAEKKRIWREMVNDELGTKQGKIKSVIADAGFFAYVNYLDTARLRVIPVIKSRSDCKEKLMEKLENCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXM1</accession>
    <name>A0A133UXM1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gln-synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_04295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000089">
        <property type="protein sequence ID" value="KXA98928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98928">
        <property type="protein sequence ID" value="KXA98928"/>
        <property type="gene ID" value="AKJ40_04295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="103"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA98928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="329" mass="36814" checksum="B095BF9E6158ADBF" modified="2016-07-06" version="1" fragment="single">MERSERIIEEVEREDVEYVQLQFTNVEGKLKSMTVHVSQIGEAIDEGLGFDGSSVTGYADVEESDLVLMPDLETFQILPWKSRGKSIARLFCTVCYPNGEPHEADPRNVLDTYLRTWEKEGYTFFVGSEIEFYLLKNGNPIDDGGYLDSPPNDKAEKHRTEMAIDLRDLGFTVEKIHHEVSSGQNELDFRYSDALTTADNIIACRQALKTLGRERGLDVNYEPKPIPDGMGNGLHCHHSLGDSKTGQNLFYDPGGKYRMSDLARHFLGGELVHAPALTALAASAPNSYDRLVPGYEAPVYVSWGGPNRTVMTRTPGYEVRSGSGMRFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXR1</accession>
    <name>A0A133UXR1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000087">
        <property type="protein sequence ID" value="KXA98976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98976">
        <property type="protein sequence ID" value="KXA98976"/>
        <property type="gene ID" value="AKJ40_04225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="69" mass="7834" checksum="46C7FF585625A180" modified="2016-07-06" version="1" fragment="single">MGQKSLWDKMGLEESLAEFLEDGDDWERKKTSVDGVFILKLPEYKGNPPRLAIELNPTDSRGNPTKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXS3</accession>
    <name>A0A133UXS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000086">
        <property type="protein sequence ID" value="KXA98993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98993">
        <property type="protein sequence ID" value="KXA98993"/>
        <property type="gene ID" value="AKJ40_04205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="112" mass="13374" checksum="82D8320B2EE17F3B" modified="2016-07-06" version="1">MDFFSLNGSFGQSNRGVNMETRFDGLCEFVTRRGRMKILTRLLEELKTPTEIAERLNITRNAVYGWLNEKKRHPSNEHVLELLRILNNENKEKFRDILVEELQIFQKLIFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXS9</accession>
    <name>A0A133UXS9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000087">
        <property type="protein sequence ID" value="KXA98981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98981">
        <property type="protein sequence ID" value="KXA98981"/>
        <property type="gene ID" value="AKJ40_04250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="69" mass="7596" checksum="111A85FABF8B76FD" modified="2016-07-06" version="1">MTIKNLAQLALLLLGAACALVGLAELSRLVVLHCLSTGWKVKFYLELTAYVVGAVWVLCQFYEGVKNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXU8</accession>
    <name>A0A133UXU8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AKJ40_04170</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000084">
        <property type="protein sequence ID" value="KXA99010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99010">
        <property type="protein sequence ID" value="KXA99010"/>
        <property type="gene ID" value="AKJ40_04170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1143"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="POLXc" evidence="20">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="19">
        <location>
            <begin position="337"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KXA99010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="562" mass="62312" checksum="5880E28CA0DE2890" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXW2</accession>
    <name>A0A133UXW2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000083">
        <property type="protein sequence ID" value="KXA99022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99022">
        <property type="protein sequence ID" value="KXA99022"/>
        <property type="gene ID" value="AKJ40_04160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="123"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="282" mass="32690" checksum="2452CE90E3772A51" modified="2016-07-06" version="1">MKVETIQKINEGELDGESTLDFALSHAEKVKEDILQSWFKKGANRNDKALNEFLLIEIIRNILGAEPRGFFVLLSVSRRLRALLDLKYVDDLERYKYFKRKIKNLKGRLREISKRSLGTEGDESFAFDSSIVTADLNGYRNGKKIKKGEYDARFTYSTTKGTVIGFQTLLLFNLEKFSVRKFEIYPIDASTKKMWKEMVCDEIGTKGGKKKTVIADGGFFAYENYIQSANHRVESIINPRCDCRENLKEKLENMSPRLELFEIHDPEKKEKVMSEMKDLVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXX3</accession>
    <name>A0A133UXX3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrom_C_asm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_04110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CcmC/CycZ/HelC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000081">
        <property type="protein sequence ID" value="KXA99043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99043">
        <property type="protein sequence ID" value="KXA99043"/>
        <property type="gene ID" value="AKJ40_04110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1127"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003557">
        <property type="entry name" value="Cyt_c_biogenesis_CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01386">
        <property type="entry name" value="CCMCBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXA99043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="227" mass="25437" checksum="593443063AC755D6" modified="2016-07-06" version="1">MWRKINNATTLATLVAIPITLYFVFRYAPLLTEGFSDPLAQKIFYFHVSAAISGYVGFFIVLISSIIFLKKSDSNVDRWAVSAAEVGVVLLSITILTGPVWAKAEWGVFWRLQDPKLMSALVLWLVYIGYVVLRKNIGEEREARLAAVYAILGFTTVPISFVAQRVWRSLHPTVIVSKTGGMGPKVASTFAASVIGFAILFFALLIWRKRIEDSKFEIEKVKENLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXY4</accession>
    <name>A0A133UXY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000081">
        <property type="protein sequence ID" value="KXA99044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99044">
        <property type="protein sequence ID" value="KXA99044"/>
        <property type="gene ID" value="AKJ40_04115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="75" mass="8710" checksum="B1142F61C718EBFE" modified="2016-07-06" version="1" fragment="single">LPRLPDEIKGLENIRIIEEILFGGTDLKAVAERFKRRRKQIESAPADLKVLTRHEKGYFAPKSEHSLLIYLESHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY28</accession>
    <name>A0A133UY28_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000074">
        <property type="protein sequence ID" value="KXA99116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99116">
        <property type="protein sequence ID" value="KXA99116"/>
        <property type="gene ID" value="AKJ40_03940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="148" mass="17659" checksum="5831F028DB255923" modified="2016-07-06" version="1">MLVGSRTNEYFDELFKELKKSLGGQLHYLFAKEEHKPPEYRVLKSFVTDKLQQYKTVFNRYFYRIAKLDHGVPIACKRYGLEHNNNPIERYNGDIKQRDKVMRNFKNYESADTFLNLRRTIYNHVRPHQSLGSIAPACDAFSIFFKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY55</accession>
    <name>A0A133UY55_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrogenase expression protein HupH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000074">
        <property type="protein sequence ID" value="KXA99113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99113">
        <property type="protein sequence ID" value="KXA99113"/>
        <property type="gene ID" value="AKJ40_03920"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1057"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="246" mass="26865" checksum="6E7F3DDB65C55F1B" modified="2016-07-06" version="1">MKLKIIIPIIAEEFVEPTRKEVERLASSDVEVEVEKLEYGTASIESAFDEMLCAPEILRIAGKAESNGFDGVFIDCMGDPAVDAAREVADIPIVGPASPSMHIASEIAHSFSVVTVLENVVPLIENLATKAGVDKKLASVRSVDIPVLELEDEEKILDALVSESKETIDRDGAHSIVLGCTGMMGVAEKLRERLEEDGYDVPVIYPVGLAVRYLELLDSLDLAQSKKTYMEPPKKERNLLENLGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY68</accession>
    <name>A0A133UY68_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000071">
        <property type="protein sequence ID" value="KXA99152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99152">
        <property type="protein sequence ID" value="KXA99152"/>
        <property type="gene ID" value="AKJ40_03835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="59" mass="6622" checksum="A0420102876B69AD" modified="2016-07-06" version="1">MVMSRGKTIRIDVNAHRILVNVKEEMKEEGIGSPTLSDAVRRMNRKLDNCYSNDEEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY90</accession>
    <name>A0A133UY90_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000069">
        <property type="protein sequence ID" value="KXA99172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99172">
        <property type="protein sequence ID" value="KXA99172"/>
        <property type="gene ID" value="AKJ40_03755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="99" mass="11784" checksum="08D5A8E6CE365FAC" modified="2016-07-06" version="1" fragment="single">MIATFVFSAFLVYFAYIQTKLIKREQKSPEWEIKNLKVVVQSEEYQDEYLVNFDIENVGEGRGESLIFITPPKIRNLLFKKKRFYVLISEMHSLPYRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYB0</accession>
    <name>A0A133UYB0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000070">
        <property type="protein sequence ID" value="KXA99164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99164">
        <property type="protein sequence ID" value="KXA99164"/>
        <property type="gene ID" value="AKJ40_03805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="PTHR14025:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="184" mass="21222" checksum="DBFBC82DC3CF1853" modified="2016-07-06" version="1">MMAPTKPLVEQHRDTFLRILKLRPEDVQVLTGELDPDYRLHLWEDGEVRAYFATPQVVRNDYKLGLDLGDFSFVIFDECHRAKKKYAYTEIADAYVEDSPHPMILGLTASPGTDEETIRDVSDSLYAEHVEARTKDDPDIAPYVNEIEVKKRFVQLPDPHSSFSSLYSFQPSPYSWRALLVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYB5</accession>
    <name>A0A133UYB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_03720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000067">
        <property type="protein sequence ID" value="KXA99196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99196">
        <property type="protein sequence ID" value="KXA99196"/>
        <property type="gene ID" value="AKJ40_03720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="273"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="460" mass="51197" checksum="24CC521551A61FA7" modified="2016-07-06" version="1">MMNYISEKLTNFAKDTTFKDIPKEVREKVKLHLLDSLGIGIRGHNSTPVNAVFSAFSKLNTTDEGASVILGDRKFRAPTAAMINGTHIHSLDFDDTELEGCVHLSTCAVPSALSVGEENKASGKEIISAITVGYETMIRLGMAAPWEFHDRGMHATPFCGIFASALIAGKLMELEKSEMVNALGICGSMVTPSAQQFLVSGEPIKCIHPGIASKLGILAAIFSREGLEGPDEIFEGSLGIYKVFLGENNYSLEKLTEGLNRKWKTLDISVKTYPSCHITHSYMDCTNRILKRQDLSPKDIKEIVCVVEKTPSKVVCEPIEEKRKPKTGYGAKFSVPYCVSLVMHGKGKRVKDFEDRKVQAEKSVKDTASKVRCDTRPEIEGGLPGWVIVETINGDKFEEKQKFPKGHPKNPITEKEILEKFEKNTEKRFDKKERTNIVDKVKKLEKTEDINSLTKLLEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYJ2</accession>
    <name>A0A133UYJ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000063">
        <property type="protein sequence ID" value="KXA99241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99241">
        <property type="protein sequence ID" value="KXA99241"/>
        <property type="gene ID" value="AKJ40_03640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.962"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="127" mass="14280" checksum="4DA6757A49340CF4" modified="2016-07-06" version="1" fragment="single">SEPSSRLKQWPVQLKLVPPQAPFFDGSNLLIVADCVPFAYGNFHTDFLGENSIVVGCPKLDDAEFYVDKLEKIIERNRIEKIKVVHMEVPCCFGLNKIVEDALKSNEKNLEVEDITISVEGEVKTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYK4</accession>
    <name>A0A133UYK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000061">
        <property type="protein sequence ID" value="KXA99263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99263">
        <property type="protein sequence ID" value="KXA99263"/>
        <property type="gene ID" value="AKJ40_03570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="92" mass="10084" checksum="A31F7C04E6C20E4F" modified="2016-07-06" version="1">MTTVSIKILGLTAENRNKIKREVSLEKPDLTISDVLREVQEDIENTENVIDLDKGENNLEVTILKNGNPTPDLGEKLEDGDSIVVLTPMPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYM2</accession>
    <name>A0A133UYM2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000059">
        <property type="protein sequence ID" value="KXA99288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99288">
        <property type="protein sequence ID" value="KXA99288"/>
        <property type="gene ID" value="AKJ40_03515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="100" mass="12183" checksum="6DE23EB28190710A" modified="2016-07-06" version="1">MYVVCDSDRELNDSFEDSKGIQICHFHAVKYVDYCLWKEDAPKNFRKKMVGILKSRLATLRNSVEKFWRDEDTERLEDRIGWFREELDRWAERAEERGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYP9</accession>
    <name>A0A133UYP9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000058">
        <property type="protein sequence ID" value="KXA99301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99301">
        <property type="protein sequence ID" value="KXA99301"/>
        <property type="gene ID" value="AKJ40_03440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="87" mass="10060" checksum="8C0EC96AAD3B39F1" modified="2016-07-06" version="1">MIPVSITDVTIIALEILVAFLIITHIRELSDHTGALLDHIYLIEEKMKELDDYTKSLDEHMERLDGYVEDLDAHMKKLEKNSKENPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYQ0</accession>
    <name>A0A133UYQ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000058">
        <property type="protein sequence ID" value="KXA99305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99305">
        <property type="protein sequence ID" value="KXA99305"/>
        <property type="gene ID" value="AKJ40_03465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="157" mass="18084" checksum="D15CDEFE5CE27408" modified="2016-07-06" version="1">MMEHRRAWRSGFSTFFPEGAPLPTTGMSINNILFPFPCHVIFGDRDMVRVAINDRKLHEVEIQEREYSERAISYVKYPEHRITAEIRESVLNVKLPVMLALELYRSGVLPPDEEERFSVDLDGERKVFFQVSALRYPLGSDSGEIILTLKSADHVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYR4</accession>
    <name>A0A133UYR4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000056">
        <property type="protein sequence ID" value="KXA99336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99336">
        <property type="protein sequence ID" value="KXA99336"/>
        <property type="gene ID" value="AKJ40_03365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="128" mass="14789" checksum="593C5D6E7B766386" modified="2016-07-06" version="1">MTTREKIAQFLKNNSSKKFTPSDLKGKNGVEIGRSTIHNHLNILKDEGFVKKIGGKYAWYTYRELEEVVEETLKDELGISKDKARDIPQLIAVIQNKYRNSGDWPDKEIVEAAIRTKAEEMQMYNLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYV1</accession>
    <name>A0A133UYV1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000056">
        <property type="protein sequence ID" value="KXA99337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99337">
        <property type="protein sequence ID" value="KXA99337"/>
        <property type="gene ID" value="AKJ40_03370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="342" mass="38906" checksum="ED8F81EB84250D32" modified="2016-07-06" version="1">MEIWRELGMTTSQCELGNIQGERDSSSPSSRKTKSIEDFKLHSIHSKIPRMCENVRESFREDIKENGIREPVKVNPKDEDEILDGRERYKEAFDLGIEELPYEVANLNGISPVEYIIKSALLRRHLSKSQKAMLAVELKPELEEEAEKRKLRTLKKGEKDPDVEKKINILYYHTDQEDLVIDPMAGGASTVDACLIMGRDCRAYDIKPSRDDILKNDIREGYRKKANGADLILLDPPYGDKMVDEYGGHGFTGGSDEVGENLDQLAEESYEALSTGGKVVFIFGNTKSKKGNGDIWAPDLYQLFRDKGFETEFVYHAPYKGHSNPSGEIQQKSRDIYIFKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYY4</accession>
    <name>A0A133UYY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000053">
        <property type="protein sequence ID" value="KXA99390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99390">
        <property type="protein sequence ID" value="KXA99390"/>
        <property type="gene ID" value="AKJ40_03265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="73" mass="8772" checksum="C82120DDC6891578" modified="2016-07-06" version="1">MKESEETIDNQLRKPTKKPTLRWIFQLFEDVHYVKIEEDNNTRFEVENIRPDGETALKLLGSDYMDYYLLSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ80</accession>
    <name>A0A133UZ80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000047">
        <property type="protein sequence ID" value="KXA99480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99480">
        <property type="protein sequence ID" value="KXA99480"/>
        <property type="gene ID" value="AKJ40_03040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="84" mass="9529" checksum="96FBDE392229A570" modified="2016-07-06" version="1">MDLGTTFRTALILAKEKIYQGQKEKSGVAKKEIATNRTLWITNLSMIPFFAMLSFFVAGAQIATGCLSARSLYFYWHSFFYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZF2</accession>
    <name>A0A133UZF2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">tfb</name>
        <name evidence="11" type="ORF">AKJ40_02855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000043">
        <property type="protein sequence ID" value="KXA99550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99550">
