Universal Protein Resource (UniProt) ==================================== The Universal Protein Resource (UniProt), a collaboration between the European Bioinformatics Institute (EBI), the SIB Swiss Institute of Bioinformatics, and the Protein Information Resource (PIR), is comprised of three databases, each optimized for different uses. The UniProt Knowledgebase (UniProtKB) is the central access point for extensively curated protein information, including function, classification and cross-references. The UniProt Reference Clusters (UniRef) combine closely related sequences into a single record to speed up sequence similarity searches. The UniProt Archive (UniParc) is a comprehensive repository of all protein sequences, consisting only of unique identifiers and sequences. The UniProt Knowledgebase (UniProtKB) has been created from Swiss-Prot, TrEMBL and PIR-PSD. It consists of two parts, one containing fully manually annotated records and another one with computationally analysed records awaiting full manual annotation. The two sections will be referred to as the Swiss-Prot section of the UniProt Knowledgebase (UniProtKB/Swiss-Prot) and TrEMBL section of the UniProt Knowledgebase (UniProtKB/TrEMBL), respectively. PIR-PSD release 80.0 of 31-Dec-2004 has been fully integrated into these sections. This was the last release of PIR-PSD. This directory contains the following subdirectories: 1) Directory /current_release/knowledgebase subdirectory /complete: This directory contains the eight-weekly updates of the UniProt Knowledgebase, consisting of UniProtKB/Swiss-Prot (fully annotated curated entries) and UniProtKB/TrEMBL (computer-generated entries enriched with automated classification and annotation). Both, UniProtKB/Swiss-Prot and UniProtKB/TrEMBL, are available separately in flat file, XML and FASTA format. subdirectory /complete/docs: This directory contains various UniProt documents. subdirectory /genome_annotation_tracks: This directory contains the genome annotation tracks files which are updated in conjunction with UniProtKB. subdirectory /idmapping: This directory contains the idmapping data files which are updated in conjunction with UniProtKB. subdirectory /pan_proteomes: This directory contains the pan proteomes data files which are updated in conjunction with UniProtKB. subdirectory /proteomics_mapping: This directory contains the proteomics mapping files which are updated in conjunction with UniProtKB. subdirectory /reference_proteomes: This directory contains the reference proteomes data files which are updated in conjunction with UniProtKB. subdirectory /taxonomic_divisions: This directory contains the same data as provided in the /complete subdirectory, split into taxonomic divisions. subdirectory /variants: This directory contains the variants data files which are updated in conjunction with UniProtKB. 2) Directory /current_release/uniref This directory contains the eight-weekly updates of the UniProt Reference Clusters (UniRef). There is a subdirectory for each of the three UniRef databases (which are based on different sequence identity cut-offs): uniref100 (100%), uniref90 (90%) and uniref50 (50%). 3) Directory /current_release/rdf This directory contains UniProt data sets in RDF format. The data found in this directory is a PREVIEW and may CHANGE or be DISCONTINUED at any moment. 4) Directory /current_release/decoy This directory contains the decoy versions of UniProtKB/Swiss-Prot, UniProtKB/TrEMBL and UniRef. 5) Directory /current_release/uniparc This directory contains the eight-weekly update of UniParc, the UniProt Archive of sequences from UniProtKB and many other databases. -------------------------------------------------------------------------------- LICENSE -------------------------------------------------------------------------------- We have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) to all copyrightable parts of our databases. (c) 2002-2022 UniProt Consortium -------------------------------------------------------------------------------- DISCLAIMER -------------------------------------------------------------------------------- We make no warranties regarding the correctness of the data, and disclaim liability for damages resulting from its use. We cannot provide unrestricted permission regarding the use of the data, as some data may be covered by patents or other rights. Any medical or genetic information is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.