        <property type="protein sequence ID" value="KXA99550"/>
        <property type="gene ID" value="AKJ40_02855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.694"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="136"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="230"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXA99550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="319" mass="36058" checksum="3EA7DCDC0B762D75" modified="2016-07-06" version="1">MKNLMAGTHTSEEKKSKSSEVECPSCGNNITVRDYQQSQVVCESCGRVLKEKIKDRGPEWRAFDQEQKEERERGGPPSTETIHDKGLSTQIDWKNRDAKGNKLSPERRKKVYRLRKWHKRSRITDSKDRNLTFSLSEINRMSSQLGLSNSVQEIASKIYRKAVEENLIRGRSMEGVSSAALYAACREAKTPRTLEEIAEASRVDKREISRSYRFIARELNIDLPLTDPAKYVARFGSELNISGEAKVEAMEIIRKAQEEKLTSGKSPSGTAAAAIYIATLKSGERRTQREVAKAADVTEVTVRNRYGEIVEELDGEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZI6</accession>
    <name>A0A133UZI6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000040">
        <property type="protein sequence ID" value="KXA99603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99603">
        <property type="protein sequence ID" value="KXA99603"/>
        <property type="gene ID" value="AKJ40_02775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="95" mass="10928" checksum="B38B214086144534" modified="2016-07-06" version="1">MLHKFFLQPLKPFRTAELPQTTYPLARPSPAPLTEKNPGDDEELTHRSVFPVEDRVSAEAEVPPAVVALEQKYMDKFYLTLSNLISLHNRTLLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZK2</accession>
    <name>A0A133UZK2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000040">
        <property type="protein sequence ID" value="KXA99600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99600">
        <property type="protein sequence ID" value="KXA99600"/>
        <property type="gene ID" value="AKJ40_02750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="296" mass="34916" checksum="E7E5CDE542017244" modified="2016-07-06" version="1">MFEHGHVAFLVDLLSRHDVVESLRKHFPDHWEELLVFSMNRVVRPFPLKRVGSWMEKTSLGEFLEIDPPSGKKLSKVLGEVGVDVKSQSEFMRELIRDDEMLLYDGSMIYSTSDYNKLLEVGYDKDELFLPRVNIALHFSKDRNMPIHLRIFFGSVHVIKTIEAVIREIKDKDILFIADKGFYKNDLYDDLDEGNVKFVLPLPRDDDRIQYEKELPEMFEYRDRIIKSTSYPAGTYHLYHYEDQDLKHTETKNYYKLKLHGKDVSFNESWAGKIALLSNQKLDPEEAYLIWKNRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZP2</accession>
    <name>A0A133UZP2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_02640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000037">
        <property type="protein sequence ID" value="KXA99665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99665">
        <property type="protein sequence ID" value="KXA99665"/>
        <property type="gene ID" value="AKJ40_02640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.605"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="105"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="472" mass="52869" checksum="2F20BDB35B0EF894" modified="2016-07-06" version="1">MANIIESWLGNPLFRRVLGFFTKRSDGERRFEKILERYAGKEVDLGIRDRASYLFVERILDSVVSGAGLELEKAKENLKQGYWRKGLASVLEGIAWRGPQKPFTSYCPFLVVWNFTNACNLNCKHCYQSADKPTPDELSTKETLDAVDEMADAGLAYVAMSGGEPLMRDDFFEVAERISERDMGFSLATNGTLLTEERVKKLEELNCLYIQVSIDGRPETHNDFRGTSAFERTMEGVRNAVDSDVTVGLAMTATKDNLEDVDWVIEKTEETGADIFMHYNFIPTGRGKDIAELDISPKEREELLKKLAKNSQKRDINLLSTAPQYGRVCAEGGLETTSLTHFDTVGQEGGMGERIKFLAEFVGGCGTGRLYWALQPNGDLTPCVFLPEKLGNIREDDFLEVWKTHPFLEKIRERSGFKGNCGTCEHRNICGGCRARAYGYFDDVQGPDPGCLKNGEYLQKNSPESPLTLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZP4</accession>
    <name>A0A133UZP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_02645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000037">
        <property type="protein sequence ID" value="KXA99666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99666">
        <property type="protein sequence ID" value="KXA99666"/>
        <property type="gene ID" value="AKJ40_02645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.606"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="270"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="369" mass="42687" checksum="AE9EF0760BE45CA0" modified="2016-07-06" version="1">MEVKKTVRIKLHFLTNNKQELLEREYRDFQKAVDGGASKLYSATRQQAEKVRRQKNPKNEQPVRLRNDLLRVEEQDTEISNFWVKIPVYNPEEDRGESIWCAAIIPRKDRGEVEECDFGDSELVKEDGEWFVHLVIKKKIEIEPIRPDRPSSFSDVIAVDMGVRWIATSVALEDRETKFYGEEVREIREHCKMLRKRVGKKKVRKGKQVIKRIGNKESRKIEDRLHKISRKIVEDAKERNAIIAIGDLNGIREQEDKGRKFNDKLHKFPFNKLKRFIEYKAEWEGIRVVEVDERDTSKTCNWCGSEDTRRIGQGKFVCKECGLEDNADKNGALNIGKRALGKSINRPLSEAGALLAVPETPAEKGEAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZU9</accession>
    <name>A0A133UZU9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymidylat_synt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000035">
        <property type="protein sequence ID" value="KXA99704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99704">
        <property type="protein sequence ID" value="KXA99704"/>
        <property type="gene ID" value="AKJ40_02585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014620">
        <property type="entry name" value="Thymidylate_synthase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036752">
        <property type="entry name" value="TSase_MJ051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="2">
        <location>
            <begin position="80"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="215" mass="25166" checksum="22EB8B072FF68B88" modified="2016-07-06" version="1">MRKIKARNLPEVWFKANKEILENGVEYKVGRGSEETLTKKIAVALEITHPEERPLVDDKAPVSDLNRYTLENLFIKDEQSYDYTYGSRLRKDYDQIERVIEKFKEEPKDRQNIMVTRRPEDLDIENPPCLTVVDLEILENKLINYSYWRSWDAYAGLPSNLGGMQLLMEFMAKEIGVGTGKMVAFSKNLHLYERQFKFVEDLISGSSDWREIMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZW8</accession>
    <name>A0A133UZW8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cation_ATPase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000034">
        <property type="protein sequence ID" value="KXA99720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99720">
        <property type="protein sequence ID" value="KXA99720"/>
        <property type="gene ID" value="AKJ40_02525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="177" mass="19997" checksum="7EF764BC487011E7" modified="2016-07-06" version="1">MLLWVNLLTDGLPALALGVDPKSEDIMKRPPKRKGENIIDERIGFSILWIGFTVMIVMVLLYGRYIGQSVEKAMTMALTSFVFMKFSAIIPIRSRYGTPTVSNKWLGLAVLSSIVAQLALLYSPLNQLFDVVPIGLNSWILIIISSAGFFAFSCFMIRSEKRLLKWLKEVRNRISHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZZ5</accession>
    <name>A0A133UZZ5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP phosphorylase</fullName>
            <shortName evidence="3">AMPpase</shortName>
            <ecNumber evidence="3">2.4.2.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nucleoside monophosphate phosphorylase</fullName>
            <shortName evidence="3">NMP phosphorylase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_02465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate</text>
            <dbReference type="Rhea" id="RHEA:36975"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.57"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine</text>
            <dbReference type="Rhea" id="RHEA:36987"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="EC" id="2.4.2.57"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:36991"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="EC" id="2.4.2.57"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.57" evidence="3"/>
    <dbReference type="EMBL" id="LHXU01000032">
        <property type="protein sequence ID" value="KXA99762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99762">
        <property type="protein sequence ID" value="KXA99762"/>
        <property type="gene ID" value="AKJ40_02465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.561"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046125">
        <property type="term" value="P:pyrimidine deoxyribonucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02132">
        <property type="entry name" value="AMP_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017713">
        <property type="entry name" value="AMP_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013466">
        <property type="entry name" value="Thymidine/AMP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03327">
        <property type="entry name" value="AMP_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02645">
        <property type="entry name" value="ARCH_P_rylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="4">
        <location>
            <begin position="427"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="512" mass="55165" checksum="5116728389056826" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V004</accession>
    <name>A0A133V004_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000032">
        <property type="protein sequence ID" value="KXA99763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99763">
        <property type="protein sequence ID" value="KXA99763"/>
        <property type="gene ID" value="AKJ40_02470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025698">
        <property type="entry name" value="2TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13239">
        <property type="entry name" value="2TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="2TM" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="92" mass="10550" checksum="0AC51B6FE4BBAF5B" modified="2016-07-06" version="1">MNSDKDLKERARKRAEEKAGFYTHLGVYVAVNVFLIVIWYISLGPGGFPWFIFPLFGWGIGIVAHGIATFYGEAYIDEKAEEEYEKLKKQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0B5</accession>
    <name>A0A133V0B5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000027">
        <property type="protein sequence ID" value="KXA99888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99888">
        <property type="protein sequence ID" value="KXA99888"/>
        <property type="gene ID" value="AKJ40_02280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="179" mass="20759" checksum="C458DB7935BA91D0" modified="2016-07-06" version="1">MWEIETNSNFERLEKVLTREEKPDRIPFYEHGSEIEERVLKEIDEEIFPIEEDMSEKEKIFVDLKNHVKHQTTIGYDYVHAGAIDPDFPYALEQGRAGVSLSEGSKSISAETEEGERVFQHSSKNVIGDWEDFEDYPWPEVDEMNFSPIEWAEDLIPDTMKVLSPAPGGVFEHLTWLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0C8</accession>
    <name>A0A133V0C8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-fuculose-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_02260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:12933"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57846"/>
            <dbReference type="EC" id="4.1.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.17" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000027">
        <property type="protein sequence ID" value="KXA99884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99884">
        <property type="protein sequence ID" value="KXA99884"/>
        <property type="gene ID" value="AKJ40_02260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="7">
        <location>
            <begin position="17"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXA99884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="469" mass="51963" checksum="E759E4548EEF0D57" modified="2016-07-06" version="1">MRLGEINSTKIGEDPVQHMIDCGKIVTKIKLNNITSGNESVVVNEKSKPIEKLTMYITRSGSKLGHLDEPTAIVGTSLGKYDENMTLASSEADIHKEIHTKRLQKNPDLESSACLHAHTLHAAALTMQHRGPGKEEIDIPKKYQTENLGGSVPVFISQYGSGAADMTENVPEILANNPGIIIGHHGAFGVGEDLEICLRYLADLEDASKKIISDLTIPEKRKKIDNRVPDGWQNKYSVAGSSGSEGPETGEMTPETIESYAKKDEDSKYYNEIFSEFRETGQDLADFEMDPYSRSALSHRIGNSIYITRAGVDFSNLGKKDIFVFKMGEGKEIRPGICEGWVHERIYEEMSTSYIAHLVPEYSTRYSIHCGDSIIPIDVEGQYINKRIPVADPGSYVLSEENVDSVVEALETNEKVAYIKGLGGFSISQSVLYETLHFLESAESSVKMIELAESIGVDVKSLQKKFEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0F0</accession>
    <name>A0A133V0F0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SufBD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000026">
        <property type="protein sequence ID" value="KXA99912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99912">
        <property type="protein sequence ID" value="KXA99912"/>
        <property type="gene ID" value="AKJ40_02245"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.460"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="306" mass="33515" checksum="9EC69D3671D15C54" modified="2016-07-06" version="1">MEVKQLYKAAEIEDALSDPETAHLVLDRDEVVGMNKVPGLTVEPQQIEDGVDVYINLDEGTVVEKPVHLCFGVTDREAIQRIILDIEIEDNAEIGILAHCVFPRALDVKHVMDADIRIGKNAKYTYLEKHIHSPEGGVNVVPSARVELGENSRFESDFELVKGRVGELDIDYETTCRKDSVMEMTAKVDGRGDDVVKISETGNLVGEGARGVLTTRVALREKARAEVFNKLTADAPYARGHVDCKEIVQGEGSAKAVPIVEVNHPKAHVTHEAAIGSVDTKQLETLMSRGLSEDESVDLIIEGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0P1</accession>
    <name>A0A133V0P1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000023">
        <property type="protein sequence ID" value="KXB00007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00007">
        <property type="protein sequence ID" value="KXB00007"/>
        <property type="gene ID" value="AKJ40_02065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="96" mass="11590" checksum="7D55114A754ECE41" modified="2016-07-06" version="1" fragment="single">AIVIYQIRNLSQAKKVKFGREFRGYTDKSNRGQYEYYREGLLDEIPHRKFVRGVLLIKREDRKKMIDFMNEYKVEVHTRNVELTPEDIEILSSHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0U2</accession>
    <name>A0A133V0U2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000022">
        <property type="protein sequence ID" value="KXB00035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00035">
        <property type="protein sequence ID" value="KXB00035"/>
        <property type="gene ID" value="AKJ40_01990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="299" mass="32576" checksum="151DA83D6F9C9DC3" modified="2016-07-06" version="1">MERAYGHNGVPEIDFLTPSTISEAVNLLQEYGSRSKILAGGTDLVFLMRDRAITPEHVIDIKEISEIQGLEKDENNLNIGAITKVRDIQKSELVKNQFTALNQAASQLGSTQVRNMATVGGNLCRASPSGDICCAMLALEANLKINGPEGTREINIDNFFKGPSETALEGGEILTQIQVPNVRENEETGFLKVGRVGVDIAKINTAVKMKFEGEVCTDCRISLGAAGPTPLRMKEAEKIVKEDIEVGADNKDVLKDVEDTVSKSCSPITDVRCTEEFARTNGGKIIARTIRDILKRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V100</accession>
    <name>A0A133V100_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DHNA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000019">
        <property type="protein sequence ID" value="KXB00130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00130">
        <property type="protein sequence ID" value="KXB00130"/>
        <property type="gene ID" value="AKJ40_01845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.335"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036839">
        <property type="entry name" value="MptD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007181">
        <property type="entry name" value="MtpD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04038">
        <property type="entry name" value="DHNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143560">
        <property type="entry name" value="SSF143560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHNA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="129" mass="14404" checksum="73A986C1E5178749" modified="2016-07-06" version="1">MVSTKLSEGDPGAKYFSREVTPRERAIFEGAITLGALYHQFVGTPIRDPAALERAIEESALAHPFIDEAEAEISETEKENENSYEYPELSGKALTIKLTANYEGAVAEMEMRRIPEMDYPLMFIKSVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V109</accession>
    <name>A0A133V109_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000019">
        <property type="protein sequence ID" value="KXB00129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00129">
        <property type="protein sequence ID" value="KXB00129"/>
        <property type="gene ID" value="AKJ40_01835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="SSF64076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="113" mass="12504" checksum="E4A0B39808629A87" modified="2016-07-06" version="1">MEIESYNFGEIVIDGKKYTNDVIVYPDRVEGDWWRKEGHSLHPEDIGGVLDFQPEVLIVGTGAYGRMDVPSGTAERIESNGIELIVKGTEEACETYNMIKGSKEAVAALHLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V128</accession>
    <name>A0A133V128_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000018">
        <property type="protein sequence ID" value="KXB00160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00160">
        <property type="protein sequence ID" value="KXB00160"/>
        <property type="gene ID" value="AKJ40_01815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="207" mass="23979" checksum="01E30A9071DD41BD" modified="2016-07-06" version="1">MTQEPVSDKESSFAPDGTGIPTSMKKNWESENNGGNHEGYDYMVGMAGTTYGIYSAVEFPKNPNAHESPFFEPLLQRTAAHYSSIDLVSGDSAFLARDNCDLVIEAGGIPRFYPKRGITLKRRGSWSWTNMLMNLIENPQGWLREYHQRSNIETTYSTLKRDFQTPLRKKIKKRREIEKHARICDYNLKRLCYIRRLEEIPIHWKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V171</accession>
    <name>A0A133V171_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_01690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00200">
        <property type="protein sequence ID" value="KXB00200"/>
        <property type="gene ID" value="AKJ40_01690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="234" mass="26155" checksum="1524DFEBF9517019" modified="2016-07-06" version="1">MATLEARGLSKDFDGTVALDGVDIDVDMGERVGLIGPNGSGKTTLVNVVTGNLKGSGKVTFDGEDITGRPTPELARKGLLRTFQIPRPFNDLTIYRNVLLPLTNIGEFDNPEERVVNVLEEIGLKDRADSKPTELNLIDLRRLELARTLVLEPDILFLDEVLAGLRRREWEELMEIIRELTMESGIVMIEHVMEAVMQFSERVVVLNEGKVLAKGQPEEIMRNEKVVNTYLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V198</accession>
    <name>A0A133V198_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00191">
        <property type="protein sequence ID" value="KXB00191"/>
        <property type="gene ID" value="AKJ40_01720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="83"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="492" mass="54204" checksum="58FE718CE7D53EF7" modified="2016-07-06" version="1">MKDKGQVQYAILGLVIVSIIVSGASLAVLSGSFSGVKEKVNALSEDLSNVSSQLNTIEDKVTGMQKKPGEEEKQPARKTSQEPIKIGTLQPVTGQFAAAGRNWLITMRMWEERINSGFPQEGGLPLKNDAGETVYHPVKIIQYDSASDPSKVPGLVSKLLNIDKVDILFSSYSTNMTKPGMPLASEEGILYVGDFATDANEDQNYSNYVSMIPNGPTPSIAWSKAFLQKAKEEGYTTVASLITRTEMNEGIHNKIPKVAENLGMEMVYHKTAPPGTTSFDSMFRAIKAKNPDVVYCAAYPTSAVAMIKTVNSLGYTPKMIGGGLIGLQYTSVMQSLGSSLNGWIVNQSYAPNLPEVKAGLWKRTEDVVSVYQKRVKGGKADQLGYYITPPAWAGMQVVEKAIRNTKSTDGDKLADYIFQKDEFKTVWGRISFSREARGEWTYARWLWPQIKGLEEGSLKELRQNNTWAIVANNGPYDLTTGKFVPYDKLRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1A2</accession>
    <name>A0A133V1A2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alba domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000016">
        <property type="protein sequence ID" value="KXB00228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00228">
        <property type="protein sequence ID" value="KXB00228"/>
        <property type="gene ID" value="AKJ40_01660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alba" evidence="1">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="82" mass="9167" checksum="B116D5C545898547" modified="2016-07-06" version="1">MEEIRIGEKSKGEYISAVLWAFRNSHDSVVVAGLGTRISKSFDIVGEVVETLDNVEKKNSETFEKEGVPGIRITLSKREVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1D8</accession>
    <name>A0A133V1D8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000016">
        <property type="protein sequence ID" value="KXB00225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00225">
        <property type="protein sequence ID" value="KXB00225"/>
        <property type="gene ID" value="AKJ40_01645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="101" mass="10588" checksum="52014C8DFFEF6670" modified="2016-07-06" version="1">MFNFYSLPFTVNRLTVSRLTVSRSTFSSRSAGPAGRAGGLLGPVLTMRAEKVMGSAGFLRAAGPVFFRSISAERVNVDSNRTSAGPVISICTRAVGGSVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1E2</accession>
    <name>A0A133V1E2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4147 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000015">
        <property type="protein sequence ID" value="KXB00259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00259">
        <property type="protein sequence ID" value="KXB00259"/>
        <property type="gene ID" value="AKJ40_01600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4147" evidence="1">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="145" mass="16195" checksum="C9761A009C3AF0E8" modified="2016-07-06" version="1">MIENKEEILSSGNRKPKEICLQVIVHALKSVNPSIEIGKRVSISSKKLRIFGKQIDLDKINDIYVIGGGKASYAMAEELENKLSDRIREGVIVTKYGYMRKPFSKLKVVEANHPVPDQNGLEAGEEILQIASEAEKDDLVNPTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1F8</accession>
    <name>A0A133V1F8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000016">
        <property type="protein sequence ID" value="KXB00226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00226">
        <property type="protein sequence ID" value="KXB00226"/>
        <property type="gene ID" value="AKJ40_01650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="139" mass="16089" checksum="0BE8DC980460BD7C" modified="2016-07-06" version="1">MPSENTEIDDNARKVAARLQGLKVRRGVIIRDEYGLSDEDLTEALDSASDEALEAIDELWITDEPSEEFLAVLGEKRDEAYDLRTSFLRKTKWIQILIRWARTSSPWDDTYLRLCIPAILRDLRGKRIEKLQRGEVINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1I8</accession>
    <name>A0A133V1I8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000015">
        <property type="protein sequence ID" value="KXB00256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00256">
        <property type="protein sequence ID" value="KXB00256"/>
        <property type="gene ID" value="AKJ40_01575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.270"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040506">
        <property type="entry name" value="RACo_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17650">
        <property type="entry name" value="RACo_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="634" mass="71149" checksum="62C624A6D7C61704" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1P9</accession>
    <name>A0A133V1P9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00377">
        <property type="protein sequence ID" value="KXB00377"/>
        <property type="gene ID" value="AKJ40_01440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.168"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043101">
        <property type="term" value="P:purine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="37"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="203" mass="22895" checksum="05683C544022DE4B" modified="2016-07-06" version="1">MEEVRKEFIEKIRKEGEVLSTDFLKVDSFLNHQIDTRLIDKAGRLIAEKFRDKEITKVVTAEAGGNIIAYATTVHLNELTPRQVPVIYAKKGVPKTMKDQTVQKIESATKEQETELALSREYLNKEDKVLIVDDFLYTGLTSEALVGLIESTGADIVGFAFIIAKRNFGGLKRLKKYDLPIFTLVEIEKLDPETGEITFANQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1Q1</accession>
    <name>A0A133V1Q1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00374">
        <property type="protein sequence ID" value="KXB00374"/>
        <property type="gene ID" value="AKJ40_01420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="156" mass="18023" checksum="D7E1707BBCE5D6BC" modified="2016-07-06" version="1">MKKFYKWLNDREYPERVVWIKTTRKNSNSKLPEKLLTEEDIEKLIETAENPRDKAFIALLWETGARIGELLDLRADSFQDRSQGKKVVINGKTGVRRLPIISSIPQLQNWLNNHSEKGGTEAPLWCKLSGEKRGRGDFLSLRYENVEQSCGKGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1T7</accession>
    <name>A0A133V1T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00418">
        <property type="protein sequence ID" value="KXB00418"/>
        <property type="gene ID" value="AKJ40_01335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="137" mass="15787" checksum="633EB3CC3F1F8AE2" modified="2016-07-06" version="1">MPKYEGVVFPLYTEMIKKGVKDGKDVFAKFSRRDVASGMDLYLYGSGDNGAKKIIAKAEVKASDSLKPNEVWEKYNERLFQHKEDFDDYTSNRRNKEMLVLELENLQLLDEPIEIPTGKNMTVAGLYVDEKMKKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1Y8</accession>
    <name>A0A133V1Y8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00467">
        <property type="protein sequence ID" value="KXB00467"/>
        <property type="gene ID" value="AKJ40_01250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="84" mass="9818" checksum="87A707165C130C4E" modified="2016-07-06" version="1">MSRERRSRLDVYADILEAVKGGSKKTHIVYQANLNFKRCKKYLDNLRGNGLIKAESNSPLVWSITEEGKEFLKKYDDMRDILPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V235</accession>
    <name>A0A133V235_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00514">
        <property type="protein sequence ID" value="KXB00514"/>
        <property type="gene ID" value="AKJ40_01170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="117"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="476" mass="55645" checksum="4190472D8AFFA8AA" modified="2016-07-06" version="1">MIDAPKPVQKAFERLKKQETGYLQLKEIDGRYYVHRSTSVWDKAEKKPKKISEHLGTITLDGEYKPKTPRTNVPVTDREIYEYSNSRLAYHLLQNVHDSLKNYTPYADELVSMAIIRAIDPQPLRMHPSRWEKLYISRDMNVTVNPKHLSSVLKSVGKEKTWWHDLFSGLMETDDLLLYDLTTVFSQSQNIKRAEKGYNRKKLYINQIGVILAFSTENNLPAGVDVFRGSVKDITTFKEFLELLEPDEVGFIVDRGLFSEPLIKDLRKEGLSYVMPLRKDSKYIDLRWLQWQDPFTYRKRTIRWARRHTDIGTLYLFDDPKLRGDQEEALLRKLKEGALTREKYEKKKERAGIIAIISDLNRPGPEIYDLYKGRQDVELAFDAMKNHLDADKTYLQSDEAVRGYFFVTFLALRIYFGILKKLREAEKTSEISVDEVFYELSKVERIVEPGGKEVYSHIPKKTREIIDLFPQALPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V282</accession>
    <name>A0A133V282_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00525">
        <property type="protein sequence ID" value="KXB00525"/>
        <property type="gene ID" value="AKJ40_01225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="144" mass="16677" checksum="EE6F339F8A8145EA" modified="2016-07-06" version="1">MTVEIELDEEERNFLDDFVKKGTKKAREITRANVLRLADMGRPVTDIAELVGVHRKTVWEIKKRYQEEGLESALKDKPSPGHPKKWTEEHEAEIIATACSSPPEGRKRWTIRLLRDELQKKSGFEDINRETIRLVLKKTKLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2C2</accession>
    <name>A0A133V2C2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00590">
        <property type="protein sequence ID" value="KXB00590"/>
        <property type="gene ID" value="AKJ40_01160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="201" mass="22934" checksum="A808460CE257C0DB" modified="2016-07-06" version="1">MPSREEHVRHCKNLYGYGFKEIHKWMDGTVRSRGQSHRVDRHNIKKTPDKAYDIFKDKVPRRYRKYIKDAVKDHIELDKRERSSSKTSYKKGQKYENPEEIGISEVAIFIIAFILFALPIMYGIGFEYALCISFSFGLSGLVTTKAGLWSVLIPAFAIGVSFWLFNPGFDIYSIYLLSIGIFLGAVAGIGLRKTIKGLPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2D0</accession>
    <name>A0A133V2D0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00581">
        <property type="protein sequence ID" value="KXB00581"/>
        <property type="gene ID" value="AKJ40_01095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF357" evidence="1">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="82" mass="9883" checksum="56EE5401BEF39949" modified="2016-07-06" version="1">MLRNELENKIEKWSHKLDEKLNRIRAVDDHGERILENAEAYRRDSDHFFENDELIESFESLIWAWAFLEIGENLNHLATIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2D6</accession>
    <name>A0A133V2D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000008">
        <property type="protein sequence ID" value="KXB00591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00591">
        <property type="protein sequence ID" value="KXB00591"/>
        <property type="gene ID" value="AKJ40_01165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="89" mass="9680" checksum="483D4000D13A2B4A" modified="2016-07-06" version="1" fragment="single">MHWDGHAGLTLIIFSILLAAFGYNLNVLFLLAIALVVSFVPDFDLDSKYFDHRGRSHSGGVAIIVGLVFGSVMFYVKGLTWGLLGFFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2I4</accession>
    <name>A0A133V2I4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00657">
        <property type="protein sequence ID" value="KXB00657"/>
        <property type="gene ID" value="AKJ40_01020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="85" mass="9342" checksum="6A0F603966058CFB" modified="2016-07-06" version="1">MPEAVVLIAAESRILARVKPSPEDILEKVSQLEGVQKAAVITGPYDIAAWVEADSMDKITQTLIEKIRSIEGVKKTVTHMVIRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2J7</accession>
    <name>A0A133V2J7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00651">
        <property type="protein sequence ID" value="KXB00651"/>
        <property type="gene ID" value="AKJ40_00985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="125" mass="13620" checksum="C54CB3EEFCF3B781" modified="2016-07-06" version="1">MEMNKKIAIYPIIIGLLMIGMWSALLGTGQVSEVGTALLEISYHLVAEFLTAVLLIVGGFGLYGGRRWGFGVFSVSMGLLLYSVINSTGYYAAQGDVAMVGMFTVLTILTALLLIVSLWKWDNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2M2</accession>
    <name>A0A133V2M2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00694">
        <property type="protein sequence ID" value="KXB00694"/>
        <property type="gene ID" value="AKJ40_00925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="65" mass="7298" checksum="91B6C14D1E43FB60" modified="2016-07-06" version="1">MVFFQGNALFLSSLTETGISELRVKGPIFRGGKRAKVANSEKHYSDTQVSSKYKCPVKQKLYRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2M9</accession>
    <name>A0A133V2M9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000007">
        <property type="protein sequence ID" value="KXB00656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00656">
        <property type="protein sequence ID" value="KXB00656"/>
        <property type="gene ID" value="AKJ40_01015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="76" mass="8527" checksum="0D02A193D273C3FD" modified="2016-07-06" version="1">MVEALILINTTTGVMDRVYREVKGLEQVRKSAKVTGQHDIVAVARTEVMGEIRNTLMEKIRNIDGVKETTTSLVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2P5</accession>
    <name>A0A133V2P5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00727">
        <property type="protein sequence ID" value="KXB00727"/>
        <property type="gene ID" value="AKJ40_00780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="532" mass="61168" checksum="E62D2F1FA9AF84E3" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2P9</accession>
    <name>A0A133V2P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00714">
        <property type="protein sequence ID" value="KXB00714"/>
        <property type="gene ID" value="AKJ40_00705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="127" mass="14341" checksum="4B6A749F548D996F" modified="2016-07-06" version="1">MGPPRKLRAPKNMRTAFRLRAEVGLRPAGFMRAKSYLRPATQMRAISPMGSTDEMQADIHLENHESDASSKGNETHTRFASHILWEVHWTLASRMACKTHCQVASHTSSETRTGSASREIHLRKCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Q6</accession>
    <name>A0A133V2Q6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">radA</name>
        <name evidence="8" type="ORF">AKJ40_00880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00686">
        <property type="protein sequence ID" value="KXB00686"/>
        <property type="gene ID" value="AKJ40_00880"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.782"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="6">
        <location>
            <begin position="76"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="7">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="311" mass="34083" checksum="A6D703F368454EB8" modified="2016-07-06" version="1">MAELTDLKGVGRSTAEELTDSGYSTVKSVATATPPELSGAVSMGEGKAGKLIRRAQEAAEDLGFELGTELMERRGEVERIPTGSDGLDEMLGGGVETQCITEFYGEFRTGKTQLSHQLSVNAQTLDGEEGRTPHVVYIDTEHTFRPERIEKMAEAVEIEPDRALQNIHVARASTTDHQMLLAEKTSEIADEEEVKLVVVDGLMSNFRTEYVGRGALAERQQKLGKHLNGLHDLAEDHNLAVFVTNHVQSDPNSFFGDPTKPIGGHVLGHSATVRVYLRKSKKESRKARLVDHPGLPPDSVKFKITEEGVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Q9</accession>
    <name>A0A133V2Q9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00724">
        <property type="protein sequence ID" value="KXB00724"/>
        <property type="gene ID" value="AKJ40_00760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="334" mass="37740" checksum="15021060261D931B" modified="2016-07-06" version="1">MIGEIVSNNPHQSFFDWVRGRFPCPNCGSTIEKFSTSELFPEEFSTRGKPASNLVLVPLIRVSVFLASCIFSDALYVDTMKGQPVNIHFRCSHCGYNEIIWKKYGRLVQGPIFYRGNNATSVNGATKVAAERFLQRKFRDWVSKNRQNGKKVLEAATSDLSLHLYYYPSADTIGERERIEERYRLLEISEDDFLRAFVGMKHKSDFLDLVEKEWLSVGDSKERERILSFNKEFKRKIAQSSAYRGNKSQDDRIASFLETIDLESVCVANVGQNGMAALANDLCQALFPPASLMLLSWELGENLMHRLKGQGSNLLVAEKLRLGGKEVGIGDIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2R0</accession>
    <name>A0A133V2R0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00711">
        <property type="protein sequence ID" value="KXB00711"/>
        <property type="gene ID" value="AKJ40_00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="113" mass="11585" checksum="7C23B29083B2EF2A" modified="2016-07-06" version="1">MGLKSAAACIPTTGLIIGAARIPSLDLNPPGARKLNVGLIIVPTCTMLAGLKSSLAHTSAVGLSSPAAHAAVELHGRGVRTFSADLSLFPIRNPPANSRCLWFRGFLSLGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2S0</accession>
    <name>A0A133V2S0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA_ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00734">
        <property type="protein sequence ID" value="KXB00734"/>
        <property type="gene ID" value="AKJ40_00815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="225" mass="26244" checksum="DB2F388E0C71D0A0" modified="2016-07-06" version="1">MEKAPKYPKMRHLPWSKAAARGNKYFDSVEDAMFYGNDNVVVTEKIDGSNVCLTGENLFARSHGHEPRHKSFDMLKKMYHEGIRHRIPEQLAVYGEWLYAKHSIEYSSLPSYLLIFDVLDMEKERWGSWKDVVRVSRELGLETVPLLYRGEWTDVLRHTNPEGKSEYGDEREGLVFRYGLSFPLKEFDLAVGKVVRRGHIQTDEHWKKGEIERNEKVQAKEEGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2S3</accession>
    <name>A0A133V2S3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00739">
        <property type="protein sequence ID" value="KXB00739"/>
        <property type="gene ID" value="AKJ40_00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="139" mass="15708" checksum="8A2D0D3AC34FA8D9" modified="2016-07-06" version="1">MWKRERGPEKMSEKRLKKISGRERDILLRACKGYVSTLFTMMLKGDDEVESEEKDAQNLDRVRVDFHHSTQRILRMGNYHVDREKVGFLAVITGILSLWTGVCTAFGPLSPKIGLPIIGVLVGLSTASGITWFIHGNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2T3</accession>
    <name>A0A133V2T3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00735">
        <property type="protein sequence ID" value="KXB00735"/>
        <property type="gene ID" value="AKJ40_00820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="349" mass="39781" checksum="E16EE5A7983CD841" modified="2016-07-06" version="1">MEVKVIGMPRMSPGGTKKAVLRYLSKKNFRDEVTKYRIWKDNEHPKRTTVYNTMGELDEKELLKKKKVGKTPTGQEKYHYAPTLSGVLAALRFNHFPSDDMGEVASKQVELLPLVFGKWDKLMRSENGGKILLPKFTRLRERLWGVFVEPTQRGQLPPEEPRHPPTELSIRRRMYEGLLSPELFENIVSDTRREFIQLVMDDPELSEFVHQLSVIKRNEAEHHLANYRAAAESLEERNPKRFADEPIPEKGEVGGTYALFERKVEDLKGGLSRSNIPEQVKSAFRNEHCPISTESAPCPIEENAWCVSTKVGNVYLIVEAGKLAAFGDRTAKLNRLVLRLEEGVLGNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2T6</accession>
    <name>A0A133V2T6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00762">
        <property type="protein sequence ID" value="KXB00762"/>
        <property type="gene ID" value="AKJ40_00625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="72" mass="8252" checksum="6906FD3B442DD352" modified="2016-07-06" version="1">MLIPEEGEKLICPDCGNEEELQSKEDYKLQEEAGGKKAPGIAVVEEEREKKFKKPEYDIDTDVSPELFEESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2U3</accession>
    <name>A0A133V2U3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00726">
        <property type="protein sequence ID" value="KXB00726"/>
        <property type="gene ID" value="AKJ40_00775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="124" mass="14040" checksum="9DBFB3B7C299CE02" modified="2016-07-06" version="1">MQSRIESYTEGVTSGPTDEYVEEKRISPWFPFPHSKVGSRLKSFGCGAILVGGEKAERVELAGPGWRRSVCEKAPQWKIWKKEWGFSVLVCTSHTSPFRVGRIEQKAKRDLENGALERAEEERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2U4</accession>
    <name>A0A133V2U4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Meth_synt_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00759">
        <property type="protein sequence ID" value="KXB00759"/>
        <property type="gene ID" value="AKJ40_00605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.517"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="333" mass="38489" checksum="F74FDCB156309B4C" modified="2016-07-06" version="1">MREKLFELGLDVPILPTTAVGSYPKPEKLERARLRFLKGEIEEEDLRPLEEKATREWIEIQEEVGLDIFVDGEMYRGDMTAYFARKLEGFEMSGLVRSYGNRYYRKPIIKGDIDWAASATVDYWSFAQDLTDKPVKGVVTGPYTMMDWSFNEYYADRKEACLALAKNLRKEVEALVEAGAKIIQIDEPALSARPEELSEFARDAMRIMTKNLDAYFITHICYGAFEFIYPQMLELPVDNFDLEMSNSDLNLTKLFEKEPFTKDISFGVIDVHNHVVEDEKTTEARLERALQVLPPEKIWVDPDCGLKTRKKKEAIEKLKRLVSAARDTRNKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2V5</accession>
    <name>A0A133V2V5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00763">
        <property type="protein sequence ID" value="KXB00763"/>
        <property type="gene ID" value="AKJ40_00635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.524"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007294">
        <property type="entry name" value="DUF401"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39556">
        <property type="entry name" value="PTHR39556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04165">
        <property type="entry name" value="DUF401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="400" mass="43680" checksum="EC908AD81D7A5DAA" modified="2016-07-06" version="1">MTHELLAWIGFFITIAILIVGSKIHLGLSFISGGVILGLFTLSPSETFIQIHRTLTNPADIIFTVALTLIPIIAGVLQETGGIDRIVENLKLGKKSFLGISPALIGLLPIPGGALFSAPLIDKAGGTTEGHVKTGINVWFRHLLYFIYPLSPFLIIPAKIANLSVYQVIKYQIPFLVIAIGIGYIFLLRKTSGEINFSSEASFRKLMPPLSVILIAPILDFILQKIFQFKIGEISMLIAISSSLMLALLINGSLKNVIKKSIKKTKPWNFSLLILGVLIFLNIFETSNMKNLIAALSLSKATLTIGFGFLLGVATGRIDLPATIVFPIFLTAYKLNSIPPIIFSITYFAIFIGYVITPIHPCVGLTLEYFNAEINKFLKLMIPPTLLSLAVAIATWSILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2V9</accession>
    <name>A0A133V2V9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000004">
        <property type="protein sequence ID" value="KXB00770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00770">
        <property type="protein sequence ID" value="KXB00770"/>
        <property type="gene ID" value="AKJ40_00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="61" mass="6801" checksum="54C69C0C0F6DE77E" modified="2016-07-06" version="1">MTLRCECGGELELLKVLDGDNGNGEGWAYEKYQCVRCGEIGSYSVNWGPWGQNERKRGCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Y1</accession>
    <name>A0A133V2Y1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_00440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00794">
        <property type="protein sequence ID" value="KXB00794"/>
        <property type="gene ID" value="AKJ40_00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="SSF110993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="SSF116742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="267" mass="30623" checksum="0F0C4E214B70F60A" modified="2016-07-06" version="1">MVERRWEWPEKNELVMCTVKEVFDQGAYLKLDEYGDKIGMVHISEIASGWIKNIRRHVKEGQKTVCKVLDVDKNKKHIDLSIRRVKDSQRSWKSEQWKRERKAENLLDQAAKRLDEDLDTAYEKIGFPLQEKEGEIYTVFEEAARKGREFLEEKLDVEDKWIDVMMELIETSVEAPTVEVKGYVDLKTPSPSGIEVISSSLQKARDSNSDPDTQIEIQYIGAPTYAIKIEGPTYKKAENVLKNTAETAISLIEEDGGTGQFYTEKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Z0</accession>
    <name>A0A133V2Z0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00812">
        <property type="protein sequence ID" value="KXB00812"/>
        <property type="gene ID" value="AKJ40_00425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.355"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005287">
        <property type="entry name" value="CHP00375"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00375">
        <property type="entry name" value="TIGR00375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="388" mass="44278" checksum="AF72AC49593A2920" modified="2016-07-06" version="1">MVFDTIAEQAIYKGLDFVGTGDILHPKWMEMLKKGLEKVDEGTYQHSEHGTKFVLTTEVEDEQKVHHLLIFPSIQKVEEFREKLEPYSSDMYIDGRPKVDLTGVEIAEFAADSDSLIGPSHAFTPWTSIFKEFESLEECYEDQLKNVDFLELGLSADTFLADRIGELGKLSFLSNSDAHSPWPNKLGREFNRFELSEPNASELFESIKKRKNITLNVGLDPELGKYHLTACSRCYKRFSLKEAEKSGWKCNKCGGTIKKGVYNRIGELSEFEKPQSPDFRPYYLHTVPLTEIIALAWNFSNPRSSQVQKTWRSLVEEFDNEITVLVDTPIDEIENFTDSEIAFMIQAFRNKELDIVPGGGGKYGELERPAKVINAQKKETQKKLSEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Z8</accession>
    <name>A0A133V2Z8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AKJ40_00540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00810">
        <property type="protein sequence ID" value="KXB00810"/>
        <property type="gene ID" value="AKJ40_00540"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.378"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="315"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB00810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="551" mass="61888" checksum="B3DFF75274C7661B" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V316</accession>
    <name>A0A133V316_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00842">
        <property type="protein sequence ID" value="KXB00842"/>
        <property type="gene ID" value="AKJ40_00330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.75"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="405" mass="46838" checksum="B247A08D66BD7EA2" modified="2016-07-06" version="1">MKKKLVDYRDFVGESKISEIYRKGTRLSKFHILHVNSTYYGGGVAEILRNMTLLMNEIGVDVGWRAMIGSPDFFRVTKKFHNALQGDEIDLTDMKKKVYEETSEEFASFTHVDHDMVIVHDPQPLPLITCYRKRQPWIWRCHIDLSNPNEEVWDYLKSFAVAYDQYVFQMDEFAAKGFSDEYDIIRPSIDPLTTKNTDIEDPTVEKYLNNAGIDSSRPIISQISRFDKWKDPFGVLEVFKIIKEEMDCQLVLIGSMATDDPEGQEVYDRLRREINGMDDVIIIADAHDIMVNSVQRASDVVLQKSLKEGFSLTVSEALWKETPVVGSEIGGIPTQIIDGKNGYLVNPRDYKEVAEKTMDILSSETLQEKMGRKGRERVREKFLITRHIEDWLDLWHNLLTECKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V318</accession>
    <name>A0A133V318_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7 8">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="10" type="ORF">AKJ40_00275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7 8"/>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00834">
        <property type="protein sequence ID" value="KXB00834"/>
        <property type="gene ID" value="AKJ40_00275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.62"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB00834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="337" mass="36314" checksum="BA30515A5F68EAFB" modified="2016-07-06" version="1">MPCTIIAGGQWGDEGKGKISSFLSLKDEPTKVARSGVGPNAGHTVHWKGEEYGLREISCGFVQEKAEVLIGPGVLINPEVVLDEIEKTGIGERIGIDPKCPIIEQKHIEQDKSSKHLESEIGTTGTGCGPANSERANRSIKLAREIDELEEFITDVPKKINEGIKNGEKVIIEGSQGFGLSLYFGTYPYVTSKDVTASSLAADVGVGPTSVDEVVLVFKSFVSRVGAGPFPTEMSPEEAEAKGIAETATVTGRKRRIGEFDFDLANRSAMINGATQLALTNVDRLFDGNKGVKEYEELTKDAKKFIEKVEQNIGTPVTLVSTGPDTEDTLDLRSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V321</accession>
    <name>A0A133V321_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_00250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00830">
        <property type="protein sequence ID" value="KXB00830"/>
        <property type="gene ID" value="AKJ40_00250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.56"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="7">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="6">
        <location>
            <begin position="191"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB00830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="603" mass="69661" checksum="C7EB82A2C55ED78A" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V328</accession>
    <name>A0A133V328_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH asnC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_00320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00841">
        <property type="protein sequence ID" value="KXB00841"/>
        <property type="gene ID" value="AKJ40_00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="155" mass="17933" checksum="DC7752F04C75BC77" modified="2016-07-06" version="1">MKDLDKKIILQLLKDAEQPIVDIAEEVGASRQTVSKKIKKFKESGTIKDMTANLNPEKFGFDVRAYVFLQEDPQEEIREDNEEKINEITQVSKFFRLFGRYSGLLEVWCKNREDLTSLVKKIHELEGISETETFIVHSVVKDKPADPFSEILKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V334</accession>
    <name>A0A133V334_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_00280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00835">
        <property type="protein sequence ID" value="KXB00835"/>
        <property type="gene ID" value="AKJ40_00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB00835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="66" mass="7203" checksum="CDD24F9B99BF8509" modified="2016-07-06" version="1">MSELPIAAVDRIIRKAGARRVSESAARELAEVLEEYALEIAEEAAELADHAGRKTVRDTDIRLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V345</accession>
    <name>A0A133V345_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_00300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00853">
        <property type="protein sequence ID" value="KXB00853"/>
        <property type="gene ID" value="AKJ40_00300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="145" mass="16434" checksum="F0E0E997C69BA8CA" modified="2016-07-06" version="1">MDEIDIKIVKELEKNGRASFRKIAGKLEVSEGTVYNRVKKMQETGVIKGFSVRSDSMKLGKGLEAVIGLRVDGGHLMEVEEELSKRDPVRCVYDVTGEYDVVVIGRFETRAELNEFIKSVLAMNHVERSSTHFVLNVIKEDLRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V361</accession>
    <name>A0A133V361_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00865">
        <property type="protein sequence ID" value="KXB00865"/>
        <property type="gene ID" value="AKJ40_00025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.5"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="177"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="325" mass="37313" checksum="E0A1F4035DB635BF" modified="2016-07-06" version="1">MKTGKIEDICTLLRKKLEEAVEKRSYDSAFLSGGLDTSVINYIASRQGNDFESISVGFEDSSMKDLKYAEIIEEELNLDLHVFTFDFEEAKNAARDVVEIMRSFDPIEIRNDISLHIGLKKAKELGLESILTGDGSDELLAGYPFLYKLPQDEMEEELDKIWRVMNFSSQQIGKNLGISVELPYLDEQFKKFAMNISSDVKVGEWNEEKFGKWILRKAYEDKLPIEIIWRKKIPIEIGSGTTILPDKFKSNLDEDYFKAKKEEVAKEDEVLVRSEEQLFYYQIYKSLYGPPKAEDPDKSKCPYCKTNVSEKVTFCRTCGSGLGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V365</accession>
    <name>A0A133V365_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="9" type="primary">nnrD</name>
        <name evidence="10" type="synonym">nnrE</name>
        <name evidence="13" type="ORF">AKJ40_00125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00879">
        <property type="protein sequence ID" value="KXB00879"/>
        <property type="gene ID" value="AKJ40_00125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.27"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="130"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB00879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="504" mass="53759" checksum="7C651718F8CF6E15" modified="2016-07-06" version="1">MIALDRMQALEINSDWRGVSRRLLMENAGAQLAKEINERKSPSEAVIYAGTGNNGGDGFVAARHLINQDVKIVLVLLGRPRDITTTEAQANWQILSGMEGDIDFRIIRDSKDFQNFSEINSDVAIDAMLGTGIRGTPREPVASAIGSFNKLDSYKIAVDVPTGVDPETGEVHGNASECDLTITFHDSKPGLMGASEEFVGEIIVRDIGIPITAEKRAGPGDVRLAIPPRDEESHKGQNGRLLIVGGGSRYVGAPALAGLAALRAGTDLVTIALPSRIANIVNSFSPDLITMQLPEEDLIPEAIPKISDQLEDSTAVLIGPGLGLGTRTEDAVIELMETIATDYPDLPVLLDADGLKIVSERPDLLKESNSIVTPHAGEFEILSGKKLSSKKKERIATVSETAEELRTSILLKAHVDICADEEGKVILNDTGNPGMTVGGTGDVLGGIISAFLSRGVKPFQAAVAGSFVCGLAGDICSEERGYEFTASDVKDNIPNAIERARKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V389</accession>
    <name>A0A133V389_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_00210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00893">
        <property type="protein sequence ID" value="KXB00893"/>
        <property type="gene ID" value="AKJ40_00210"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.45"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB00893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="292" mass="33249" checksum="6D3CE2C41BBE6E6C" modified="2016-07-06" version="1">MGVIELDSLTKYYGEIRGIENLSFEVEEGEIFGYLGPNGAGKTTTIRTLLGFLKPTSGRARVLGRDIGKEIVEIKQEVGYIPGDLSLYGNLTGKEFLDYFASLRSSNSSMLDDLLDTFEVPFERKIEGFSRGMKQKLAIVQAFMHDPKLVIMDEPTAGLDPLMQQKLYEFLEQEKEKGKTLFFSSHILSEVDKICDRVGIIREGRLVALEGIESLKSKRGKVVRVKIEGDPEKFDGPEDTKIEDGGWIQFIVREDINYWIEKLSKFNVLDLEVQNFSLEDIFMHYYEEGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V3A7</accession>
    <name>A0A133V3A7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_00020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00896">
        <property type="protein sequence ID" value="KXB00896"/>
        <property type="gene ID" value="AKJ40_00020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB00896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="190" mass="20955" checksum="C549E886F28933C1" modified="2016-07-06" version="1">MNSSNFGPRPLFDEGQVRRALELIGEHEPIGRKKLAEKLGIGEGSMRTILNRLKEKGLITSTARGHVLTDKGDRELGERSRKFLEIDVGDLTVGKVSVATMVKDAIEKVRRGIEQRDEAIKVGAQGATTLVYRDEDLELLCSETQLDKEIKSELLEFFQPSENDIIVIGTADSKKYAERGALAAAESLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UUV1</accession>
    <name>A0A133UUV1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000125">
        <property type="protein sequence ID" value="KXA97993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA97993">
        <property type="protein sequence ID" value="KXA97993"/>
        <property type="gene ID" value="AKJ40_04990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA97993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="82" mass="9402" checksum="426F1F951FBA84F6" modified="2016-07-06" version="1">MLKNILLFIGLGFSNPVFPDMGSQFLTAAILETLIPEKLVDPLNCFLLKIFLIGLGIQKFEQKLENTEKFKIPYINRVSYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UV20</accession>
    <name>A0A133UV20_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000123">
        <property type="protein sequence ID" value="KXA98052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98052">
        <property type="protein sequence ID" value="KXA98052"/>
        <property type="gene ID" value="AKJ40_04965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA98052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="381" mass="43526" checksum="AFB05373E402DD62" modified="2016-07-06" version="1" fragment="single">MSEGNQMVESPKIDVRVFRLTPEMDEPKYEAFEVPKLPKMTVLDALEYITEEIGRDIAYRSSCGIAHCGQCAVSVNGERVLACLHMIEEDKITIEPLPNFPIIRDLVVDFDRRRNETQKHLHLIRNKDMEQFPEKIDPTQMEKVIDFSQCIECQICQGVCPIIPGYMEWPGPSHFSWVSRFNTDPRDGGKNNRLNNIGNELWYCSNCNSCVNDCPWEIPIRDGINELRSQVIETGFLPKALQDSLESTLTSGSPYQGARKKRNQWISAGEEKAFSDSKKTLYFVGCTSSYDTRAQEIPKALVKIFDKANIEIGILDDEETCCGGPIKNIGEIGLFEMLKDENIKKFNDYGVENIVTHCPHSFNTFKKDYLEGEGDYKIYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVU9</accession>
    <name>A0A133UVU9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000115">
        <property type="protein sequence ID" value="KXA98322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98322">
        <property type="protein sequence ID" value="KXA98322"/>
        <property type="gene ID" value="AKJ40_04835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="59" mass="6686" checksum="AC64F355D35075DB" modified="2016-07-06" version="1">MFRFSINQDWEAVLAPEDYEGSRDLIKKGKGSRRSPNPPLRKKCLCENSKKKSGSRTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UVY8</accession>
    <name>A0A133UVY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_04820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.157" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000114">
        <property type="protein sequence ID" value="KXA98375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98375">
        <property type="protein sequence ID" value="KXA98375"/>
        <property type="gene ID" value="AKJ40_04820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.183"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA98375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="142" mass="15768" checksum="E6C09515ACFD036C" modified="2016-07-06" version="1" fragment="single">PSPVPVMDLVEVIKGMKTSGETFDTVWKTVEELGKTPIEVEDSPGFVVNRILIPMINEAFFTLQEGVAKKEAIDDAFKLGANHPMGPLEVADLIGLDTVLHIMEILHEEIGDSKYRPCPLLRKYVRAGKLGRKTGEGVYKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWG6</accession>
    <name>A0A133UWG6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000105">
        <property type="protein sequence ID" value="KXA98537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98537">
        <property type="protein sequence ID" value="KXA98537"/>
        <property type="gene ID" value="AKJ40_04685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="157" mass="16258" checksum="7CD621CFD2C08FFE" modified="2016-07-06" version="1">MDRGENMVRAFSWCLVLTLAIVFSVYPIASRELTFLAGPVLLVLGLAPLAVLKINNESLTSVGADIAFGAFDTGFMTIATLVGATFAGILGAVIGAGAGDAITDAWAGLIEGKVASWLRKRGIDEARRPFKTSMGKMSGCLLGAGVTVSFASIIGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWK5</accession>
    <name>A0A133UWK5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000103">
        <property type="protein sequence ID" value="KXA98574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98574">
        <property type="protein sequence ID" value="KXA98574"/>
        <property type="gene ID" value="AKJ40_04655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="131" mass="15058" checksum="7DC21999B15BDF89" modified="2016-07-06" version="1">MEQKCPDCGSSNLKGAGTAENKYVTKQAYRCKECGRYFVERDGFEGKSYPKEVIVEALHLYVEGMSLSKIRIHMDQHHGYSPSDGSILNWVREYSEIVEKFEKEQMGDPEIGRKIHLDEVVLKVGKKRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWL7</accession>
    <name>A0A133UWL7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000103">
        <property type="protein sequence ID" value="KXA98575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98575">
        <property type="protein sequence ID" value="KXA98575"/>
        <property type="gene ID" value="AKJ40_04660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="175" mass="20611" checksum="8E91F03161BE66E0" modified="2016-07-06" version="1">MNAIDKKTKYNLNTKFIQSRTNENFDEYFKELKNVIGEQVREIYEKEKQKPPEDRNLVTFVTDKLDQYKNAFENHFTHMADFDFGVPIAQSEYGLEHNNNPIERHNGDIKQRYKVMRNFKSYETAAAFLNLRRTIYNHVRPHQSLGHTPGEEAGIDLDLAKNRLLDLIETCATQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UWP1</accession>
    <name>A0A133UWP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000101">
        <property type="protein sequence ID" value="KXA98614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98614">
        <property type="protein sequence ID" value="KXA98614"/>
        <property type="gene ID" value="AKJ40_04615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="81" mass="9565" checksum="901017AB6F44789D" modified="2016-07-06" version="1">MTPNQTGLGMKCPLEISAQFATLVFLRIESPLTEHRTSNNHNLKFSQLNMKIRKKWELIRKNLRECEVIILRMVLVRKMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX19</accession>
    <name>A0A133UX19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000096">
        <property type="protein sequence ID" value="KXA98732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98732">
        <property type="protein sequence ID" value="KXA98732"/>
        <property type="gene ID" value="AKJ40_04510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="169" mass="19248" checksum="14001C9CB21DA70D" modified="2016-07-06" version="1">MNKKMLEKAYELGFEFEKNYHGCAQCVIGAIYELFPEMKERKVFQSASGLAAGIGLSTEGHCGALSAGVMILSQKFGRTLRKIEDSEERRFKAYRLSEKLVEKFLGVYSSVKCKEIQKKLMGRSFYLFDPDDWEAFEKIGGHKKVCPDVVGKATKWTVEILLNEKENKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX61</accession>
    <name>A0A133UX61_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000094">
        <property type="protein sequence ID" value="KXA98784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98784">
        <property type="protein sequence ID" value="KXA98784"/>
        <property type="gene ID" value="AKJ40_04460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="109" mass="12822" checksum="14ABD18B71C4259B" modified="2016-07-06" version="1">MRRGPVPGYDELVDHYERQLDRFKRKDIPPMIVVGEGCEVTPVIGLSEEFRERREGVEKHEPGDLEEDPAARLMYLICLFTPDRKVARFYDKLTLELLHEFRGDEAEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UX95</accession>
    <name>A0A133UX95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000093">
        <property type="protein sequence ID" value="KXA98815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98815">
        <property type="protein sequence ID" value="KXA98815"/>
        <property type="gene ID" value="AKJ40_04435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA98815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="82" mass="9545" checksum="B235C4D25B75685D" modified="2016-07-06" version="1">MKIEDLGFVKASKYRQKILKELTEGKEIPSEIAKKLDTSKPQISSTLKELKERKIVECVTPERRKGRIYDLTEKGRKIVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXH8</accession>
    <name>A0A133UXH8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_04365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000091">
        <property type="protein sequence ID" value="KXA98881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98881">
        <property type="protein sequence ID" value="KXA98881"/>
        <property type="gene ID" value="AKJ40_04365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA98881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="63" mass="6997" checksum="46B16771C7529973" modified="2016-07-06" version="1">MKGTVKFFDGRKNYGFIEPKGRGEDHFVHASDIESGPLNEGDEVEFDSEQGDKGPRAVNVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXL1</accession>
    <name>A0A133UXL1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000090">
        <property type="protein sequence ID" value="KXA98922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98922">
        <property type="protein sequence ID" value="KXA98922"/>
        <property type="gene ID" value="AKJ40_04325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="107" mass="11554" checksum="FF062D7F7660D7F6" modified="2016-07-06" version="1">MNMIDRIKNHVRRSWEFGKAKSDSILGDSHGQALTTILNLVIAGIALVIGVYIFSEVAGQINTTDNSQLDNIIGDIYGAYGMTPIILIVLIAGAIISVLLAFRGRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXS0</accession>
    <name>A0A133UXS0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000087">
        <property type="protein sequence ID" value="KXA98980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA98980">
        <property type="protein sequence ID" value="KXA98980"/>
        <property type="gene ID" value="AKJ40_04245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA98980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="60" mass="7012" checksum="1ECA404024C4D147" modified="2016-07-06" version="1">MVRLECDEEKFTPPIKEKKGKSSRIIELERKFKKTKRKAGPNRKRPNPILANHTGQNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXV9</accession>
    <name>A0A133UXV9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ40_04145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000083">
        <property type="protein sequence ID" value="KXA99019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99019">
        <property type="protein sequence ID" value="KXA99019"/>
        <property type="gene ID" value="AKJ40_04145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.1134"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="548" mass="58641" checksum="216EECF5BE7E95A4" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXY1</accession>
    <name>A0A133UXY1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DRTGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_04125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000082">
        <property type="protein sequence ID" value="KXA99031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99031">
        <property type="protein sequence ID" value="KXA99031"/>
        <property type="gene ID" value="AKJ40_04125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="217"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="341" mass="37229" checksum="F2C7BF252036B6BF" modified="2016-07-06" version="1">MSRNLSVVSTENGIGKTAFALALGMVAKEHEIEVGYMKPLGTRLRTRYGKPLDEDSVLAKKVLELDSEIEDLNPVIYSETFIEQAMKGREKTVKLRKKILNSYKKLSKNKDLMIIEGGGKLNTGGIINLTDFDIAELFDSDVVLLGQFDSPVDLDDLLDGTARIGKHLLGVIFNAVSEMNLGKIETLVTPLLNSKNIPILGVLPRKKELAGIKVRELSEELGAENITNVSGDASIARFLVGAMTGEDALRYLRRVKDTAFITGGDRSDIQRAALESPGIKCLILTGGFEPPGAIIGKAEEKNIPILVVQSDTLTAVETAEEIIRTGRTRKVQDGHFWIPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXY5</accession>
    <name>A0A133UXY5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TP_methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_04100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000081">
        <property type="protein sequence ID" value="KXA99041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99041">
        <property type="protein sequence ID" value="KXA99041"/>
        <property type="gene ID" value="AKJ40_04100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="244" mass="26272" checksum="8C0F7FE7E7BA390B" modified="2016-07-06" version="1">MTGKVYLVGCGPGTPDLLTIRAVNVLESADVVLHDRLIDDHVLEHTKDEVEEIYVGKKAGESNKQEWINELLVSKAEEGNVVARLKNGNPVIFARGGEELQYLKERGIDVEIVPGLSSATSLAPLIGVPLTKRGVSSSLSILTGVGKGGSDSSWENVGDTGVVLMTVKNLSRVVEKLTESKMSKRTLSVLISSGSTSDERILVSQLDRIPELAEFVGIEPPFNTGGGGSRRGIIGHKRPDFRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXZ0</accession>
    <name>A0A133UXZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000079">
        <property type="protein sequence ID" value="KXA99054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99054">
        <property type="protein sequence ID" value="KXA99054"/>
        <property type="gene ID" value="AKJ40_04065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018645">
        <property type="entry name" value="DUF2072"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09845">
        <property type="entry name" value="DUF2072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="144" mass="15682" checksum="9B25044E35202F07" modified="2016-07-06" version="1">MNHECLNCGNTLKFASEGSPYEGCPKCGCRLFSYARGQPPELDVETAEKVEDVGGARAGREIVEEVETVLLELDEVGGGGVLEDLKFNLESIKVKGDGVFEISLDKLAGEKPLIVELKEGKYHVHLSSLFGASKKRIDLEDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UXZ5</accession>
    <name>A0A133UXZ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_04025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000078">
        <property type="protein sequence ID" value="KXA99063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99063">
        <property type="protein sequence ID" value="KXA99063"/>
        <property type="gene ID" value="AKJ40_04025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="297" mass="32655" checksum="0EE04C050DD4CFA2" modified="2016-07-06" version="1">MILNELIGVLLGTSAAFFFALSLVFIRKATVSGESLEAVIVVTSTNLAIFLPVSLVFHYPDFDLTKESLLAFAGSGLIGSFLGRYCFFEGTRRIGASRMSPLSKGSLIIATLIGLLIFREAITTGHFFGIFILFIGIVLVGYEMRISNSKIHNPSRVDYLFPLAGMVFAGLIDPIVKFGLLENTPVTVGLAIRFIFGFIVIVFYFLSKGMSPLKPFRVKDSHLYIKAGIVNSFAQISFFSALSISRIVVVSPFKNISPLFMLFLSYLYLKRLEDITDFLIVGSVLVIGGAMLIGFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY05</accession>
    <name>A0A133UY05_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_04035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000078">
        <property type="protein sequence ID" value="KXA99065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99065">
        <property type="protein sequence ID" value="KXA99065"/>
        <property type="gene ID" value="AKJ40_04035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="75" mass="8652" checksum="AA23ABD6CCEE8487" modified="2016-07-06" version="1">MVTERLIPFAPREVTREKMWELYEEYKERVSNLEGLKNGGGCLVPIMRITRMLLSQGTGKRGRRSLSVRSGTIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY33</accession>
    <name>A0A133UY33_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000074">
        <property type="protein sequence ID" value="KXA99112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99112">
        <property type="protein sequence ID" value="KXA99112"/>
        <property type="gene ID" value="AKJ40_03915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="68" mass="7246" checksum="F79D574C1ED1C5A3" modified="2016-07-06" version="1">MELDCSVDVVGEAFYYDFSELFVPFSGEDVASVFFGYDRVHGLVLVSLPVEILIQSSGGLGAGKRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY73</accession>
    <name>A0A133UY73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000073">
        <property type="protein sequence ID" value="KXA99124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99124">
        <property type="protein sequence ID" value="KXA99124"/>
        <property type="gene ID" value="AKJ40_03885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="313" mass="34734" checksum="DFFEAADCFDA7B014" modified="2016-07-06" version="1">MSEFEPEGIYPALPTPISEDGTINYGASEEHIRYLEEEGGVQGVVPAGCTGHAATLGDRGGIFDEHVEYIARVSEMTDLPVIGGTGMNSTRQTIELASEVEKEADVDAHLVISPYQNCPPQDLIVEHYRILADELKEPLIAYNVPGRTGRNIEADTTMQLAEIEGVIGMKEASLDYEQIHEIGHRIQGRDDIESFNLGSGDDSANHFVFEQGGTFGISVSGNVHPEAVVEVWEKGYREQNHQAAFERNRELMPLHDAMFQAGEKNPLSVQYALNLMGFDFGTPRMPLSREPREDEEYQNQAELREVLDGFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UY97</accession>
    <name>A0A133UY97_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000072">
        <property type="protein sequence ID" value="KXA99141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99141">
        <property type="protein sequence ID" value="KXA99141"/>
        <property type="gene ID" value="AKJ40_03875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="116" mass="12956" checksum="C34933F5BA190039" modified="2016-07-06" version="1">MVKVGVQDFPFNIPDMTGSLDLKDIWDSCPEKHRRTVDDTDLDDSEFVRGALISVLAGFLCKAAGVEPEPKQVERVTKDGKYRGRLLDRASSSALNVGNQLKGRRWMNEIATAFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYA8</accession>
    <name>A0A133UYA8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000070">
        <property type="protein sequence ID" value="KXA99163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99163">
        <property type="protein sequence ID" value="KXA99163"/>
        <property type="gene ID" value="AKJ40_03800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="109" mass="12869" checksum="FC612CCC2B527D0E" modified="2016-07-06" version="1">MSEEEFQELKEILMDHLGRKEPRQRLVEQDELRGYLEHSWIYKGENGGKPIVERIPGARERGKPVWILNLNGQTTWAPVPKDEKKVEDAYRKTLPHPYSFTYSLFLLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYB7</accession>
    <name>A0A133UYB7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4Fe-4S domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ40_03740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000068">
        <property type="protein sequence ID" value="KXA99183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99183">
        <property type="protein sequence ID" value="KXA99183"/>
        <property type="gene ID" value="AKJ40_03740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.989"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046356">
        <property type="term" value="P:acetyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016041">
        <property type="entry name" value="Ac-CoA_synth_d_su_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016218">
        <property type="entry name" value="AcylCoA_decarb/synth_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03599">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000376">
        <property type="entry name" value="AcCoA_decarb_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methoxybenzimidazolylcob(I)amide binding" evidence="5">
        <location>
            <begin position="380"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>5-methoxybenzimidazolylcob(I)amide</name>
            <dbReference type="ChEBI" id="CHEBI:157765"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>5-methoxybenzimidazolylcob(I)amide</name>
            <dbReference type="ChEBI" id="CHEBI:157765"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>5-methoxybenzimidazolylcob(I)amide</name>
            <dbReference type="ChEBI" id="CHEBI:157765"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000376-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000376-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXA99183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="460" mass="51228" checksum="92CCDFC705416212" modified="2016-07-06" version="1">MEIYRLLPGDNCGECGTKTCMGFATKLIGRKGEVDDCPLMTEPEYEEERKELIGLLTPPVRPVKVGKGENAFEIGGEEVIYRHEKTWYNRPPMIIDVDDKMEEKELIERVEKISDYSRIKIGEVLTYNGIAVRAKSGDPFNFKKTVKLVDENTEYPLVLCSFDPEVLESGLEIVSNQNPLIYAANKDNWENVADLAIEHGCPMTISSTDINEIAEISTRSLARGVEDDQIVLDPGTNPLDLRSTTNRLIKLRRAAIEDEFEALRFPLLGIPSTTWMVEESENDAAFMEATTACALVDNSIDALILHSDEVWSLMPTLILRQDLYQDPRNPASVEPELREVGEPDENSPLLITCNFALTYYTVEGDSEGVDCYIYPVDTDGTSVTSAVAGDLMTAQKIVDAIEEHDFEEIVSHKTLILPGDAAVLSGQIEVDSGWNVLVGPKDSSGIKDFLDDNWPPKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYC7</accession>
    <name>A0A133UYC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000069">
        <property type="protein sequence ID" value="KXA99175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99175">
        <property type="protein sequence ID" value="KXA99175"/>
        <property type="gene ID" value="AKJ40_03775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="119" mass="14247" checksum="C538305FBC29946C" modified="2016-07-06" version="1">MELVDVDRFGKVFVYWVDKGVFAVRDEHDLSTLRRLQPLLYRCYELFRAEVVGGRNYIENWSVIDHCKYNRFIFRQPRTRQVTEDGDDIRTLLNSNSALAHLFSNILVKTLQREFYKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYD8</accession>
    <name>A0A133UYD8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000068">
        <property type="protein sequence ID" value="KXA99185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99185">
        <property type="protein sequence ID" value="KXA99185"/>
        <property type="gene ID" value="AKJ40_03750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="128" mass="15072" checksum="DC20D0B80A62B93D" modified="2016-07-06" version="1">MVWIPEEIKEEFKEVIPDEIYDRIVTEKETRDVNELKELLEEKNHPIITRWVDVSDNLIRETINFIKEKGGKVEPKEASEALGLNEVQFRRVIDEMKDRGILGGEPGGYLDGLNYRWLRGDVCEWPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYI9</accession>
    <name>A0A133UYI9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_03485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000059">
        <property type="protein sequence ID" value="KXA99282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99282">
        <property type="protein sequence ID" value="KXA99282"/>
        <property type="gene ID" value="AKJ40_03485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="83" mass="10009" checksum="297F6AE9B8C3D1C9" modified="2016-07-06" version="1" fragment="single">MRREGSWAWADMLLDFIENPQKWLRECHTRSNVESGFSTFKRHFLSPLRKCIQRRRKTEAFARACDYNLKRASYVRRQEGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYJ6</accession>
    <name>A0A133UYJ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ40_03615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="LHXU01000063">
        <property type="protein sequence ID" value="KXA99237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99237">
        <property type="protein sequence ID" value="KXA99237"/>
        <property type="gene ID" value="AKJ40_03615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.956"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXA99237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="400" mass="44170" checksum="ACC2EC154F393B33" modified="2016-07-06" version="1">MEKSVEEVRTEIPFLDSGIIYLDNAATTPTPESVIEAMFEYYHEYSANIGRGVHKTAKRATEAFESSRKKIAKVIGSDSKEVVYTKNTTEGLNLLAKGLNLEKGDKVIATVLDHHSNLIPWQRLEEEKGIELKILRECPDFVIDPCAVEEAIDERTRIVTMPSVSNAFGTRQPVEEVGEITQENDVLFSVDAAQSVGHMPVDVKEIECDFMATPGHKGLLGPQGTGFLYVREELIEDIKPLLCGGGIVKGVEEHTCELINPPQVFDAGTPNIPGIIGLGKAAEYVLDIGLEKIERRERKLGDRILDIAELDNVHVYGLGSREKLGGVVSFNLEGLDSHEVSSLLDEIGNIATRSGHHCAEPAMKHFDIGGNVRASVHYYNTMEEMEEFLEVLDEISKELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYM5</accession>
    <name>A0A133UYM5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ40_03580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="LHXU01000061">
        <property type="protein sequence ID" value="KXA99264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99264">
        <property type="protein sequence ID" value="KXA99264"/>
        <property type="gene ID" value="AKJ40_03580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.945"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXA99264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="635" mass="70987" checksum="1E6318A026007D05" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYU3</accession>
    <name>A0A133UYU3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PglZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_03350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000055">
        <property type="protein sequence ID" value="KXA99355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99355">
        <property type="protein sequence ID" value="KXA99355"/>
        <property type="gene ID" value="AKJ40_03350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PglZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="328" mass="36825" checksum="F3ACFC74FB05228D" modified="2016-07-06" version="1">MTAILPKTEDRLNFTEENGEFSVLYDGTGINSRNDRIEKLSSEDLSIYRDTSSLLKCDPEEIKSEIERGKRIIVFSQEIDLTGESLDAPSLSKFKKNIGDINKVIETLQKGGVETVYVITDHGFLYKPREMASESVSKPEGNIVKFGRRYAIGRDLNSDFVIFPNIKDYGIDSDLDFAFPRSLGTFKKRGGSRKYLHGGISLQEMIVPVVRIVSNGKETEKKTVVKITDVPDRIANPYFKVGVKLVSSALDTGEKRVRIEPKQFGKEIGDNVYCSAGVTESTATVKLDLDEVEDQSGELELYFYDDETEVLIDQKQINLDLVYTDGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UYZ8</accession>
    <name>A0A133UYZ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000051">
        <property type="protein sequence ID" value="KXA99418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99418">
        <property type="protein sequence ID" value="KXA99418"/>
        <property type="gene ID" value="AKJ40_03180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.806"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="163" mass="17475" checksum="0C25D62E73314FDD" modified="2016-07-06" version="1">MIEEKEKISLTVNENDYSVEVKPDKSLLWVLRNKLGLTGPKEGCGKGECGACTVLLDDSPVNSCLVLAVQADGKEVVTIEGIADGDELHPIQESFIEKGAIQCGFCTPGMIVTAKSLLDENPNPTEKEIKKYIAGNICRCTGYSKIIDAIKHASKKMSSSGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ38</accession>
    <name>A0A133UZ38_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_S49 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_03115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000049">
        <property type="protein sequence ID" value="KXA99453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99453">
        <property type="protein sequence ID" value="KXA99453"/>
        <property type="gene ID" value="AKJ40_03115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="2">
        <location>
            <begin position="113"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="280" mass="30464" checksum="BC5BFC76ED0E7295" modified="2016-07-06" version="1">MVLVFKRLSSGGIRRKDSNSKKLFKIIGILIVLALVAAGFYYLGSLDLGGVKVGKKPKVAVVNVTGVIENFQTAHRVSKTAKDKTVKAAVIKVNSPGGYVSPSFQLESAISKLAEEKPTVGAVGQLGASGAYLAVSAVDNLYVHHSSLVGALGVIAIWISYKEYYENKGIEHYVFKTGPHKDMYAPWRGPTENEKEMIRKEINRIEDRMLGEIIQNRPSLENNLPLSLVKGEIVRGFESVEINLAEGIIGTYEEAIEKAAEAADLSEGEYQVVRAENLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZ48</accession>
    <name>A0A133UZ48_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_03075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000048">
        <property type="protein sequence ID" value="KXA99464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99464">
        <property type="protein sequence ID" value="KXA99464"/>
        <property type="gene ID" value="AKJ40_03075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="63" mass="6778" checksum="4ECA97F5C1D3CF97" modified="2016-07-06" version="1">MKEPVVDKDTCQGHMVCVGIAPEVFEIEDDGKSSVKNPEGADESTIQEAIDGCPADAISWKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZA2</accession>
    <name>A0A133UZA2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000045">
        <property type="protein sequence ID" value="KXA99523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99523">
        <property type="protein sequence ID" value="KXA99523"/>
        <property type="gene ID" value="AKJ40_02970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="89" mass="10547" checksum="5C443F9509D93DAE" modified="2016-07-06" version="1" fragment="single">MKSQRRETELHTVWYGPDCEVVWGGENTVFRADFWEGKIEDGEYPEDYVYDVYWHIGPSAHYWKTGKHSVEVILNGDVVETLEFNNSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZC6</accession>
    <name>A0A133UZC6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000045">
        <property type="protein sequence ID" value="KXA99519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99519">
        <property type="protein sequence ID" value="KXA99519"/>
        <property type="gene ID" value="AKJ40_02950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="126" mass="15037" checksum="BB9822DB96EE38E6" modified="2016-07-06" version="1">MTKINLFHIDNIYVFKHYFEESDIFEELRDYYNSFEYRFEVKEDEVEDAVEKLEKHGYNVNIVEKRDIPDYTVVIGKYEKHADLLKKSVDVIEVGDKKALVLKDKVAKEEALDRGEEPDEGWETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZD5</accession>
    <name>A0A133UZD5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000043">
        <property type="protein sequence ID" value="KXA99554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99554">
        <property type="protein sequence ID" value="KXA99554"/>
        <property type="gene ID" value="AKJ40_02875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="PTHR14025:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="170" mass="19995" checksum="14A677660BEA8447" modified="2016-07-06" version="1">MRTGDLKVLVATSVGEEGLDVPSVDPVVFYEPVPSGVRYIQRKGRTGRKSKGKAIILVTEETHDATYLKVSEKRRKKMKTVVEGLNTKLEKMERKIPQLEKNPMPREIIAEAEKYSPPKKRKSPRPKSGWGRGQNHPNWRRKRKNTWRKNGRKSLEETFYYFRDIYRYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZF1</accession>
    <name>A0A133UZF1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_02805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000041">
        <property type="protein sequence ID" value="KXA99578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99578">
        <property type="protein sequence ID" value="KXA99578"/>
        <property type="gene ID" value="AKJ40_02805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.681"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="3">
        <location>
            <begin position="322"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXA99578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="681" mass="78870" checksum="CD2E3B07AF0542FF" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZH4</accession>
    <name>A0A133UZH4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000041">
        <property type="protein sequence ID" value="KXA99581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99581">
        <property type="protein sequence ID" value="KXA99581"/>
        <property type="gene ID" value="AKJ40_02790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="147" mass="17059" checksum="41F0A9E69DD86465" modified="2016-07-06" version="1">MEIRNFQATDLQRVVKIERESFRSPWPEILFRRRSEMDPDGFSVATCESKVVGYVIGRIEIKKGLELGHLMNLAVDEEYRRQGIGSLLLKEIEDYFKREGARGIWLETREGNRAAENFYSKHGYEQIDVQEGYYSDGTDALIMCKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZK3</accession>
    <name>A0A133UZK3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000039">
        <property type="protein sequence ID" value="KXA99625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99625">
        <property type="protein sequence ID" value="KXA99625"/>
        <property type="gene ID" value="AKJ40_02710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="217" mass="24985" checksum="A0CFDB1D428E4C12" modified="2016-07-06" version="1">MFSSLEGINPENVGIVNTVKYETGVSMNYKYSGPDIRGIKDSASCQPRLLNELSNRRKKKSRKAAYLAKREYKKFGGMEIPVVKESTNDKEKNDRTIVKSLSKYERKNDVRTVLLTADTQMADICEMESVDRFYSKYPEDYSLNECSYHEFLKLVFDLSVTFGLVKLNSVVIFGEFGGKGPDEPDKMKLKVLNEKLFKKFEKHSKICRELSELNIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZL1</accession>
    <name>A0A133UZL1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000040">
        <property type="protein sequence ID" value="KXA99599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99599">
        <property type="protein sequence ID" value="KXA99599"/>
        <property type="gene ID" value="AKJ40_02745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="109" mass="12894" checksum="EFB3D2FE6D26A76B" modified="2016-07-06" version="1">MEKPGRIEKAFDVLQNLLETDRPYVSSEEVFRGYLFASFISLTTYYVVLNFLQDHEVNNRVSVKDVLFEFSKIRIKDRGHPAFSEIPKKVRELAEELKVENIMHKIWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZS6</accession>
    <name>A0A133UZS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="LHXU01000036">
        <property type="protein sequence ID" value="KXA99684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99684">
        <property type="protein sequence ID" value="KXA99684"/>
        <property type="gene ID" value="AKJ40_02635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.602"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="192" mass="21461" checksum="D514CDFE48A1B332" modified="2016-07-06" version="1">MKVAVIDNIDSFVYNLVQYIGVLGAQPTVRRNDSSLEEIEEIEPDRIVISPGPKTPKDSGISPEVVKKLGKEIPTLGVCLGHQAIAYAFGGKISPADRLMHGKTSMINHDGGKLYRDVPNPFEATRYHSLIVDQSTLPDCFRVTARTKDEHREIMGIEHEEYPIMGVQFHPESILTPLGKRIVKNFLEVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZS8</accession>
    <name>A0A133UZS8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000035">
        <property type="protein sequence ID" value="KXA99705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99705">
        <property type="protein sequence ID" value="KXA99705"/>
        <property type="gene ID" value="AKJ40_02590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="141" mass="16576" checksum="AEEDD780E40F9CF8" modified="2016-07-06" version="1">MNILFASVNNAEIRSELLKEEANKSFENREFDYHYLDESITIPTGVERAAPWHFCSLTEEINEIEKNRCYKINYCLMYVLEEIEDLYEKFPKIDLYVLLFPKNPLRSGAISSHSRKFVCVKNDIDRIIDALASIVKYLDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-06-17" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZZ8</accession>
    <name>A0A133UZZ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000032">
        <property type="protein sequence ID" value="KXA99759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99759">
        <property type="protein sequence ID" value="KXA99759"/>
        <property type="gene ID" value="AKJ40_02445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGGY_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="170" mass="19204" checksum="92A6CA701FE5C22D" modified="2016-07-06" version="1" fragment="single">VVLPYFKGERCPIWDVNARGNVLGLTLYHTKAHLFRAFLEAVGYSLRHNIEVGGEMGLDVKDVCKIVGGISSSSLWTEILTDITGKKIVAPSGGVGAPLGNALLVGVGTDLFDDYDEIRSWIKSDEIFSPSKENQKIYDRYYEIYRKLYKDIKDDMHKLTEISEKNYHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133UZZ9</accession>
    <name>A0A133UZZ9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl12p</name>
        <name evidence="4" type="synonym">rpl12</name>
        <name evidence="6" type="ORF">AKJ40_02475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000032">
        <property type="protein sequence ID" value="KXA99764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99764">
        <property type="protein sequence ID" value="KXA99764"/>
        <property type="gene ID" value="AKJ40_02475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.563"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_L12_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXA99764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="101" mass="11037" checksum="4CBADECED384DDBE" modified="2016-07-06" version="1">MEYIYAAMILHSVGQEVTEENISKLLEAAGVEVDEARVKALTTALEDVNIDEAIETAAMPAAAPAPETSEEEEEKKKAEKEEKEEEKEEEEEAPGLGGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V008</accession>
    <name>A0A133V008_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_02460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000032">
        <property type="protein sequence ID" value="KXA99761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99761">
        <property type="protein sequence ID" value="KXA99761"/>
        <property type="gene ID" value="AKJ40_02460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="155"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXA99761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="295" mass="31853" checksum="E60EBC993CCB19F3" modified="2016-07-06" version="1">MQIDIASALLATLSAVFFAVEISLIRKSTVKGEPIDAAMITMWINLLIFAPLTLFYYPDFGLKIKTILAFTAAGIFGSFLARICLYEGTKRVGASKSSPILKGDLLIASLVGLIILEEPITSGHISGILVLLAGVILVSYEMEKEKTGSNWKPKIGLLYPFGAMIFSGLSRPFAKVGLSAGTPVIAGLTVKFFVATAILSTYYIKKGNSPLAPFKARGRNYFIGAGIATSIGMWLIYSALRSSRVVVVMPFWSLSPLFVLVISYFFLKRLESISGKLILGTILVIIGTTLTGIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V058</accession>
    <name>A0A133V058_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000029">
        <property type="protein sequence ID" value="KXA99832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99832">
        <property type="protein sequence ID" value="KXA99832"/>
        <property type="gene ID" value="AKJ40_02335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="61" mass="7219" checksum="69F4B88336043F62" modified="2016-07-06" version="1" fragment="single">LIREIDELGLQPYSYPEPLDPIDKEDIKLVYWLAIAPKEEEKKRLTGFISQNTLKKYEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0A9</accession>
    <name>A0A133V0A9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000028">
        <property type="protein sequence ID" value="KXA99855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99855">
        <property type="protein sequence ID" value="KXA99855"/>
        <property type="gene ID" value="AKJ40_02295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="63" mass="6937" checksum="0471CCD877961671" modified="2016-07-06" version="1">MEVIPFTKTTALGIESIGNLSESLEMNGEGGSFTDRHPTGLKYCGIVKKGFRETPLKLFLKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0F1</accession>
    <name>A0A133V0F1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="8" type="ORF">AKJ40_02230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000026">
        <property type="protein sequence ID" value="KXA99910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99910">
        <property type="protein sequence ID" value="KXA99910"/>
        <property type="gene ID" value="AKJ40_02230"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.457"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="215"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXA99910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="340" mass="36078" checksum="F203D9A1117351E2" modified="2016-07-06" version="1">MTESTSEVEEDYEGLSKETQPSILVLGCGGAGCNTVSHMAEEDLDNVKLVAVNTDAQDLIHSDAEEKILIGREITGGLGTGSNLEKGEKSALENKETLKEVLSGYELVFLTCGMGGGTGAGAGPVIADIAKGLGALTVGVVTLPFKSEGEIRNKNSIEGLFNFREAADTTIVIPDDKLLEIAPDLSLEEAFKLADSVLVDTITGITELMSETGLINLDFEDVRTTFEDGDMGVVGFGEASGVNRAERTVDKAIENPLMDMKVENAKRALISITGSEDMTLDEAEKVTGIVSEKLQPDAKVAWGARISEDLTNTVMVMLIVSGAEKLEGRDEVVDLGLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0H3</accession>
    <name>A0A133V0H3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_02160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000025">
        <property type="protein sequence ID" value="KXA99933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99933">
        <property type="protein sequence ID" value="KXA99933"/>
        <property type="gene ID" value="AKJ40_02160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXA99933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="291" mass="33516" checksum="74B7D6B6DB247676" modified="2016-07-06" version="1">MLAKAFGVPGYFLWSPLTFLIRFFLIEHFCCCPDCGSTDVVRDGFGERKTMPDIPMLECNDCGRDFCLRANTVFYWKHASMGELFIVSWIFFGKGSRRWMREWIRGLGKFCCSEWFERLEKTLSEAAGNFSEFLDGFFQADEMYIHSFGKKLLIFGVKRGDGKIFETVLRGHSAFEFKTALDKADEEIGPIVGLDTDAHTSCPLATEWLGILHRPVNRSEEGFVNEKGVHSNGVENLWSHDRDWIEAARGYGSMETLKRVVKAHQVYHNQIKESPVPVWSFLKLIYEEFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0I0</accession>
    <name>A0A133V0I0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ORF">AKJ40_02180</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="LHXU01000025">
        <property type="protein sequence ID" value="KXA99940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99940">
        <property type="protein sequence ID" value="KXA99940"/>
        <property type="gene ID" value="AKJ40_02180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.446"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="164"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="310"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KXA99940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="419" mass="46938" checksum="1288183F3D15B807" modified="2016-07-06" version="1">MGLQITYEWAEVEELEAARLGKSCKACCQIADLKGIEECVVLQTCNRVEIYTVVSELQRDKGRLRKYAQTSMDLAVGDYIKFLSGVELLEHLLRLACGLESMVFGEDQILGQIEEEYETAQKEGTIGKVLNKAFEKSIMVGKKVRTETDINRGPTSVGSAAVGLAEELFGTLEDKNILIIGAGETARLVGKSLKERNPGSVTVANRTYERGLKLARKLDGEVVEFSDFTKLLPDTDVIISATGAPHFILEKRDMKGLISPGENLLIIDVANPRDVSEEVSEIENIELCDLDNLQQVRDRNLEKRKEEADKAESIIEKELDSLLKEYEGMEGDKMASEIHRKAEEIREREMSRAVRRLKKCTDSVNGVEVEVLEDLTRGLVRKTLHDPMSQIREASREGDKELLEAAEKLFDLSETRKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0J5</accession>
    <name>A0A133V0J5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM/SPASM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000025">
        <property type="protein sequence ID" value="KXA99935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99935">
        <property type="protein sequence ID" value="KXA99935"/>
        <property type="gene ID" value="AKJ40_02185"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.447"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027626">
        <property type="entry name" value="Pseudo_SAM_Halo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04347">
        <property type="entry name" value="pseudo_SAM_Halo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="36"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXA99935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="394" mass="44642" checksum="A268C6064FF6B32C" modified="2016-07-06" version="1">MIGVSKLLWGLETESDGLRYEDPSSKVKQIKHEGRHRNKPVVVWNATVKCNLSCRHCYSSAKLSSHPSELTTAEAKGLIDDLHEFGTPVLLFSGGEPLMRDDIFELIDYASGRGLRTVLSTNGTLLSSEITSNLVEAGVDYVGVSIDGLEETNDEFRGQEGAFRKALRGIKNCIDAGVKVGLRYTITRYNAHQLEEMIDLLREEGVDRYCFYHLAYSGRGEEIQKHDLSKNETRERVRSLFTMSLDLYEQGEDIEILTVGNYVDAPFLYLYAKEKLGENRAKKIYTFLKRNGGDGTGETIADIDFRGNVHPNQFWRDYTFGNIRNRPFQKIWTDTSDPVMKGLKNKEDYLKGKCANCRFLKICKGGSRVRALKVKGDIWAPDPKCYLFKEEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0J9</accession>
    <name>A0A133V0J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99971">
        <property type="protein sequence ID" value="KXA99971"/>
        <property type="gene ID" value="AKJ40_02120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="PTHR36536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="224" mass="25451" checksum="704D3A42AF41E903" modified="2016-07-06" version="1">MPSEKPLAWLGKRKEKRALNLSKKHLKKIVKTVELMKKTVHLFCENGEYIREKAEEVLDSERKADEIKDEILEELSKGSFAPLNREKIIRLIMTADDIADNARAAALKLTFLDPGSVNQELKESVKKLADFSYESTRLLKKSFSASLEDPSVVRKETGKVEKMEEKVDTFRAETLIPKLVKWADESHRPGTSILITEVENNIEDVVDRTEDCADVLREIAIGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0L7</accession>
    <name>A0A133V0L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99974">
        <property type="protein sequence ID" value="KXA99974"/>
        <property type="gene ID" value="AKJ40_02140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="118" mass="13438" checksum="4C31A76D34CC1725" modified="2016-07-06" version="1">MPEKATEEVTGRKDEKEKEELEPDIHITYKRIWAGDGRKDLAEVWTSVENAKGEKVNFTATPEAKFLPEQSTTEPLESNKERVTGVFRVDRYDEQGEIKIRVQVADVGKEATLSKDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0L9</accession>
    <name>A0A133V0L9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000024">
        <property type="protein sequence ID" value="KXA99973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXA99973">
        <property type="protein sequence ID" value="KXA99973"/>
        <property type="gene ID" value="AKJ40_02135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXA99973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="80" mass="9318" checksum="1DA64C19624CA128" modified="2016-07-06" version="1">MLIFTFPSDRFREVFDLRGTVKFFDERKNYGFIEPDEEAEDRFVHASEVETGTLNEGDIVEFDPEMGDKGPKAINVRKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0R8</accession>
    <name>A0A133V0R8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ald_Xan_dh_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000022">
        <property type="protein sequence ID" value="KXB00033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00033">
        <property type="protein sequence ID" value="KXB00033"/>
        <property type="gene ID" value="AKJ40_01980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.395"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="776" mass="85513" checksum="5E2F28921C99A08A" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0S3</accession>
    <name>A0A133V0S3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_02005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000022">
        <property type="protein sequence ID" value="KXB00038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00038">
        <property type="protein sequence ID" value="KXB00038"/>
        <property type="gene ID" value="AKJ40_02005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="38"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="248" mass="28189" checksum="8FEED1A225618581" modified="2016-07-06" version="1">MDYKIISLPIAESVGDLSQMTYVRNIGQGYTRNKYTRNNYIWYIDGPEKNIIVDTAGKAEALEKHNYPSKQINKPEEALEKVFLEPEDVDVVILTQAHFDHLQYAKKFPNAEFIIQEDELRTAKNPHPVFASIYEPIQPVLDEINFSVVEGNKEIVEGVSVMKSPGHTEGGQSVIVETEKGDAIITGLCVIDENFYPPEEVQQFLPVVPPAIHIDLKQAYDSMIEIKEKADIIVPLHEHKYTEIERIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0S4</accession>
    <name>A0A133V0S4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ40_02010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000022">
        <property type="protein sequence ID" value="KXB00039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00039">
        <property type="protein sequence ID" value="KXB00039"/>
        <property type="gene ID" value="AKJ40_02010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB00039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="326" mass="34594" checksum="70F2CF276F960442" modified="2016-07-06" version="1">MKNIVRILGTTLSVFVAGFIILAVFNFGTTAYTVLYGVLQFVGLALVWNLMFGKLNYVNFGTAGFFGTGGYITAYLLTKQITAFSLAKLFPAMIAGGLGAAGLGLVIALATMRLRGIYFAIATLAVAVVMMRVVQNTPALGAGHGLYFVPPSAPAIFSTLTELLVLVMFAVVLVAVAIIWYIDSSWIGDVFTAIGNDETAARAVGINTYRVKFSTATLHAFLFGLVGSSLVLFQTYIDPPSTFSINYSINAVAMPLLGGTGVWFGPIVGAVILATVREMMTLFWGSQYSQIIPGIVLIVVISAAPHGLTPYLQAAKRRITSIGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V0U3</accession>
    <name>A0A133V0U3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000021">
        <property type="protein sequence ID" value="KXB00064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00064">
        <property type="protein sequence ID" value="KXB00064"/>
        <property type="gene ID" value="AKJ40_01960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="186" mass="21074" checksum="CF4D06C51D0B6D39" modified="2016-07-06" version="1">MRILVEKNFEHEGETYEPGETVDLPEEVAERAIEKGAAKKVEDIEDEIEITPGGEVEPSEEEGFPEEVSMPAEEGRSEEDESDVWEELESELEEPSRSPAWRPEEVGDQLLGEVTRTGRGPNGRLLEVRTPEGEKYVLWEKVALKDLFDRVQAGDKIGVRFLGEEESSSGRSYYNYRTALKKGDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V136</accession>
    <name>A0A133V136_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000018">
        <property type="protein sequence ID" value="KXB00159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00159">
        <property type="protein sequence ID" value="KXB00159"/>
        <property type="gene ID" value="AKJ40_01810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="133" mass="15351" checksum="488D5CC2523F3CAB" modified="2016-07-06" version="1">MDYLEEDWKVKNSDYENRVNLNELLKKSVEDSENLADEKEVEIKLETIEEDMSIIGGLPPGKVFSALLRNNIRKSDCSELRILTEEKNGEIMVGVEDDGDRIPKKSRKNFPIRIMTVQPREWVEPSTLSPEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V158</accession>
    <name>A0A133V158_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RCK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000018">
        <property type="protein sequence ID" value="KXB00155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00155">
        <property type="protein sequence ID" value="KXB00155"/>
        <property type="gene ID" value="AKJ40_01790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="279"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="360" mass="39766" checksum="91C75B7DBD4135FA" modified="2016-07-06" version="1">MSPRCKRAEELDIDNCHEDYGGEKKYCLFHRPEKNYQDKIKFLNAIEEKADELKSVGEFRVSFIFKTSINFAGYIFPPMNFAYGGLEEDSLSFKKAEFRSGANSIGAVFEGKAEFQNASFHSTVSFTGVEFIGKANFRNTTFEAGAFFAGKSLEKKVTQFNDEAHFNEATFIGSANFDGVYFKKGAYFTKTKFKKSCLVYQTNAGIEEAESLVALTSNDETNLMVCKVAKDIASCRVIARVKKDEYADMYKDIGADIIVSAISSTVGLIEKAAVSSGLYGMITMGGKEGEVIEIKVSKNSEANGKAIKDLNLPKICTVGLIRREGELIAPRGDTVFEEGDQVILVGKSDEIISTIELFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V163</accession>
    <name>A0A133V163_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00187">
        <property type="protein sequence ID" value="KXB00187"/>
        <property type="gene ID" value="AKJ40_01685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="99" mass="11859" checksum="A83611365CEE63E9" modified="2016-07-06" version="1">MEGSVVIYQIRGLSQAEKAKFRRELYGYTDKSNRGQYEYYRPGLLDEVPYRKLIRGVLLIRKRDKEKISDFMEKYEAEVHIRNVELTREDTEILSSHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V165</accession>
    <name>A0A133V165_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000018">
        <property type="protein sequence ID" value="KXB00161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00161">
        <property type="protein sequence ID" value="KXB00161"/>
        <property type="gene ID" value="AKJ40_01780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="327" mass="37454" checksum="201BAB011894F961" modified="2016-07-06" version="1">MYAGVDVHKDYCHGVLMDENGEVFKEEDFDNSVKGVRRFFGGFESAQVVIEACYSWRPTLERLEEFGLEVKMAHPRKTKAIAEAEIKTDSIDATTLAHLLRARLIPESYVPPDDIRELRDKTRARAGLGKERTRMKNKIKAELEKNRITMDINPFTIKGKEKLRGFGVCTVKYYLEMLETIQEQIDEIETDFEEIAEKYEEAKLLMTIPGVGAFSALLILAEIGDIDRFPDPEKLCSYAGLVPKVHKSGNITRYGNIKKAGSKYLRWILVEDVWIHVGCADSQLTKYYRKKKREKGDGRMAAIATARKMLTAIYYMLKRGEEYRSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V178</accession>
    <name>A0A133V178_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00199">
        <property type="protein sequence ID" value="KXB00199"/>
        <property type="gene ID" value="AKJ40_01765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="101" mass="11239" checksum="6983D77D1B5C2CB3" modified="2016-07-06" version="1">MARTAKDEMLDVEKTVDGEAEYEIDSHETVEGNLKVEITVKEPNFTAEVEDPEISEIEDPEPGDVTTPYDYAHNELDTDGDFANKLRKGLEKIINGAGRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1A7</accession>
    <name>A0A133V1A7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000016">
        <property type="protein sequence ID" value="KXB00227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00227">
        <property type="protein sequence ID" value="KXB00227"/>
        <property type="gene ID" value="AKJ40_01655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="1085" mass="125684" checksum="0913C5656DC4AA1D" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1A8</accession>
    <name>A0A133V1A8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_01740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000017">
        <property type="protein sequence ID" value="KXB00201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00201">
        <property type="protein sequence ID" value="KXB00201"/>
        <property type="gene ID" value="AKJ40_01740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="116" mass="12823" checksum="A79AAFA40596374A" modified="2016-07-06" version="1">MKNQENVEPVAEPPKHPETDSWPLISPDTGGSENIMFQISETRPGGAALSHRHPNREHVFYVLSGHGTATVGDESFDVDPGDAYYVPKDVEHGIKSRTRETLKLIVVFFPAEGELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1C8</accession>
    <name>A0A133V1C8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000015">
        <property type="protein sequence ID" value="KXB00263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00263">
        <property type="protein sequence ID" value="KXB00263"/>
        <property type="gene ID" value="AKJ40_01605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="463" mass="51139" checksum="AF2F69ADA2E30CDA" modified="2016-07-06" version="1">MKRKVIEKLESIVGSDWVVVEEDQMQDYLIDETPEPVRPKPNPDVVVVKPEGVQEISEILKLANQESVPVVPRGGGTGLCGAAIPTKPSIILSLERLDDIIEIDRDNFTITCEAGVTLEKLLEELEETDDLFFPPHPGDEGAQVGGLVIENAGGARAVKYGVIRNFVKGLEIVLPTGEAMELGGKIIKNNTGLDLLDLVIGSEGILGIVTKVTFRLYPTPKERVSLVVPYGDRHSAVDTVPDMLREGLTPLSIEYMEEDLIERACEHLGEKWPVKTRGSAYLYIIVTGNDEEEAFSQCEKIGNICQEHGALDVVIADRRREQEKILNIRSNIYTALKPDSVDILDVTVPPAEIGKLMDEIEKIGEKYETYIPAYGHVADGNVHPHIMKEDGKTPPYMESMKEEIYSKTKELGGVITGEHGIGKTRIKNLPQAVGSKYIDLMKKIRKVFDPNNILNPGTVVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1G3</accession>
    <name>A0A133V1G3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000015">
        <property type="protein sequence ID" value="KXB00261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00261">
        <property type="protein sequence ID" value="KXB00261"/>
        <property type="gene ID" value="AKJ40_01615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.278"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="28"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="275" mass="29995" checksum="655CA9A9ABAD6C11" modified="2016-07-06" version="1">MGKGVEKRIVVPIKQVPDMDKVKFNKEEGRIDRSSADTEPNPFDLNALEEAVKFKEEFGGEIVAISMGPSQADSTLKEALARGADEAILLSDKFFGGADTWATAYTLSIGIKKLGNFDLILCGEKTVDGDTGQVGPEIAEILDIPHAAFVSEVLERNNDSIKVVSDAWGGSYVKKLEFPGVITVTKDVNVPRLPSLKDKMAARKAEIKLWGLDDFPEVEKDVVGIRGSPTSVNKIEIVPEPKREGKIFRDDISKSVDKLIGALKEDGVLNEVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1G5</accession>
    <name>A0A133V1G5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000015">
        <property type="protein sequence ID" value="KXB00255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00255">
        <property type="protein sequence ID" value="KXB00255"/>
        <property type="gene ID" value="AKJ40_01570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="137" mass="15877" checksum="1CA22E2B375AC8EC" modified="2016-07-06" version="1">MRELQRLRGDKKWPQAQARTRGFEKAFEEYSGLEIVKYWNEGGVMKKARDKMTQYLVAHGKPLIALGVNNTSEFRSYRSFESSRCLGALKPTLRACRCDGHWYHGPPSVTIMGLFLQFFKHFLKNSKTSGSSRYFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1G7</accession>
    <name>A0A133V1G7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_01510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000014">
        <property type="protein sequence ID" value="KXB00294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00294">
        <property type="protein sequence ID" value="KXB00294"/>
        <property type="gene ID" value="AKJ40_01510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="169"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="515" mass="59924" checksum="1FB9EEBE725B5AF8" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1K1</accession>
    <name>A0A133V1K1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000014">
        <property type="protein sequence ID" value="KXB00301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00301">
        <property type="protein sequence ID" value="KXB00301"/>
        <property type="gene ID" value="AKJ40_01560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="127" mass="14054" checksum="B400DCF0340D5729" modified="2016-07-06" version="1">MKKKKLILVGIVILALTFILFRGGSPATPRMTVSKLLESKNEMLGEKVQVDGTVLKIIRIDNRIIIGNKKNSKENLIIEIESVPPGTLTEDKPVAVTGYLRRENGYLILKRATVKTGCKSEYGGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1S4</accession>
    <name>A0A133V1S4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000012">
        <property type="protein sequence ID" value="KXB00375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00375">
        <property type="protein sequence ID" value="KXB00375"/>
        <property type="gene ID" value="AKJ40_01425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="81" mass="9735" checksum="7BBD0021EAB3866D" modified="2016-07-06" version="1">MTYADFKTRIENHRRKIRKTGEIIDENKELLTDFIRDQRINDLSDARIHKLLSHLRPVVRLLDKSFEETTEDDVKDIIAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1T9</accession>
    <name>A0A133V1T9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00417">
        <property type="protein sequence ID" value="KXB00417"/>
        <property type="gene ID" value="AKJ40_01330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="91" mass="10684" checksum="33FF025759130B97" modified="2016-07-06" version="1">MEGVDHLYLKYPVEYNLDTCSHREFLKLIFDLSVTFGFIKLNCVLIFGEFGGKGPDESDQMKLKFLDETLYDKFRKHQEICKGLTELKIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1U4</accession>
    <name>A0A133V1U4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_01345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00420">
        <property type="protein sequence ID" value="KXB00420"/>
        <property type="gene ID" value="AKJ40_01345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014948">
        <property type="entry name" value="BrxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023137">
        <property type="entry name" value="BrxA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08849">
        <property type="entry name" value="DUF1819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="255" mass="30216" checksum="AF551CFA851D49AC" modified="2016-07-06" version="1">MPSDRRYTANIHNTGSLIPESKKILKLYDKLRDVEEVREVLYKENPLSRESEGAIDKILFITRKRYLNDDPGPLIEVIKSDLNEQITNAILFYHLAKTDNLVYDLTTELLYNLHEEGTLVVNKKDVEDFLKKKEEKHPEISEWAITTRNKLIRHFLAAVKDFGLLEGSKRKKFSSYHLPSESFFYIFYRKFYDDETISEILSSKDWNLFFLDEEEIKAILNEGNRKRYIRFEESGNIRSVNPRFDSLEEYVNEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V1V8</accession>
    <name>A0A133V1V8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000011">
        <property type="protein sequence ID" value="KXB00419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00419">
        <property type="protein sequence ID" value="KXB00419"/>
        <property type="gene ID" value="AKJ40_01340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="160" mass="18347" checksum="BF3C7D00E4F3F83B" modified="2016-07-06" version="1">MVELRSEIIRRLEEYDLTNTKFFTDYGVEKFSNLFESSFSLAYHNAMCDSMIVSESELVPVDDFYTLYDLGPYVEQKVRQFLKDKDGYLKDISVELPEEVENPSDRFLNSSDSSINLGNMSEPGPDAEEEAIVQRIKNLACVYSAGIRNGEFRVGYYVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V218</accession>
    <name>A0A133V218_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000010">
        <property type="protein sequence ID" value="KXB00471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00471">
        <property type="protein sequence ID" value="KXB00471"/>
        <property type="gene ID" value="AKJ40_01270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="468"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="565" mass="62343" checksum="FA43537BE3E96C21" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2A2</accession>
    <name>A0A133V2A2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_01230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000009">
        <property type="protein sequence ID" value="KXB00526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00526">
        <property type="protein sequence ID" value="KXB00526"/>
        <property type="gene ID" value="AKJ40_01230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="111" mass="12718" checksum="F0DD017C8B6743FF" modified="2016-07-06" version="1">MFEAEETARVDAPRDLVWEWITDLGNFASQIPNATVVENGEREVTIRDSFHWVNFPPEIGEVDLKISKIEESDKVMRIKGGNRNPRHSNDGKGRRSGKRWNQSPYPIQVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2M4</accession>
    <name>A0A133V2M4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00681">
        <property type="protein sequence ID" value="KXB00681"/>
        <property type="gene ID" value="AKJ40_00850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="408" mass="46868" checksum="A1C4E8DF8545B36E" modified="2016-07-06" version="1">MPTREEHVEHCEELYGHGFEEIHEWMDGTVVSKGRGHREDRHDPGETPDKAYEIFEDKVPGDKKKFIKDAVKDHIELDMRSSGRKSQKKKLSEAERAALAEEVRKTVIGSLDDGECPYWIINQFYSSEKRDIAREILHEEGFCAEELKGTKKGAVKGAIRRIVEEGREPFVLFDLRVRMTKEGVPYYTYDSRLSAFLKEIVPEMGGEIFPARSSHLFLIVPPKAIPNQQSFSRKIKRVFGASEGIESNPYRAHLHNASEAVLGWVKERVEKDLEGFYPPEIPRKDRYPNFSGVAKAILYHKGFSESEIEKVEVYDKIRDRSDRRRWIIESILLTTPEPLPVSGIIDRFEERTDATITREYVEHVIRQGYGEAVGAQGGVKHFLDRGNPVFGKWKSGLGIIERKRGELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2P1</accession>
    <name>A0A133V2P1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00718">
        <property type="protein sequence ID" value="KXB00718"/>
        <property type="gene ID" value="AKJ40_00730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="134" mass="15865" checksum="B7CBF405F4EF86D0" modified="2016-07-06" version="1">MSGEWRFLCEDCKIEVNLPSEEQFSLQRISELSEDELRECSRSVERLKNLRKRVETEIPVLNRLGVLLSFFLEHHDHDTRLYRSDQNVETESLPWFEKWSWREDPNALKPTAVVKEGWERGLSLAEVMQNGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2P2</accession>
    <name>A0A133V2P2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000006">
        <property type="protein sequence ID" value="KXB00695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00695">
        <property type="protein sequence ID" value="KXB00695"/>
        <property type="gene ID" value="AKJ40_00930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.795"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="85" mass="9756" checksum="044342538101A83F" modified="2016-07-06" version="1">MIVRKVGPKGQVVIPSDIREMLGIRPGEQVVVEVDDGNVVIKRKEGSIADHMSQLVPEEKKRNIDEIDLDEYYESQIIRRQGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Q2</accession>
    <name>A0A133V2Q2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00719">
        <property type="protein sequence ID" value="KXB00719"/>
        <property type="gene ID" value="AKJ40_00735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="165" mass="19094" checksum="9341C0BED256C63F" modified="2016-07-06" version="1">MDPEPDFLIPVQGWRGSERKIALYLVSEEHASEDAFLSEVKSRALGVGSVKESHKKLEAVLVTDMHRNDEVSQQILELKSPPFFDEVFFDGELLDLAEYVKEEMKNKEGRFGLDVRCRECGKDDQVEVVQNGELRFHYECKRCNVTVKEKDQSKKQEIEGRKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2R2</accession>
    <name>A0A133V2R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000005">
        <property type="protein sequence ID" value="KXB00729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00729">
        <property type="protein sequence ID" value="KXB00729"/>
        <property type="gene ID" value="AKJ40_00790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="227" mass="27050" checksum="78398D5AFC48ADA7" modified="2016-07-06" version="1">MSDEEMKSIDEILQDEENPFNKLKTRLRLKFSSWKLIKMCQKWCLQCAGHWDNSDEINRYFFFSGAEREKAEELVERIQNTVERSRKIQIGKYRSDLEKDGRVPSGRTEALLKKAEANPYFTPHFLNDEAGVELTMSEVLILARNVCRVRTLDKRTDVFEDKLKEPARERLEKLWNRLLLVPKRKTASQKAYLKRFGIEKDWEASDFREPKFHGRSLFGEYYEEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2V8</accession>
    <name>A0A133V2V8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00787">
        <property type="protein sequence ID" value="KXB00787"/>
        <property type="gene ID" value="AKJ40_00395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="289" mass="33758" checksum="B672290C7F69AFD1" modified="2016-07-06" version="1" fragment="single">DWEEFHIMVRNDSNSSTNPWEDILIRAKFHGIEPENLQTEYEYNGAWNSAYEYDLRLLNSETIGSAVDLGPEEGYVIDPQTEKDLGFRVKADRPVENLRVEFQAITSNYSSENYVRKIKNPENTKLLNPVQDTYIDQQNPTTNYSEKRHLELTTQENNNSYALLKFENSNIPTSVDTAQLYLYQYWGSAFSDLKNSEVTVRIYTVPEDLNLESTTWKTGFEVSDEIVAEKEILGIREWYRFDLTDYFKSSTKDEATLLVKFSKDSFDNEERRIRFDSSEADRPPYLVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2W6</accession>
    <name>A0A133V2W6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00788">
        <property type="protein sequence ID" value="KXB00788"/>
        <property type="gene ID" value="AKJ40_00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="274" mass="31743" checksum="EE2C5320C7C55009" modified="2016-07-06" version="1">MPFAQKDPLPDPELLVPHQTKEVQELIDLVNEEDLVSFIVSEIGMGKTTLCEFLNQALPEKGEGDIVSVFLHGPSIESGEQMLRVILNRLELRVKEGDTADEFEQLRDWHENYPDFLLTIIIDEFPDISKNALNIVRSLVDLEGIVLILNGQENELLEFVEENAPALFERRRYILRLDPMNLEEIRELIMYRMAWARGGNYEARTIDPFTDEAIRVIYEKSEGVPRRALKLAGDAVYNMVEKDKQKIEPELVYEREKKKESSKSFWSFLPFVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2W7</accession>
    <name>A0A133V2W7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Digeranylgeranylglycerophospholipid reductase</fullName>
            <shortName evidence="8">DGGGPL reductase</shortName>
            <ecNumber evidence="8">1.3.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2,3-bis-O-geranylgeranylglyceryl phosphate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Geranylgeranyl reductase</fullName>
            <shortName evidence="8">GGR</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ40_00420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2</text>
            <dbReference type="Rhea" id="RHEA:64368"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:73125"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2</text>
            <dbReference type="Rhea" id="RHEA:64376"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:138139"/>
            <dbReference type="ChEBI" id="CHEBI:138140"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Reduction reaction proceeds via syn addition of hydrogen for double bonds.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00792">
        <property type="protein sequence ID" value="KXB00792"/>
        <property type="gene ID" value="AKJ40_00420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.353"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045550">
        <property type="term" value="F:geranylgeranyl reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046467">
        <property type="term" value="P:membrane lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01287">
        <property type="entry name" value="DGGGPL_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023590">
        <property type="entry name" value="DGGGPL_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="9">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="208"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="293"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB00792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="394" mass="42934" checksum="C29209FD1C867035" modified="2016-07-06" version="1">MPKSEYDVIVVGAGPAGATAAKAAAENGADVLMVDKRRELGVPVQCGEALSEEILKKLDIDPDPRWAINKINRAMLVSPSGKPVEIKQKKSAKIGYILDRKVFDKYLAILAIRSGADIRIDTFVNGLVKENGEINGVTLQGKKGEEIRSDLIIAADGVMSRVARWAGFDTTLGMEDIESGAQFKMVNVDVEEKSMMKFYFGNEIAPGGYIWIFPRGDDIANVGIGVMPKKAEKKSIEYLKDFISARPDLENGRIIEINVGGVPVSGPIEKTYGDDIMIVGDAARQVNALTGGGIDWSMHAGNIAGEVAARAVAEGDTSEGNLKEYEDRWRDEMGDSLNKYYKGKEVLMDLSDGDLDDLADSLQDVDFEKISLTSMLRVIMKANPKLMIKLRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Y8</accession>
    <name>A0A133V2Y8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor S</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transcription elongation factor IIS/RNA polymerase subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ40_00480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00800">
        <property type="protein sequence ID" value="KXB00800"/>
        <property type="gene ID" value="AKJ40_00480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB00800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="108" mass="12490" checksum="4901ABEBEA3A57DD" modified="2016-07-06" version="1">MNFCPECGNLMNPDKREEGVVLVCSNCGHEEKAGSDTDESYKMVKETKKKEKTAVVEKDQESLPKTSKKCPECGHGKAYWWMQQTRSADEPTTRFYRCVECGHTWREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V2Z5</accession>
    <name>A0A133V2Z5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ40_00535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00809">
        <property type="protein sequence ID" value="KXB00809"/>
        <property type="gene ID" value="AKJ40_00535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698270.3.peg.377"/>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB00809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="246" mass="26939" checksum="40E29102176726D9" modified="2016-07-06" version="1">MSLEKKAAKILKNSKFVVAFTGAGISTESGVPDFRGPGGIWEKYNPEMFTIQRLKSNPKEVWKKLLQIEEEFQKSEIEPNPGHLALAELEDMEILTGIITQNIDGLHQRAGNSPEKVIELHGNLRELECMNCGIHISRPVEIKEIPPTCTECGSIMKPATVLFGEKLPKSALMRAHSLAEKSDAFLVIGSSLRVQPAASFPAKASQTNADLIIVNKDSTPIDGKAEVVLKGLAGRILPEILKNIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V300</accession>
    <name>A0A133V300_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DHODB_Fe-S_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000003">
        <property type="protein sequence ID" value="KXB00811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00811">
        <property type="protein sequence ID" value="KXB00811"/>
        <property type="gene ID" value="AKJ40_00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHODB_Fe-S_bind" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="105" mass="11258" checksum="C01C623D47C7DD06" modified="2016-07-06" version="1" fragment="single">MNSCFTSGRVSFIIPKFAIFDFFVLVTGTEDGSAGIKGVTPDVVRKINLGDHYDSCLLCGPEEMMTSTADLIDKKGIPIQVSLNRYMKCGVGICGSCSLDPSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V307</accession>
    <name>A0A133V307_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ40_00290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00837">
        <property type="protein sequence ID" value="KXB00837"/>
        <property type="gene ID" value="AKJ40_00290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="127"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB00837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="387" mass="44743" checksum="E89E9D7AC2B4C009" modified="2016-07-06" version="1">MSKIFIMGAVGEMCIEATRDIVKTGDFDKFMLADKDGKKLKKLTEELDDVRIETMTLDATDKDAVAEAISGYNIVMDGLPFDKIEPTVRACLQEKIPHIDLISPLEVIDRYEKDFEENETLAVAGVGMTPGLTDLMARYGVERCDKVNEIYVYWAAYRPFAISPGLVMTTYWEMDPKTEERAYYENGEFHPQPPMQKSRTVRFEPPYEDLDVYHVPHPETFTLPKNVPEVEKVETMGTWPPQVMNMLKQMLDYGFFDTDKIEYKDEEYETLDLFAHILHQVPGGQETPLWGYALRVEVHGEKNDEKIKYILTHSHPAMEEWGGKRTYAKNVAIPMSIGAQMIQKGKIQANKGYHTAFETFKPEEFFQELKKRGIRVHVENWRHYDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V326</accession>
    <name>A0A133V326_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoCF_biosynth domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00844">
        <property type="protein sequence ID" value="KXB00844"/>
        <property type="gene ID" value="AKJ40_00350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="173"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="323" mass="35857" checksum="6F9EBB91B92F9D38" modified="2016-07-06" version="1">MKKMEISDSVGKKLAHDVIEYGPKQKRVLFERGHQIQESDIEKMKDSGNYFVFISEGKEEGVHEDEAASRMAEASVGKNLTVLRPRKGRVRILSEVPGLLKAKTEVIKEVNLTDPFIFALKGNNTGVRKREEVASAKIAPLVTEENKVKEIEELLERNKPVLEVVPPKVTKIGLIITGTEIYEGRIEDAFEPTLKEKLNKYGLEITKTTILPDEENKIKNKILEFHEKKYDLILVTGGMAVDSKDVTPSAIKKTGAEIISRGIPIFPGNMLMISKLGNSYILGIPACVLPDEKTSFDIILPRVLAKEKLNKEDIAGLGDGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V332</accession>
    <name>A0A133V332_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SER_THR_PHOSPHATASE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00843">
        <property type="protein sequence ID" value="KXB00843"/>
        <property type="gene ID" value="AKJ40_00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SER_THR_PHOSPHATASE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="270" mass="30771" checksum="1E7E12C1E19D2BED" modified="2016-07-06" version="1">MCKKIQDLVKDSKIIDLGERPKSVFVGDTHGDVEATRIIWDRFKEEVSDGETYLVFLGDYVDRGGHSQKNIDFLLSKKEKNPEGLVLLLGNHDAYHLRNLRPADFWQSLDENDYDFYKDLMHLPWLAKSEGLVAAHGALPFVSDLQELEHPTNDVFEKEDDFDIPIWISVTWGDLNRRVSGAQMDPLTGRPQFGKEVILQYLQKHDWNLLIRSHQPGMQGWSFSGNALTIFTSQAYVDMGRARERSIAIVDLENGVGGRDDVEVLGLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V336</accession>
    <name>A0A133V336_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ40_00385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000002">
        <property type="protein sequence ID" value="KXB00851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00851">
        <property type="protein sequence ID" value="KXB00851"/>
        <property type="gene ID" value="AKJ40_00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB00851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="174" mass="20356" checksum="9510307FD386CDE5" modified="2016-07-06" version="1">MNAIDKETKYNLNTKFIESRTNENFNEYFEELKNSIGQQIQEIYEKEKQKPPEDRNLVTFVTDELPQYENAFEKQLGHMADLDFGVPIAQRKYGLEHNNNPIERHNEDIKQRYKVMRNFKSYESAAAFLSLRRAIYNHVRPHQELGHTPGEEAGIDLGLGRNRLLDLIETSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V363</accession>
    <name>A0A133V363_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ40_00180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA259M10</name>
        <dbReference type="NCBI Taxonomy" id="1698270"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA259M10</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHXU01000001">
        <property type="protein sequence ID" value="KXB00888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB00888">
        <property type="protein sequence ID" value="KXB00888"/>
        <property type="gene ID" value="AKJ40_00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070341">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB00888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070341"/>
        </source>
    </evidence>
    <sequence length="59" mass="6994" checksum="F92730661E8CB57B" modified="2016-07-06" version="1">MKSAYRSQFFNPLPFNMHRVHANDATGLENSENLLQQTYFIIYLVKNIDEKNEIDLTIF</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>